Ppp1r9b cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ppp1r9b
Entrez Gene ID	84686
Full Name	protein phosphatase 1, regulatory subunit 9B
Synonyms	Neb2
General protein information	Preferred Names protein phosphatase 1, regulatory subunit 9B Names neurabin-2 PP1bp134 neurabin-II neural tissue-specific F-actin-binding protein II nuerabin 2 p130 spinophilin
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q26
Summary	interacts with protein phosphatase 1 and actin filaments; involved in regulation of synaptic transmission [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053474.1	NP_445926.1	neurabin-2

Pathways from BioSystems

Homologies

Homo sapiens (human)	PPP1R9B	NP_115984.3
Pan troglodytes (chimpanzee)	PPP1R9B	XP_003315699.2
Danio rerio (zebrafish)	LOC558232	XP_686514.3
Bos taurus (cattle)	PPP1R9B	XP_005228653.1
Mus musculus (house mouse)	Ppp1r9b	NP_758465.2
Rattus norvegicus (Norway rat)	Ppp1r9b	NP_445926.1
Xenopus tropicalis (tropical clawed frog)	ppp1r9b	XP_002935605.1
Canis lupus familiaris (dog)	PPP1R9B	XP_548196.2

Gene Ontology
Bibliography

Related articles in PubMed

The expression of plasticity-related genes in an acute model of stress is modulated by chronic desipramine in a time-dependent manner within medial prefrontal cortex.
Nava N, Treccani G, M?ller HK, Popoli M, Wegener G, Elfving B
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology27(1)19-28(2017 Jan)

The guanine nucleotide exchange factor (GEF) Asef2 promotes dendritic spine formation via Rac activation and spinophilin-dependent targeting.
Evans JC, Robinson CM, Shi M, Webb DJ
The Journal of biological chemistry290(16)10295-308(2015 Apr)

Dissociation of SHP-1 from spinophilin during platelet activation exposes an inhibitory binding site for protein phosphatase-1 (PP1).
Ma P, Foote DC, Sinnamon AJ, Brass LF
PloS one10(3)e0119496(2015)

Aging-induced proteostatic changes in the rat hippocampus identify ARP3, NEB2 and BRAG2 as a molecular circuitry for cognitive impairment.
Ottis P, Topic B, Loos M, Li KW, de Souza A, Schulz D, Smit AB, Huston JP, Korth C
PloS one8(9)e75112(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The guanine nucleotide exchange factor (GEF) Asef2 promotes dendritic spine formation via Rac activation and spinophilin-dependent targeting.
Title: The guanine nucleotide exchange factor (GEF) Asef2 promotes dendritic spine formation via Rac activation and spinophilin-dependent targeting.

Aging-induced proteostatic changes in the rat hippocampus identify ARP3, NEB2 and BRAG2 as a molecular circuitry for cognitive impairment.
Title: Aging-induced proteostatic changes in the rat hippocampus identify ARP3, NEB2 and BRAG2 as a molecular circuitry for cognitive impairment.

Data show that the PP1:spinophilin holoenzyme is dynamic in solution, which allows for an increased capture radius of spinophilin and is likely important for its biological role.
Title: Flexibility in the PP1:spinophilin holoenzyme.

The current results suggest a possible role for spinophilin in neuronal plasticity induced by environmental enrichment.
Title: Enriched environment increases spinophilin mRNA expression and spinophilin immunoreactive dendritic spines in hippocampus and cortex.

expression of spinophilin (SPL) could enhance the regulatory function of RGS8 on the M3-mAChR system, but the acceleration function of RGS8 on the M2-mediated signaling could not be enhanced by SPL
Title: Effects of spinophilin on the function of RGS8 regulating signals from M2 and M3-mAChRs.

The following Ppp1r9b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ppp1r9b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42585	NM_053474.1 Latest version!	Rattus norvegicus protein phosphatase 1, regulatory subunit 9B (Ppp1r9b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ppp1r9b ( NM_053474.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_445926.1 Rattus norvegicus protein phosphatase 1, regulatory subunit 9B (Ppp1r9b), mRNA.

