Umod cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Umod
Entrez Gene ID	22242
Full Name	uromodulin
Synonyms	THP,Urehd1,urehr4
General protein information	Preferred Names uromodulin Names uromodulin Tamm-Horsfall urinary glycoprotein uromucoid
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7 F2\|7 63.88 cM
Summary	This gene encodes a glycoprotein that is the most abundant protein in mammalian urine under physiological conditions. It is synthesized in the kidney as a glycosyl-phosphatidylinositol anchored protein and released into urine as a soluble form by proteolytic cleavage. It is thought to regulate water and salt balance in the thick ascending limb of Henle and to protect against urinary tract infection and calcium oxalate crystal formation. In mouse deficiency of this gene is associated with increased susceptibility to bacterial infections and formation of calcium crystals in kidneys. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].

mRNA and Protein(s)

mRNA	Protein	Name
NM_009470.5	NP_033496.1	uromodulin preproprotein
NM_001278605.1	NP_001265534.1	uromodulin preproprotein

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	UMOD	NP_001003003.1
Xenopus tropicalis (tropical clawed frog)	LOC100491925	XP_002932034.2
Xenopus tropicalis (tropical clawed frog)	LOC101731733	XP_004918346.1
Xenopus tropicalis (tropical clawed frog)	LOC101732035	XP_004918350.1
Homo sapiens (human)	UMOD	NP_001265543.1
Pan troglodytes (chimpanzee)	UMOD	XP_003954410.1
	UMOD	XP_001086040.2
Xenopus tropicalis (tropical clawed frog)	LOC101731793	XP_004918347.1
Bos taurus (cattle)	UMOD	NP_776638.1
Mus musculus (house mouse)	Umod	NP_001265534.1
Rattus norvegicus (Norway rat)	Umod	NP_058778.1
Xenopus tropicalis (tropical clawed frog)	LOC100491428	XP_002932031.1
Xenopus tropicalis (tropical clawed frog)	LOC100492097	XP_004918349.1

Gene Ontology
Bibliography

Related articles in PubMed

Urinary uromodulin carries an intact ZP domain generated by a conserved C-terminal proteolytic cleavage.
Santambrogio S, Cattaneo A, Bernascone I, Schwend T, Jovine L, Bachi A, Rampoldi L
Biochemical and biophysical research communications370(3)410-3(2008 Jun)

Tamm-Horsfall protein is a critical renal defense factor protecting against calcium oxalate crystal formation.
Mo L, Huang HY, Zhu XH, Shapiro E, Hasty DL, Wu XR
Kidney international66(3)1159-66(2004 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Endoplasmic reticulum stress and apoptosis are key features in a mouse model of kidney disease driven by the uromodulin p.Cys147Trp mutation.
Title: Uromodulin p.Cys147Trp mutation drives kidney disease by activating ER stress and apoptosis.

results strongly suggest that the progressive worsening of kidney functions reflects the accumulation of the deleterious effects of the misfolded mutant THP and the compensatory responses
Title: Point mutation in D8C domain of Tamm-Horsfall protein/uromodulin in transgenic mice causes progressive renal damage and hyperuricemia.

Consistently, pathway enrichment analysis indicates that mutant uromodulin expression affects ER function and protein homeostasis.
Title: Mutant uromodulin expression leads to altered homeostasis of the endoplasmic reticulum and activates the unfolded protein response.

we show that Tamm-Horsfall protein deficiency stimulates proximal epithelial activation of the Interleukin-23/Interleukin-17 axis and systemic neutrophilia.
Title: Tamm-Horsfall Protein Regulates Granulopoiesis and Systemic Neutrophil Homeostasis.

TNFalpha regulates uromodulin expression in a homeostatic setting, but the impact of TNFalpha on uromodulin during kidney injury is superseded by other factors that could inhibit HNF1beta-mediated expression of uromodulin.
Title: The role of tumor necrosis factor alpha in regulating the expression of Tamm-Horsfall Protein (uromodulin) in thick ascending limbs during kidney injury.

