Pstpip2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pstpip2
Entrez Gene ID	19201
Full Name	proline-serine-threonine phosphatase-interacting protein 2
Synonyms	MAYP,cmo
General protein information	Preferred Names proline-serine-threonine phosphatase-interacting protein 2 Names proline-serine-threonine phosphatase-interacting protein 2 PEST phosphatase-interacting protein 2 macrophage actin-associated tyrosine-phosphorylated protein pp37
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 18 Map Location: 18 E3\|18 52.38 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_013831.4	NP_038859.3	proline-serine-threonine phosphatase-interacting protein 2

Pathways from BioSystems

Homologies

Bos taurus (cattle)	PSTPIP2	NP_001094582.1
Homo sapiens (human)	PSTPIP2	NP_077748.3
Rattus norvegicus (Norway rat)	Pstpip2	NP_001258210.1
Danio rerio (zebrafish)	si:ch211-251f6.4	XP_003199344.2
Xenopus tropicalis (tropical clawed frog)	pstpip2	XP_002936560.2
Mus musculus (house mouse)	Pstpip2	NP_038859.3
Gallus gallus (chicken)	PSTPIP2	XP_001233737.1
Pan troglodytes (chimpanzee)	PSTPIP2	XP_001145075.1
Canis lupus familiaris (dog)	PSTPIP2	XP_005622906.1

Gene Ontology
Bibliography

Related articles in PubMed

NLRP3 inflammasome plays a redundant role with caspase 8 to promote IL-1?-mediated osteomyelitis.
Gurung P, Burton A, Kanneganti TD
Proceedings of the National Academy of Sciences of the United States of America113(16)4452-7(2016 Apr)

BAR Proteins PSTPIP1/2 Regulate Podosome Dynamics and the Resorption Activity of Osteoclasts.
Sztacho M, Segeletz S, Sanchez-Fernandez MA, Czupalla C, Niehage C, Hoflack B
PloS one11(10)e0164829(2016)

PSTPIP2, a Protein Associated with Autoinflammatory Disease, Interacts with Inhibitory Enzymes SHIP1 and Csk.
Drobek A, Kralova J, Skopcova T, Kucova M, Nov?k P, Angelisov? P, Otahal P, Alberich-Jorda M, Brdicka T
Journal of immunology (Baltimore, Md. : 1950)195(7)3416-26(2015 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

a new PSTPIP1/PTPN6/SHIP1/2-dependent negative feedback mechanism that counterbalances Src and PI(3,4,5)P3 signalling to control osteoclast cell polarity and activity during bone resorption
Title: BAR Proteins PSTPIP1/2 Regulate Podosome Dynamics and the Resorption Activity of Osteoclasts.

SHIP1 and Csk are part of the PSTPIP2-dependent inhibitory network that prevents the development of autoinflammatory disease.
Title: PSTPIP2, a Protein Associated with Autoinflammatory Disease, Interacts with Inhibitory Enzymes SHIP1 and Csk.

PSTPIP2 could play a role in innate immunity and development of autoinflammatory bone disorders, and may be associated with the pathogenesis of SAPHO syndrome.
Title: Increased neutrophil infiltration, IL-1 production and a SAPHO syndrome-like phenotype in PSTPIP2-deficient mice.

inflammasome-independent production of IL-1beta has a critical role in osteolytic bone disease; PSTPIP2 is a negative regulator of caspase-1-autonomous IL-1beta production
Title: Critical role for inflammasome-independent IL-1? production in osteomyelitis.

IL-1beta has a role in mediating autoinflammatory disease in Pstpip2-deficient mice
Title: Inflammasome-independent IL-1? mediates autoinflammatory disease in Pstpip2-deficient mice.

The following Pstpip2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pstpip2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu15747	NM_013831.4 Latest version!	Mus musculus proline-serine-threonine phosphatase-interacting protein 2 (Pstpip2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pstpip2 ( NM_013831.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_038859.3 Mus musculus proline-serine-threonine phosphatase-interacting protein 2 (Pstpip2), mRNA.

Price & Availability↑

CloneID	OMu15747
Clone ID Related Accession (Same CDS sequence)	NM_013831.4
Accession Version	NM_013831.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1005bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-14
Organism	Mus musculus(house mouse)
Product	proline-serine-threonine phosphatase-interacting protein 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY194204.1, AK157994.1, AC157649.4 and AK132418.1. On Mar 2, 2007 this sequence version replaced NM_013831.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK132418.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849377 [ECO:0000348] ##Evidence-Data-END##

