TBPL1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TBPL1
Entrez Gene ID	9519
Full Name	TATA-box binding protein like 1
Synonyms	MGC:8389,MGC:9620,STUD,TLF,TLP,TRF2
General protein information	Preferred Names TATA-box binding protein like 1 Names TATA box-binding protein-like protein 1 21-kDA TBP-like protein TATA box-binding protein-related factor 2 TBP-like 1 TBP-related factor 2 TBP-related protein second TBP of unique DNA protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6q23.2
Summary	This gene encodes a member of the TATA box-binding protein family. TATA box-binding proteins play a critical role in transcription by RNA polymerase II as components of the transcription factor IID (TFIID) complex. The encoded protein does not bind to the TATA box and initiates transcription from TATA-less promoters. This gene plays a critical role in spermatogenesis, and single nucleotide polymorphisms in this gene may be associated with male infertility. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3. [provided by RefSeq, Nov 2011].
Disorder MIM:	605521

mRNA and Protein(s)

mRNA	Protein	Name
XM_017011513.1	XP_016867002.1	TATA box-binding protein-like protein 1 isoform X1
NM_001253676.1	NP_001240605.1	TATA box-binding protein-like protein 1
XM_024446592.1	XP_024302360.1	TATA box-binding protein-like protein 1 isoform X1
NM_004865.4	NP_004856.1	TATA box-binding protein-like protein 1
NM_004865.3	NP_004856.1	TATA box-binding protein-like protein 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	TBPL1	NP_001092762.1
Bos taurus (cattle)	TBPL1	NP_001069758.1
Mus musculus (house mouse)	Tbpl1	NP_035733.1
Homo sapiens (human)	TBPL1	NP_001240605.1
Gallus gallus (chicken)	TBPL1	NP_990086.1
Danio rerio (zebrafish)	tbpl1	NP_991285.1
Canis lupus familiaris (dog)	TBPL1	NP_001239188.1
Rattus norvegicus (Norway rat)	Tbpl1	NP_001120673.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007517	XP_308361.4
Caenorhabditis elegans (roundworm)	tlf-1	NP_492356.1
Xenopus tropicalis (tropical clawed frog)	tbpl1	NP_001004932.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

TBP-like Protein (TLP) Disrupts the p53-MDM2 Interaction and Induces Long-lasting p53 Activation.
Maeda R, Tamashiro H, Takano K, Takahashi H, Suzuki H, Saito S, Kojima W, Adachi N, Ura K, Endo T, Tamura TA
The Journal of biological chemistry292(8)3201-3212(2017 02)

Ubiquitin-proteasome-dependent degradation of TBP-like protein is prevented by direct binding of TFIIA.
Isogai M, Suzuki H, Maeda R, Tamura TA
Genes to cells : devoted to molecular & cellular mechanisms21(11)1223-1232(2016 Nov)

Tumor suppressor microRNA-18a regulates tumor proliferation and invasion by targeting TBPL1 in colorectal cancer cells.
Liu G, Liu Y, Yang Z, Wang J, Li D, Zhang X
Molecular medicine reports12(5)7643-8(2015 Nov)

MiR-133b acts as a tumor suppressor and negatively regulates TBPL1 in colorectal cancer cells.
Xiang KM, Li XR
Asian Pacific journal of cancer prevention : APJCP15(8)3767-72(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TLP Prevents p53 Degradation through Disrupting the p53-MDM2 Interaction.
Title: TBP-like Protein (TLP) Disrupts the p53-MDM2 Interaction and Induces Long-lasting p53 Activation.

The interaction of TBP-like protein with TFIIA is essential to suppress proteasome-dependent turnover of TBP-like protein
Title: Ubiquitin-proteasome-dependent degradation of TBP-like protein is prevented by direct binding of TFIIA.

miR18a exhibits a protective role in colorectal cancer (CRC) via inhibiting proliferation, invasion and migration of CRC cells by directly targeting the TBPL1 gene.
Title: Tumor suppressor microRNA-18a regulates tumor proliferation and invasion by targeting TBPL1 in colorectal cancer cells.

results suggest that activation of the p21 upstream promoter is mediated by interaction between specific regions of TLP and p53
Title: Interaction between transactivation domain of p53 and middle part of TBP-like protein (TLP) is involved in TLP-stimulated and p53-activated transcription from the p21 upstream promoter.

