Ppp1r9b cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ppp1r9b
Entrez Gene ID	217124
Full Name	protein phosphatase 1, regulatory subunit 9B
Synonyms	SPL,Spn
General protein information	Preferred Names protein phosphatase 1, regulatory subunit 9B Names neurabin-2 neurabin-II spinophilin
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11\|11 D

mRNA and Protein(s)

mRNA	Protein	Name
NM_172261.3	NP_758465.2	neurabin-2

Pathways from BioSystems

Homologies

Homo sapiens (human)	PPP1R9B	NP_115984.3
Pan troglodytes (chimpanzee)	PPP1R9B	XP_003315699.2
Danio rerio (zebrafish)	LOC558232	XP_686514.3
Bos taurus (cattle)	PPP1R9B	XP_005228653.1
Mus musculus (house mouse)	Ppp1r9b	NP_758465.2
Rattus norvegicus (Norway rat)	Ppp1r9b	NP_445926.1
Xenopus tropicalis (tropical clawed frog)	ppp1r9b	XP_002935605.1
Canis lupus familiaris (dog)	PPP1R9B	XP_548196.2

Gene Ontology
Bibliography

Related articles in PubMed

Age-dependent differential regulation of anxiety- and depression-related behaviors by neurabin and spinophilin.
Wu H, Cottingham C, Chen L, Wang H, Che P, Liu K, Wang Q
PloS one12(7)e0180638(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

two homologs neurabin and spinophilin play important yet distinct roles in the regulation of anxiety- and depression-like behaviors in an age-dependent manner.
Title: Age-dependent differential regulation of anxiety- and depression-related behaviors by neurabin and spinophilin.

results indicate that spinophilin plays an important role in regulating the activity of Group I mGluRs as well as their influence on synaptic activity.
Title: Role of Spinophilin in Group I Metabotropic Glutamate Receptor Endocytosis, Signaling, and Synaptic Plasticity.

COPS5 overexpression reduced spinophilin in both the cortex (19%, p < 0.05) and the hippocampus (20%, p < 0.05), leading to significant deficits in learning and memory skills
Title: COPS5 protein overexpression increases amyloid plaque burden, decreases spinophilin-immunoreactive puncta, and exacerbates learning and memory deficits in the mouse brain.

Canonical betaAR-mediated signaling coupled to PKA activation results in phosphorylation of spinophilin, disrupting its interaction with alpha2AARs and accelerating alpha2AAR endocytic responses.
Title: Cross-talk from ?-adrenergic receptors modulates ?2A-adrenergic receptor endocytosis in sympathetic neurons via protein kinase A and spinophilin.

RanBP9 overexpression in transgenic mice led to striking reduction in the levels of spinophilin.
Title: RanBP9 aggravates synaptic damage in the mouse brain and is inversely correlated to spinophilin levels in Alzheimer's brain synaptosomes.

The following Ppp1r9b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ppp1r9b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu13358	NM_172261.3 Latest version!	Mus musculus protein phosphatase 1, regulatory subunit 9B (Ppp1r9b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$482.30 $689.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ppp1r9b ( NM_172261.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_758465.2 Mus musculus protein phosphatase 1, regulatory subunit 9B (Ppp1r9b), mRNA.

