Pvalb cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pvalb
Entrez Gene ID	19293
Full Name	parvalbumin
Synonyms	PV,Parv,Pva
General protein information	Preferred Names parvalbumin Names parvalbumin alpha
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 15 Map Location: 15 E1\|15 36.93 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_013645.3	NP_038673.2	parvalbumin alpha
NM_001330686.1	NP_001317615.1	parvalbumin alpha
XM_006520643.2	XP_006520706.1	parvalbumin alpha isoform X1
NM_013645.4	NP_038673.2	parvalbumin alpha

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PVALB	XP_525585.2
Canis lupus familiaris (dog)	PVALB	XP_003431553.1
Mus musculus (house mouse)	Pvalb	NP_038673.2
Homo sapiens (human)	PVALB	NP_002845.1
	LOC697272	XP_001085875.2
Xenopus tropicalis (tropical clawed frog)	LOC100486372	XP_004913949.1
Bos taurus (cattle)	PVALB	NP_001069582.1
Rattus norvegicus (Norway rat)	Pvalb	NP_071944.1
Gallus gallus (chicken)	PVALB	NP_001152787.1
Danio rerio (zebrafish)	pvalb6	NP_991136.1

Gene Ontology
Bibliography

Related articles in PubMed

Parvalbumin: calcium and magnesium buffering in the distal nephron.
Olinger E, Schwaller B, Loffing J, Gailly P, Devuyst O
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association27(11)3988-94(2012 Nov)

Fine localization of genes on distal murine chromosome 15.
Adolph S, Berchtold MW, Hameister H
Cytogenetics and cell genetics52(3-4)177-9(1989)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The calcium-binding protein parvalbumin (PV) is a crucial marker in defining the most predominant interneuron subtype within the cerebral cortex.
Title: NPY+-, but not PV+- GABAergic neurons mediated long-range inhibition from infra- to prelimbic cortex.

Thus PV+ GP neurons are synaptically positioned to directly coordinate activity between BG input nuclei, the striatum and STN, and thalamic-output from the SNr.
Title: Globus Pallidus Externus Neurons Expressing parvalbumin Interconnect the Subthalamic Nucleus and Striatal Interneurons.

"reduction of PV(+) neurons" was in all cases, i.e., in PV+/-, Shank1-/- and Shank3B-/- mice, was due to a reduction in Pvalb mRNA and PV protein
Title: Reduction in parvalbumin expression not loss of the parvalbumin-expressing GABA interneuron subpopulation in genetic parvalbumin and shank mouse models of autism.

dysfunction of parvalbumin positive interneurons signaling in the prefrontal cortex (PFC) specifically produces deficits in the cognitive domain, but does not give rise to PFC-dependent correlates of negative or positive symptoms.
Title: Parvalbumin-positive interneurons of the prefrontal cortex support working memory and cognitive flexibility.

Parvalbumin and Npas1 neurons have different topologies within the basal ganglia.
Title: Parvalbumin+ Neurons and Npas1+ Neurons Are Distinct Neuron Classes in the Mouse External Globus Pallidus.

The following Pvalb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pvalb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu19404	NM_001330686.1 Latest version!	Mus musculus parvalbumin (Pvalb), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu19404	NM_013645.4 Latest version!	Mus musculus parvalbumin (Pvalb), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu19404	XM_006520643.2 Latest version!	Mus musculus parvalbumin (Pvalb), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OMu19404	NM_013645.3	Mus musculus parvalbumin (Pvalb), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pvalb ( NM_013645.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_038673.2 Mus musculus parvalbumin (Pvalb), mRNA.

Price & Availability↑

CloneID	OMu19404
Clone ID Related Accession (Same CDS sequence)	NM_013645.3 , NM_001330686.1 , XM_006520643.2 , NM_013645.4
Accession Version	NM_013645.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 333bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-14
Organism	Mus musculus(House mouse)
Product	parvalbumin alpha
Comment

ATGTCGATGA CAGACGTGCT CAGCGCTGAG GACATCAAGA AGGCGATAGG AGCCTTTGCT 
GCTGCAGACT CCTTCGACCA CAAAAAGTTC TTCCAGATGG TGGGCCTGAA GAAAAAGAAC 
CCGGATGAGG TGAAGAAGGT GTTCCATATT CTGGACAAAG ACAAAAGTGG CTTCATTGAG 
GAGGATGAGC TGGGGTCCAT TCTGAAGGGC TTCTCCTCAG ATGCCAGAGA CTTGTCTGCT 
AAAGAAACAA AGACGCTTCT GGCCGCTGGA GACAAGGATG GGGACGGCAA GATTGGGGTT 
GAAGAATTCT CCACTCTGGT GGCTGAAAGC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_038673.2
Translation	MSMTDVLSAEDIKKAIGAFAAADSFDHKKFFQMVGLKKKNPDEVKKVFHILDKDKSGFIEEDELGSILKGFSSDARDLSAKETKTLLAAGDKDGDGKIGVEEFSTLVAES

