Slc9a2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc9a2
Entrez Gene ID	226999
Full Name	solute carrier family 9 (sodium/hydrogen exchanger), member 2
Synonyms	2210416H12Rik,4932415O19Rik,AV333884,NHE2
General protein information	Preferred Names solute carrier family 9 (sodium/hydrogen exchanger), member 2 Names sodium/hydrogen exchanger 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1 B\|1 19.66 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_001033289.2	NP_001028461.2	sodium/hydrogen exchanger 2 precursor

Pathways from BioSystems

Homologies

	SLC9A2	XP_001108368.1
Danio rerio (zebrafish)	slc9a2	NP_001107567.1
Pan troglodytes (chimpanzee)	SLC9A2	XP_525838.2
Gallus gallus (chicken)	SLC9A2	XP_416918.4
Mus musculus (house mouse)	Slc9a2	NP_001028461.2
Homo sapiens (human)	SLC9A2	NP_003039.2
Canis lupus familiaris (dog)	SLC9A2	XP_005626049.1
Bos taurus (cattle)	SLC9A2	XP_002691231.3
Rattus norvegicus (Norway rat)	Slc9a2	NP_001106806.1
Xenopus tropicalis (tropical clawed frog)	LOC101732511	XP_004911848.1

Gene Ontology
Bibliography

Related articles in PubMed

Intestinal brush-border Na+/H+ exchanger-3 drives H+-coupled iron absorption in the mouse.
Shawki A, Engevik MA, Kim RS, Knight PB, Baik RA, Anthony SR, Worrell RT, Shull GE, Mackenzie B
American journal of physiology. Gastrointestinal and liver physiology311(3)G423-30(2016 Sep)

The distinct roles of anion transporters Slc26a3 (DRA) and Slc26a6 (PAT-1) in fluid and electrolyte absorption in the murine small intestine.
Xia W, Yu Q, Riederer B, Singh AK, Engelhardt R, Yeruva S, Song P, Tian DA, Soleiman M, Seidler U
Pflugers Archiv : European journal of physiology466(8)1541-56(2014 Aug)

Molecular transport machinery involved in orchestrating luminal acid-induced duodenal bicarbonate secretion in vivo.
Singh AK, Liu Y, Riederer B, Engelhardt R, Thakur BK, Soleimani M, Seidler U
The Journal of physiology591(21)5377-91(2013 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

functional NHE2, but not NHE1, is essential for mouse gastric epithelial restitution and TFFs activate epithelial repair via NHE2
Title: Trefoil factor 2 requires Na/H exchanger 2 activity to enhance mouse gastric epithelial repair.

Mucosa from NHE2(-/-) mice displayed a shift of occludin and claudin-1 expression to the Triton-X-soluble membrane fractions and showed disruption of occludin and claudin-1 localization patterns following injury.
Title: Mice lacking the Na+/H+ exchanger 2 have impaired recovery of intestinal barrier function.

Here, we show that NHE10 is highly expressed in OCs in response to receptor activator of nuclear factor-kappaB ligand signaling and is required for OC differentiation and survival.
Title: NHE10, an osteoclast-specific member of the Na+/H+ exchanger family, regulates osteoclast differentiation and survival [corrected].

Renal tissue renin activity and plasma renin concentration were elevated three- and twofold, respectively, in NHE2 knckout mice.
Title: Increased renal renin content in mice lacking the Na+/H+ exchanger NHE2.

This study demonstrated that constitutive absence of NHE2 results in a compensatory increase in a Na(+)-dependent, EIPA-sensitive acid extruder distinct from NHE1, NHE3, or SITS-sensitive transporters.
Title: NHE2 is the main apical NHE in mouse colonic crypts but an alternative Na+-dependent acid extrusion mechanism is upregulated in NHE2-null mice.

