Ywhah cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ywhah
Entrez Gene ID	22629
Full Name	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
General protein information	Preferred Names tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide Names 14-3-3 protein eta 14-3-3 eta
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5\|5 B1

mRNA and Protein(s)

mRNA	Protein	Name
NM_011738.2	NP_035868.1	14-3-3 protein eta

Pathways from BioSystems

Homologies

Homo sapiens (human)	YWHAH	NP_003396.1
Pan troglodytes (chimpanzee)	YWHAH	XP_001151423.1
Bos taurus (cattle)	YWHAH	NP_776917.2
Mus musculus (house mouse)	Ywhah	NP_035868.1
Danio rerio (zebrafish)	ywhah	NP_998329.1
Rattus norvegicus (Norway rat)	Ywhah	NP_037184.1
	YWHAH	XP_001111998.1
Gallus gallus (chicken)	YWHAH	NP_001007840.1
Canis lupus familiaris (dog)	YWHAH	XP_003433473.2
Xenopus tropicalis (tropical clawed frog)	ywhah	NP_001016868.1

Gene Ontology
Bibliography

Related articles in PubMed

Myocardial 14-3-3? protein protects against mitochondria mediated apoptosis.
Sreedhar R, Arumugam S, Thandavarayan RA, Giridharan VV, Karuppagounder V, Pitchaimani V, Afrin R, Miyashita S, Nomoto M, Harima M, Gurusamy N, Suzuki K, Watanabe K
Cellular signalling27(4)770-6(2015 Apr)

Evidence for the requirement of 14-3-3eta (YWHAH) in meiotic spindle assembly during mouse oocyte maturation.
De S, Kline D
BMC developmental biology1310(2013 Apr)

14-3-3? plays a role in cardiac ventricular compaction by regulating the cardiomyocyte cell cycle.
Kosaka Y, Cieslik KA, Li L, Lezin G, Maguire CT, Saijoh Y, Toyo-oka K, Gambello MJ, Vatta M, Wynshaw-Boris A, Baldini A, Yost HJ, Brunelli L
Molecular and cellular biology32(24)5089-102(2012 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results suggest that 14-3-3 eta has a protective role against mitochondria mediated cardiomyocyte apoptosis with the involvement of Ask-1/JNK signaling during high fat diet induced type 2 diabetes mellitus.
Title: Myocardial 14-3-3? protein protects against mitochondria mediated apoptosis.

14-3-3 eta plays a regulatory role in chondrogenic differentiation.
Title: 14-3-3 ? inhibits chondrogenic differentiation of ATDC5 cell.

The myocardial NF-kappaB activation, inhibitor of kappa B-alpha degradation and mRNA expression of proinflammatory cytokines were significantly increased in DN 14-3-3 mice compared to WT mice.(14-3-3 protein eta)
Title: Depletion of 14-3-3 protein exacerbates cardiac oxidative stress, inflammation and remodeling process via modulation of MAPK/NF-?B signaling pathways after streptozotocin-induced diabetes mellitus.

Inhibition of a single protective isoform, 14-3-3theta;, by shRNA did not increase vulnerability to neurotoxic injury, but toxicity was enhanced by broad-based inhibition of 14-3-3 action with the peptide inhibitor difopein.
Title: Differential neuroprotective effects of 14-3-3 proteins in models of Parkinson's disease.

Targeting of dominant-negative 14-3-3eta (DN-14-3-3) to murine postnatal cardiac tissue potentiates Ask1, c-jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (MAPK) activation
Title: Role of 14-3-3-mediated p38 mitogen-activated protein kinase inhibition in cardiac myocyte survival.

The following Ywhah gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ywhah cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu08718	NM_011738.2 Latest version!	Mus musculus tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide (Ywhah), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ywhah ( NM_011738.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035868.1 Mus musculus tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide (Ywhah), mRNA.