Target ORF information:

RefSeq Version	NM_013645.3
Organism	Mus musculus(House mouse)
Definition	Mus musculus parvalbumin (Pvalb), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013645.3

ORF Insert Sequence:

ATGTCGATGA CAGACGTGCT CAGCGCTGAG GACATCAAGA AGGCGATAGG AGCCTTTGCT 
GCTGCAGACT CCTTCGACCA CAAAAAGTTC TTCCAGATGG TGGGCCTGAA GAAAAAGAAC 
CCGGATGAGG TGAAGAAGGT GTTCCATATT CTGGACAAAG ACAAAAGTGG CTTCATTGAG 
GAGGATGAGC TGGGGTCCAT TCTGAAGGGC TTCTCCTCAG ATGCCAGAGA CTTGTCTGCT 
AAAGAAACAA AGACGCTTCT GGCCGCTGGA GACAAGGATG GGGACGGCAA GATTGGGGTT 
GAAGAATTCT CCACTCTGGT GGCTGAAAGC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Pvalb ( NM_001330686.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001317615.1 Mus musculus parvalbumin (Pvalb), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu19404
Clone ID Related Accession (Same CDS sequence)	NM_013645.3 , NM_001330686.1 , XM_006520643.2 , NM_013645.4
Accession Version	NM_001330686.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 333bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-31
Organism	Mus musculus(house mouse)
Product	parvalbumin alpha
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK131986.1, DV051867.1 and AI645659.1. On Sep 1, 2016 this sequence version replaced XM_006520643.3. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK131986.1, AK013561.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849385 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCGATGA CAGACGTGCT CAGCGCTGAG GACATCAAGA AGGCGATAGG AGCCTTTGCT 
GCTGCAGACT CCTTCGACCA CAAAAAGTTC TTCCAGATGG TGGGCCTGAA GAAAAAGAAC 
CCGGATGAGG TGAAGAAGGT GTTCCATATT CTGGACAAAG ACAAAAGTGG CTTCATTGAG 
GAGGATGAGC TGGGGTCCAT TCTGAAGGGC TTCTCCTCAG ATGCCAGAGA CTTGTCTGCT 
AAAGAAACAA AGACGCTTCT GGCCGCTGGA GACAAGGATG GGGACGGCAA GATTGGGGTT 
GAAGAATTCT CCACTCTGGT GGCTGAAAGC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001317615.1
CDS	93..425
Translation	MSMTDVLSAEDIKKAIGAFAAADSFDHKKFFQMVGLKKKNPDEVKKVFHILDKDKSGFIEEDELGSILKGFSSDARDLSAKETKTLLAAGDKDGDGKIGVEEFSTLVAES

Target ORF information:

RefSeq Version	NM_001330686.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus parvalbumin (Pvalb), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001330686.1

ORF Insert Sequence:

ATGTCGATGA CAGACGTGCT CAGCGCTGAG GACATCAAGA AGGCGATAGG AGCCTTTGCT 
GCTGCAGACT CCTTCGACCA CAAAAAGTTC TTCCAGATGG TGGGCCTGAA GAAAAAGAAC 
CCGGATGAGG TGAAGAAGGT GTTCCATATT CTGGACAAAG ACAAAAGTGG CTTCATTGAG 
GAGGATGAGC TGGGGTCCAT TCTGAAGGGC TTCTCCTCAG ATGCCAGAGA CTTGTCTGCT 
AAAGAAACAA AGACGCTTCT GGCCGCTGGA GACAAGGATG GGGACGGCAA GATTGGGGTT 
GAAGAATTCT CCACTCTGGT GGCTGAAAGC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Pvalb ( NM_013645.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_038673.2 Mus musculus parvalbumin (Pvalb), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu19404
Clone ID Related Accession (Same CDS sequence)	NM_013645.3 , NM_001330686.1 , XM_006520643.2 , NM_013645.4
Accession Version	NM_013645.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 333bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Mus musculus(house mouse)
Product	parvalbumin alpha
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL589692.10, CK622340.1, AA467036.1, DV051867.1 and AI645659.1. On Sep 1, 2016 this sequence version replaced NM_013645.3. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC027424.1, DV051867.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849385 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCGATGA CAGACGTGCT CAGCGCTGAG GACATCAAGA AGGCGATAGG AGCCTTTGCT 
GCTGCAGACT CCTTCGACCA CAAAAAGTTC TTCCAGATGG TGGGCCTGAA GAAAAAGAAC 
CCGGATGAGG TGAAGAAGGT GTTCCATATT CTGGACAAAG ACAAAAGTGG CTTCATTGAG 
GAGGATGAGC TGGGGTCCAT TCTGAAGGGC TTCTCCTCAG ATGCCAGAGA CTTGTCTGCT 
AAAGAAACAA AGACGCTTCT GGCCGCTGGA GACAAGGATG GGGACGGCAA GATTGGGGTT 
GAAGAATTCT CCACTCTGGT GGCTGAAAGC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_038673.2
CDS	72..404
Translation	MSMTDVLSAEDIKKAIGAFAAADSFDHKKFFQMVGLKKKNPDEVKKVFHILDKDKSGFIEEDELGSILKGFSSDARDLSAKETKTLLAAGDKDGDGKIGVEEFSTLVAES