Price & Availability↑

CloneID	ORa42585
Clone ID Related Accession (Same CDS sequence)	NM_053474.1
Accession Version	NM_053474.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2454bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Rattus norvegicus(Norway rat)
Product	neurabin-2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF016252.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF016252.1, BC160878.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGATGAAGA CGGAGCCTCG GGGGCCCGGG GGTCCCCTCC GGAGCGCCTC CCCGCACCGC 
AGCGCCTACG AAGCGGGCAT CCAGGCACTA AAGCCTCCCG ATGCTCCCGG GCCTGACGAG 
GCACCCAAGG CGGCCCACCA TAAGAAATAT GGCTCCAACG TCCACCGCAT CAAAAGTATG 
TTCCTGCAGA TGGGCACCAC CACGGGGCCG CCGGGTGAGG CAGGCGGCGC CTCAGGCATG 
GCCGAAGCCC CACGGGCGTC CGATCGCGGC GTGCGCCTTT CCCTGCCGCG GGCCAGCAGC 
CTGAACGAGA ACGTGGACCA CAGTGCCCTG CTCAAGCTGG GCACCAGTGT GTCGGAGCGC 
GTGAGCCGTT TCGACTCCAA GCCCGCGCCC TCGGCGCAGC CGGCTCCGCC GCCGCACCCG 
CCGTCCCGGC TGCAGGAGAC GCGGAAGCTG TTCGAACGGA GCGTCCCCGC GGCCTCGGGT 
GGCGACAAGG AGGCCGTGGC GCGGCGGCTG CTGAGGCAGG AGCGCGCCAG CCTGCAGGAC 
CGGAAGCTGG ACGTCGTGGT GCGCTTTAAC GGCAGCACCG AGGCGCTGGA CAAGCTGGAT 
GCTGACGCCG TGTCGCCGAC GGTCAGCCAG CTCAGTGCGG TCTTCGAGAA AGCCGACTCG 
AGGACCGGCC TTCACCGTGC ACCCGGTCCC CCTCGGGCCG CGGGGGCGCC CCAGGTCAAC 
TCGAAGCTGG TCACCAAGCG GTCCCGGGTG TTCCAGCCAC CGCCGCCGCC TCCCGCCCCG 
TCGGGGGATG CCGCGACAGA GAAGGATCGT GGCCCCGGAG GGCAGCAGCC CCCACAGCAC 
CGAGTGGCCC CTGCCCGACC TCCGCCAAAG CCGCGGGAGG TACGCAAGAT CAAACCGGTG 
GAGGTTGAGG AAAGTGGGGA GTCTGAGGCT GAGTCGGCTC CCGGGGAAGT GATCCAGGCC 
GAGGTGACCG TCCATGCAGC CTTGGAGAAT GGCAGCACCA CAGCCACCAC AGCCAGCCCT 
GCACCCGAGG AACCCAAGGC CGAAGCGGTC CCCGAAGAGG AGGCGTCGTC GTCAGTGGCG 
ACACTAGAGA GGGGGGTGGA CAATGGCCGG GCCCCGGACA TGGCACCCGA GGAGGTGGAT 
GAATCCAAAA AGGAGGACTT CTCAGAAGCG GACTTGGTAG ACGTGAGCGC CTACAGTGGA 
CTCGGGGAGG ACTCTGGGGG CAGTGCCCTG GAAGAGGACG ATGAAGAAGA TGAAGAGGAC 
GGGGAGCCCC CCTACGAGCC GGAATCAGGG TGTGTGGAGA TTCCTGGGCT TTCAGAGGAA 
GAGGACCCAG CCCCGAGCCG GAAGATCCAT TTCAGCACCG CACCGATCCA AGTATTCAGC 
ACCTACTCCA ATGAGGACTA TGACCGACGC AATGAGGATG TGGACCCCAT GGCGGCCTCT 