The following Umod gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Umod cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu19761	NM_009470.5 Latest version!	Mus musculus uromodulin (Umod), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00
OMu19761	NM_001278605.1 Latest version!	Mus musculus uromodulin (Umod), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Umod ( NM_009470.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033496.1 Mus musculus uromodulin (Umod), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu19761
Clone ID Related Accession (Same CDS sequence)	NM_009470.5 , NM_001278605.1
Accession Version	NM_009470.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1929bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Mus musculus(house mouse)
Product	uromodulin preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC125147.4, AK085460.1 and AK164688.1. On Jul 2, 2013 this sequence version replaced NM_009470.4. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK144065.1, AK164688.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849385 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGATCC CTTTGACCTG GATGCTGCTG GTAATGATGG TAACCTCCTG GTTCACTCTG 
GCTGAAGCCA GTAACTCAAC AGAAGCGAGA CGGTGTTCTG AATGCCACAA CAACGCCACC 
TGCACGGTGG ATGGTGTGGT CACAACGTGC TCCTGCCAGA CCGGCTTCAC TGGTGATGGG 
CTGGTGTGTG AGGACATGGA TGAGTGTGCT ACCCCATGGA CTCACAACTG CTCCAACAGC 
AGCTGTGTGA ACACCCCGGG CTCGTTTAAG TGCTCCTGTC AGGATGGTTT TCGTCTGACG 
CCTGAGCTGA GCTGCACTGA TGTGGATGAG TGCTCAGAGC AGGGGCTCAG TAACTGTCAT 
GCCCTGGCCA CCTGTGTCAA CACAGAAGGC GACTACTTGT GCGTGTGTCC CGAGGGCTTT 
ACAGGGGATG GTTGGTACTG TGAGTGCTCC CCAGGCTCCT GTGAGCCAGG ACTGGACTGC 
TTGCCCCAGG GCCCGGATGG AAAGCTGGTG TGTCAAGACC CCTGCAATAC ATATGAGACC 
CTGACTGAGT ACTGGCGCAG CACAGAGTAT GGTGTGGGCT ACTCCTGTGA CGCGGGTCTG 
CACGGCTGGT ACCGGTTCAC AGGCCAGGGT GGCGTTCGCA TGGCTGAGAC CTGTGTGCCC 
GTCCTGCGAT GCAACACGGC GGCACCCATG TGGCTCAATG GCTCTCATCC CTCGAGTAGT 
GAAGGCATTG TGAGCCGCAC GGCCTGTGCA CACTGGAGCG ACCAATGCTG CCGGTGGTCC 
