Itpka cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Itpka
Entrez Gene ID	228550
Full Name	inositol 1,4,5-trisphosphate 3-kinase A
General protein information	Preferred Names inositol 1,4,5-trisphosphate 3-kinase A Names inositol-trisphosphate 3-kinase A IP3 3-kinase A IP3-kinase A IP3K A insP 3-kinase A
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 2 Map Location: 2\|2 E5

mRNA and Protein(s)

mRNA	Protein	Name
NM_146125.2	NP_666237.1	inositol-trisphosphate 3-kinase A

Pathways from BioSystems

Homologies

Bos taurus (cattle)	ITPKA	NP_001076988.1
Xenopus tropicalis (tropical clawed frog)	LOC100486229	XP_002935396.2
	ITPKA	XP_001099176.2
Rattus norvegicus (Norway rat)	Itpka	NP_112307.2
Danio rerio (zebrafish)	LOC564528	XP_692949.1
Homo sapiens (human)	ITPKA	NP_002211.1
Pan troglodytes (chimpanzee)	ITPKA	XP_001149577.1
Canis lupus familiaris (dog)	ITPKA	XP_544631.3
Mus musculus (house mouse)	Itpka	NP_666237.1
Gallus gallus (chicken)	ITPKA	NP_990212.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002194	XP_565625.4

Gene Ontology
Bibliography

Related articles in PubMed

The role of inositol 1,4,5-trisphosphate 3-kinase A in regulating emotional behavior and amygdala function.
Chung S, Kim IH, Lee D, Park K, Kim JY, Lee YK, Kim EJ, Lee HW, Choi JS, Son GH, Sun W, Shin KS, Kim H
Scientific reports623757(2016 Apr)

Inositol-1,4,5-trisphosphate 3-kinase A regulates dendritic morphology and shapes synaptic Ca2+ transients.
Windhorst S, Minge D, B?hring R, H?ser S, Schob C, Blechner C, Lin HY, Mayr GW, Kindler S
Cellular signalling24(3)750-7(2012 Mar)

Inositol 1,4,5-trisphosphate 3-kinase-A is a new cell motility-promoting protein that increases the metastatic potential of tumor cells by two functional activities.
Windhorst S, Fliegert R, Blechner C, M?llmann K, Hosseini Z, G?nther T, Eiben M, Chang L, Lin HY, Fanick W, Schumacher U, Brandt B, Mayr GW
The Journal of biological chemistry285(8)5541-54(2010 Feb)

Inositol 1,4,5-trisphosphate 3-kinase a functions as a scaffold for synaptic Rac signaling.
Kim IH, Park SK, Hong ST, Jo YS, Kim EJ, Park EH, Han SB, Shin HS, Sun W, Kim HT, Soderling SH, Kim H
The Journal of neuroscience : the official journal of the Society for Neuroscience29(44)14039-49(2009 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Findings demonstrate that IP3K-A plays an important role in regulating affective states by modulating metabotropic receptor signaling pathways and neural activity in the amygdala.
Title: The role of inositol 1,4,5-trisphosphate 3-kinase A in regulating emotional behavior and amygdala function.

At synapses of Inositol-1,4,5-trisphosphate 3-kinase-A deficient neurons the levels of Ins(1,4,5)P3-5-phosphatase (inpp5a) and sarcoplasmic/endoplasmic reticulum calcium ATPase pump-2b (serca2b) were increased.
Title: Inositol-1,4,5-trisphosphate 3-kinase A regulates dendritic morphology and shapes synaptic Ca2+ transients.

Inositol 1,4,5-trisphosphate 3-kinase-A is a new cell motility-promoting protein that increases the metastatic potential of tumor cells by two functional activities.
Title: Inositol 1,4,5-trisphosphate 3-kinase-A is a new cell motility-promoting protein that increases the metastatic potential of tumor cells by two functional activities.

Inositol 1,4,5-trisphosphate 3-kinase A is critical for spatial and temporal regulation of spine actin remodeling, synaptic plasticity, and learning and memory via an activity-dependent Rac scaffolding mechanism.
Title: Inositol 1,4,5-trisphosphate 3-kinase a functions as a scaffold for synaptic Rac signaling.

These data show that the absence of expression of the three isoenzymes of Itpk does not prevent the formation of IP5 and IP6, at least in mouse embryonic fibroblasts.[Itpka, Itpkb, Itpkc]
Title: The absence of expression of the three isoenzymes of the inositol 1,4,5-trisphosphate 3-kinase does not prevent the formation of inositol pentakisphosphate and hexakisphosphate in mouse embryonic fibroblasts.

The following Itpka gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Itpka cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu12241	NM_146125.2 Latest version!	Mus musculus inositol 1,4,5-trisphosphate 3-kinase A (Itpka), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$272.30 $389.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Itpka ( NM_146125.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_666237.1 Mus musculus inositol 1,4,5-trisphosphate 3-kinase A (Itpka), mRNA.

