Tmprss4 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tmprss4
Entrez Gene ID	214523
Full Name	transmembrane protease, serine 4
Synonyms	mCAP2
General protein information	Preferred Names transmembrane protease, serine 4 Names transmembrane protease serine 4 channel-activating protease 2 membrane-type serine protease 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9\|9 A5.2

mRNA and Protein(s)

mRNA	Protein	Name
NM_145403.2	NP_663378.1	transmembrane protease serine 4
NM_001364528.1	NP_001351457.1	transmembrane protease serine 4 isoform 2
NM_145403.3	NP_663378.1	transmembrane protease serine 4 isoform 1
XM_017313272.1	XP_017168761.1	transmembrane protease serine 4 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	TMPRSS4	NP_001167022.1
Pan troglodytes (chimpanzee)	TMPRSS4	XP_001159793.1
Rattus norvegicus (Norway rat)	Tmprss4	NP_001102468.1
Gallus gallus (chicken)	TMPRSS4	XP_001233789.3
Danio rerio (zebrafish)	tmprss4a	NP_001071206.1
Drosophila melanogaster (fruit fly)	lambdaTry	NP_610673.1
	TMPRSS4	XP_001092969.2
Canis lupus familiaris (dog)	TMPRSS4	XP_005619775.1
Bos taurus (cattle)	TMPRSS4	NP_001095443.1
Mus musculus (house mouse)	Tmprss4	NP_663378.1
Danio rerio (zebrafish)	tmprss4b	NP_001119849.1
Xenopus tropicalis (tropical clawed frog)	tmprss4	NP_001039074.1

Gene Ontology
Bibliography

Related articles in PubMed

The Proteolytic Activation of (H3N2) Influenza A Virus Hemagglutinin Is Facilitated by Different Type II Transmembrane Serine Proteases.
K?hn N, Bergmann S, K?sterke N, Lambertz RL, Keppner A, van den Brand JM, P?hlmann S, Wei? S, Hummler E, Hatesuer B, Schughart K
Journal of virology90(9)4298-307(2016 May)

Epithelial Sodium Channel-Mediated Sodium Transport Is Not Dependent on the Membrane-Bound Serine Protease CAP2/Tmprss4.
Keppner A, Andreasen D, M?rillat AM, Bapst J, Ansermet C, Wang Q, Maillard M, Malsure S, Nobile A, Hummler E
PloS one10(8)e0135224(2015)

TMPRSS4 is a type II transmembrane serine protease involved in cancer and viral infections.
Ohler A, Becker-Pauly C
Biological chemistry393(9)907-14(2012 Sep)

TMPRSS4-dependent activation of the epithelial sodium channel requires cleavage of the ?-subunit distal to the furin cleavage site.
Passero CJ, Mueller GM, Myerburg MM, Carattino MD, Hughey RP, Kleyman TR
American journal of physiology. Renal physiology302(1)F1-8(2012 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Epithelial Sodium Channel-Mediated Sodium Transport Is Not Dependent on the Membrane-Bound Serine Protease CAP2/Tmprss4
Title: Epithelial Sodium Channel-Mediated Sodium Transport Is Not Dependent on the Membrane-Bound Serine Protease CAP2/Tmprss4.

Progression and metastatic potential of several cancers is concordant with an increased expression of TMPRSS4.
Title: TMPRSS4 is a type II transmembrane serine protease involved in cancer and viral infections.

TMPRSS4 primarily activates ENaC by cleaving basic residues within the tract gammaK173-K186 distal to the furin cleavage site, thereby releasing a previously defined key inhibitory tract encompassing gammaR158-F168 from the gamma-subunit.
Title: TMPRSS4-dependent activation of the epithelial sodium channel requires cleavage of the ?-subunit distal to the furin cleavage site.

mutations in conserved residues of mCAP2 located in two protein-protein interacting domains significantly modulated ENaC activation
Title: Activation of epithelial sodium channels by mouse channel activating proteases (mCAP) expressed in Xenopus oocytes requires catalytic activity of mCAP3 and mCAP2 but not mCAP1.