ACAGAGATCC AGGTGAAGGC TTGCCCAGGT GGCTTCTATA TTTACAACTT GACAGCGCCC 
CCTGAGTGCA ATCTGGCTTA CTGCACCGAT CCTAGTTCCG TGGAGGGGAC TTGCGAAGAA 
TGCAGGGTAG ATGAAGATTG CATATCGGAT AACGGCAGAT GGCGCTGCCA GTGTAAACAG 
GACTCCAACA TCACAGATGT CTCCCAATTG GAGTACAGGC TGGAGTGTGG GGCCAATGAC 
ATCAAGATGT CCCTCAGAAA GTGCCAGCTA CAGAGTTTGG GCTTTATGAA TGTCTTCATG 
TACCTGAATG ACAGACAATG CTCAGGCTTC AGTGAGAGTG ATGAACGAGA CTGGATGTCC 
ATAGTGACCC CTGCCAGGAA TGGTCCCTGT GGGACAGTAT TGAGGAGAAA CGAAACCCAT 
GCCACCTACA GCAACACCCT CTACCTGGCA AATGCGATCA TCATTCGGGA CATCATCATA 
AGAATGAACT TTGAATGCTC TTACCCTCTG GACATGAAAG TCAGCCTGAA GACCTCCCTA 
CAGCCCATGG TCAGTGCCCT GAACATCAGC TTGGGTGGGA CAGGCAAGTT CACCGTGCGG 
ATGGCATTGT TCCAGAGCCC TACCTACACA CAGCCCCACC AAGGTCCTTC TGTGATGCTG 
TCCACTGAGG CTTTTCTGTA TGTGGGCACC ATGCTGGATG GGGGTGACTT GTCCCGGTTT 
GTACTGCTAA TGACCAACTG CTATGCCACA CCCAGTAGCA ACTCCACAGA CCCTGTGAAA 
TACTTCATTA TCCAGGACAG TTGTCCACGT ACAGAAGATA CAACCATTCA GGTGACAGAG 
AATGGCGAGT CATCTCAGGC CCGATTTTCT GTTCAGATGT TCCGGTTTGC AGGAAACTAC 
GACCTTGTCT ACCTTCACTG CGAGGTGTAC CTATGTGACT CTACGAGTGA ACAGTGTAAA 
CCTACCTGCT CTGGTACTAG ATTTCGAAGT GGGAACTTCA TAGATCAGAC CCGTGTCCTG 
AACTTGGGTC CCATAACACG ACAAGGTGTC CAGGCCTCAG TGTCCAAGGC TGCTTCCAGC 
AACTTGAGGC TCCTGAGCAT CTGGCTGCTG TTGTTTCCCT CAGCCACTTT GATCTTCATG 
GTTCAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033496.1
CDS	200..2128
Translation	MGIPLTWMLLVMMVTSWFTLAEASNSTEARRCSECHNNATCTVDGVVTTCSCQTGFTGDGLVCEDMDECATPWTHNCSNSSCVNTPGSFKCSCQDGFRLTPELSCTDVDECSEQGLSNCHALATCVNTEGDYLCVCPEGFTGDGWYCECSPGSCEPGLDCLPQGPDGKLVCQDPCNTYETLTEYWRSTEYGVGYSCDAGLHGWYRFTGQGGVRMAETCVPVLRCNTAAPMWLNGSHPSSSEGIVSRTACAHWSDQCCRWSTEIQVKACPGGFYIYNLTAPPECNLAYCTDPSSVEGTCEECRVDEDCISDNGRWRCQCKQDSNITDVSQLEYRLECGANDIKMSLRKCQLQSLGFMNVFMYLNDRQCSGFSESDERDWMSIVTPARNGPCGTVLRRNETHATYSNTLYLANAIIIRDIIIRMNFECSYPLDMKVSLKTSLQPMVSALNISLGGTGKFTVRMALFQSPTYTQPHQGPSVMLSTEAFLYVGTMLDGGDLSRFVLLMTNCYATPSSNSTDPVKYFIIQDSCPRTEDTTIQVTENGESSQARFSVQMFRFAGNYDLVYLHCEVYLCDSTSEQCKPTCSGTRFRSGNFIDQTRVLNLGPITRQGVQASVSKAASSNLRLLSIWLLLFPSATLIFMVQ

