Nat3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nat3
Entrez Gene ID	17962
Full Name	N-acetyltransferase 3
General protein information	Preferred Names N-acetyltransferase 3 Names arylamine N-acetyltransferase 3 N-acetyltransferase type 3 NAT-3 arylamide acetylase 3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 8 Map Location: 8 B3.2\|8 33.39 cM

mRNA and Protein(s)

mRNA	Protein	Name
XM_011242275.1	XP_011240577.1	arylamine N-acetyltransferase 3 isoform X1
NM_008674.2	NP_032700.1	arylamine N-acetyltransferase 3

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Nat3	NP_032700.1
Rattus norvegicus (Norway rat)	Nat3	NP_001013070.1

Gene Ontology
Bibliography

Related articles in PubMed

Effect of arylamine acetyltransferase Nat3 gene knockout on N-acetylation in the mouse.
Sugamori KS, Brenneman D, Wong S, Gaedigk A, Yu V, Abramovici H, Rozmahel R, Grant DM
Drug metabolism and disposition: the biological fate of chemicals35(7)1064-70(2007 Jul)

Identification and functional characterization of novel polymorphisms associated with the genes for arylamine N-acetyltransferases in mice.
Boukouvala S, Price N, Sim E
Pharmacogenetics12(5)385-94(2002 Jul)

In silico sequence analysis of arylamine N-acetyltransferases: evidence for an absence of lateral gene transfer from bacteria to vertebrates and first description of paralogs in bacteria.
Rodrigues-Lima F, Dupret JM
Biochemical and biophysical research communications293(2)783-92(2002 May)

Chromosome mapping of the genes for murine arylamine N-acetyltransferases (NATs), enzymes involved in the metabolism of carcinogens: identification of a novel upstream noncoding exon for murine Nat2.
Fakis G, Boukouvala S, Buckle V, Payton M, Denning C, Sim E
Cytogenetics and cell genetics90(1-2)134-8(2000)

Immunochemical detection of arylamine N-acetyltransferase during mouse embryonic development and in adult mouse brain.
Stanley LA, Copp AJ, Pope J, Rolls S, Smelt V, Perry VH, Sim E
Teratology58(5)174-82(1998 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Generated Nat3 knockout mouse, showing that Nat3 is unlikely to play a significant role in the N-acetylation of arylamines either in wild-type mice or in mice lacking Nat1 and Nat2 activities.
Title: Effect of arylamine acetyltransferase Nat3 gene knockout on N-acetylation in the mouse.

The following Nat3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nat3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu17975	NM_008674.2 Latest version!	Mus musculus N-acetyltransferase 3 (Nat3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu68295	XM_011242275.1 Latest version!	Mus musculus N-acetyltransferase 3 (Nat3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nat3 ( NM_008674.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032700.1 Mus musculus N-acetyltransferase 3 (Nat3), mRNA.

Price & Availability↑

CloneID	OMu17975
Clone ID Related Accession (Same CDS sequence)	NM_008674.2
Accession Version	NM_008674.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 873bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	arylamine N-acetyltransferase 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK077364.1. On or before May 4, 2006 this sequence version replaced XM_977468.1, NM_008674.1. Sequence Note: An in-frame AUG is located 51 codons upstream of the annotated translation start site but is not being annotated as a start site since it is not conserved and is in a weak Kozak sequence context. ##Evidence-Data-START## Transcript exon combination :: AK077364.1, BB618160.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849384, SAMN00849387 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END##