The following Slc9a2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc9a2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu17645	NM_001033289.2 Latest version!	Mus musculus solute carrier family 9 (sodium/hydrogen exchanger), member 2 (Slc9a2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$482.30 $689.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc9a2 ( NM_001033289.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001028461.2 Mus musculus solute carrier family 9 (sodium/hydrogen exchanger), member 2 (Slc9a2), mRNA.

Price & Availability↑

CloneID	OMu17645
Clone ID Related Accession (Same CDS sequence)	NM_001033289.2
Accession Version	NM_001033289.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2445bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-02
Organism	Mus musculus(house mouse)
Product	sodium/hydrogen exchanger 2 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC103685.1. On Sep 18, 2005 this sequence version replaced NM_001033289.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC103685.1, AK077026.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849376, SAMN00849377 [ECO:0000348] ##Evidence-Data-END##

ATGGGCCCCC GGGGCACCGC GCACAGCGTG CGGGCGCCAC TGTCTTGGCT GCTGCTGCTG 
CTGCTGTCTC TGCAGGTGGC AGTGCCGGCG GGCGCGCTGG CCGAGACCCT GCTGGACGCA 
CCCAGGGCCA GGGGTGCCAG CTCCAACCCG CCAAGTCCTG CCAGTGTGGT GGCCCCGGGA 
ACGACGCCGT TCGAGGAAAG TCGGTTGCCC GTGTTCACCC TGGATTACCC CCACGTGCAA 
ATCCCTTTCG AGATCACTTT GTGGATCCTA CTGGCCTCCT TGGCCAAGAT TGGTTTTCAT 
CTCTATCACA AGTTGCCCAC AATCGTGCCG GAGAGCTGCC TTCTCATAAT GGTCGGGCTT 
CTACTGGGTG GGATTATCTT CGGTGTTGAT GAGAAGTCTC CCCCGGCAAT GAAGACAGAT 
GTGTTTTTCC TATACCTCCT GCCACCCATC GTTCTGGATG CTGGCTACTT CATGCCAACT 
CGCCCCTTCT TTGAGAACTT CGGCACCATT TTCTGGTATG CTGTGGTAGG CACACTGTGG 
AATTCCATTG GCATTGGGGT GTCTTTGTTT GGCATCTGCC AGATTGAGGC GTTTGGCCTC 
AGTGACATCA CCCTGCTCCA GAACCTGCTC TTCGGCAGCC TGATTTCAGC TGTGGACCCC 
GTGGCTGTGC TTGCTGTCTT TGAGAACATT CACGTCAATG AACAGCTCTA TATCCTGGTT 
TTTGGCGAGT CTCTGCTCAA CGATGCAGTC ACAGTGGTCC TGTACAACTT GTTCAAGTCC 
TTCTGCCAGA TGAAAACCAT CCAGACCGTA GACGTGTTTG CTGGCATCGC TAACTTCTTC 
GTCGTGGGTA TTGGCGGGGT GCTGATTGGC ATCCTCCTGG GATTCATAGC AGCGTTTACC 
ACCCGTTTCA CACACAACAT CCGGGTCATT GAGCCACTCT TTGTCTTCTT GTACAGCTAC 
TTGTCCTACA TCACTGCTGA AATGTTCCAC CTTTCAGGCA TCATGGCGAT CACAGCGTGT 
GCCATGACAA TGAATAAGTA CGTGGAAGAG AACGTGTCTC AGAAGTCCTA CACAACCATC 