Target ORF information:

RefSeq Version	NM_009470.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus uromodulin (Umod), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009470.5

ORF Insert Sequence:

ATGGGGATCC CTTTGACCTG GATGCTGCTG GTAATGATGG TAACCTCCTG GTTCACTCTG 
GCTGAAGCCA GTAACTCAAC AGAAGCGAGA CGGTGTTCTG AATGCCACAA CAACGCCACC 
TGCACGGTGG ATGGTGTGGT CACAACGTGC TCCTGCCAGA CCGGCTTCAC TGGTGATGGG 
CTGGTGTGTG AGGACATGGA TGAGTGTGCT ACCCCATGGA CTCACAACTG CTCCAACAGC 
AGCTGTGTGA ACACCCCGGG CTCGTTTAAG TGCTCCTGTC AGGATGGTTT TCGTCTGACG 
CCTGAGCTGA GCTGCACTGA TGTGGATGAG TGCTCAGAGC AGGGGCTCAG TAACTGTCAT 
GCCCTGGCCA CCTGTGTCAA CACAGAAGGC GACTACTTGT GCGTGTGTCC CGAGGGCTTT 
ACAGGGGATG GTTGGTACTG TGAGTGCTCC CCAGGCTCCT GTGAGCCAGG ACTGGACTGC 
TTGCCCCAGG GCCCGGATGG AAAGCTGGTG TGTCAAGACC CCTGCAATAC ATATGAGACC 
CTGACTGAGT ACTGGCGCAG CACAGAGTAT GGTGTGGGCT ACTCCTGTGA CGCGGGTCTG 
CACGGCTGGT ACCGGTTCAC AGGCCAGGGT GGCGTTCGCA TGGCTGAGAC CTGTGTGCCC 
GTCCTGCGAT GCAACACGGC GGCACCCATG TGGCTCAATG GCTCTCATCC CTCGAGTAGT 
GAAGGCATTG TGAGCCGCAC GGCCTGTGCA CACTGGAGCG ACCAATGCTG CCGGTGGTCC 
ACAGAGATCC AGGTGAAGGC TTGCCCAGGT GGCTTCTATA TTTACAACTT GACAGCGCCC 
CCTGAGTGCA ATCTGGCTTA CTGCACCGAT CCTAGTTCCG TGGAGGGGAC TTGCGAAGAA 
TGCAGGGTAG ATGAAGATTG CATATCGGAT AACGGCAGAT GGCGCTGCCA GTGTAAACAG 
GACTCCAACA TCACAGATGT CTCCCAATTG GAGTACAGGC TGGAGTGTGG GGCCAATGAC 
ATCAAGATGT CCCTCAGAAA GTGCCAGCTA CAGAGTTTGG GCTTTATGAA TGTCTTCATG 
TACCTGAATG ACAGACAATG CTCAGGCTTC AGTGAGAGTG ATGAACGAGA CTGGATGTCC 
ATAGTGACCC CTGCCAGGAA TGGTCCCTGT GGGACAGTAT TGAGGAGAAA CGAAACCCAT 
GCCACCTACA GCAACACCCT CTACCTGGCA AATGCGATCA TCATTCGGGA CATCATCATA 
AGAATGAACT TTGAATGCTC TTACCCTCTG GACATGAAAG TCAGCCTGAA GACCTCCCTA 
CAGCCCATGG TCAGTGCCCT GAACATCAGC TTGGGTGGGA CAGGCAAGTT CACCGTGCGG 
ATGGCATTGT TCCAGAGCCC TACCTACACA CAGCCCCACC AAGGTCCTTC TGTGATGCTG 
TCCACTGAGG CTTTTCTGTA TGTGGGCACC ATGCTGGATG GGGGTGACTT GTCCCGGTTT 
GTACTGCTAA TGACCAACTG CTATGCCACA CCCAGTAGCA ACTCCACAGA CCCTGTGAAA 
TACTTCATTA TCCAGGACAG TTGTCCACGT ACAGAAGATA CAACCATTCA GGTGACAGAG 