ATGGACATTG AAGCATACTT TGAAAGAATT GGTTACCAGA AGTCCAGCAA CAAACTGGAC 
TTGCAGACAT TAACTGAAAT CCTTCAGCAT CAGATACGGG CTATTCCTTT TGAGAACTTG 
AACATCCATT GTGGGAAAAC CATGGAACTG AGCTTAGAGG ACACCTTTCA TCAAATTGTG 
AGGAAGAAGC GGGGAGGGTG GTGTCTTCAA GTCAACCATC TTCTCTACTG GGCTCTGGCC 
ATGATAGGGT TTGAGACCAC AATGTTAGGA GGATGTGTTT ATGTCCCTTC AGCCTGCAAG 
TATAGTAACA CTATGATACA CCTTCTACTA CAGGTGACCA TCAGTGGCAA AACATATATT 
GTAGATAGTG CATTCCCATT TTCCTGCCAG CTATGGGAGC CTCTGGAGTT GACATCTGGG 
AAGGATCAGC CTCAGGTTCC TGCCATCTTC CACCTGAGAG AAGAGAATGG AACCTGGTAC 
CTGGAACAAA CTAAAAGACA AGAATATGTT TCAAACCAAG AATTCATTGA TTCTAATTTT 
CTTGAGAAGA ACACACATCG AAAAATATAT TCTTTTACTC TTGAACCACG AACGATTGAA 
GATTTCTGGA GTATAAGTAC ATACTACCAG GTATCTCGAA CATCTGTGAT GACAAACACA 
TCACTTTGTT CCCTACATAC CAAAGACGGA GTCCATGGCT TAATGGGCAC CATTCTTGCC 
TATAAGAAGT TCAATTATAA GGACAATATA GATCTGGTAG AGTTTAAGAC TCTGAAGGAA 
GAAGAAATAG AAGAAGTCCT GAAGAGTGTT TTTGGAATTC ACTTGGAGAC AAAGCTTGTG 
CCCAAATGTG GCAATGTCTT TTTTACTATT TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032700.1
CDS	239..1111
Translation	MDIEAYFERIGYQKSSNKLDLQTLTEILQHQIRAIPFENLNIHCGKTMELSLEDTFHQIVRKKRGGWCLQVNHLLYWALAMIGFETTMLGGCVYVPSACKYSNTMIHLLLQVTISGKTYIVDSAFPFSCQLWEPLELTSGKDQPQVPAIFHLREENGTWYLEQTKRQEYVSNQEFIDSNFLEKNTHRKIYSFTLEPRTIEDFWSISTYYQVSRTSVMTNTSLCSLHTKDGVHGLMGTILAYKKFNYKDNIDLVEFKTLKEEEIEEVLKSVFGIHLETKLVPKCGNVFFTI

Target ORF information:

RefSeq Version	NM_008674.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus N-acetyltransferase 3 (Nat3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008674.2

ORF Insert Sequence:

ATGGACATTG AAGCATACTT TGAAAGAATT GGTTACCAGA AGTCCAGCAA CAAACTGGAC 
TTGCAGACAT TAACTGAAAT CCTTCAGCAT CAGATACGGG CTATTCCTTT TGAGAACTTG 
AACATCCATT GTGGGAAAAC CATGGAACTG AGCTTAGAGG ACACCTTTCA TCAAATTGTG 
AGGAAGAAGC GGGGAGGGTG GTGTCTTCAA GTCAACCATC TTCTCTACTG GGCTCTGGCC 
ATGATAGGGT TTGAGACCAC AATGTTAGGA GGATGTGTTT ATGTCCCTTC AGCCTGCAAG 
TATAGTAACA CTATGATACA CCTTCTACTA CAGGTGACCA TCAGTGGCAA AACATATATT 
GTAGATAGTG CATTCCCATT TTCCTGCCAG CTATGGGAGC CTCTGGAGTT GACATCTGGG 
AAGGATCAGC CTCAGGTTCC TGCCATCTTC CACCTGAGAG AAGAGAATGG AACCTGGTAC 
CTGGAACAAA CTAAAAGACA AGAATATGTT TCAAACCAAG AATTCATTGA TTCTAATTTT 
CTTGAGAAGA ACACACATCG AAAAATATAT TCTTTTACTC TTGAACCACG AACGATTGAA 
GATTTCTGGA GTATAAGTAC ATACTACCAG GTATCTCGAA CATCTGTGAT GACAAACACA 
TCACTTTGTT CCCTACATAC CAAAGACGGA GTCCATGGCT TAATGGGCAC CATTCTTGCC 
TATAAGAAGT TCAATTATAA GGACAATATA GATCTGGTAG AGTTTAAGAC TCTGAAGGAA 
GAAGAAATAG AAGAAGTCCT GAAGAGTGTT TTTGGAATTC ACTTGGAGAC AAAGCTTGTG 
CCCAAATGTG GCAATGTCTT TTTTACTATT TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Nat3 ( XM_011242275.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011240577.1 Mus musculus N-acetyltransferase 3 (Nat3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu68295
Clone ID Related Accession (Same CDS sequence)	XM_011242275.1
Accession Version	XM_011242275.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1026bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	arylamine N-acetyltransferase 3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000074.6) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAACAAAC GCTGTAGAAG AGCCACCAGG GTTGCTGTGC TCCAGCCTCT TGTCACAGGA 
ACTATCAGCC TTCAGGGACC CAGACATGAA AGGAGAGTAG CAGATGGACA GGCGGTGGCT 
GTCAGGCGCT TAGAGAGGAC ACAGCTGGGG ACCATGGACA TTGAAGCATA CTTTGAAAGA 
ATTGGTTACC AGAAGTCCAG CAACAAACTG GACTTGCAGA CATTAACTGA AATCCTTCAG 
CATCAGATAC GGGCTATTCC TTTTGAGAAC TTGAACATCC ATTGTGGGAA AACCATGGAA 
CTGAGCTTAG AGGACACCTT TCATCAAATT GTGAGGAAGA AGCGGGGAGG GTGGTGTCTT 
CAAGTCAACC ATCTTCTCTA CTGGGCTCTG GCCATGATAG GGTTTGAGAC CACAATGTTA 
GGAGGATGTG TTTATGTCCC TTCAGCCTGC AAGTATAGTA ACACTATGAT ACACCTTCTA 
CTACAGGTGA CCATCAGTGG CAAAACATAT ATTGTAGATA GTGCATTCCC ATTTTCCTGC 
CAGCTATGGG AGCCTCTGGA GTTGACATCT GGGAAGGATC AGCCTCAGGT TCCTGCCATC 
TTCCACCTGA GAGAAGAGAA TGGAACCTGG TACCTGGAAC AAACTAAAAG ACAAGAATAT 
GTTTCAAACC AAGAATTCAT TGATTCTAAT TTTCTTGAGA AGAACACACA TCGAAAAATA 
TATTCTTTTA CTCTTGAACC ACGAACGATT GAAGATTTCT GGAGTATAAG TACATACTAC 
CAGGTATCTC GAACATCTGT GATGACAAAC ACATCACTTT GTTCCCTACA TACCAAAGAC 
GGAGTCCATG GCTTAATGGG CACCATTCTT GCCTATAAGA AGTTCAATTA TAAGGACAAT 
ATAGATCTGG TAGAGTTTAA GACTCTGAAG GAAGAAGAAA TAGAAGAAGT CCTGAAGAGT 
GTTTTTGGAA TTCACTTGGA GACAAAGCTT GTGCCCAAAT GTGGCAATGT CTTTTTTACT 
ATTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011240577.1
CDS	86..1111
Translation	MNKRCRRATRVAVLQPLVTGTISLQGPRHERRVADGQAVAVRRLERTQLGTMDIEAYFERIGYQKSSNKLDLQTLTEILQHQIRAIPFENLNIHCGKTMELSLEDTFHQIVRKKRGGWCLQVNHLLYWALAMIGFETTMLGGCVYVPSACKYSNTMIHLLLQVTISGKTYIVDSAFPFSCQLWEPLELTSGKDQPQVPAIFHLREENGTWYLEQTKRQEYVSNQEFIDSNFLEKNTHRKIYSFTLEPRTIEDFWSISTYYQVSRTSVMTNTSLCSLHTKDGVHGLMGTILAYKKFNYKDNIDLVEFKTLKEEEIEEVLKSVFGIHLETKLVPKCGNVFFTI

Target ORF information:

RefSeq Version	XM_011242275.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus N-acetyltransferase 3 (Nat3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011242275.1

ORF Insert Sequence:

ATGAACAAAC GCTGTAGAAG AGCCACCAGG GTTGCTGTGC TCCAGCCTCT TGTCACAGGA 
ACTATCAGCC TTCAGGGACC CAGACATGAA AGGAGAGTAG CAGATGGACA GGCGGTGGCT 
GTCAGGCGCT TAGAGAGGAC ACAGCTGGGG ACCATGGACA TTGAAGCATA CTTTGAAAGA 
ATTGGTTACC AGAAGTCCAG CAACAAACTG GACTTGCAGA CATTAACTGA AATCCTTCAG 
CATCAGATAC GGGCTATTCC TTTTGAGAAC TTGAACATCC ATTGTGGGAA AACCATGGAA 
CTGAGCTTAG AGGACACCTT TCATCAAATT GTGAGGAAGA AGCGGGGAGG GTGGTGTCTT 
CAAGTCAACC ATCTTCTCTA CTGGGCTCTG GCCATGATAG GGTTTGAGAC CACAATGTTA 
GGAGGATGTG TTTATGTCCC TTCAGCCTGC AAGTATAGTA ACACTATGAT ACACCTTCTA 
CTACAGGTGA CCATCAGTGG CAAAACATAT ATTGTAGATA GTGCATTCCC ATTTTCCTGC 
CAGCTATGGG AGCCTCTGGA GTTGACATCT GGGAAGGATC AGCCTCAGGT TCCTGCCATC 
TTCCACCTGA GAGAAGAGAA TGGAACCTGG TACCTGGAAC AAACTAAAAG ACAAGAATAT 
GTTTCAAACC AAGAATTCAT TGATTCTAAT TTTCTTGAGA AGAACACACA TCGAAAAATA 
TATTCTTTTA CTCTTGAACC ACGAACGATT GAAGATTTCT GGAGTATAAG TACATACTAC 
CAGGTATCTC GAACATCTGT GATGACAAAC ACATCACTTT GTTCCCTACA TACCAAAGAC 
GGAGTCCATG GCTTAATGGG CACCATTCTT GCCTATAAGA AGTTCAATTA TAAGGACAAT 
ATAGATCTGG TAGAGTTTAA GACTCTGAAG GAAGAAGAAA TAGAAGAAGT CCTGAAGAGT 
GTTTTTGGAA TTCACTTGGA GACAAAGCTT GTGCCCAAAT GTGGCAATGT CTTTTTTACT 
ATTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Effect of arylamine acetyltransferase Nat3 gene knockout on N-acetylation in the mouse.
Drug metabolism and disposition: the biological fate of chemicals35(7)1064-70(2007 Jul)
Sugamori KS,Brenneman D,Wong S,Gaedigk A,Yu V,Abramovici H,Rozmahel R,Grant DM

Identification and functional characterization of novel polymorphisms associated with the genes for arylamine N-acetyltransferases in mice.
Pharmacogenetics12(5)385-94(2002 Jul)
Boukouvala S,Price N,Sim E

In silico sequence analysis of arylamine N-acetyltransferases: evidence for an absence of lateral gene transfer from bacteria to vertebrates and first description of paralogs in bacteria.
Biochemical and biophysical research communications293(2)783-92(2002 May)
Rodrigues-Lima F,Dupret JM

Chromosome mapping of the genes for murine arylamine N-acetyltransferases (NATs), enzymes involved in the metabolism of carcinogens: identification of a novel upstream noncoding exon for murine Nat2.
Cytogenetics and cell genetics90(1-2)134-8(2000)
Fakis G,Boukouvala S,Buckle V,Payton M,Denning C,Sim E

Immunochemical detection of arylamine N-acetyltransferase during mouse embryonic development and in adult mouse brain.
Teratology58(5)174-82(1998 Nov)
Stanley LA,Copp AJ,Pope J,Rolls S,Smelt V,Perry VH,Sim E