AAGTACTTCA TGAAGATGCT GAGCAGCGTG AGCGAGACCC TGATCTTCAT CTTCATGGGC 
GTGTCCACTG TTGGGAAGAA CCACGAGTGG AACTGGGCTT TCGTCTGCTT TACCCTGGCC 
TTCTGCCTGA TCTGGCGAGC ACTGGGCGTC TTTGTCCTGA CTCAGGTGAT TAACTGGTTC 
CGGACCATCC CGCTAACCTT CAAGGACCAG TTCATCATTG CCTACGGAGG GCTCCGTGGC 
GCCATCTGCT TTGCACTGGT GTTTCTCCTC CCTGCTACTG TGTTTCCCCG AAAGAAGCTG 
TTCATCACGG CTGCTATTGT CGTTATATTC TTCACTGTCT TCATCCTGGG TATAACCATC 
CGGCCACTGG TGGAATTTCT TGATGTTAAG AGATCCAATA AGAAGCAGCA AGCTGTCAGT 
GAAGAGATCC ACTGTCGGTT TTTTGATCAT GTGAAGACTG GGATTGAAGA TGTGTGTGGA 
CACTGGGGTC ACAACTTCTG GAGAGACAAG TTTAAGAAGT TTGATGACAA ATACCTTCGG 
AAGCTTCTGA TTCGGGAAAA CCAACCCAAG TCCAGTATTG TGTCCTTATA TAAAAAGCTT 
GAGATAAAGC ATGCCATTGA AATGGCAGAG ACAGGGATGA TAAGCACTGT CCCCTCATTT 
GCATCTCTCA ATGACTGCCG TGAAGAGAAA ATAAGGAAGC TCACGCCAGG CGAAATGGAT 
GAAATTAGAG AGATATTATC ACGGAATCTC TATCAAATCC GTCAGCGGAC CTTGTCCTAT 
AACAGACACA ACCTGACGGC AGACACAAGC GAGAGGCAAG CCAAGGAGAT CCTGATTCGC 
AGGCGGCACA GTCTTCGGGA AAGTCTCAGG AAAGACAACA GCTCAAACCG CGAGCGCAGG 
GCTTCCACTT CAACCTCCCG ATATTTATCC TTACCTAAGA ACACAAAGCT TCCAGAGAAG 
CTGCAGAAGA AGAAGAAGGT TTCAAATGCA GATGGAAATA GCAGCGACTC GGACCCAGAT 
GTTGGAACCA CTGTGCTCAA TTTGCAGCCC AGGACCAGGC GCTTCTTGCC AGATCAGTTC 
TCAAAGAAAG CCTCCCAGGC CTACAAAATG GAATGGAAGA ACGAGGTGGA TGTGGGTTCT 
GTGCGAGTGC CCCCCAGCGT CTCTCCAGCG CCCCGCAGTA AAGACGGGGG CACCCAAACA 
CCGGGGTTGC TGAGGCAGCC CCTGCTCTCC AAAGACCAAC GGTTTGGCCG GGGTAGGGAA 
GACAGTTTGA CTGAAGACGT TCCACCCAAG CCCCCACCAA GGTTGGTGCG ACGAGCGTCA 
GAACCCGGGA ACAGGAAAGG CCGCCTTGGC AATGAAAAGC CATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001028461.2
CDS	163..2607
Translation	MGPRGTAHSVRAPLSWLLLLLLSLQVAVPAGALAETLLDAPRARGASSNPPSPASVVAPGTTPFEESRLPVFTLDYPHVQIPFEITLWILLASLAKIGFHLYHKLPTIVPESCLLIMVGLLLGGIIFGVDEKSPPAMKTDVFFLYLLPPIVLDAGYFMPTRPFFENFGTIFWYAVVGTLWNSIGIGVSLFGICQIEAFGLSDITLLQNLLFGSLISAVDPVAVLAVFENIHVNEQLYILVFGESLLNDAVTVVLYNLFKSFCQMKTIQTVDVFAGIANFFVVGIGGVLIGILLGFIAAFTTRFTHNIRVIEPLFVFLYSYLSYITAEMFHLSGIMAITACAMTMNKYVEENVSQKSYTTIKYFMKMLSSVSETLIFIFMGVSTVGKNHEWNWAFVCFTLAFCLIWRALGVFVLTQVINWFRTIPLTFKDQFIIAYGGLRGAICFALVFLLPATVFPRKKLFITAAIVVIFFTVFILGITIRPLVEFLDVKRSNKKQQAVSEEIHCRFFDHVKTGIEDVCGHWGHNFWRDKFKKFDDKYLRKLLIRENQPKSSIVSLYKKLEIKHAIEMAETGMISTVPSFASLNDCREEKIRKLTPGEMDEIREILSRNLYQIRQRTLSYNRHNLTADTSERQAKEILIRRRHSLRESLRKDNSSNRERRASTSTSRYLSLPKNTKLPEKLQKKKKVSNADGNSSDSDPDVGTTVLNLQPRTRRFLPDQFSKKASQAYKMEWKNEVDVGSVRVPPSVSPAPRSKDGGTQTPGLLRQPLLSKDQRFGRGREDSLTEDVPPKPPPRLVRRASEPGNRKGRLGNEKP