AATGGCGAGT CATCTCAGGC CCGATTTTCT GTTCAGATGT TCCGGTTTGC AGGAAACTAC 
GACCTTGTCT ACCTTCACTG CGAGGTGTAC CTATGTGACT CTACGAGTGA ACAGTGTAAA 
CCTACCTGCT CTGGTACTAG ATTTCGAAGT GGGAACTTCA TAGATCAGAC CCGTGTCCTG 
AACTTGGGTC CCATAACACG ACAAGGTGTC CAGGCCTCAG TGTCCAAGGC TGCTTCCAGC 
AACTTGAGGC TCCTGAGCAT CTGGCTGCTG TTGTTTCCCT CAGCCACTTT GATCTTCATG 
GTTCAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Umod ( NM_001278605.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001265534.1 Mus musculus uromodulin (Umod), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu19761
Clone ID Related Accession (Same CDS sequence)	NM_009470.5 , NM_001278605.1
Accession Version	NM_001278605.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1929bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	uromodulin preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BB843740.1, AK165507.1 and AC125147.4. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK165507.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849385 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGATCC CTTTGACCTG GATGCTGCTG GTAATGATGG TAACCTCCTG GTTCACTCTG 
GCTGAAGCCA GTAACTCAAC AGAAGCGAGA CGGTGTTCTG AATGCCACAA CAACGCCACC 
TGCACGGTGG ATGGTGTGGT CACAACGTGC TCCTGCCAGA CCGGCTTCAC TGGTGATGGG 
CTGGTGTGTG AGGACATGGA TGAGTGTGCT ACCCCATGGA CTCACAACTG CTCCAACAGC 
AGCTGTGTGA ACACCCCGGG CTCGTTTAAG TGCTCCTGTC AGGATGGTTT TCGTCTGACG 
CCTGAGCTGA GCTGCACTGA TGTGGATGAG TGCTCAGAGC AGGGGCTCAG TAACTGTCAT 
GCCCTGGCCA CCTGTGTCAA CACAGAAGGC GACTACTTGT GCGTGTGTCC CGAGGGCTTT 
ACAGGGGATG GTTGGTACTG TGAGTGCTCC CCAGGCTCCT GTGAGCCAGG ACTGGACTGC 
TTGCCCCAGG GCCCGGATGG AAAGCTGGTG TGTCAAGACC CCTGCAATAC ATATGAGACC 
CTGACTGAGT ACTGGCGCAG CACAGAGTAT GGTGTGGGCT ACTCCTGTGA CGCGGGTCTG 
CACGGCTGGT ACCGGTTCAC AGGCCAGGGT GGCGTTCGCA TGGCTGAGAC CTGTGTGCCC 
GTCCTGCGAT GCAACACGGC GGCACCCATG TGGCTCAATG GCTCTCATCC CTCGAGTAGT 
GAAGGCATTG TGAGCCGCAC GGCCTGTGCA CACTGGAGCG ACCAATGCTG CCGGTGGTCC 
