Sts cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sts
Entrez Gene ID	20905
Full Name	steroid sulfatase
Synonyms	ArsC
General protein information	Preferred Names steroid sulfatase Names steryl-sulfatase ASC arylsulfatase C steryl-sulfate sulfohydrolase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: X\|Y Map Location: X;Y\|XY 75.0 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_009293.1	NP_033319.1	steryl-sulfatase precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Altered brain gene expression but not steroid biochemistry in a genetic mouse model of neurodevelopmental disorder.
Trent S, Fry JP, Ojarikre OA, Davies W
Molecular autism5(1)21(2014 Mar)

Hepatic overexpression of steroid sulfatase ameliorates mouse models of obesity and type 2 diabetes through sex-specific mechanisms.
Jiang M, He J, Kucera H, Gaikwad NW, Zhang B, Xu M, O'Doherty RM, Selcer KW, Xie W
The Journal of biological chemistry289(12)8086-97(2014 Mar)

Altered serotonergic function may partially account for behavioral endophenotypes in steroid sulfatase-deficient mice.
Trent S, Cassano T, Bedse G, Ojarikre OA, Humby T, Davies W
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology37(5)1267-74(2012 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Overexpression of STS in the liver improved metabolic functions in mouse models of obesity and type 2 diabetes through sex-specific mechanisms.
Title: Hepatic overexpression of steroid sulfatase ameliorates mouse models of obesity and type 2 diabetes through sex-specific mechanisms.

These data suggest that inactivating mutations and functional variants within STS might exert their influence on ADHD vulnerability, and disorder endophenotypes through modulation of the serotonergic system.
Title: Altered serotonergic function may partially account for behavioral endophenotypes in steroid sulfatase-deficient mice.

steroid sulfatase may influence core and associated ADHD behavioural endophenotypes via both developmental and ongoing mechanisms, and that the 39,X(Y*)O model may represent a useful tool for elucidating the neurobiological basis of these endophenotypes.
Title: Steroid sulfatase-deficient mice exhibit endophenotypes relevant to attention deficit hyperactivity disorder.

analysis of brain pathways mediating the pro-aggressive effect of the steroid sulfatase (Sts) gene
Title: Brain pathways mediating the pro-aggressive effect of the steroid sulfatase (Sts) gene.

Our data suggest that variation within STS may be particularly associated with the inattentive subtype of ADHD
Title: Converging pharmacological and genetic evidence indicates a role for steroid sulfatase in attention.

The following Sts gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sts cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu20631	NM_009293.1 Latest version!	Mus musculus steroid sulfatase (Sts), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$370.30 $529.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sts ( NM_009293.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033319.1 Mus musculus steroid sulfatase (Sts), mRNA.

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CloneID	OMu20631
Clone ID Related Accession (Same CDS sequence)	NM_009293.1
Accession Version	NM_009293.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1875bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-09
Organism	Mus musculus(house mouse)
Product	steryl-sulfatase precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U37545.1. On Dec 7, 2005 this sequence version replaced XM_918599.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U37545.1 [ECO:0000332] ##Evidence-Data-END##

