Tnp2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tnp2
Entrez Gene ID	21959
Full Name	transition protein 2
Synonyms	TP2,Tp-2
General protein information	Preferred Names transition protein 2 Names nuclear transition protein 2 transition protein 2 (alt.)
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 16 Map Location: 16 A1\|16 5.83 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_013694.4	NP_038722.3	nuclear transition protein 2

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Tnp2	NP_038722.3
Rattus norvegicus (Norway rat)	Tnp2	NP_058753.2

Gene Ontology
Bibliography

Related articles in PubMed

IP6K1 is essential for chromatoid body formation and temporal regulation of
Malla AB, Bhandari R
Journal of cell science130(17)2854-2866(2017 Sep)

Histone Variant H2A.L.2 Guides Transition Protein-Dependent Protamine Assembly in Male Germ Cells.
Barral S, Morozumi Y, Tanaka H, Montellier E, Govin J, de Dieuleveult M, Charbonnier G, Cout? Y, Puthier D, Buchou T, Boussouar F, Urahama T, Fenaille F, Curtet S, H?ry P, Fernandez-Nunez N, Shiota H, G?rard M, Rousseaux S, Kurumizaka H, Khochbin S
Molecular cell66(1)89-101.e8(2017 Apr)

The Antagonistic Gene Paralogs Upf3a and Upf3b Govern Nonsense-Mediated RNA Decay.
Shum EY, Jones SH, Shao A, Dumdie J, Krause MD, Chan WK, Lou CH, Espinoza JL, Song HW, Phan MH, Ramaiah M, Huang L, McCarrey JR, Peterson KJ, De Rooij DG, Cook-Andersen H, Wilkinson MF
Cell165(2)382-95(2016 Apr)

JMJD1C Exhibits Multiple Functions in Epigenetic Regulation during Spermatogenesis.
Nakajima R, Okano H, Noce T
PloS one11(9)e0163466(2016)

Rfx2 is required for spermatogenesis in the mouse.
Shawlot W, Vazquez-Chantada M, Wallingford JB, Finnell RH
Genesis (New York, N.Y. : 2000)(2015 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The association of Tp2 expression via binding to the conserved RNA binding motifs of GRTH protein and the basis for understanding GRTH in the regulation of the genes essential for germ cell elongation and completion of spermatogenesis is revealed.
Title: Elucidation of RNA binding regions of gonadotropin-regulated testicular RNA helicase (GRTH/DDX25) to transcripts of a chromatin remodeling protein essential for spermatogenesis.

Testis-specific miRNA-469 up-regulated in gonadotropin-regulated testicular RNA helicase (GRTH/DDX25)-null mice silences transition protein 2 and protamine 2 messages at sites within coding region: implications of its role in germ cell development.
Title: Testis-specific miRNA-469 up-regulated in gonadotropin-regulated testicular RNA helicase (GRTH/DDX25)-null mice silences transition protein 2 and protamine 2 messages at sites within coding region: implications of its role in germ cell development.

Cannabinoid receptor 1 influences chromatin remodeling in mouse spermatids by affecting content of transition protein 2 mRNA.
Title: Cannabinoid receptor 1 influences chromatin remodeling in mouse spermatids by affecting content of transition protein 2 mRNA and histone displacement.

Data show that Parp2 interacts significantly with both the transition protein TP2 and the transition chaperone HSPA2, whereas Parp1 binds weakly to HSPA2.
Title: Parp2 is required for the differentiation of post-meiotic germ cells: identification of a spermatid-specific complex containing Parp1, Parp2, TP2 and HSPA2.

These results show clearly that a strict temporal and stage-specific Tnp2 translation is necessary for the correct differentiation of round spermatids into mature spermatozoa and for male fertility.
Title: Premature translation of transition protein 2 mRNA causes sperm abnormalities and male infertility.

The following Tnp2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tnp2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu09802	NM_013694.4 Latest version!	Mus musculus transition protein 2 (Tnp2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tnp2 ( NM_013694.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_038722.3 Mus musculus transition protein 2 (Tnp2), mRNA.