Price & Availability↑

CloneID	OMu13358
Clone ID Related Accession (Same CDS sequence)	NM_172261.3
Accession Version	NM_172261.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2454bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	neurabin-2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY508450.1 and AI841686.1. On Oct 30, 2009 this sequence version replaced NM_172261.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY508450.1, SRR1660811.124403.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGATGAAGA CGGAGCCTCG GGGGCCCGGG GGTCCCCTCC GGAGCGCCTC CCCGCACCGC 
AGCGCCTACG AAGCGGGCAT CCAGGCACTA AAGCCTCCCG ATGCACCCGG GCCCGACGAG 
GCACCCAAGG CGGCCCACCA TAAGAAATAT GGCTCCAACG TCCACCGCAT CAAAAGTATG 
TTCCTGCAGA TGGGCACCAC CGCGGGGCCG CCGGGTGAGG CAGGCGGAGG CGCAGGCATG 
GCCGAGGCCC CACGGGCGTC CGATCGCGGG GTGCGCCTGT CCCTGCCGCG GGCCAGCAGC 
CTGAACGAGA ACGTAGACCA CAGTGCCCTG CTCAAGCTGG GCACCAGTGT GTCGGAGCGC 
GTGAGCCGCT TCGACTCCAA GCCCGCGCCC TCGGCGCAGC CCGCTCCTCC GCCGCACCCG 
CCGTCCCGGC TGCAGGAGAC GCGGAAGCTG TTCGAACGGA GCGTCCCCGC GGCCTCGGGT 
GGCGACAAGG AGGCCGTGGC GCGGCGGCTG CTGAGGCAGG AGCGCGCCGG CCTGCAGGAC 
CGGAAGCTGG ACGTCGTGGT GCGCTTTAAC GGCAGCACCG AGGCGCTGGA CAAGCTGGAT 
GCTGACGCCG TGTCGCCGAC GGTCAGCCAG CTCAGTGCGG TCTTCGAGAA AGCCGACTCG 
AGGACCGGCC TTCACCGTGC ACCCGGCCCC CCTCGGGCAG CCGGGGCGCC CCAGGTCAAC 
TCGAAGCTGG TCACTAAGCG GTCCCGGGTG TTCCAGCCAC CGCCGCCGCC TCCCGCCCCG 
TCGGGGGATG GCGCGACCGA GAAGGAGCGT GGCCCCGGAG GGCAGCAGCC CCCACAGCAC 
CGGGTGGCCC CTGCCCGACC TCCGCCTAAG CCGCGGGAGG TGCGCAAGAT CAAGCCGGTG 
GAGGTTGAAG AAAGTGGGGA GTCTGAGGCC GAGTCGGCTC CCGGGGAAGT GATCCAGGCC 
GAGGTGACGG TCCATGCAGC CTTGGAGAAT GGCAGCACCC CGGCCACCAC AGCCAGCCCT 
GCACCCGAGG AACCCAAGGC CGAAGCGGTC CCCGAGGAGG AGGCGGCGGC GTCAGTGGCG 
ACGCTAGAGA GGGGGGTGGA CAATGGCCGG GCCCCGGACA TGGCACCTGA GGAGGTGGAT 
GAATCCAAGA AGGAGGACTT CTCGGAAGCG GACTTGGTGG ATGTGAGCGC CTACAGTGGA 
CTCGGGGAGG ACTCTGGGGG CAGTGCCCTG GAGGAGGACG ATGAAGAAGA CGAAGAGGAC 
GGGGAGCCCC CCTATGAGCC GGAGTCAGGG TGTGTGGAGA TTCCCGGGCT CTCAGAGGAA 
GAGGACCCGG CCCCGAGCCG GAAGATCCAT TTCAGCACCG CACCGATCCA AGTATTCAGC 