ATGCCCAGGC CCCGCCCCCT GCTCCTCGCC GTCATGGCCG CCACGCTCGC TGACATCATC 
CTCGCCGCGG ATCCCGCCCC CGCAGGCCCC GCCCCCCGGC CGCCCAACTT CCTGCTCATC 
ATGGCCGACG ACCTGGGCAT CGGTGACCTC GGCTGCTACG GCAACAAAAC GCTCAGGACG 
CCGCACCTCG ACCGCCTGGC CCGCGAGGGG GTGAAGCTGA CGCAGCACCT GGCGGCCGCC 
CCGCTCTGCA CCCCCAGCCG CGCCGCCTTC CTGACCGGGC GCTACCCGCC GCGCTCAGGC 
ATGGCGGCGC ACGGCCGCGT GGGCGTGTAC CTGTTCACGG CGTCGTCGGG GGGCCTCCCG 
CCCAGCGAGG TCACCATGGC GCGGCTGCTG AAGGGGCGGG GCTACGCCAC GGCGCTCATT 
GGGAAGTGGC ACCTGGGTCT GAGCTGCCGC GGGGCCACCG ACTTCTGCCA CCACCCCCTG 
CGCCACGGCT TCGACCGCTT CCTGGGCGTC CCGACCACCA ACCTGCGCGA CTGCCGGCCG 
GGGGCGGGCA CCGTGTTCGG CCCCGCCCTG CGCGTGTTCG CGGCCGGGCC CCTGGCGGCG 
CTGGGGGCGT CGCTGGCGGC CATGGCGGCG GCGCGGTGGG CGGGGCTGGC GCGGGTGCCG 
GGCTGGGCCC TGGCGGGGAC GGCGGCGGCC ATGTTGGCGG TGGGCGGGCC GCGCTCGGCT 
TCCTGCCTCG GCTTCCGCCC GGCCAACTGC TTCCTCATGG ACGACCTCGC CGTGGCGCAG 
CGGCCCACGG ACTACGGCGG ACTCACGCGG CGCCTGGCGG ACGAGGCCGC GCTCTTCCTG 
CGGAGGAACC GGGCCCGCCC CTTCCTGCTC TTCCTGTCCT TCCTGCACGT CCACACCGCG 
CACTTCGCCG ACCCCGGGTT CGCGGGGCGG AGCCTGCACG GGGCCTACGG CGACAGCGTG 
GAGGAGATGG ACTGGGGCGT GGGCCGCGTG CTGGCGGCGC TGGACGAGCT GGGCCTGGCG 
CGCGAGACGC TCGTCTACTT CACCTCGGAC CACGGGGCCC ACGTGGAGGA GCTGGGGCCG 
CGCGGCGAGC GCATGGGCGG CAGCAACGGC GTCTTCCGCG GCGGGAAGGG CAACAACTGG 
GAGGGCGGCG TCCGCGTCCC CTGCCTCGTG CGTTGGCCCC GCGAGCTCAG CCCCGGCCGC 
GTCGTCGCGG AGCCCACGAG CCTCATGGAC GTCTTCCCCA CCGTGGCGCG GCTGGCGGGG 
GCGGAGCTGC CCGGGGACAG GGTGATTGAC GGCCGGGACC TGATGCCGCT GCTGCGCGGC 
GACGCCCAGC GCTCGGAGCA CGAGTTCCTG TTCCACTACT GCAACGCCTA CCTGCAGGCC 
GTGCGCTGGC ACAACGGCAG CGCGGTGTGG AAGGCCTTCT ACTTCACGCC CAACTTCGCG 
CCCGCGGGCG CCAACGGCTG CTTCTCGACC CACGTCTGCC TCTGCGCCGG CCCCGCCCAC 
GTCACCGCCC ACGACCCCCC CCTGCTGTTC GACCTCACGC GCGACCCCGG CGAGCGCCGC 
CCCCTGACCC CCGAGGCCGA GCCCCGGCAC CGCGAGGTCC TGGACGCCAT CGACGCCGCC 
GCCCGCGCCC ACCGCGCCCG GCTCCGCCCC GCGCCCGACC AGCTCGCCCC GCGGCACCTG 
ATGTGGAAGC CGTGGCTGCA GCTGTGGGGC GGGGGCGGGG CCGGGGGCGG GGCCGGCGCC 
CAGGACGACT CAGGCCACGC CCACGGCGAT GGAAGCCACG CCCACGACGA CCCAGGCCAC 
GCCCAGGACA GAGGCGATGA CGACGCCCAC TACGGAGGCC ACGCCACGAC ACGGACTCAG 
GCCACGCCAC GATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033319.1
CDS	256..2130
Translation	MPRPRPLLLAVMAATLADIILAADPAPAGPAPRPPNFLLIMADDLGIGDLGCYGNKTLRTPHLDRLAREGVKLTQHLAAAPLCTPSRAAFLTGRYPPRSGMAAHGRVGVYLFTASSGGLPPSEVTMARLLKGRGYATALIGKWHLGLSCRGATDFCHHPLRHGFDRFLGVPTTNLRDCRPGAGTVFGPALRVFAAGPLAALGASLAAMAAARWAGLARVPGWALAGTAAAMLAVGGPRSASCLGFRPANCFLMDDLAVAQRPTDYGGLTRRLADEAALFLRRNRARPFLLFLSFLHVHTAHFADPGFAGRSLHGAYGDSVEEMDWGVGRVLAALDELGLARETLVYFTSDHGAHVEELGPRGERMGGSNGVFRGGKGNNWEGGVRVPCLVRWPRELSPGRVVAEPTSLMDVFPTVARLAGAELPGDRVIDGRDLMPLLRGDAQRSEHEFLFHYCNAYLQAVRWHNGSAVWKAFYFTPNFAPAGANGCFSTHVCLCAGPAHVTAHDPPLLFDLTRDPGERRPLTPEAEPRHREVLDAIDAAARAHRARLRPAPDQLAPRHLMWKPWLQLWGGGGAGGGAGAQDDSGHAHGDGSHAHDDPGHAQDRGDDDAHYGGHATTRTQATPR

Target ORF information:

RefSeq Version	NM_009293.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus steroid sulfatase (Sts), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009293.1

ORF Insert Sequence:

ATGCCCAGGC CCCGCCCCCT GCTCCTCGCC GTCATGGCCG CCACGCTCGC TGACATCATC 
CTCGCCGCGG ATCCCGCCCC CGCAGGCCCC GCCCCCCGGC CGCCCAACTT CCTGCTCATC 
ATGGCCGACG ACCTGGGCAT CGGTGACCTC GGCTGCTACG GCAACAAAAC GCTCAGGACG 
CCGCACCTCG ACCGCCTGGC CCGCGAGGGG GTGAAGCTGA CGCAGCACCT GGCGGCCGCC 
CCGCTCTGCA CCCCCAGCCG CGCCGCCTTC CTGACCGGGC GCTACCCGCC GCGCTCAGGC 
ATGGCGGCGC ACGGCCGCGT GGGCGTGTAC CTGTTCACGG CGTCGTCGGG GGGCCTCCCG 
CCCAGCGAGG TCACCATGGC GCGGCTGCTG AAGGGGCGGG GCTACGCCAC GGCGCTCATT 
GGGAAGTGGC ACCTGGGTCT GAGCTGCCGC GGGGCCACCG ACTTCTGCCA CCACCCCCTG 
CGCCACGGCT TCGACCGCTT CCTGGGCGTC CCGACCACCA ACCTGCGCGA CTGCCGGCCG 
GGGGCGGGCA CCGTGTTCGG CCCCGCCCTG CGCGTGTTCG CGGCCGGGCC CCTGGCGGCG 
CTGGGGGCGT CGCTGGCGGC CATGGCGGCG GCGCGGTGGG CGGGGCTGGC GCGGGTGCCG 
GGCTGGGCCC TGGCGGGGAC GGCGGCGGCC ATGTTGGCGG TGGGCGGGCC GCGCTCGGCT 
TCCTGCCTCG GCTTCCGCCC GGCCAACTGC TTCCTCATGG ACGACCTCGC CGTGGCGCAG 
CGGCCCACGG ACTACGGCGG ACTCACGCGG CGCCTGGCGG ACGAGGCCGC GCTCTTCCTG 
CGGAGGAACC GGGCCCGCCC CTTCCTGCTC TTCCTGTCCT TCCTGCACGT CCACACCGCG 
CACTTCGCCG ACCCCGGGTT CGCGGGGCGG AGCCTGCACG GGGCCTACGG CGACAGCGTG 
GAGGAGATGG ACTGGGGCGT GGGCCGCGTG CTGGCGGCGC TGGACGAGCT GGGCCTGGCG 
CGCGAGACGC TCGTCTACTT CACCTCGGAC CACGGGGCCC ACGTGGAGGA GCTGGGGCCG 
CGCGGCGAGC GCATGGGCGG CAGCAACGGC GTCTTCCGCG GCGGGAAGGG CAACAACTGG 
GAGGGCGGCG TCCGCGTCCC CTGCCTCGTG CGTTGGCCCC GCGAGCTCAG CCCCGGCCGC 
GTCGTCGCGG AGCCCACGAG CCTCATGGAC GTCTTCCCCA CCGTGGCGCG GCTGGCGGGG 
GCGGAGCTGC CCGGGGACAG GGTGATTGAC GGCCGGGACC TGATGCCGCT GCTGCGCGGC 
GACGCCCAGC GCTCGGAGCA CGAGTTCCTG TTCCACTACT GCAACGCCTA CCTGCAGGCC 
GTGCGCTGGC ACAACGGCAG CGCGGTGTGG AAGGCCTTCT ACTTCACGCC CAACTTCGCG 
CCCGCGGGCG CCAACGGCTG CTTCTCGACC CACGTCTGCC TCTGCGCCGG CCCCGCCCAC 
GTCACCGCCC ACGACCCCCC CCTGCTGTTC GACCTCACGC GCGACCCCGG CGAGCGCCGC 
CCCCTGACCC CCGAGGCCGA GCCCCGGCAC CGCGAGGTCC TGGACGCCAT CGACGCCGCC 
GCCCGCGCCC ACCGCGCCCG GCTCCGCCCC GCGCCCGACC AGCTCGCCCC GCGGCACCTG 
ATGTGGAAGC CGTGGCTGCA GCTGTGGGGC GGGGGCGGGG CCGGGGGCGG GGCCGGCGCC 
CAGGACGACT CAGGCCACGC CCACGGCGAT GGAAGCCACG CCCACGACGA CCCAGGCCAC 
GCCCAGGACA GAGGCGATGA CGACGCCCAC TACGGAGGCC ACGCCACGAC ACGGACTCAG 
GCCACGCCAC GATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Altered brain gene expression but not steroid biochemistry in a genetic mouse model of neurodevelopmental disorder.
Molecular autism5(1)21(2014 Mar)
Trent S,Fry JP,Ojarikre OA,Davies W

Hepatic overexpression of steroid sulfatase ameliorates mouse models of obesity and type 2 diabetes through sex-specific mechanisms.
The Journal of biological chemistry289(12)8086-97(2014 Mar)
Jiang M,He J,Kucera H,Gaikwad NW,Zhang B,Xu M,O'Doherty RM,Selcer KW,Xie W

Altered serotonergic function may partially account for behavioral endophenotypes in steroid sulfatase-deficient mice.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology37(5)1267-74(2012 Apr)
Trent S,Cassano T,Bedse G,Ojarikre OA,Humby T,Davies W

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Sts cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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