The following Tmprss4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tmprss4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu11512	NM_145403.3 Latest version!	Mus musculus transmembrane protease, serine 4 (Tmprss4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$251.30 $359.00
OMu82772	NM_001364528.1 Latest version!	Mus musculus transmembrane protease, serine 4 (Tmprss4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OMu82772	XM_017313272.1 Latest version!	Mus musculus transmembrane protease, serine 4 (Tmprss4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OMu11512	NM_145403.2	Mus musculus transmembrane protease, serine 4 (Tmprss4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$251.30 $359.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tmprss4 ( NM_145403.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_663378.1 Mus musculus transmembrane protease, serine 4 (Tmprss4), mRNA.

Price & Availability↑

CloneID	OMu11512
Clone ID Related Accession (Same CDS sequence)	NM_145403.2 , NM_145403.3
Accession Version	NM_145403.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1308bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-02
Organism	Mus musculus(house mouse)
Product	transmembrane protease serine 4
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC166051.5 and AC122305.4. On Nov 17, 2006 this sequence version replaced NM_145403.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AY043240.1, BC021368.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGGAGTCAG ACAGTGGCCA ACCCCTCAAC AACCGTGATA TTGTTCCCTT TCGCAAACCC 
CGAAGGCCCC AGGAGACCTT CAAAAAGGTG GGGATCCCCA TCATTGCAGT GCTGCTGAGC 
CTGATAGCCC TCGTGATTGT GGCCCTTCTC ATCAAGGTGA TTCTGGATAA ATACTACTTC 
ATCTGCGGCA GTCCCCTGAC CTTCATTCAG AGGGGCCAGT TGTGTGACGG CCACCTTGAC 
TGCGCCTCAG GGGAGGATGA GGAACACTGT GTCAAGGACT TCCCTGAAAA GCCCGGAGTG 
GCAGTCCGGC TCTCCAAGGA CAGATCCACC CTGCAGGTGC TGGATGCAGC CACAGGGACC 
TGGGCCTCAG TCTGTTTCGA CAACTTCACA GAAGCACTGG CCAAGACAGC CTGCAGACAG 
ATGGGCTATG ACAGCCAGCC CGCTTTCAGA GCAGTGGAGA TCCGTCCAGA TCAGAACCTC 
CCTGTTGCTC AAGTCACAGG AAACAGCCAG GAACTTCAGG TGCAGAATGG AAGCAGATCC 
TGCCTCTCAG GCTCCCTGGT TTCCTTGCGC TGCCTTGACT GTGGAAAGAG CCTGAAGACT 
CCTCGTGTGG TGGGTGGGGT GGAGGCCCCT GTGGATTCTT GGCCGTGGCA GGTCAGCATC 
CAGTACAACA AGCAGCATGT CTGTGGTGGG AGCATCCTGG ATCCCCACTG GATCCTCACA 
GCAGCCCACT GCTTCAGGAA GTATCTTGAT GTGTCAAGCT GGAAGGTCAG GGCAGGCTCA 
AACATACTGG GTAACTCTCC ATCCTTGCCT GTGGCCAAGA TCTTCATCGC TGAACCCAAT 
CCTCTGTACC CCAAAGAGAA GGACATTGCC CTTGTTAAGC TGCAGATGCC ACTCACATTC 
TCAGGCTCAG TCAGGCCCAT CTGCCTGCCC TTCTCTGATG AGGTGCTTGT CCCAGCCACA 
CCAGTCTGGG TCATTGGATG GGGCTTTACA GAAGAAAACG GAGGAAAGAT GTCTGACATG 
CTACTGCAGG CATCAGTCCA GGTCATTGAC AGCACACGGT GCAATGCAGA GGATGCCTAC 
GAAGGGGAAG TGACCGCTGA GATGCTGTGT GCAGGTACCC CACAGGGTGG CAAGGACACC 
TGCCAGGGTG ACAGTGGTGG GCCTTTGATG TACCATTCTG ACAAGTGGCA GGTAGTAGGC 
ATCGTGAGCT GGGGCCATGG ATGCGGCGGC CCAAGTACTC CTGGAGTGTA TACCAAGGTC 
ACTGCCTATC TCAACTGGAT CTACAATGTT CGGAAGTCTG AGATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_663378.1
CDS	289..1596
Translation	MESDSGQPLNNRDIVPFRKPRRPQETFKKVGIPIIAVLLSLIALVIVALLIKVILDKYYFICGSPLTFIQRGQLCDGHLDCASGEDEEHCVKDFPEKPGVAVRLSKDRSTLQVLDAATGTWASVCFDNFTEALAKTACRQMGYDSQPAFRAVEIRPDQNLPVAQVTGNSQELQVQNGSRSCLSGSLVSLRCLDCGKSLKTPRVVGGVEAPVDSWPWQVSIQYNKQHVCGGSILDPHWILTAAHCFRKYLDVSSWKVRAGSNILGNSPSLPVAKIFIAEPNPLYPKEKDIALVKLQMPLTFSGSVRPICLPFSDEVLVPATPVWVIGWGFTEENGGKMSDMLLQASVQVIDSTRCNAEDAYEGEVTAEMLCAGTPQGGKDTCQGDSGGPLMYHSDKWQVVGIVSWGHGCGGPSTPGVYTKVTAYLNWIYNVRKSEM