Western blotting and immunohistochemistry both indicated a higher TBPL1 protein expression level in colorectal cancer tissue. siRNA for TBPL1 transfection obviously slowed down the cell proliferation in both SW-620 and HT-29 cells.
Title: MiR-133b acts as a tumor suppressor and negatively regulates TBPL1 in colorectal cancer cells.

The following TBPL1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TBPL1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu04662	NM_001253676.1 Latest version!	Homo sapiens TATA-box binding protein like 1 (TBPL1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu04662	NM_004865.4 Latest version!	Homo sapiens TATA-box binding protein like 1 (TBPL1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu04662	XM_024446592.1 Latest version!	Homo sapiens TATA-box binding protein like 1 (TBPL1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu04662	XM_017011513.1 Latest version!	Homo sapiens TATA-box binding protein like 1 (TBPL1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu04662	NM_004865.3	Homo sapiens TATA-box binding protein like 1 (TBPL1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TBPL1 ( NM_001253676.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001240605.1 Homo sapiens TATA-box binding protein like 1 (TBPL1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu04662
Clone ID Related Accession (Same CDS sequence)	XM_017011513.1 , NM_001253676.1 , XM_024446592.1 , NM_004865.4 , NM_004865.3
Accession Version	NM_001253676.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 561bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	TATA box-binding protein-like protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI828497.1, AK292320.1, AI187713.1 and R42082.1. This sequence is a reference standard in the RefSeqGene project. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.219187.1, SRR1660809.242937.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATGCAG ACAGTGATGT TGCATTGGAC ATTCTAATTA CAAATGTAGT CTGTGTTTTT 
AGAACAAGAT GTCATTTAAA CTTAAGGAAG ATTGCTTTGG AAGGAGCAAA TGTAATTTAT 
AAACGTGATG TTGGAAAAGT ATTAATGAAG CTTAGAAAAC CTAGAATTAC AGCTACAATT 
TGGTCCTCAG GAAAAATTAT TTGCACTGGA GCAACAAGTG AAGAAGAAGC TAAATTTGGT 
GCCAGACGCT TAGCCCGTAG TCTGCAGAAA CTAGGTTTTC AGGTAATATT TACAGATTTT 
AAGGTTGTTA ACGTTCTGGC AGTGTGTAAC ATGCCATTTG AAATCCGTTT GCCAGAATTC 
ACAAAGAACA ATAGACCTCA TGCCAGTTAC GAACCTGAAC TTCATCCTGC TGTGTGCTAT 
CGGATAAAAT CTCTAAGAGC TACATTACAG ATTTTTTCAA CAGGAAGTAT CACAGTAACA 
GGGCCCAATG TAAAGGCTGT TGCTACTGCT GTGGAACAGA TTTACCCATT TGTGTTTGAA 
AGCAGGAAAG AAATTTTATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001240605.1
CDS	606..1166
Translation	MDADSDVALDILITNVVCVFRTRCHLNLRKIALEGANVIYKRDVGKVLMKLRKPRITATIWSSGKIICTGATSEEEAKFGARRLARSLQKLGFQVIFTDFKVVNVLAVCNMPFEIRLPEFTKNNRPHASYEPELHPAVCYRIKSLRATLQIFSTGSITVTGPNVKAVATAVEQIYPFVFESRKEIL

Target ORF information:

RefSeq Version	NM_001253676.1
Organism	Homo sapiens(human)
Definition	Homo sapiens TATA-box binding protein like 1 (TBPL1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001253676.1

ORF Insert Sequence:

ATGGATGCAG ACAGTGATGT TGCATTGGAC ATTCTAATTA CAAATGTAGT CTGTGTTTTT 
AGAACAAGAT GTCATTTAAA CTTAAGGAAG ATTGCTTTGG AAGGAGCAAA TGTAATTTAT 
AAACGTGATG TTGGAAAAGT ATTAATGAAG CTTAGAAAAC CTAGAATTAC AGCTACAATT 
TGGTCCTCAG GAAAAATTAT TTGCACTGGA GCAACAAGTG AAGAAGAAGC TAAATTTGGT 
GCCAGACGCT TAGCCCGTAG TCTGCAGAAA CTAGGTTTTC AGGTAATATT TACAGATTTT 
AAGGTTGTTA ACGTTCTGGC AGTGTGTAAC ATGCCATTTG AAATCCGTTT GCCAGAATTC 
ACAAAGAACA ATAGACCTCA TGCCAGTTAC GAACCTGAAC TTCATCCTGC TGTGTGCTAT 
CGGATAAAAT CTCTAAGAGC TACATTACAG ATTTTTTCAA CAGGAAGTAT CACAGTAACA 
GGGCCCAATG TAAAGGCTGT TGCTACTGCT GTGGAACAGA TTTACCCATT TGTGTTTGAA 
AGCAGGAAAG AAATTTTATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TBPL1 ( NM_004865.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004856.1 Homo sapiens TATA-box binding protein like 1 (TBPL1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu04662
Clone ID Related Accession (Same CDS sequence)	XM_017011513.1 , NM_001253676.1 , XM_024446592.1 , NM_004865.4 , NM_004865.3
Accession Version	NM_004865.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 561bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Homo sapiens(human)
Product	TATA box-binding protein-like protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI560657.1, BC017559.2, R42082.1 and AL035699.4. On Nov 22, 2018 this sequence version replaced NM_004865.3. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.187292.1, SRR1803617.34051.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000237264.9/ ENSP00000237264.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGATGCAG ACAGTGATGT TGCATTGGAC ATTCTAATTA CAAATGTAGT CTGTGTTTTT 
AGAACAAGAT GTCATTTAAA CTTAAGGAAG ATTGCTTTGG AAGGAGCAAA TGTAATTTAT 
AAACGTGATG TTGGAAAAGT ATTAATGAAG CTTAGAAAAC CTAGAATTAC AGCTACAATT 
TGGTCCTCAG GAAAAATTAT TTGCACTGGA GCAACAAGTG AAGAAGAAGC TAAATTTGGT 
GCCAGACGCT TAGCCCGTAG TCTGCAGAAA CTAGGTTTTC AGGTAATATT TACAGATTTT 
AAGGTTGTTA ACGTTCTGGC AGTGTGTAAC ATGCCATTTG AAATCCGTTT GCCAGAATTC 
ACAAAGAACA ATAGACCTCA TGCCAGTTAC GAACCTGAAC TTCATCCTGC TGTGTGCTAT 
CGGATAAAAT CTCTAAGAGC TACATTACAG ATTTTTTCAA CAGGAAGTAT CACAGTAACA 
GGGCCCAATG TAAAGGCTGT TGCTACTGCT GTGGAACAGA TTTACCCATT TGTGTTTGAA 
AGCAGGAAAG AAATTTTATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004856.1
CDS	247..807
Translation	MDADSDVALDILITNVVCVFRTRCHLNLRKIALEGANVIYKRDVGKVLMKLRKPRITATIWSSGKIICTGATSEEEAKFGARRLARSLQKLGFQVIFTDFKVVNVLAVCNMPFEIRLPEFTKNNRPHASYEPELHPAVCYRIKSLRATLQIFSTGSITVTGPNVKAVATAVEQIYPFVFESRKEIL

Target ORF information:

RefSeq Version	NM_004865.4
Organism	Homo sapiens(human)
Definition	Homo sapiens TATA-box binding protein like 1 (TBPL1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004865.4

ORF Insert Sequence:

ATGGATGCAG ACAGTGATGT TGCATTGGAC ATTCTAATTA CAAATGTAGT CTGTGTTTTT 
AGAACAAGAT GTCATTTAAA CTTAAGGAAG ATTGCTTTGG AAGGAGCAAA TGTAATTTAT 
AAACGTGATG TTGGAAAAGT ATTAATGAAG CTTAGAAAAC CTAGAATTAC AGCTACAATT 
TGGTCCTCAG GAAAAATTAT TTGCACTGGA GCAACAAGTG AAGAAGAAGC TAAATTTGGT 
GCCAGACGCT TAGCCCGTAG TCTGCAGAAA CTAGGTTTTC AGGTAATATT TACAGATTTT 
AAGGTTGTTA ACGTTCTGGC AGTGTGTAAC ATGCCATTTG AAATCCGTTT GCCAGAATTC 
ACAAAGAACA ATAGACCTCA TGCCAGTTAC GAACCTGAAC TTCATCCTGC TGTGTGCTAT 
CGGATAAAAT CTCTAAGAGC TACATTACAG ATTTTTTCAA CAGGAAGTAT CACAGTAACA 
GGGCCCAATG TAAAGGCTGT TGCTACTGCT GTGGAACAGA TTTACCCATT TGTGTTTGAA 
AGCAGGAAAG AAATTTTATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TBPL1 ( NM_004865.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004856.1 Homo sapiens TATA-box binding protein like 1 (TBPL1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu04662
Clone ID Related Accession (Same CDS sequence)	XM_017011513.1 , NM_001253676.1 , XM_024446592.1 , NM_004865.4 , NM_004865.3
Accession Version	NM_004865.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 561bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	TATA box-binding protein-like protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI560657.1, BC017559.2 and R42082.1. On Nov 30, 2011 this sequence version replaced NM_004865.2. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.386513.1, SRR1803617.36878.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATGCAG ACAGTGATGT TGCATTGGAC ATTCTAATTA CAAATGTAGT CTGTGTTTTT 
AGAACAAGAT GTCATTTAAA CTTAAGGAAG ATTGCTTTGG AAGGAGCAAA TGTAATTTAT 
AAACGTGATG TTGGAAAAGT ATTAATGAAG CTTAGAAAAC CTAGAATTAC AGCTACAATT 
TGGTCCTCAG GAAAAATTAT TTGCACTGGA GCAACAAGTG AAGAAGAAGC TAAATTTGGT 
GCCAGACGCT TAGCCCGTAG TCTGCAGAAA CTAGGTTTTC AGGTAATATT TACAGATTTT 
AAGGTTGTTA ACGTTCTGGC AGTGTGTAAC ATGCCATTTG AAATCCGTTT GCCAGAATTC 
ACAAAGAACA ATAGACCTCA TGCCAGTTAC GAACCTGAAC TTCATCCTGC TGTGTGCTAT 
CGGATAAAAT CTCTAAGAGC TACATTACAG ATTTTTTCAA CAGGAAGTAT CACAGTAACA 
GGGCCCAATG TAAAGGCTGT TGCTACTGCT GTGGAACAGA TTTACCCATT TGTGTTTGAA 
AGCAGGAAAG AAATTTTATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004856.1
CDS	308..868
Translation	MDADSDVALDILITNVVCVFRTRCHLNLRKIALEGANVIYKRDVGKVLMKLRKPRITATIWSSGKIICTGATSEEEAKFGARRLARSLQKLGFQVIFTDFKVVNVLAVCNMPFEIRLPEFTKNNRPHASYEPELHPAVCYRIKSLRATLQIFSTGSITVTGPNVKAVATAVEQIYPFVFESRKEIL

Target ORF information:

RefSeq Version	NM_004865.3
Organism	Homo sapiens(human)
Definition	Homo sapiens TATA-box binding protein like 1 (TBPL1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004865.3

ORF Insert Sequence:

ATGGATGCAG ACAGTGATGT TGCATTGGAC ATTCTAATTA CAAATGTAGT CTGTGTTTTT 
AGAACAAGAT GTCATTTAAA CTTAAGGAAG ATTGCTTTGG AAGGAGCAAA TGTAATTTAT 
AAACGTGATG TTGGAAAAGT ATTAATGAAG CTTAGAAAAC CTAGAATTAC AGCTACAATT 
TGGTCCTCAG GAAAAATTAT TTGCACTGGA GCAACAAGTG AAGAAGAAGC TAAATTTGGT 
GCCAGACGCT TAGCCCGTAG TCTGCAGAAA CTAGGTTTTC AGGTAATATT TACAGATTTT 
AAGGTTGTTA ACGTTCTGGC AGTGTGTAAC ATGCCATTTG AAATCCGTTT GCCAGAATTC 
ACAAAGAACA ATAGACCTCA TGCCAGTTAC GAACCTGAAC TTCATCCTGC TGTGTGCTAT 
CGGATAAAAT CTCTAAGAGC TACATTACAG ATTTTTTCAA CAGGAAGTAT CACAGTAACA 
GGGCCCAATG TAAAGGCTGT TGCTACTGCT GTGGAACAGA TTTACCCATT TGTGTTTGAA 
AGCAGGAAAG AAATTTTATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TBPL1 ( XM_017011513.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016867002.1 Homo sapiens TATA-box binding protein like 1 (TBPL1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu04662
Clone ID Related Accession (Same CDS sequence)	XM_017011513.1 , NM_001253676.1 , XM_024446592.1 , NM_004865.4 , NM_004865.3
Accession Version	XM_017011513.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 561bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	TATA box-binding protein-like protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGATGCAG ACAGTGATGT TGCATTGGAC ATTCTAATTA CAAATGTAGT CTGTGTTTTT 
AGAACAAGAT GTCATTTAAA CTTAAGGAAG ATTGCTTTGG AAGGAGCAAA TGTAATTTAT 
AAACGTGATG TTGGAAAAGT ATTAATGAAG CTTAGAAAAC CTAGAATTAC AGCTACAATT 
TGGTCCTCAG GAAAAATTAT TTGCACTGGA GCAACAAGTG AAGAAGAAGC TAAATTTGGT 
GCCAGACGCT TAGCCCGTAG TCTGCAGAAA CTAGGTTTTC AGGTAATATT TACAGATTTT 
AAGGTTGTTA ACGTTCTGGC AGTGTGTAAC ATGCCATTTG AAATCCGTTT GCCAGAATTC 
ACAAAGAACA ATAGACCTCA TGCCAGTTAC GAACCTGAAC TTCATCCTGC TGTGTGCTAT 
CGGATAAAAT CTCTAAGAGC TACATTACAG ATTTTTTCAA CAGGAAGTAT CACAGTAACA 
GGGCCCAATG TAAAGGCTGT TGCTACTGCT GTGGAACAGA TTTACCCATT TGTGTTTGAA 
AGCAGGAAAG AAATTTTATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016867002.1
CDS	881..1441
Translation	MDADSDVALDILITNVVCVFRTRCHLNLRKIALEGANVIYKRDVGKVLMKLRKPRITATIWSSGKIICTGATSEEEAKFGARRLARSLQKLGFQVIFTDFKVVNVLAVCNMPFEIRLPEFTKNNRPHASYEPELHPAVCYRIKSLRATLQIFSTGSITVTGPNVKAVATAVEQIYPFVFESRKEIL

Target ORF information:

RefSeq Version	XM_017011513.1
Organism	Homo sapiens(human)
Definition	Homo sapiens TATA-box binding protein like 1 (TBPL1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017011513.1

ORF Insert Sequence:

ATGGATGCAG ACAGTGATGT TGCATTGGAC ATTCTAATTA CAAATGTAGT CTGTGTTTTT 
AGAACAAGAT GTCATTTAAA CTTAAGGAAG ATTGCTTTGG AAGGAGCAAA TGTAATTTAT 
AAACGTGATG TTGGAAAAGT ATTAATGAAG CTTAGAAAAC CTAGAATTAC AGCTACAATT 
TGGTCCTCAG GAAAAATTAT TTGCACTGGA GCAACAAGTG AAGAAGAAGC TAAATTTGGT 
GCCAGACGCT TAGCCCGTAG TCTGCAGAAA CTAGGTTTTC AGGTAATATT TACAGATTTT 
AAGGTTGTTA ACGTTCTGGC AGTGTGTAAC ATGCCATTTG AAATCCGTTT GCCAGAATTC 
ACAAAGAACA ATAGACCTCA TGCCAGTTAC GAACCTGAAC TTCATCCTGC TGTGTGCTAT 
CGGATAAAAT CTCTAAGAGC TACATTACAG ATTTTTTCAA CAGGAAGTAT CACAGTAACA 
GGGCCCAATG TAAAGGCTGT TGCTACTGCT GTGGAACAGA TTTACCCATT TGTGTTTGAA 
AGCAGGAAAG AAATTTTATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TBPL1 ( XM_024446592.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024302360.1 Homo sapiens TATA-box binding protein like 1 (TBPL1), transcript variant X1, mRNA.