ACAGAGATCC AGGTGAAGGC TTGCCCAGGT GGCTTCTATA TTTACAACTT GACAGCGCCC 
CCTGAGTGCA ATCTGGCTTA CTGCACCGAT CCTAGTTCCG TGGAGGGGAC TTGCGAAGAA 
TGCAGGGTAG ATGAAGATTG CATATCGGAT AACGGCAGAT GGCGCTGCCA GTGTAAACAG 
GACTCCAACA TCACAGATGT CTCCCAATTG GAGTACAGGC TGGAGTGTGG GGCCAATGAC 
ATCAAGATGT CCCTCAGAAA GTGCCAGCTA CAGAGTTTGG GCTTTATGAA TGTCTTCATG 
TACCTGAATG ACAGACAATG CTCAGGCTTC AGTGAGAGTG ATGAACGAGA CTGGATGTCC 
ATAGTGACCC CTGCCAGGAA TGGTCCCTGT GGGACAGTAT TGAGGAGAAA CGAAACCCAT 
GCCACCTACA GCAACACCCT CTACCTGGCA AATGCGATCA TCATTCGGGA CATCATCATA 
AGAATGAACT TTGAATGCTC TTACCCTCTG GACATGAAAG TCAGCCTGAA GACCTCCCTA 
CAGCCCATGG TCAGTGCCCT GAACATCAGC TTGGGTGGGA CAGGCAAGTT CACCGTGCGG 
ATGGCATTGT TCCAGAGCCC TACCTACACA CAGCCCCACC AAGGTCCTTC TGTGATGCTG 
TCCACTGAGG CTTTTCTGTA TGTGGGCACC ATGCTGGATG GGGGTGACTT GTCCCGGTTT 
GTACTGCTAA TGACCAACTG CTATGCCACA CCCAGTAGCA ACTCCACAGA CCCTGTGAAA 
TACTTCATTA TCCAGGACAG TTGTCCACGT ACAGAAGATA CAACCATTCA GGTGACAGAG 
AATGGCGAGT CATCTCAGGC CCGATTTTCT GTTCAGATGT TCCGGTTTGC AGGAAACTAC 
GACCTTGTCT ACCTTCACTG CGAGGTGTAC CTATGTGACT CTACGAGTGA ACAGTGTAAA 
CCTACCTGCT CTGGTACTAG ATTTCGAAGT GGGAACTTCA TAGATCAGAC CCGTGTCCTG 
AACTTGGGTC CCATAACACG ACAAGGTGTC CAGGCCTCAG TGTCCAAGGC TGCTTCCAGC 
AACTTGAGGC TCCTGAGCAT CTGGCTGCTG TTGTTTCCCT CAGCCACTTT GATCTTCATG 
GTTCAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001265534.1
CDS	144..2072
Translation	MGIPLTWMLLVMMVTSWFTLAEASNSTEARRCSECHNNATCTVDGVVTTCSCQTGFTGDGLVCEDMDECATPWTHNCSNSSCVNTPGSFKCSCQDGFRLTPELSCTDVDECSEQGLSNCHALATCVNTEGDYLCVCPEGFTGDGWYCECSPGSCEPGLDCLPQGPDGKLVCQDPCNTYETLTEYWRSTEYGVGYSCDAGLHGWYRFTGQGGVRMAETCVPVLRCNTAAPMWLNGSHPSSSEGIVSRTACAHWSDQCCRWSTEIQVKACPGGFYIYNLTAPPECNLAYCTDPSSVEGTCEECRVDEDCISDNGRWRCQCKQDSNITDVSQLEYRLECGANDIKMSLRKCQLQSLGFMNVFMYLNDRQCSGFSESDERDWMSIVTPARNGPCGTVLRRNETHATYSNTLYLANAIIIRDIIIRMNFECSYPLDMKVSLKTSLQPMVSALNISLGGTGKFTVRMALFQSPTYTQPHQGPSVMLSTEAFLYVGTMLDGGDLSRFVLLMTNCYATPSSNSTDPVKYFIIQDSCPRTEDTTIQVTENGESSQARFSVQMFRFAGNYDLVYLHCEVYLCDSTSEQCKPTCSGTRFRSGNFIDQTRVLNLGPITRQGVQASVSKAASSNLRLLSIWLLLFPSATLIFMVQ