Price & Availability↑

CloneID	OMu09802
Clone ID Related Accession (Same CDS sequence)	NM_013694.4
Accession Version	NM_013694.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 354bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	nuclear transition protein 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC092529.1. On Apr 11, 2005 this sequence version replaced NM_013694.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC092529.1, CN839027.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849381 [ECO:0000348] ##Evidence-Data-END##

ATGGACACCA AGATGCAGAG CCTTCCCACC ACTCATCCCC ACCCCCACAG CTCCTCGCGG 
CCTCAAAGTC ACACCAGTAA CCAGTGCAAT CAGTGCACCT GCAGCCACCA CTGCCGGAGC 
TGCAGCCAGG CAGGCCACGC GGGCTCTAGC TCCAGCCCCA GCCCTGGCCC GCCCATGAAG 
CACCCCAAGC CATCCGTGCA CTCTCGACAC TCACCTGCAA GACCCAGCCA CCGCGGGAGC 
TGCCCCAAGA ACAGGAAGAC CTTTGAAGGG AAAGTGAGCA AGAGAAAGGC CGTCAGGAGG 
CGGAAACGGA CTCACAGAGC TAAGAGGCGT AGCTCAGGGC GAAGATACAA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_038722.3
CDS	55..408
Translation	MDTKMQSLPTTHPHPHSSSRPQSHTSNQCNQCTCSHHCRSCSQAGHAGSSSSPSPGPPMKHPKPSVHSRHSPARPSHRGSCPKNRKTFEGKVSKRKAVRRRKRTHRAKRRSSGRRYK

Target ORF information:

RefSeq Version	NM_013694.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus transition protein 2 (Tnp2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013694.4

ORF Insert Sequence:

ATGGACACCA AGATGCAGAG CCTTCCCACC ACTCATCCCC ACCCCCACAG CTCCTCGCGG 
CCTCAAAGTC ACACCAGTAA CCAGTGCAAT CAGTGCACCT GCAGCCACCA CTGCCGGAGC 
TGCAGCCAGG CAGGCCACGC GGGCTCTAGC TCCAGCCCCA GCCCTGGCCC GCCCATGAAG 
CACCCCAAGC CATCCGTGCA CTCTCGACAC TCACCTGCAA GACCCAGCCA CCGCGGGAGC 
TGCCCCAAGA ACAGGAAGAC CTTTGAAGGG AAAGTGAGCA AGAGAAAGGC CGTCAGGAGG 
CGGAAACGGA CTCACAGAGC TAAGAGGCGT AGCTCAGGGC GAAGATACAA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

IP6K1 is essential for chromatoid body formation and temporal regulation of
Journal of cell science130(17)2854-2866(2017 Sep)
Malla AB,Bhandari R

Histone Variant H2A.L.2 Guides Transition Protein-Dependent Protamine Assembly in Male Germ Cells.
Molecular cell66(1)89-101.e8(2017 Apr)
Barral S,Morozumi Y,Tanaka H,Montellier E,Govin J,de Dieuleveult M,Charbonnier G,Cout? Y,Puthier D,Buchou T,Boussouar F,Urahama T,Fenaille F,Curtet S,H?ry P,Fernandez-Nunez N,Shiota H,G?rard M,Rousseaux S,Kurumizaka H,Khochbin S

The Antagonistic Gene Paralogs Upf3a and Upf3b Govern Nonsense-Mediated RNA Decay.
Cell165(2)382-95(2016 Apr)
Shum EY,Jones SH,Shao A,Dumdie J,Krause MD,Chan WK,Lou CH,Espinoza JL,Song HW,Phan MH,Ramaiah M,Huang L,McCarrey JR,Peterson KJ,De Rooij DG,Cook-Andersen H,Wilkinson MF

JMJD1C Exhibits Multiple Functions in Epigenetic Regulation during Spermatogenesis.
PloS one11(9)e0163466(2016)
Nakajima R,Okano H,Noce T

Rfx2 is required for spermatogenesis in the mouse.
Genesis (New York, N.Y. : 2000)(2015 Aug)
Shawlot W,Vazquez-Chantada M,Wallingford JB,Finnell RH

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Tnp2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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