Target ORF information:

RefSeq Version	NM_145403.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus transmembrane protease, serine 4 (Tmprss4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145403.2

ORF Insert Sequence:

ATGGAGTCAG ACAGTGGCCA ACCCCTCAAC AACCGTGATA TTGTTCCCTT TCGCAAACCC 
CGAAGGCCCC AGGAGACCTT CAAAAAGGTG GGGATCCCCA TCATTGCAGT GCTGCTGAGC 
CTGATAGCCC TCGTGATTGT GGCCCTTCTC ATCAAGGTGA TTCTGGATAA ATACTACTTC 
ATCTGCGGCA GTCCCCTGAC CTTCATTCAG AGGGGCCAGT TGTGTGACGG CCACCTTGAC 
TGCGCCTCAG GGGAGGATGA GGAACACTGT GTCAAGGACT TCCCTGAAAA GCCCGGAGTG 
GCAGTCCGGC TCTCCAAGGA CAGATCCACC CTGCAGGTGC TGGATGCAGC CACAGGGACC 
TGGGCCTCAG TCTGTTTCGA CAACTTCACA GAAGCACTGG CCAAGACAGC CTGCAGACAG 
ATGGGCTATG ACAGCCAGCC CGCTTTCAGA GCAGTGGAGA TCCGTCCAGA TCAGAACCTC 
CCTGTTGCTC AAGTCACAGG AAACAGCCAG GAACTTCAGG TGCAGAATGG AAGCAGATCC 
TGCCTCTCAG GCTCCCTGGT TTCCTTGCGC TGCCTTGACT GTGGAAAGAG CCTGAAGACT 
CCTCGTGTGG TGGGTGGGGT GGAGGCCCCT GTGGATTCTT GGCCGTGGCA GGTCAGCATC 
CAGTACAACA AGCAGCATGT CTGTGGTGGG AGCATCCTGG ATCCCCACTG GATCCTCACA 
GCAGCCCACT GCTTCAGGAA GTATCTTGAT GTGTCAAGCT GGAAGGTCAG GGCAGGCTCA 
AACATACTGG GTAACTCTCC ATCCTTGCCT GTGGCCAAGA TCTTCATCGC TGAACCCAAT 
CCTCTGTACC CCAAAGAGAA GGACATTGCC CTTGTTAAGC TGCAGATGCC ACTCACATTC 
TCAGGCTCAG TCAGGCCCAT CTGCCTGCCC TTCTCTGATG AGGTGCTTGT CCCAGCCACA 
CCAGTCTGGG TCATTGGATG GGGCTTTACA GAAGAAAACG GAGGAAAGAT GTCTGACATG 
CTACTGCAGG CATCAGTCCA GGTCATTGAC AGCACACGGT GCAATGCAGA GGATGCCTAC 
GAAGGGGAAG TGACCGCTGA GATGCTGTGT GCAGGTACCC CACAGGGTGG CAAGGACACC 
TGCCAGGGTG ACAGTGGTGG GCCTTTGATG TACCATTCTG ACAAGTGGCA GGTAGTAGGC 
ATCGTGAGCT GGGGCCATGG ATGCGGCGGC CCAAGTACTC CTGGAGTGTA TACCAAGGTC 
ACTGCCTATC TCAACTGGAT CTACAATGTT CGGAAGTCTG AGATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Tmprss4 ( NM_145403.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_663378.1 Mus musculus transmembrane protease, serine 4 (Tmprss4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu11512
Clone ID Related Accession (Same CDS sequence)	NM_145403.2 , NM_145403.3
Accession Version	NM_145403.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1308bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-23
Organism	Mus musculus(house mouse)