ACCTACTCCA ACGAGGACTA TGACCGACGC AATGAGGATG TGGATCCCAT GGCAGCCTCT 
GCGGAATATG AGCTAGAGAA GCGAGTGGAG AGGTTGGAGC TGTTTCCTGT GGAGCTGGAG 
AAGGACTCTG AGGGCTTGGG CATCAGCATC ATTGGCATGG GCGCCGGAGC CGACATGGGC 
CTGGAGAAGC TGGGCATCTT CGTCAAGACT GTGACTGAGG GTGGTGCAGC CCATCGGGAT 
GGCAGGATCC AAGTGAACGA CCTGCTGGTG GAGGTGGATG GGACGAGCCT GGTGGGAGTG 
ACCCAGAGCT TTGCAGCCTC TGTACTTAGG AACACCAAAG GCCGAGTGCG GTTCATGATT 
GGCCGGGAGC GGCCTGGAGA ACAGAGTGAA GTGGCCCAGC TAATTCAGCA GACCTTGGAG 
CAGGAGCGAT GGCAGCGGGA GATGATGGAG CAGAGATACG CCCAGTATGG AGAGGATGAT 
GAGGAGACAG GAGAGTATGC CACCGACGAA GATGAAGAAC TGAGCCCAAC GTTCCCAGGG 
GGTGAAATGG CCATTGAGGT GTTTGAACTA GCAGAGAACG AGGATGCGCT GTCCCCCGTG 
GAGATGGAGC CCGAAAAGCT GGTGCACAAG TTCAAGGAGC TCCAGATCAA GCATGCTGTC 
ACTGAAGCGG AAATCCAGCA GCTGAAACGG AAGTTGCAGA GTCTGGAGCA GGAGAAAGGG 
CGCTGGCGGG TAGAGAAGGC CCAGCTGGAG CAGAGCGTGG AGGAGAATAA GGAGCGGATG 
GAGAAGCTAG AGGGCTACTG GGGTGAGGCC CAGAGCCTGT GCCAGGCTGT GGATGAGCAC 
CTGCGGGAGA CCCAGGCCCA GTATCAGGCC CTGGAGCGCA AGTACAGCAA GGCCAAGCGT 
CTCATCAAGG ACTACCAGCA AAAGGAGATC GAGTTCCTGA AAAAAGAGAC AGCCCAGCGT 
CGGGTACTGG AAGAGTCGGA GCTAGCCAGG AAGGAGGAAA TGGACAAACT TCTGGACAAG 
ATCTCAGAAC TGGAAGGAAA CCTGCAGACA CTGAGGAACT CCAATTCTAC TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_758465.2
CDS	337..2790
Translation	MMKTEPRGPGGPLRSASPHRSAYEAGIQALKPPDAPGPDEAPKAAHHKKYGSNVHRIKSMFLQMGTTAGPPGEAGGGAGMAEAPRASDRGVRLSLPRASSLNENVDHSALLKLGTSVSERVSRFDSKPAPSAQPAPPPHPPSRLQETRKLFERSVPAASGGDKEAVARRLLRQERAGLQDRKLDVVVRFNGSTEALDKLDADAVSPTVSQLSAVFEKADSRTGLHRAPGPPRAAGAPQVNSKLVTKRSRVFQPPPPPPAPSGDGATEKERGPGGQQPPQHRVAPARPPPKPREVRKIKPVEVEESGESEAESAPGEVIQAEVTVHAALENGSTPATTASPAPEEPKAEAVPEEEAAASVATLERGVDNGRAPDMAPEEVDESKKEDFSEADLVDVSAYSGLGEDSGGSALEEDDEEDEEDGEPPYEPESGCVEIPGLSEEEDPAPSRKIHFSTAPIQVFSTYSNEDYDRRNEDVDPMAASAEYELEKRVERLELFPVELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTSLVGVTQSFAASVLRNTKGRVRFMIGRERPGEQSEVAQLIQQTLEQERWQREMMEQRYAQYGEDDEETGEYATDEDEELSPTFPGGEMAIEVFELAENEDALSPVEMEPEKLVHKFKELQIKHAVTEAEIQQLKRKLQSLEQEKGRWRVEKAQLEQSVEENKERMEKLEGYWGEAQSLCQAVDEHLRETQAQYQALERKYSKAKRLIKDYQQKEIEFLKKETAQRRVLEESELARKEEMDKLLDKISELEGNLQTLRNSNST