GCGGAATACG AGCTGGAGAA GCGAGTGGAG AGGTTGGAGC TGTTTCCTGT GGAGTTGGAG 
AAGGACTCTG AGGGCCTGGG CATCAGCATC ATTGGCATGG GAGCCGGAGC CGACATGGGC 
CTGGAGAAGC TGGGCATCTT CGTCAAGACT GTGACTGAGG GTGGTGCAGC CCATCGGGAT 
GGCAGGATCC AAGTGAACGA TCTCCTGGTA GAGGTGGACG GGACGAGCCT GGTGGGAGTG 
ACCCAGAGCT TTGCAGCCTC TGTGCTTAGG AACACCAAAG GCAGAGTGCG GTTCATGATT 
GGCCGGGAGC GGCCTGGAGA ACAGAGTGAA GTGGCCCAGC TAATTCAGCA GACCTTGGAG 
CAGGAGAGGT GGCAGCGGGA GATGATGGAG CAGAGATACG CCCAGTATGG AGAAGACGAT 
GAGGAGACAG GAGAGTATGC CACCGATGAA GATGAAGAAC TGAGCCCGAC ATTTCCAGGG 
GGTGAAATGG CCATCGAGGT GTTTGAACTA GCAGAGAATG AGGATGCACT GTCCCCTGTG 
GAGATGGAGC CTGAAAAGCT GGTGCACAAG TTCAAGGAGC TCCAGATCAA GCATGCTGTC 
ACTGAAGCGG AAATCCAGCA GCTGAAGCGG AAGTTGCAGA GTCTGGAGCA GGAGAAAGGG 
CGCTGGCGGG TGGAGAAGGC CCAGCTGGAG CAGAGTGTGG AGGAGAATAA GGAGCGGATG 
GAGAAGCTAG AAGGCTACTG GGGTGAGGCC CAGAGCCTGT GCCAGGCTGT GGATGAGCAC 
CTGCGGGAGA CTCAGGCCCA GTATCAGGCC CTGGAGCGAA AGTACAGCAA GGCCAAGCGT 
CTCATCAAGG ACTACCAGCA AAAGGAGATC GAGTTCCTGA AAAAAGAGAC CGCCCAGCGT 
CGGGTACTGG AAGAGTCGGA GCTAGCCAGG AAGGAGGAAA TGGACAAACT TCTGGATAAG 
ATCTCAGAAC TGGAAGGAAA CCTGCAAACA CTGAGGAATT CCAATTCTAC TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_445926.1
CDS	514..2967
Translation	MMKTEPRGPGGPLRSASPHRSAYEAGIQALKPPDAPGPDEAPKAAHHKKYGSNVHRIKSMFLQMGTTTGPPGEAGGASGMAEAPRASDRGVRLSLPRASSLNENVDHSALLKLGTSVSERVSRFDSKPAPSAQPAPPPHPPSRLQETRKLFERSVPAASGGDKEAVARRLLRQERASLQDRKLDVVVRFNGSTEALDKLDADAVSPTVSQLSAVFEKADSRTGLHRAPGPPRAAGAPQVNSKLVTKRSRVFQPPPPPPAPSGDAATEKDRGPGGQQPPQHRVAPARPPPKPREVRKIKPVEVEESGESEAESAPGEVIQAEVTVHAALENGSTTATTASPAPEEPKAEAVPEEEASSSVATLERGVDNGRAPDMAPEEVDESKKEDFSEADLVDVSAYSGLGEDSGGSALEEDDEEDEEDGEPPYEPESGCVEIPGLSEEEDPAPSRKIHFSTAPIQVFSTYSNEDYDRRNEDVDPMAASAEYELEKRVERLELFPVELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTSLVGVTQSFAASVLRNTKGRVRFMIGRERPGEQSEVAQLIQQTLEQERWQREMMEQRYAQYGEDDEETGEYATDEDEELSPTFPGGEMAIEVFELAENEDALSPVEMEPEKLVHKFKELQIKHAVTEAEIQQLKRKLQSLEQEKGRWRVEKAQLEQSVEENKERMEKLEGYWGEAQSLCQAVDEHLRETQAQYQALERKYSKAKRLIKDYQQKEIEFLKKETAQRRVLEESELARKEEMDKLLDKISELEGNLQTLRNSNST