Product	transmembrane protease serine 4 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC166051.5 and AC122305.4. On Jun 21, 2018 this sequence version replaced NM_145403.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AY043240.1, BC021368.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGTCAG ACAGTGGCCA ACCCCTCAAC AACCGTGATA TTGTTCCCTT TCGCAAACCC 
CGAAGGCCCC AGGAGACCTT CAAAAAGGTG GGGATCCCCA TCATTGCAGT GCTGCTGAGC 
CTGATAGCCC TCGTGATTGT GGCCCTTCTC ATCAAGGTGA TTCTGGATAA ATACTACTTC 
ATCTGCGGCA GTCCCCTGAC CTTCATTCAG AGGGGCCAGT TGTGTGACGG CCACCTTGAC 
TGCGCCTCAG GGGAGGATGA GGAACACTGT GTCAAGGACT TCCCTGAAAA GCCCGGAGTG 
GCAGTCCGGC TCTCCAAGGA CAGATCCACC CTGCAGGTGC TGGATGCAGC CACAGGGACC 
TGGGCCTCAG TCTGTTTCGA CAACTTCACA GAAGCACTGG CCAAGACAGC CTGCAGACAG 
ATGGGCTATG ACAGCCAGCC CGCTTTCAGA GCAGTGGAGA TCCGTCCAGA TCAGAACCTC 
CCTGTTGCTC AAGTCACAGG AAACAGCCAG GAACTTCAGG TGCAGAATGG AAGCAGATCC 
TGCCTCTCAG GCTCCCTGGT TTCCTTGCGC TGCCTTGACT GTGGAAAGAG CCTGAAGACT 
CCTCGTGTGG TGGGTGGGGT GGAGGCCCCT GTGGATTCTT GGCCGTGGCA GGTCAGCATC 
CAGTACAACA AGCAGCATGT CTGTGGTGGG AGCATCCTGG ATCCCCACTG GATCCTCACA 
GCAGCCCACT GCTTCAGGAA GTATCTTGAT GTGTCAAGCT GGAAGGTCAG GGCAGGCTCA 
AACATACTGG GTAACTCTCC ATCCTTGCCT GTGGCCAAGA TCTTCATCGC TGAACCCAAT 
CCTCTGTACC CCAAAGAGAA GGACATTGCC CTTGTTAAGC TGCAGATGCC ACTCACATTC 
TCAGGCTCAG TCAGGCCCAT CTGCCTGCCC TTCTCTGATG AGGTGCTTGT CCCAGCCACA 
CCAGTCTGGG TCATTGGATG GGGCTTTACA GAAGAAAACG GAGGAAAGAT GTCTGACATG 
CTACTGCAGG CATCAGTCCA GGTCATTGAC AGCACACGGT GCAATGCAGA GGATGCCTAC 
GAAGGGGAAG TGACCGCTGA GATGCTGTGT GCAGGTACCC CACAGGGTGG CAAGGACACC 
TGCCAGGGTG ACAGTGGTGG GCCTTTGATG TACCATTCTG ACAAGTGGCA GGTAGTAGGC 
ATCGTGAGCT GGGGCCATGG ATGCGGCGGC CCAAGTACTC CTGGAGTGTA TACCAAGGTC 
ACTGCCTATC TCAACTGGAT CTACAATGTT CGGAAGTCTG AGATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_663378.1
CDS	249..1556
Translation	MESDSGQPLNNRDIVPFRKPRRPQETFKKVGIPIIAVLLSLIALVIVALLIKVILDKYYFICGSPLTFIQRGQLCDGHLDCASGEDEEHCVKDFPEKPGVAVRLSKDRSTLQVLDAATGTWASVCFDNFTEALAKTACRQMGYDSQPAFRAVEIRPDQNLPVAQVTGNSQELQVQNGSRSCLSGSLVSLRCLDCGKSLKTPRVVGGVEAPVDSWPWQVSIQYNKQHVCGGSILDPHWILTAAHCFRKYLDVSSWKVRAGSNILGNSPSLPVAKIFIAEPNPLYPKEKDIALVKLQMPLTFSGSVRPICLPFSDEVLVPATPVWVIGWGFTEENGGKMSDMLLQASVQVIDSTRCNAEDAYEGEVTAEMLCAGTPQGGKDTCQGDSGGPLMYHSDKWQVVGIVSWGHGCGGPSTPGVYTKVTAYLNWIYNVRKSEM