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CloneID	OHu04662
Clone ID Related Accession (Same CDS sequence)	XM_017011513.1 , NM_001253676.1 , XM_024446592.1 , NM_004865.4 , NM_004865.3
Accession Version	XM_024446592.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 561bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	TATA box-binding protein-like protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGATGCAG ACAGTGATGT TGCATTGGAC ATTCTAATTA CAAATGTAGT CTGTGTTTTT 
AGAACAAGAT GTCATTTAAA CTTAAGGAAG ATTGCTTTGG AAGGAGCAAA TGTAATTTAT 
AAACGTGATG TTGGAAAAGT ATTAATGAAG CTTAGAAAAC CTAGAATTAC AGCTACAATT 
TGGTCCTCAG GAAAAATTAT TTGCACTGGA GCAACAAGTG AAGAAGAAGC TAAATTTGGT 
GCCAGACGCT TAGCCCGTAG TCTGCAGAAA CTAGGTTTTC AGGTAATATT TACAGATTTT 
AAGGTTGTTA ACGTTCTGGC AGTGTGTAAC ATGCCATTTG AAATCCGTTT GCCAGAATTC 
ACAAAGAACA ATAGACCTCA TGCCAGTTAC GAACCTGAAC TTCATCCTGC TGTGTGCTAT 
CGGATAAAAT CTCTAAGAGC TACATTACAG ATTTTTTCAA CAGGAAGTAT CACAGTAACA 
GGGCCCAATG TAAAGGCTGT TGCTACTGCT GTGGAACAGA TTTACCCATT TGTGTTTGAA 
AGCAGGAAAG AAATTTTATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024302360.1
CDS	778..1338
Translation	MDADSDVALDILITNVVCVFRTRCHLNLRKIALEGANVIYKRDVGKVLMKLRKPRITATIWSSGKIICTGATSEEEAKFGARRLARSLQKLGFQVIFTDFKVVNVLAVCNMPFEIRLPEFTKNNRPHASYEPELHPAVCYRIKSLRATLQIFSTGSITVTGPNVKAVATAVEQIYPFVFESRKEIL

Target ORF information:

RefSeq Version	XM_024446592.1
Organism	Homo sapiens(human)
Definition	Homo sapiens TATA-box binding protein like 1 (TBPL1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024446592.1

ORF Insert Sequence:

ATGGATGCAG ACAGTGATGT TGCATTGGAC ATTCTAATTA CAAATGTAGT CTGTGTTTTT 
AGAACAAGAT GTCATTTAAA CTTAAGGAAG ATTGCTTTGG AAGGAGCAAA TGTAATTTAT 
AAACGTGATG TTGGAAAAGT ATTAATGAAG CTTAGAAAAC CTAGAATTAC AGCTACAATT 
TGGTCCTCAG GAAAAATTAT TTGCACTGGA GCAACAAGTG AAGAAGAAGC TAAATTTGGT 
GCCAGACGCT TAGCCCGTAG TCTGCAGAAA CTAGGTTTTC AGGTAATATT TACAGATTTT 
AAGGTTGTTA ACGTTCTGGC AGTGTGTAAC ATGCCATTTG AAATCCGTTT GCCAGAATTC 
ACAAAGAACA ATAGACCTCA TGCCAGTTAC GAACCTGAAC TTCATCCTGC TGTGTGCTAT 
CGGATAAAAT CTCTAAGAGC TACATTACAG ATTTTTTCAA CAGGAAGTAT CACAGTAACA 
GGGCCCAATG TAAAGGCTGT TGCTACTGCT GTGGAACAGA TTTACCCATT TGTGTTTGAA 
AGCAGGAAAG AAATTTTATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

TBP-like Protein (TLP) Disrupts the p53-MDM2 Interaction and Induces Long-lasting p53 Activation.
The Journal of biological chemistry292(8)3201-3212(2017 02)
Maeda R,Tamashiro H,Takano K,Takahashi H,Suzuki H,Saito S,Kojima W,Adachi N,Ura K,Endo T,Tamura TA

Ubiquitin-proteasome-dependent degradation of TBP-like protein is prevented by direct binding of TFIIA.
Genes to cells : devoted to molecular & cellular mechanisms21(11)1223-1232(2016 Nov)
Isogai M,Suzuki H,Maeda R,Tamura TA

Tumor suppressor microRNA-18a regulates tumor proliferation and invasion by targeting TBPL1 in colorectal cancer cells.
Molecular medicine reports12(5)7643-8(2015 Nov)
Liu G,Liu Y,Yang Z,Wang J,Li D,Zhang X

MiR-133b acts as a tumor suppressor and negatively regulates TBPL1 in colorectal cancer cells.
Asian Pacific journal of cancer prevention : APJCP15(8)3767-72(2014)
Xiang KM,Li XR

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TBPL1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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