Target ORF information:

RefSeq Version	NM_053474.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus protein phosphatase 1, regulatory subunit 9B (Ppp1r9b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053474.1

ORF Insert Sequence:

ATGATGAAGA CGGAGCCTCG GGGGCCCGGG GGTCCCCTCC GGAGCGCCTC CCCGCACCGC 
AGCGCCTACG AAGCGGGCAT CCAGGCACTA AAGCCTCCCG ATGCTCCCGG GCCTGACGAG 
GCACCCAAGG CGGCCCACCA TAAGAAATAT GGCTCCAACG TCCACCGCAT CAAAAGTATG 
TTCCTGCAGA TGGGCACCAC CACGGGGCCG CCGGGTGAGG CAGGCGGCGC CTCAGGCATG 
GCCGAAGCCC CACGGGCGTC CGATCGCGGC GTGCGCCTTT CCCTGCCGCG GGCCAGCAGC 
CTGAACGAGA ACGTGGACCA CAGTGCCCTG CTCAAGCTGG GCACCAGTGT GTCGGAGCGC 
GTGAGCCGTT TCGACTCCAA GCCCGCGCCC TCGGCGCAGC CGGCTCCGCC GCCGCACCCG 
CCGTCCCGGC TGCAGGAGAC GCGGAAGCTG TTCGAACGGA GCGTCCCCGC GGCCTCGGGT 
GGCGACAAGG AGGCCGTGGC GCGGCGGCTG CTGAGGCAGG AGCGCGCCAG CCTGCAGGAC 
CGGAAGCTGG ACGTCGTGGT GCGCTTTAAC GGCAGCACCG AGGCGCTGGA CAAGCTGGAT 
GCTGACGCCG TGTCGCCGAC GGTCAGCCAG CTCAGTGCGG TCTTCGAGAA AGCCGACTCG 
AGGACCGGCC TTCACCGTGC ACCCGGTCCC CCTCGGGCCG CGGGGGCGCC CCAGGTCAAC 
TCGAAGCTGG TCACCAAGCG GTCCCGGGTG TTCCAGCCAC CGCCGCCGCC TCCCGCCCCG 
TCGGGGGATG CCGCGACAGA GAAGGATCGT GGCCCCGGAG GGCAGCAGCC CCCACAGCAC 
CGAGTGGCCC CTGCCCGACC TCCGCCAAAG CCGCGGGAGG TACGCAAGAT CAAACCGGTG 
GAGGTTGAGG AAAGTGGGGA GTCTGAGGCT GAGTCGGCTC CCGGGGAAGT GATCCAGGCC 
GAGGTGACCG TCCATGCAGC CTTGGAGAAT GGCAGCACCA CAGCCACCAC AGCCAGCCCT 
GCACCCGAGG AACCCAAGGC CGAAGCGGTC CCCGAAGAGG AGGCGTCGTC GTCAGTGGCG 
ACACTAGAGA GGGGGGTGGA CAATGGCCGG GCCCCGGACA TGGCACCCGA GGAGGTGGAT 
GAATCCAAAA AGGAGGACTT CTCAGAAGCG GACTTGGTAG ACGTGAGCGC CTACAGTGGA 
CTCGGGGAGG ACTCTGGGGG CAGTGCCCTG GAAGAGGACG ATGAAGAAGA TGAAGAGGAC 
GGGGAGCCCC CCTACGAGCC GGAATCAGGG TGTGTGGAGA TTCCTGGGCT TTCAGAGGAA 
GAGGACCCAG CCCCGAGCCG GAAGATCCAT TTCAGCACCG CACCGATCCA AGTATTCAGC 
ACCTACTCCA ATGAGGACTA TGACCGACGC AATGAGGATG TGGACCCCAT GGCGGCCTCT 
GCGGAATACG AGCTGGAGAA GCGAGTGGAG AGGTTGGAGC TGTTTCCTGT GGAGTTGGAG 
AAGGACTCTG AGGGCCTGGG CATCAGCATC ATTGGCATGG GAGCCGGAGC CGACATGGGC 
CTGGAGAAGC TGGGCATCTT CGTCAAGACT GTGACTGAGG GTGGTGCAGC CCATCGGGAT 
GGCAGGATCC AAGTGAACGA TCTCCTGGTA GAGGTGGACG GGACGAGCCT GGTGGGAGTG 