Target ORF information:

RefSeq Version	NM_145403.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus transmembrane protease, serine 4 (Tmprss4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145403.3

ORF Insert Sequence:

ATGGAGTCAG ACAGTGGCCA ACCCCTCAAC AACCGTGATA TTGTTCCCTT TCGCAAACCC 
CGAAGGCCCC AGGAGACCTT CAAAAAGGTG GGGATCCCCA TCATTGCAGT GCTGCTGAGC 
CTGATAGCCC TCGTGATTGT GGCCCTTCTC ATCAAGGTGA TTCTGGATAA ATACTACTTC 
ATCTGCGGCA GTCCCCTGAC CTTCATTCAG AGGGGCCAGT TGTGTGACGG CCACCTTGAC 
TGCGCCTCAG GGGAGGATGA GGAACACTGT GTCAAGGACT TCCCTGAAAA GCCCGGAGTG 
GCAGTCCGGC TCTCCAAGGA CAGATCCACC CTGCAGGTGC TGGATGCAGC CACAGGGACC 
TGGGCCTCAG TCTGTTTCGA CAACTTCACA GAAGCACTGG CCAAGACAGC CTGCAGACAG 
ATGGGCTATG ACAGCCAGCC CGCTTTCAGA GCAGTGGAGA TCCGTCCAGA TCAGAACCTC 
CCTGTTGCTC AAGTCACAGG AAACAGCCAG GAACTTCAGG TGCAGAATGG AAGCAGATCC 
TGCCTCTCAG GCTCCCTGGT TTCCTTGCGC TGCCTTGACT GTGGAAAGAG CCTGAAGACT 
CCTCGTGTGG TGGGTGGGGT GGAGGCCCCT GTGGATTCTT GGCCGTGGCA GGTCAGCATC 
CAGTACAACA AGCAGCATGT CTGTGGTGGG AGCATCCTGG ATCCCCACTG GATCCTCACA 
GCAGCCCACT GCTTCAGGAA GTATCTTGAT GTGTCAAGCT GGAAGGTCAG GGCAGGCTCA 
AACATACTGG GTAACTCTCC ATCCTTGCCT GTGGCCAAGA TCTTCATCGC TGAACCCAAT 
CCTCTGTACC CCAAAGAGAA GGACATTGCC CTTGTTAAGC TGCAGATGCC ACTCACATTC 
TCAGGCTCAG TCAGGCCCAT CTGCCTGCCC TTCTCTGATG AGGTGCTTGT CCCAGCCACA 
CCAGTCTGGG TCATTGGATG GGGCTTTACA GAAGAAAACG GAGGAAAGAT GTCTGACATG 
CTACTGCAGG CATCAGTCCA GGTCATTGAC AGCACACGGT GCAATGCAGA GGATGCCTAC 
GAAGGGGAAG TGACCGCTGA GATGCTGTGT GCAGGTACCC CACAGGGTGG CAAGGACACC 
TGCCAGGGTG ACAGTGGTGG GCCTTTGATG TACCATTCTG ACAAGTGGCA GGTAGTAGGC 
ATCGTGAGCT GGGGCCATGG ATGCGGCGGC CCAAGTACTC CTGGAGTGTA TACCAAGGTC 
ACTGCCTATC TCAACTGGAT CTACAATGTT CGGAAGTCTG AGATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Tmprss4 ( NM_001364528.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001351457.1 Mus musculus transmembrane protease, serine 4 (Tmprss4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu82772
Clone ID Related Accession (Same CDS sequence)	NM_001364528.1 , XM_017313272.1