Target ORF information:

RefSeq Version	NM_001278605.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus uromodulin (Umod), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001278605.1

ORF Insert Sequence:

ATGGGGATCC CTTTGACCTG GATGCTGCTG GTAATGATGG TAACCTCCTG GTTCACTCTG 
GCTGAAGCCA GTAACTCAAC AGAAGCGAGA CGGTGTTCTG AATGCCACAA CAACGCCACC 
TGCACGGTGG ATGGTGTGGT CACAACGTGC TCCTGCCAGA CCGGCTTCAC TGGTGATGGG 
CTGGTGTGTG AGGACATGGA TGAGTGTGCT ACCCCATGGA CTCACAACTG CTCCAACAGC 
AGCTGTGTGA ACACCCCGGG CTCGTTTAAG TGCTCCTGTC AGGATGGTTT TCGTCTGACG 
CCTGAGCTGA GCTGCACTGA TGTGGATGAG TGCTCAGAGC AGGGGCTCAG TAACTGTCAT 
GCCCTGGCCA CCTGTGTCAA CACAGAAGGC GACTACTTGT GCGTGTGTCC CGAGGGCTTT 
ACAGGGGATG GTTGGTACTG TGAGTGCTCC CCAGGCTCCT GTGAGCCAGG ACTGGACTGC 
TTGCCCCAGG GCCCGGATGG AAAGCTGGTG TGTCAAGACC CCTGCAATAC ATATGAGACC 
CTGACTGAGT ACTGGCGCAG CACAGAGTAT GGTGTGGGCT ACTCCTGTGA CGCGGGTCTG 
CACGGCTGGT ACCGGTTCAC AGGCCAGGGT GGCGTTCGCA TGGCTGAGAC CTGTGTGCCC 
GTCCTGCGAT GCAACACGGC GGCACCCATG TGGCTCAATG GCTCTCATCC CTCGAGTAGT 
GAAGGCATTG TGAGCCGCAC GGCCTGTGCA CACTGGAGCG ACCAATGCTG CCGGTGGTCC 
ACAGAGATCC AGGTGAAGGC TTGCCCAGGT GGCTTCTATA TTTACAACTT GACAGCGCCC 
CCTGAGTGCA ATCTGGCTTA CTGCACCGAT CCTAGTTCCG TGGAGGGGAC TTGCGAAGAA 
TGCAGGGTAG ATGAAGATTG CATATCGGAT AACGGCAGAT GGCGCTGCCA GTGTAAACAG 
GACTCCAACA TCACAGATGT CTCCCAATTG GAGTACAGGC TGGAGTGTGG GGCCAATGAC 
ATCAAGATGT CCCTCAGAAA GTGCCAGCTA CAGAGTTTGG GCTTTATGAA TGTCTTCATG 
TACCTGAATG ACAGACAATG CTCAGGCTTC AGTGAGAGTG ATGAACGAGA CTGGATGTCC 
ATAGTGACCC CTGCCAGGAA TGGTCCCTGT GGGACAGTAT TGAGGAGAAA CGAAACCCAT 
GCCACCTACA GCAACACCCT CTACCTGGCA AATGCGATCA TCATTCGGGA CATCATCATA 
AGAATGAACT TTGAATGCTC TTACCCTCTG GACATGAAAG TCAGCCTGAA GACCTCCCTA 
CAGCCCATGG TCAGTGCCCT GAACATCAGC TTGGGTGGGA CAGGCAAGTT CACCGTGCGG 
ATGGCATTGT TCCAGAGCCC TACCTACACA CAGCCCCACC AAGGTCCTTC TGTGATGCTG 
TCCACTGAGG CTTTTCTGTA TGTGGGCACC ATGCTGGATG GGGGTGACTT GTCCCGGTTT 
GTACTGCTAA TGACCAACTG CTATGCCACA CCCAGTAGCA ACTCCACAGA CCCTGTGAAA 
TACTTCATTA TCCAGGACAG TTGTCCACGT ACAGAAGATA CAACCATTCA GGTGACAGAG 
AATGGCGAGT CATCTCAGGC CCGATTTTCT GTTCAGATGT TCCGGTTTGC AGGAAACTAC 
GACCTTGTCT ACCTTCACTG CGAGGTGTAC CTATGTGACT CTACGAGTGA ACAGTGTAAA 
CCTACCTGCT CTGGTACTAG ATTTCGAAGT GGGAACTTCA TAGATCAGAC CCGTGTCCTG 
AACTTGGGTC CCATAACACG ACAAGGTGTC CAGGCCTCAG TGTCCAAGGC TGCTTCCAGC 
AACTTGAGGC TCCTGAGCAT CTGGCTGCTG TTGTTTCCCT CAGCCACTTT GATCTTCATG 
GTTCAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Urinary uromodulin carries an intact ZP domain generated by a conserved C-terminal proteolytic cleavage.
Biochemical and biophysical research communications370(3)410-3(2008 Jun)
Santambrogio S,Cattaneo A,Bernascone I,Schwend T,Jovine L,Bachi A,Rampoldi L

Tamm-Horsfall protein is a critical renal defense factor protecting against calcium oxalate crystal formation.
Kidney international66(3)1159-66(2004 Sep)
Mo L,Huang HY,Zhu XH,Shapiro E,Hasty DL,Wu XR

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Umod cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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