ACCCAGAGCT TTGCAGCCTC TGTGCTTAGG AACACCAAAG GCAGAGTGCG GTTCATGATT 
GGCCGGGAGC GGCCTGGAGA ACAGAGTGAA GTGGCCCAGC TAATTCAGCA GACCTTGGAG 
CAGGAGAGGT GGCAGCGGGA GATGATGGAG CAGAGATACG CCCAGTATGG AGAAGACGAT 
GAGGAGACAG GAGAGTATGC CACCGATGAA GATGAAGAAC TGAGCCCGAC ATTTCCAGGG 
GGTGAAATGG CCATCGAGGT GTTTGAACTA GCAGAGAATG AGGATGCACT GTCCCCTGTG 
GAGATGGAGC CTGAAAAGCT GGTGCACAAG TTCAAGGAGC TCCAGATCAA GCATGCTGTC 
ACTGAAGCGG AAATCCAGCA GCTGAAGCGG AAGTTGCAGA GTCTGGAGCA GGAGAAAGGG 
CGCTGGCGGG TGGAGAAGGC CCAGCTGGAG CAGAGTGTGG AGGAGAATAA GGAGCGGATG 
GAGAAGCTAG AAGGCTACTG GGGTGAGGCC CAGAGCCTGT GCCAGGCTGT GGATGAGCAC 
CTGCGGGAGA CTCAGGCCCA GTATCAGGCC CTGGAGCGAA AGTACAGCAA GGCCAAGCGT 
CTCATCAAGG ACTACCAGCA AAAGGAGATC GAGTTCCTGA AAAAAGAGAC CGCCCAGCGT 
CGGGTACTGG AAGAGTCGGA GCTAGCCAGG AAGGAGGAAA TGGACAAACT TCTGGATAAG 
ATCTCAGAAC TGGAAGGAAA CCTGCAAACA CTGAGGAATT CCAATTCTAC TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The expression of plasticity-related genes in an acute model of stress is modulated by chronic desipramine in a time-dependent manner within medial prefrontal cortex.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology27(1)19-28(2017 Jan)
Nava N,Treccani G,M?ller HK,Popoli M,Wegener G,Elfving B

The guanine nucleotide exchange factor (GEF) Asef2 promotes dendritic spine formation via Rac activation and spinophilin-dependent targeting.
The Journal of biological chemistry290(16)10295-308(2015 Apr)
Evans JC,Robinson CM,Shi M,Webb DJ

Dissociation of SHP-1 from spinophilin during platelet activation exposes an inhibitory binding site for protein phosphatase-1 (PP1).
PloS one10(3)e0119496(2015)
Ma P,Foote DC,Sinnamon AJ,Brass LF

Aging-induced proteostatic changes in the rat hippocampus identify ARP3, NEB2 and BRAG2 as a molecular circuitry for cognitive impairment.
PloS one8(9)e75112(2013)
Ottis P,Topic B,Loos M,Li KW,de Souza A,Schulz D,Smit AB,Huston JP,Korth C

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Ppp1r9b cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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