Accession Version	NM_001364528.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 888bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-23
Organism	Mus musculus(house mouse)
Product	transmembrane protease serine 4 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK078890.1 and EH103381.1. ##Evidence-Data-START## Transcript exon combination :: AK078890.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCTATG ACAGCCAGCC CGCTTTCAGA GCAGTGGAGA TCCGTCCAGA TCAGAACCTC 
CCTGTTGCTC AAGTCACAGG AAACAGCCAG GAACTTCAGG TGCAGAATGG AAGCAGATCC 
TGCCTCTCAG GCTCCCTGGT TTCCTTGCGC TGCCTTGACT GTGGAAAGAG CCTGAAGACT 
CCTCGTGTGG TGGGTGGGGT GGAGGCCCCT GTGGATTCTT GGCCGTGGCA GGTCAGCATC 
CAGTACAACA AGCAGCATGT CTGTGGTGGG AGCATCCTGG ATCCCCACTG GATCCTCACA 
GCAGCCCACT GCTTCAGGAA GTATCTTGAT GTGTCAAGCT GGAAGGTCAG GGCAGGCTCA 
AACATACTGG GTAACTCTCC ATCCTTGCCT GTGGCCAAGA TCTTCATCGC TGAACCCAAT 
CCTCTGTACC CCAAAGAGAA GGACATTGCC CTTGTTAAGC TGCAGATGCC ACTCACATTC 
TCAGGCTCAG TCAGGCCCAT CTGCCTGCCC TTCTCTGATG AGGTGCTTGT CCCAGCCACA 
CCAGTCTGGG TCATTGGATG GGGCTTTACA GAAGAAAACG GAGGAAAGAT GTCTGACATG 
CTACTGCAGG CATCAGTCCA GGTCATTGAC AGCACACGGT GCAATGCAGA GGATGCCTAC 
GAAGGGGAAG TGACCGCTGA GATGCTGTGT GCAGGTACCC CACAGGGTGG CAAGGACACC 
TGCCAGGGTG ACAGTGGTGG GCCTTTGATG TACCATTCTG ACAAGTGGCA GGTAGTAGGC 
ATCGTGAGCT GGGGCCATGG ATGCGGCGGC CCAAGTACTC CTGGAGTGTA TACCAAGGTC 
ACTGCCTATC TCAACTGGAT CTACAATGTT CGGAAGTCTG AGATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001351457.1
CDS	565..1452
Translation	MGYDSQPAFRAVEIRPDQNLPVAQVTGNSQELQVQNGSRSCLSGSLVSLRCLDCGKSLKTPRVVGGVEAPVDSWPWQVSIQYNKQHVCGGSILDPHWILTAAHCFRKYLDVSSWKVRAGSNILGNSPSLPVAKIFIAEPNPLYPKEKDIALVKLQMPLTFSGSVRPICLPFSDEVLVPATPVWVIGWGFTEENGGKMSDMLLQASVQVIDSTRCNAEDAYEGEVTAEMLCAGTPQGGKDTCQGDSGGPLMYHSDKWQVVGIVSWGHGCGGPSTPGVYTKVTAYLNWIYNVRKSEM

Target ORF information:

RefSeq Version	NM_001364528.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus transmembrane protease, serine 4 (Tmprss4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001364528.1

ORF Insert Sequence:

ATGGGCTATG ACAGCCAGCC CGCTTTCAGA GCAGTGGAGA TCCGTCCAGA TCAGAACCTC 
CCTGTTGCTC AAGTCACAGG AAACAGCCAG GAACTTCAGG TGCAGAATGG AAGCAGATCC 
TGCCTCTCAG GCTCCCTGGT TTCCTTGCGC TGCCTTGACT GTGGAAAGAG CCTGAAGACT 
CCTCGTGTGG TGGGTGGGGT GGAGGCCCCT GTGGATTCTT GGCCGTGGCA GGTCAGCATC 
CAGTACAACA AGCAGCATGT CTGTGGTGGG AGCATCCTGG ATCCCCACTG GATCCTCACA 
GCAGCCCACT GCTTCAGGAA GTATCTTGAT GTGTCAAGCT GGAAGGTCAG GGCAGGCTCA 
AACATACTGG GTAACTCTCC ATCCTTGCCT GTGGCCAAGA TCTTCATCGC TGAACCCAAT 
CCTCTGTACC CCAAAGAGAA GGACATTGCC CTTGTTAAGC TGCAGATGCC ACTCACATTC 
TCAGGCTCAG TCAGGCCCAT CTGCCTGCCC TTCTCTGATG AGGTGCTTGT CCCAGCCACA 
CCAGTCTGGG TCATTGGATG GGGCTTTACA GAAGAAAACG GAGGAAAGAT GTCTGACATG 
CTACTGCAGG CATCAGTCCA GGTCATTGAC AGCACACGGT GCAATGCAGA GGATGCCTAC 
GAAGGGGAAG TGACCGCTGA GATGCTGTGT GCAGGTACCC CACAGGGTGG CAAGGACACC 
TGCCAGGGTG ACAGTGGTGG GCCTTTGATG TACCATTCTG ACAAGTGGCA GGTAGTAGGC 
ATCGTGAGCT GGGGCCATGG ATGCGGCGGC CCAAGTACTC CTGGAGTGTA TACCAAGGTC 
ACTGCCTATC TCAACTGGAT CTACAATGTT CGGAAGTCTG AGATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Tmprss4 ( XM_017313272.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017168761.1 Mus musculus transmembrane protease, serine 4 (Tmprss4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu82772
Clone ID Related Accession (Same CDS sequence)	NM_001364528.1 , XM_017313272.1
Accession Version	XM_017313272.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 888bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	transmembrane protease serine 4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000075.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGCTATG ACAGCCAGCC CGCTTTCAGA GCAGTGGAGA TCCGTCCAGA TCAGAACCTC 
CCTGTTGCTC AAGTCACAGG AAACAGCCAG GAACTTCAGG TGCAGAATGG AAGCAGATCC 
TGCCTCTCAG GCTCCCTGGT TTCCTTGCGC TGCCTTGACT GTGGAAAGAG CCTGAAGACT 
CCTCGTGTGG TGGGTGGGGT GGAGGCCCCT GTGGATTCTT GGCCGTGGCA GGTCAGCATC 
CAGTACAACA AGCAGCATGT CTGTGGTGGG AGCATCCTGG ATCCCCACTG GATCCTCACA 
GCAGCCCACT GCTTCAGGAA GTATCTTGAT GTGTCAAGCT GGAAGGTCAG GGCAGGCTCA 
AACATACTGG GTAACTCTCC ATCCTTGCCT GTGGCCAAGA TCTTCATCGC TGAACCCAAT 
CCTCTGTACC CCAAAGAGAA GGACATTGCC CTTGTTAAGC TGCAGATGCC ACTCACATTC 
TCAGGCTCAG TCAGGCCCAT CTGCCTGCCC TTCTCTGATG AGGTGCTTGT CCCAGCCACA 
CCAGTCTGGG TCATTGGATG GGGCTTTACA GAAGAAAACG GAGGAAAGAT GTCTGACATG 
CTACTGCAGG CATCAGTCCA GGTCATTGAC AGCACACGGT GCAATGCAGA GGATGCCTAC 
GAAGGGGAAG TGACCGCTGA GATGCTGTGT GCAGGTACCC CACAGGGTGG CAAGGACACC 
TGCCAGGGTG ACAGTGGTGG GCCTTTGATG TACCATTCTG ACAAGTGGCA GGTAGTAGGC 
ATCGTGAGCT GGGGCCATGG ATGCGGCGGC CCAAGTACTC CTGGAGTGTA TACCAAGGTC 
ACTGCCTATC TCAACTGGAT CTACAATGTT CGGAAGTCTG AGATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017168761.1
CDS	689..1576
Translation	MGYDSQPAFRAVEIRPDQNLPVAQVTGNSQELQVQNGSRSCLSGSLVSLRCLDCGKSLKTPRVVGGVEAPVDSWPWQVSIQYNKQHVCGGSILDPHWILTAAHCFRKYLDVSSWKVRAGSNILGNSPSLPVAKIFIAEPNPLYPKEKDIALVKLQMPLTFSGSVRPICLPFSDEVLVPATPVWVIGWGFTEENGGKMSDMLLQASVQVIDSTRCNAEDAYEGEVTAEMLCAGTPQGGKDTCQGDSGGPLMYHSDKWQVVGIVSWGHGCGGPSTPGVYTKVTAYLNWIYNVRKSEM