Price & Availability↑

CloneID	OMu08718
Clone ID Related Accession (Same CDS sequence)	NM_011738.2
Accession Version	NM_011738.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 741bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	14-3-3 protein eta
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB183421.1, AK149224.1 and CD770463.1. On Dec 18, 2007 this sequence version replaced NM_011738.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC061497.1, AK149224.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGGATC GAGAGCAGCT GCTGCAGCGG GCGCGACTGG CGGAGCAGGC GGAGCGCTAC 
GACGATATGG CCTCCGCCAT GAAGGCGGTG ACAGAGCTGA ATGAACCACT ATCTAACGAA 
GATCGAAATC TCCTCTCTGT GGCCTACAAG AATGTAGTTG GTGCCAGGCG ATCTTCTTGG 
AGGGTTATTA GTAGCATTGA GCAGAAAACC ATGGCAGATG GGAATGAGAA GAAGTTGGAG 
AAAGTTAAAG CCTACCGGGA GAAGATTGAA AAGGAGCTGG AGACAGTTTG CAATGATGTC 
TTGGCTCTGC TTGACAAGTT CCTTATCAAG AACTGCAATG ATTTTCAGTA TGAGAGCAAG 
GTGTTCTACC TGAAAATGAA GGGCGATTAC TACCGCTACC TGGCAGAGGT GGCTTCTGGG 
GAGAAGAAAA ACAGTGTGGT TGAAGCTTCT GAGGCCGCGT ATAAGGAAGC CTTCGAAATC 
AGCAAAGAGC ACATGCAGCC AACACACCCC ATCCGGCTTG GCCTGGCCCT CAATTTTTCT 
GTGTTCTACT ATGAGATCCA GAATGCACCA GAGCAAGCCT GCCTCTTAGC CAAACAAGCC 
TTCGATGATG CTATAGCTGA GCTGGACACA TTAAACGAGG ATTCCTATAA GGACTCCACT 
CTCATCATGC AGTTGCTGCG AGACAACCTC ACCCTCTGGA CGAGCGACCA GCAGGATGAA 
GAAGCAGGAG AAGGCAACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035868.1
CDS	253..993
Translation	MGDREQLLQRARLAEQAERYDDMASAMKAVTELNEPLSNEDRNLLSVAYKNVVGARRSSWRVISSIEQKTMADGNEKKLEKVKAYREKIEKELETVCNDVLALLDKFLIKNCNDFQYESKVFYLKMKGDYYRYLAEVASGEKKNSVVEASEAAYKEAFEISKEHMQPTHPIRLGLALNFSVFYYEIQNAPEQACLLAKQAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDEEAGEGN

Target ORF information:

RefSeq Version	NM_011738.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide (Ywhah), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011738.2

ORF Insert Sequence:

ATGGGGGATC GAGAGCAGCT GCTGCAGCGG GCGCGACTGG CGGAGCAGGC GGAGCGCTAC 
GACGATATGG CCTCCGCCAT GAAGGCGGTG ACAGAGCTGA ATGAACCACT ATCTAACGAA 
GATCGAAATC TCCTCTCTGT GGCCTACAAG AATGTAGTTG GTGCCAGGCG ATCTTCTTGG 
AGGGTTATTA GTAGCATTGA GCAGAAAACC ATGGCAGATG GGAATGAGAA GAAGTTGGAG 
AAAGTTAAAG CCTACCGGGA GAAGATTGAA AAGGAGCTGG AGACAGTTTG CAATGATGTC 
TTGGCTCTGC TTGACAAGTT CCTTATCAAG AACTGCAATG ATTTTCAGTA TGAGAGCAAG 
GTGTTCTACC TGAAAATGAA GGGCGATTAC TACCGCTACC TGGCAGAGGT GGCTTCTGGG 
GAGAAGAAAA ACAGTGTGGT TGAAGCTTCT GAGGCCGCGT ATAAGGAAGC CTTCGAAATC 
AGCAAAGAGC ACATGCAGCC AACACACCCC ATCCGGCTTG GCCTGGCCCT CAATTTTTCT 
GTGTTCTACT ATGAGATCCA GAATGCACCA GAGCAAGCCT GCCTCTTAGC CAAACAAGCC 
TTCGATGATG CTATAGCTGA GCTGGACACA TTAAACGAGG ATTCCTATAA GGACTCCACT 
CTCATCATGC AGTTGCTGCG AGACAACCTC ACCCTCTGGA CGAGCGACCA GCAGGATGAA 
GAAGCAGGAG AAGGCAACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Myocardial 14-3-3? protein protects against mitochondria mediated apoptosis.
Cellular signalling27(4)770-6(2015 Apr)
Sreedhar R,Arumugam S,Thandavarayan RA,Giridharan VV,Karuppagounder V,Pitchaimani V,Afrin R,Miyashita S,Nomoto M,Harima M,Gurusamy N,Suzuki K,Watanabe K

Evidence for the requirement of 14-3-3eta (YWHAH) in meiotic spindle assembly during mouse oocyte maturation.
BMC developmental biology1310(2013 Apr)
De S,Kline D

14-3-3? plays a role in cardiac ventricular compaction by regulating the cardiomyocyte cell cycle.
Molecular and cellular biology32(24)5089-102(2012 Dec)
Kosaka Y,Cieslik KA,Li L,Lezin G,Maguire CT,Saijoh Y,Toyo-oka K,Gambello MJ,Vatta M,Wynshaw-Boris A,Baldini A,Yost HJ,Brunelli L

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Ywhah cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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