Target ORF information:

RefSeq Version	NM_013645.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus parvalbumin (Pvalb), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013645.4

ORF Insert Sequence:

ATGTCGATGA CAGACGTGCT CAGCGCTGAG GACATCAAGA AGGCGATAGG AGCCTTTGCT 
GCTGCAGACT CCTTCGACCA CAAAAAGTTC TTCCAGATGG TGGGCCTGAA GAAAAAGAAC 
CCGGATGAGG TGAAGAAGGT GTTCCATATT CTGGACAAAG ACAAAAGTGG CTTCATTGAG 
GAGGATGAGC TGGGGTCCAT TCTGAAGGGC TTCTCCTCAG ATGCCAGAGA CTTGTCTGCT 
AAAGAAACAA AGACGCTTCT GGCCGCTGGA GACAAGGATG GGGACGGCAA GATTGGGGTT 
GAAGAATTCT CCACTCTGGT GGCTGAAAGC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Pvalb ( XM_006520643.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006520706.1 Mus musculus parvalbumin (Pvalb), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu19404
Clone ID Related Accession (Same CDS sequence)	NM_013645.3 , NM_001330686.1 , XM_006520643.2 , NM_013645.4
Accession Version	XM_006520643.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 333bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-08
Organism	Mus musculus(House mouse)
Product	parvalbumin alpha isoform X1
Comment

ATGTCGATGA CAGACGTGCT CAGCGCTGAG GACATCAAGA AGGCGATAGG AGCCTTTGCT 
GCTGCAGACT CCTTCGACCA CAAAAAGTTC TTCCAGATGG TGGGCCTGAA GAAAAAGAAC 
CCGGATGAGG TGAAGAAGGT GTTCCATATT CTGGACAAAG ACAAAAGTGG CTTCATTGAG 
GAGGATGAGC TGGGGTCCAT TCTGAAGGGC TTCTCCTCAG ATGCCAGAGA CTTGTCTGCT 
AAAGAAACAA AGACGCTTCT GGCCGCTGGA GACAAGGATG GGGACGGCAA GATTGGGGTT 
GAAGAATTCT CCACTCTGGT GGCTGAAAGC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006520706.1
Translation	MSMTDVLSAEDIKKAIGAFAAADSFDHKKFFQMVGLKKKNPDEVKKVFHILDKDKSGFIEEDELGSILKGFSSDARDLSAKETKTLLAAGDKDGDGKIGVEEFSTLVAES

Target ORF information:

RefSeq Version	XM_006520643.2
Organism	Mus musculus(House mouse)
Definition	Mus musculus parvalbumin (Pvalb), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006520643.2

ORF Insert Sequence:

ATGTCGATGA CAGACGTGCT CAGCGCTGAG GACATCAAGA AGGCGATAGG AGCCTTTGCT 
GCTGCAGACT CCTTCGACCA CAAAAAGTTC TTCCAGATGG TGGGCCTGAA GAAAAAGAAC 
CCGGATGAGG TGAAGAAGGT GTTCCATATT CTGGACAAAG ACAAAAGTGG CTTCATTGAG 
GAGGATGAGC TGGGGTCCAT TCTGAAGGGC TTCTCCTCAG ATGCCAGAGA CTTGTCTGCT 
AAAGAAACAA AGACGCTTCT GGCCGCTGGA GACAAGGATG GGGACGGCAA GATTGGGGTT 
GAAGAATTCT CCACTCTGGT GGCTGAAAGC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Parvalbumin: calcium and magnesium buffering in the distal nephron.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association27(11)3988-94(2012 Nov)
Olinger E,Schwaller B,Loffing J,Gailly P,Devuyst O

Fine localization of genes on distal murine chromosome 15.
Cytogenetics and cell genetics52(3-4)177-9(1989)
Adolph S,Berchtold MW,Hameister H

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Pvalb cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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