Price & Availability↑

CloneID	OMu12241
Clone ID Related Accession (Same CDS sequence)	NM_146125.2
Accession Version	NM_146125.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1380bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	inositol-trisphosphate 3-kinase A
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AL844536.13. On Nov 17, 2006 this sequence version replaced NM_146125.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: BC027291.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGACCCTGC CCGGGCGCCC GACGGGCATG GCGCGGCCAC GGGGCGCGGG GCCCTGCAGC 
CCCGGGCTGG AGAGGGCTCC GCGCCGGAGC GTCGGGGAGC TGCGCCTGCT CTTCGAAGCG 
CGCTGCGCCG CAGTCGCCGC TGCAGCAGCC GCAGGGGAGC CCCGGGCCCG CGGGGCCAAG 
CGGCGTGGGG GACAAGTGCC CAACGGGCTC CCGCGTGCTG CCCCTGCCCC GGTGATCCCT 
CAGCTCACTG TGACAAGCGA GGAGGATGTG ACCCCGGCCA GCCCAGGGCC GCCAGACCAG 
GAGGGGAACT GGCTCCCAGC TGCGGGGTCG CACCTGCAGC AGCCACGCCG CCTCTCCACC 
TCGTCCCTCT CCTCCACCGG CTCCTCGTCG CTGCTCGAGG ACTCGGAGGA CGATCTGCTG 
AGCGACAGTG AGAGCAGGAG CCGCGGCAAC GTGCAGCTGG AAACCAGCGA GGACGTGGGG 
CAGAAAAGCC ACTGGCAGAA GATCCGTACC ATGGTCAATC TGCCTGTCAT GAGTCCTTTC 
AGAAAGCGCT ACTCCTGGGT GCAGTTAGCA GGGCACACAG GGAGTTTCAA AGCTGCCGGC 
ACCAGTGGCC TGATCCTGAA ACGCAGCTCG GAGCCTGAAC ACTACTGCCT GGTGCGGCTG 
ATGGCTGACG TGCTGCGTGG GTGTGTGCCG GCCTTCCATG GCATAGTCGA GCGGGATGGT 
GAAAGCTACT TGCAGTTACA GGACCTGCTC GATGGCTTCG ATGGGCCTTG TGTGCTTGAC 
TGCAAGATGG GTGTCAGAAC TTACCTGGAA GAGGAGCTGA CCAAAGCCCG AGAACGACCC 
AAGCTGCGGA AGGACATGTA TAAGAAGATG CTGGCAGTGG ACCCTGAGGC ACCTACTGAG 
GAGGAGCATG CGCAGCGCGC CGTCACCAAA CCACGCTACA TGCAATGGCG CGAAGGCATC 
AGCTCCAGCA CTACACTCGG CTTTCGCATT GAGGGCATCA AGAAAGCCGA TGGATCTTGC 
AGTACTGATT TCAAAACTAC ACGAAGCCGA GAGCAAGTGA CCCGTGTCTT TGAGGAGTTC 
ATGCAAGGAG ATGCAGAAGT GCTGAGGAGG TATCTGAACC GCCTACAGCA GATCCGGGAT 
ACCCTGGAGA TCTCTGATTT CTTTAGACGG CACGAGGTGA TTGGCAGCTC ACTCCTCTTC 
GTGCATGACC ATTGCCATCG TGCTGGTGTG TGGCTCATCG ATTTTGGCAA GACCACGCCT 
CTCCCCGATG GCCAGATCCT GGATCATCGG AGGCCCTGGG AGGAGGGCAA CCGTGAGGAC 
GGCTATTTGC TGGGGCTGGA CAATCTCATT GGCATCTTGG CCAGCCTGGC TGAGAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_666237.1
CDS	43..1422
Translation	MTLPGRPTGMARPRGAGPCSPGLERAPRRSVGELRLLFEARCAAVAAAAAAGEPRARGAKRRGGQVPNGLPRAAPAPVIPQLTVTSEEDVTPASPGPPDQEGNWLPAAGSHLQQPRRLSTSSLSSTGSSSLLEDSEDDLLSDSESRSRGNVQLETSEDVGQKSHWQKIRTMVNLPVMSPFRKRYSWVQLAGHTGSFKAAGTSGLILKRSSEPEHYCLVRLMADVLRGCVPAFHGIVERDGESYLQLQDLLDGFDGPCVLDCKMGVRTYLEEELTKARERPKLRKDMYKKMLAVDPEAPTEEEHAQRAVTKPRYMQWREGISSSTTLGFRIEGIKKADGSCSTDFKTTRSREQVTRVFEEFMQGDAEVLRRYLNRLQQIRDTLEISDFFRRHEVIGSSLLFVHDHCHRAGVWLIDFGKTTPLPDGQILDHRRPWEEGNREDGYLLGLDNLIGILASLAER

Target ORF information:

RefSeq Version	NM_146125.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus inositol 1,4,5-trisphosphate 3-kinase A (Itpka), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_146125.2

ORF Insert Sequence:

ATGACCCTGC CCGGGCGCCC GACGGGCATG GCGCGGCCAC GGGGCGCGGG GCCCTGCAGC 
CCCGGGCTGG AGAGGGCTCC GCGCCGGAGC GTCGGGGAGC TGCGCCTGCT CTTCGAAGCG 
CGCTGCGCCG CAGTCGCCGC TGCAGCAGCC GCAGGGGAGC CCCGGGCCCG CGGGGCCAAG 
CGGCGTGGGG GACAAGTGCC CAACGGGCTC CCGCGTGCTG CCCCTGCCCC GGTGATCCCT 
CAGCTCACTG TGACAAGCGA GGAGGATGTG ACCCCGGCCA GCCCAGGGCC GCCAGACCAG 
GAGGGGAACT GGCTCCCAGC TGCGGGGTCG CACCTGCAGC AGCCACGCCG CCTCTCCACC 
TCGTCCCTCT CCTCCACCGG CTCCTCGTCG CTGCTCGAGG ACTCGGAGGA CGATCTGCTG 
AGCGACAGTG AGAGCAGGAG CCGCGGCAAC GTGCAGCTGG AAACCAGCGA GGACGTGGGG 
CAGAAAAGCC ACTGGCAGAA GATCCGTACC ATGGTCAATC TGCCTGTCAT GAGTCCTTTC 
AGAAAGCGCT ACTCCTGGGT GCAGTTAGCA GGGCACACAG GGAGTTTCAA AGCTGCCGGC 
ACCAGTGGCC TGATCCTGAA ACGCAGCTCG GAGCCTGAAC ACTACTGCCT GGTGCGGCTG 
ATGGCTGACG TGCTGCGTGG GTGTGTGCCG GCCTTCCATG GCATAGTCGA GCGGGATGGT 
GAAAGCTACT TGCAGTTACA GGACCTGCTC GATGGCTTCG ATGGGCCTTG TGTGCTTGAC 
TGCAAGATGG GTGTCAGAAC TTACCTGGAA GAGGAGCTGA CCAAAGCCCG AGAACGACCC 
AAGCTGCGGA AGGACATGTA TAAGAAGATG CTGGCAGTGG ACCCTGAGGC ACCTACTGAG 
GAGGAGCATG CGCAGCGCGC CGTCACCAAA CCACGCTACA TGCAATGGCG CGAAGGCATC 
AGCTCCAGCA CTACACTCGG CTTTCGCATT GAGGGCATCA AGAAAGCCGA TGGATCTTGC 
AGTACTGATT TCAAAACTAC ACGAAGCCGA GAGCAAGTGA CCCGTGTCTT TGAGGAGTTC 
ATGCAAGGAG ATGCAGAAGT GCTGAGGAGG TATCTGAACC GCCTACAGCA GATCCGGGAT 
ACCCTGGAGA TCTCTGATTT CTTTAGACGG CACGAGGTGA TTGGCAGCTC ACTCCTCTTC 
GTGCATGACC ATTGCCATCG TGCTGGTGTG TGGCTCATCG ATTTTGGCAA GACCACGCCT 
CTCCCCGATG GCCAGATCCT GGATCATCGG AGGCCCTGGG AGGAGGGCAA CCGTGAGGAC 
GGCTATTTGC TGGGGCTGGA CAATCTCATT GGCATCTTGG CCAGCCTGGC TGAGAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The role of inositol 1,4,5-trisphosphate 3-kinase A in regulating emotional behavior and amygdala function.
Scientific reports623757(2016 Apr)
Chung S,Kim IH,Lee D,Park K,Kim JY,Lee YK,Kim EJ,Lee HW,Choi JS,Son GH,Sun W,Shin KS,Kim H

Inositol-1,4,5-trisphosphate 3-kinase A regulates dendritic morphology and shapes synaptic Ca2+ transients.
Cellular signalling24(3)750-7(2012 Mar)
Windhorst S,Minge D,B?hring R,H?ser S,Schob C,Blechner C,Lin HY,Mayr GW,Kindler S

Inositol 1,4,5-trisphosphate 3-kinase-A is a new cell motility-promoting protein that increases the metastatic potential of tumor cells by two functional activities.
The Journal of biological chemistry285(8)5541-54(2010 Feb)
Windhorst S,Fliegert R,Blechner C,M?llmann K,Hosseini Z,G?nther T,Eiben M,Chang L,Lin HY,Fanick W,Schumacher U,Brandt B,Mayr GW

Inositol 1,4,5-trisphosphate 3-kinase a functions as a scaffold for synaptic Rac signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience29(44)14039-49(2009 Nov)
Kim IH,Park SK,Hong ST,Jo YS,Kim EJ,Park EH,Han SB,Shin HS,Sun W,Kim HT,Soderling SH,Kim H

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Itpka cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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