Target ORF information:

RefSeq Version	XM_017313272.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus transmembrane protease, serine 4 (Tmprss4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017313272.1

ORF Insert Sequence:

ATGGGCTATG ACAGCCAGCC CGCTTTCAGA GCAGTGGAGA TCCGTCCAGA TCAGAACCTC 
CCTGTTGCTC AAGTCACAGG AAACAGCCAG GAACTTCAGG TGCAGAATGG AAGCAGATCC 
TGCCTCTCAG GCTCCCTGGT TTCCTTGCGC TGCCTTGACT GTGGAAAGAG CCTGAAGACT 
CCTCGTGTGG TGGGTGGGGT GGAGGCCCCT GTGGATTCTT GGCCGTGGCA GGTCAGCATC 
CAGTACAACA AGCAGCATGT CTGTGGTGGG AGCATCCTGG ATCCCCACTG GATCCTCACA 
GCAGCCCACT GCTTCAGGAA GTATCTTGAT GTGTCAAGCT GGAAGGTCAG GGCAGGCTCA 
AACATACTGG GTAACTCTCC ATCCTTGCCT GTGGCCAAGA TCTTCATCGC TGAACCCAAT 
CCTCTGTACC CCAAAGAGAA GGACATTGCC CTTGTTAAGC TGCAGATGCC ACTCACATTC 
TCAGGCTCAG TCAGGCCCAT CTGCCTGCCC TTCTCTGATG AGGTGCTTGT CCCAGCCACA 
CCAGTCTGGG TCATTGGATG GGGCTTTACA GAAGAAAACG GAGGAAAGAT GTCTGACATG 
CTACTGCAGG CATCAGTCCA GGTCATTGAC AGCACACGGT GCAATGCAGA GGATGCCTAC 
GAAGGGGAAG TGACCGCTGA GATGCTGTGT GCAGGTACCC CACAGGGTGG CAAGGACACC 
TGCCAGGGTG ACAGTGGTGG GCCTTTGATG TACCATTCTG ACAAGTGGCA GGTAGTAGGC 
ATCGTGAGCT GGGGCCATGG ATGCGGCGGC CCAAGTACTC CTGGAGTGTA TACCAAGGTC 
ACTGCCTATC TCAACTGGAT CTACAATGTT CGGAAGTCTG AGATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Proteolytic Activation of (H3N2) Influenza A Virus Hemagglutinin Is Facilitated by Different Type II Transmembrane Serine Proteases.
Journal of virology90(9)4298-307(2016 May)
K?hn N,Bergmann S,K?sterke N,Lambertz RL,Keppner A,van den Brand JM,P?hlmann S,Wei? S,Hummler E,Hatesuer B,Schughart K

Epithelial Sodium Channel-Mediated Sodium Transport Is Not Dependent on the Membrane-Bound Serine Protease CAP2/Tmprss4.
PloS one10(8)e0135224(2015)
Keppner A,Andreasen D,M?rillat AM,Bapst J,Ansermet C,Wang Q,Maillard M,Malsure S,Nobile A,Hummler E

TMPRSS4 is a type II transmembrane serine protease involved in cancer and viral infections.
Biological chemistry393(9)907-14(2012 Sep)
Ohler A,Becker-Pauly C

TMPRSS4-dependent activation of the epithelial sodium channel requires cleavage of the ?-subunit distal to the furin cleavage site.
American journal of physiology. Renal physiology302(1)F1-8(2012 Jan)
Passero CJ,Mueller GM,Myerburg MM,Carattino MD,Hughey RP,Kleyman TR

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Tmprss4 cDNA ORF clone, Mus musculus(house mouse)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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