Target ORF information:

RefSeq Version	NM_172261.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus protein phosphatase 1, regulatory subunit 9B (Ppp1r9b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172261.3

ORF Insert Sequence:

ATGATGAAGA CGGAGCCTCG GGGGCCCGGG GGTCCCCTCC GGAGCGCCTC CCCGCACCGC 
AGCGCCTACG AAGCGGGCAT CCAGGCACTA AAGCCTCCCG ATGCACCCGG GCCCGACGAG 
GCACCCAAGG CGGCCCACCA TAAGAAATAT GGCTCCAACG TCCACCGCAT CAAAAGTATG 
TTCCTGCAGA TGGGCACCAC CGCGGGGCCG CCGGGTGAGG CAGGCGGAGG CGCAGGCATG 
GCCGAGGCCC CACGGGCGTC CGATCGCGGG GTGCGCCTGT CCCTGCCGCG GGCCAGCAGC 
CTGAACGAGA ACGTAGACCA CAGTGCCCTG CTCAAGCTGG GCACCAGTGT GTCGGAGCGC 
GTGAGCCGCT TCGACTCCAA GCCCGCGCCC TCGGCGCAGC CCGCTCCTCC GCCGCACCCG 
CCGTCCCGGC TGCAGGAGAC GCGGAAGCTG TTCGAACGGA GCGTCCCCGC GGCCTCGGGT 
GGCGACAAGG AGGCCGTGGC GCGGCGGCTG CTGAGGCAGG AGCGCGCCGG CCTGCAGGAC 
CGGAAGCTGG ACGTCGTGGT GCGCTTTAAC GGCAGCACCG AGGCGCTGGA CAAGCTGGAT 
GCTGACGCCG TGTCGCCGAC GGTCAGCCAG CTCAGTGCGG TCTTCGAGAA AGCCGACTCG 
AGGACCGGCC TTCACCGTGC ACCCGGCCCC CCTCGGGCAG CCGGGGCGCC CCAGGTCAAC 
TCGAAGCTGG TCACTAAGCG GTCCCGGGTG TTCCAGCCAC CGCCGCCGCC TCCCGCCCCG 
TCGGGGGATG GCGCGACCGA GAAGGAGCGT GGCCCCGGAG GGCAGCAGCC CCCACAGCAC 
CGGGTGGCCC CTGCCCGACC TCCGCCTAAG CCGCGGGAGG TGCGCAAGAT CAAGCCGGTG 
GAGGTTGAAG AAAGTGGGGA GTCTGAGGCC GAGTCGGCTC CCGGGGAAGT GATCCAGGCC 
GAGGTGACGG TCCATGCAGC CTTGGAGAAT GGCAGCACCC CGGCCACCAC AGCCAGCCCT 
GCACCCGAGG AACCCAAGGC CGAAGCGGTC CCCGAGGAGG AGGCGGCGGC GTCAGTGGCG 
ACGCTAGAGA GGGGGGTGGA CAATGGCCGG GCCCCGGACA TGGCACCTGA GGAGGTGGAT 
GAATCCAAGA AGGAGGACTT CTCGGAAGCG GACTTGGTGG ATGTGAGCGC CTACAGTGGA 
CTCGGGGAGG ACTCTGGGGG CAGTGCCCTG GAGGAGGACG ATGAAGAAGA CGAAGAGGAC 
GGGGAGCCCC CCTATGAGCC GGAGTCAGGG TGTGTGGAGA TTCCCGGGCT CTCAGAGGAA 
GAGGACCCGG CCCCGAGCCG GAAGATCCAT TTCAGCACCG CACCGATCCA AGTATTCAGC 
ACCTACTCCA ACGAGGACTA TGACCGACGC AATGAGGATG TGGATCCCAT GGCAGCCTCT 
GCGGAATATG AGCTAGAGAA GCGAGTGGAG AGGTTGGAGC TGTTTCCTGT GGAGCTGGAG 
AAGGACTCTG AGGGCTTGGG CATCAGCATC ATTGGCATGG GCGCCGGAGC CGACATGGGC 
CTGGAGAAGC TGGGCATCTT CGTCAAGACT GTGACTGAGG GTGGTGCAGC CCATCGGGAT 
GGCAGGATCC AAGTGAACGA CCTGCTGGTG GAGGTGGATG GGACGAGCCT GGTGGGAGTG 
ACCCAGAGCT TTGCAGCCTC TGTACTTAGG AACACCAAAG GCCGAGTGCG GTTCATGATT 
GGCCGGGAGC GGCCTGGAGA ACAGAGTGAA GTGGCCCAGC TAATTCAGCA GACCTTGGAG 
CAGGAGCGAT GGCAGCGGGA GATGATGGAG CAGAGATACG CCCAGTATGG AGAGGATGAT 
GAGGAGACAG GAGAGTATGC CACCGACGAA GATGAAGAAC TGAGCCCAAC GTTCCCAGGG 
GGTGAAATGG CCATTGAGGT GTTTGAACTA GCAGAGAACG AGGATGCGCT GTCCCCCGTG 
GAGATGGAGC CCGAAAAGCT GGTGCACAAG TTCAAGGAGC TCCAGATCAA GCATGCTGTC 
ACTGAAGCGG AAATCCAGCA GCTGAAACGG AAGTTGCAGA GTCTGGAGCA GGAGAAAGGG 
CGCTGGCGGG TAGAGAAGGC CCAGCTGGAG CAGAGCGTGG AGGAGAATAA GGAGCGGATG 
GAGAAGCTAG AGGGCTACTG GGGTGAGGCC CAGAGCCTGT GCCAGGCTGT GGATGAGCAC 
CTGCGGGAGA CCCAGGCCCA GTATCAGGCC CTGGAGCGCA AGTACAGCAA GGCCAAGCGT 
CTCATCAAGG ACTACCAGCA AAAGGAGATC GAGTTCCTGA AAAAAGAGAC AGCCCAGCGT 
CGGGTACTGG AAGAGTCGGA GCTAGCCAGG AAGGAGGAAA TGGACAAACT TCTGGACAAG 
ATCTCAGAAC TGGAAGGAAA CCTGCAGACA CTGAGGAACT CCAATTCTAC TTAA