Target ORF information:

RefSeq Version	NM_001033289.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus solute carrier family 9 (sodium/hydrogen exchanger), member 2 (Slc9a2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001033289.2

ORF Insert Sequence:

ATGGGCCCCC GGGGCACCGC GCACAGCGTG CGGGCGCCAC TGTCTTGGCT GCTGCTGCTG 
CTGCTGTCTC TGCAGGTGGC AGTGCCGGCG GGCGCGCTGG CCGAGACCCT GCTGGACGCA 
CCCAGGGCCA GGGGTGCCAG CTCCAACCCG CCAAGTCCTG CCAGTGTGGT GGCCCCGGGA 
ACGACGCCGT TCGAGGAAAG TCGGTTGCCC GTGTTCACCC TGGATTACCC CCACGTGCAA 
ATCCCTTTCG AGATCACTTT GTGGATCCTA CTGGCCTCCT TGGCCAAGAT TGGTTTTCAT 
CTCTATCACA AGTTGCCCAC AATCGTGCCG GAGAGCTGCC TTCTCATAAT GGTCGGGCTT 
CTACTGGGTG GGATTATCTT CGGTGTTGAT GAGAAGTCTC CCCCGGCAAT GAAGACAGAT 
GTGTTTTTCC TATACCTCCT GCCACCCATC GTTCTGGATG CTGGCTACTT CATGCCAACT 
CGCCCCTTCT TTGAGAACTT CGGCACCATT TTCTGGTATG CTGTGGTAGG CACACTGTGG 
AATTCCATTG GCATTGGGGT GTCTTTGTTT GGCATCTGCC AGATTGAGGC GTTTGGCCTC 
AGTGACATCA CCCTGCTCCA GAACCTGCTC TTCGGCAGCC TGATTTCAGC TGTGGACCCC 
GTGGCTGTGC TTGCTGTCTT TGAGAACATT CACGTCAATG AACAGCTCTA TATCCTGGTT 
TTTGGCGAGT CTCTGCTCAA CGATGCAGTC ACAGTGGTCC TGTACAACTT GTTCAAGTCC 
TTCTGCCAGA TGAAAACCAT CCAGACCGTA GACGTGTTTG CTGGCATCGC TAACTTCTTC 
GTCGTGGGTA TTGGCGGGGT GCTGATTGGC ATCCTCCTGG GATTCATAGC AGCGTTTACC 
ACCCGTTTCA CACACAACAT CCGGGTCATT GAGCCACTCT TTGTCTTCTT GTACAGCTAC 
TTGTCCTACA TCACTGCTGA AATGTTCCAC CTTTCAGGCA TCATGGCGAT CACAGCGTGT 
GCCATGACAA TGAATAAGTA CGTGGAAGAG AACGTGTCTC AGAAGTCCTA CACAACCATC 
AAGTACTTCA TGAAGATGCT GAGCAGCGTG AGCGAGACCC TGATCTTCAT CTTCATGGGC 
GTGTCCACTG TTGGGAAGAA CCACGAGTGG AACTGGGCTT TCGTCTGCTT TACCCTGGCC 
TTCTGCCTGA TCTGGCGAGC ACTGGGCGTC TTTGTCCTGA CTCAGGTGAT TAACTGGTTC 
CGGACCATCC CGCTAACCTT CAAGGACCAG TTCATCATTG CCTACGGAGG GCTCCGTGGC 
GCCATCTGCT TTGCACTGGT GTTTCTCCTC CCTGCTACTG TGTTTCCCCG AAAGAAGCTG 
TTCATCACGG CTGCTATTGT CGTTATATTC TTCACTGTCT TCATCCTGGG TATAACCATC 
CGGCCACTGG TGGAATTTCT TGATGTTAAG AGATCCAATA AGAAGCAGCA AGCTGTCAGT 
GAAGAGATCC ACTGTCGGTT TTTTGATCAT GTGAAGACTG GGATTGAAGA TGTGTGTGGA 