ATGACGGGCT CGCTGTTCAA GGGGAACTTC TGGAGCACGG ACATTCTCAG CACCATTGGC 
TACGACAGCA TTATCCAGCA CCTGAACAAT GGCCGTAAGA ACTGCAAGGA GTTTGAAGAC 
TTTTTGAAAG AAAGAGCATC AATTGAAGAG AAATATGGCA AAGACCTGCT GAACCTCTCC 
AGGAAGAAGC CGTGTGGACA GTCTGAGATC AATACCTTGA AGAGAGCCCT TGAGGTCTTC 
AAGCAGCAAG TAGACAACGT GGCTCAATGT CACATTCAGC TTGCGCAGAC TCTAAGAGAA 
GAGGCCAGGA AGATGGAAGA ATTCCGGGAA AAGCAGAAGC TGCAGCGGAA AAAGACAGAA 
ACAATAATGG ATGCTGCCCA CAAGCAAAGG AACGCACAGT TCAAGAAAGC CATGGATGCC 
AAGAAGAATT ATGAGCAAAA GTGCCGGGAC AAGGATGAGG CAGAGCAAGC TGTCCACCGC 
AGCGCCAATG TGGCCAACCA ACGGCAACAA GAAAAGCTTT TTGTGAAACT GGCCACTTCA 
AAGACTGCAG TAGAGGATTC AGACAAAGCG TACATGTTGC ACATCAACAT GCTGGAGAAG 
GTTCGAGAAG ACTGGCAGAG TGAACACATT AAGGCCTGCG AGGTGTTCGA GGCTCAGGAA 
TGTGAACGAA TCAACTTCTT CCGGAATGCA CTGTGGTTGC ATCTGAATCA GCTGTCACAA 
CAATGTGTCG CAAATGACGA GATGTATGAG CAAGTCCGTA AGAGTTTAGA AACATGCAGC 
ATTGAGAAGG ACATCCAGTA TTTTGTGAAC CAGCGGAAAA CTGGACAGAC TCCCCCAGCA 
CCCATCATGT ATGAGAACTT CTACTCTCCT CAGCGGAATG CTGCCCCACC AGGAAAGACT 
ACAGGGCCCA ATCCAGCAAG GAGAGGACCT CTCCCTGTCC CTAAGCGGAT ACCAGATGAT 
CCTGATTACT CTGTGGTTGA AGATTACAGT TTGCTCTATC AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_038859.3
CDS	169..1173
Translation	MTGSLFKGNFWSTDILSTIGYDSIIQHLNNGRKNCKEFEDFLKERASIEEKYGKDLLNLSRKKPCGQSEINTLKRALEVFKQQVDNVAQCHIQLAQTLREEARKMEEFREKQKLQRKKTETIMDAAHKQRNAQFKKAMDAKKNYEQKCRDKDEAEQAVHRSANVANQRQQEKLFVKLATSKTAVEDSDKAYMLHINMLEKVREDWQSEHIKACEVFEAQECERINFFRNALWLHLNQLSQQCVANDEMYEQVRKSLETCSIEKDIQYFVNQRKTGQTPPAPIMYENFYSPQRNAAPPGKTTGPNPARRGPLPVPKRIPDDPDYSVVEDYSLLYQ

Target ORF information:

RefSeq Version	NM_013831.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus proline-serine-threonine phosphatase-interacting protein 2 (Pstpip2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013831.4

ORF Insert Sequence:

ATGACGGGCT CGCTGTTCAA GGGGAACTTC TGGAGCACGG ACATTCTCAG CACCATTGGC 
TACGACAGCA TTATCCAGCA CCTGAACAAT GGCCGTAAGA ACTGCAAGGA GTTTGAAGAC 
TTTTTGAAAG AAAGAGCATC AATTGAAGAG AAATATGGCA AAGACCTGCT GAACCTCTCC 
AGGAAGAAGC CGTGTGGACA GTCTGAGATC AATACCTTGA AGAGAGCCCT TGAGGTCTTC 
AAGCAGCAAG TAGACAACGT GGCTCAATGT CACATTCAGC TTGCGCAGAC TCTAAGAGAA 
GAGGCCAGGA AGATGGAAGA ATTCCGGGAA AAGCAGAAGC TGCAGCGGAA AAAGACAGAA 
ACAATAATGG ATGCTGCCCA CAAGCAAAGG AACGCACAGT TCAAGAAAGC CATGGATGCC 
AAGAAGAATT ATGAGCAAAA GTGCCGGGAC AAGGATGAGG CAGAGCAAGC TGTCCACCGC 
AGCGCCAATG TGGCCAACCA ACGGCAACAA GAAAAGCTTT TTGTGAAACT GGCCACTTCA 
AAGACTGCAG TAGAGGATTC AGACAAAGCG TACATGTTGC ACATCAACAT GCTGGAGAAG 
GTTCGAGAAG ACTGGCAGAG TGAACACATT AAGGCCTGCG AGGTGTTCGA GGCTCAGGAA 
TGTGAACGAA TCAACTTCTT CCGGAATGCA CTGTGGTTGC ATCTGAATCA GCTGTCACAA 
CAATGTGTCG CAAATGACGA GATGTATGAG CAAGTCCGTA AGAGTTTAGA AACATGCAGC 
ATTGAGAAGG ACATCCAGTA TTTTGTGAAC CAGCGGAAAA CTGGACAGAC TCCCCCAGCA 
CCCATCATGT ATGAGAACTT CTACTCTCCT CAGCGGAATG CTGCCCCACC AGGAAAGACT 
ACAGGGCCCA ATCCAGCAAG GAGAGGACCT CTCCCTGTCC CTAAGCGGAT ACCAGATGAT 
CCTGATTACT CTGTGGTTGA AGATTACAGT TTGCTCTATC AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

NLRP3 inflammasome plays a redundant role with caspase 8 to promote IL-1?-mediated osteomyelitis.
Proceedings of the National Academy of Sciences of the United States of America113(16)4452-7(2016 Apr)
Gurung P,Burton A,Kanneganti TD

BAR Proteins PSTPIP1/2 Regulate Podosome Dynamics and the Resorption Activity of Osteoclasts.
PloS one11(10)e0164829(2016)
Sztacho M,Segeletz S,Sanchez-Fernandez MA,Czupalla C,Niehage C,Hoflack B

PSTPIP2, a Protein Associated with Autoinflammatory Disease, Interacts with Inhibitory Enzymes SHIP1 and Csk.
Journal of immunology (Baltimore, Md. : 1950)195(7)3416-26(2015 Oct)
Drobek A,Kralova J,Skopcova T,Kucova M,Nov?k P,Angelisov? P,Otahal P,Alberich-Jorda M,Brdicka T

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Pstpip2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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