CACTGGGGTC ACAACTTCTG GAGAGACAAG TTTAAGAAGT TTGATGACAA ATACCTTCGG 
AAGCTTCTGA TTCGGGAAAA CCAACCCAAG TCCAGTATTG TGTCCTTATA TAAAAAGCTT 
GAGATAAAGC ATGCCATTGA AATGGCAGAG ACAGGGATGA TAAGCACTGT CCCCTCATTT 
GCATCTCTCA ATGACTGCCG TGAAGAGAAA ATAAGGAAGC TCACGCCAGG CGAAATGGAT 
GAAATTAGAG AGATATTATC ACGGAATCTC TATCAAATCC GTCAGCGGAC CTTGTCCTAT 
AACAGACACA ACCTGACGGC AGACACAAGC GAGAGGCAAG CCAAGGAGAT CCTGATTCGC 
AGGCGGCACA GTCTTCGGGA AAGTCTCAGG AAAGACAACA GCTCAAACCG CGAGCGCAGG 
GCTTCCACTT CAACCTCCCG ATATTTATCC TTACCTAAGA ACACAAAGCT TCCAGAGAAG 
CTGCAGAAGA AGAAGAAGGT TTCAAATGCA GATGGAAATA GCAGCGACTC GGACCCAGAT 
GTTGGAACCA CTGTGCTCAA TTTGCAGCCC AGGACCAGGC GCTTCTTGCC AGATCAGTTC 
TCAAAGAAAG CCTCCCAGGC CTACAAAATG GAATGGAAGA ACGAGGTGGA TGTGGGTTCT 
GTGCGAGTGC CCCCCAGCGT CTCTCCAGCG CCCCGCAGTA AAGACGGGGG CACCCAAACA 
CCGGGGTTGC TGAGGCAGCC CCTGCTCTCC AAAGACCAAC GGTTTGGCCG GGGTAGGGAA 
GACAGTTTGA CTGAAGACGT TCCACCCAAG CCCCCACCAA GGTTGGTGCG ACGAGCGTCA 
GAACCCGGGA ACAGGAAAGG CCGCCTTGGC AATGAAAAGC CATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Intestinal brush-border Na+/H+ exchanger-3 drives H+-coupled iron absorption in the mouse.
American journal of physiology. Gastrointestinal and liver physiology311(3)G423-30(2016 Sep)
Shawki A,Engevik MA,Kim RS,Knight PB,Baik RA,Anthony SR,Worrell RT,Shull GE,Mackenzie B

The distinct roles of anion transporters Slc26a3 (DRA) and Slc26a6 (PAT-1) in fluid and electrolyte absorption in the murine small intestine.
Pflugers Archiv : European journal of physiology466(8)1541-56(2014 Aug)
Xia W,Yu Q,Riederer B,Singh AK,Engelhardt R,Yeruva S,Song P,Tian DA,Soleiman M,Seidler U

Molecular transport machinery involved in orchestrating luminal acid-induced duodenal bicarbonate secretion in vivo.
The Journal of physiology591(21)5377-91(2013 Nov)
Singh AK,Liu Y,Riederer B,Engelhardt R,Thakur BK,Soleimani M,Seidler U

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Slc9a2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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