Acbd3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Acbd3
Entrez Gene ID	170760
Full Name	acyl-Coenzyme A binding domain containing 3
Synonyms	60kDa,8430407O11Rik,D1Ertd10e,GCP60,GOLPH1,Gocap1,Pap7
General protein information	Preferred Names acyl-Coenzyme A binding domain containing 3 Names Golgi resident protein GCP60 PBR associated protein PBR- and PKA-associated protein 7 acyl-CoA-binding domain-containing protein 3 golgi complex associated protein 1, 60 kDa golgi complex-associated protein 1 golgi phosphoprotein 1 peripheral benzodiazepine receptor-associated protein PAP7 peripherial benzodiazepine receptor associated protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1 H4\|1 84.46 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_133225.3	NP_573488.2	Golgi resident protein GCP60

Pathways from BioSystems

Homologies

Homo sapiens (human)	ACBD3	NP_073572.2
Canis lupus familiaris (dog)	ACBD3	XP_005622687.1
Rattus norvegicus (Norway rat)	Acbd3	NP_878263.1
Xenopus tropicalis (tropical clawed frog)	acbd3	NP_001096198.1
Pan troglodytes (chimpanzee)	ACBD3	XP_001140648.1
Danio rerio (zebrafish)	zgc:162964	NP_001082856.1
Mus musculus (house mouse)	Acbd3	NP_573488.2
Bos taurus (cattle)	ACBD3	NP_001178112.1
Gallus gallus (chicken)	ACBD3	NP_001026214.1
	ACBD3	XP_001091471.1

Gene Ontology
Bibliography

Related articles in PubMed

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Acyl-CoA-binding domain containing 3 modulates NAD+ metabolism through activating poly(ADP-ribose) polymerase 1.
Chen Y, Bang S, Park S, Shi H, Kim SF
The Biochemical journal469(2)189-98(2015 Jul)

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H
Nucleic acids research42(Database issue)D802-9(2014 Jan)

The mammalian Golgi regulates numb signaling in asymmetric cell division by releasing ACBD3 during mitosis.
Zhou Y, Atkins JB, Rompani SB, Bancescu DL, Petersen PH, Tang H, Zou K, Stewart SB, Zhong W
Cell129(1)163-78(2007 Apr)

Protein-protein interactions mediate mitochondrial cholesterol transport and steroid biosynthesis.
Liu J, Rone MB, Papadopoulos V
The Journal of biological chemistry281(50)38879-93(2006 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

these findings suggest that ACBD3 has prominent impacts on cellular NAD(+) metabolism via regulating PARP1 activation-dependent auto-modification and thus cell metabolism and function.
Title: Acyl-CoA-binding domain containing 3 modulates NAD+ metabolism through activating poly(ADP-ribose) polymerase 1.

Study reports that ACBD3 is a Numb partner in cell-fate specification, ACBD3 and Numb proteins interact through an essential Numb domain, and the respective loss- and gain-of-function mutant mice share phenotypic similarities.
Title: The mammalian Golgi regulates numb signaling in asymmetric cell division by releasing ACBD3 during mitosis.

These results suggest that PBR, in addition to its role in cholesterol and coproporphyrinogen III transport, is also directing the mitochondrial PPIX import, a function that can be ascribed to the 18kDa PBR protein alone
Title: Protoporphyrin IX binding and transport by recombinant mouse PBR.

The following Acbd3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Acbd3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu09948	NM_133225.3 Latest version!	Mus musculus acyl-Coenzyme A binding domain containing 3 (Acbd3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Acbd3 ( NM_133225.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_573488.2 Mus musculus acyl-Coenzyme A binding domain containing 3 (Acbd3), mRNA.

Price & Availability↑

CloneID	OMu09948
Clone ID Related Accession (Same CDS sequence)	NM_133225.3
Accession Version	NM_133225.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1578bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	Golgi resident protein GCP60
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK030371.1, BC060602.1 and BU756506.1. On May 8, 2009 this sequence version replaced NM_133225.2. ##Evidence-Data-START## Transcript exon combination :: AK030371.1, SRR1660819.52586.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCGC AGCTGAACGT AGAGCAGCTC GAGGTGTCGC TCGACGGTCT CACGCTGAGC 
CCGGACTCGG AGGAGAGGCC CGGCGCGGAG GGGGCCCCGC CGCAGACGCC GCCGTCCTCG 
GCCCCGGGGA ATGGACTGGG CTCCGGCGCC TCGGGGCAGC AGCGGGAGCC CGGGGAGGCG 
GCGGCTGAGG GCGCGGCCGA GGAGGCGCGG CGGATGGAGC AGCACTGGGG CTTTGGCCTG 
GAGGAGCTTT ACGGCCTGGC GCTGCGCTTC TACAAAATAA AAGATGGCAA AGCCTTTCAT 
CCAACTTATG AAGAAAAACT GAAGTTCGTG GCACTGCATA AGCAAGTTCT TTTGGGCCCA 
TATAACCCAG ACACGTCCCC TGAGGTTGGA TTCTTTGATG TGTTGGGGAA TGATAGGAGG 
AGAGAATGGG CAGCTCTGGG AAACATGTCC AAGGAGGATG CCATGGTAGA GTTTGTGAAG 
CTTCTAAATA AGTGTTGTCC TCTCCTCTCG GCATATGTTG CGTCCCACAG AATAGAGAAG 
GAAGAAGAAG AGAAAAGAAG AAAGGCGGAG GAGGAGCGAA GGCAGCGTGA AGAGGAAGAA 
CGAGAGCGGC TGCAAAAGGA AGAAGAGAAG CGGAAGCGAG AGGAGGAAGA CCGGCTGAGA 
CGGGAGGAGG AAGAGAGGCG GCGGATAGAG GAAGAGAGGC TTCGGCTGGA ACAGCAAAAG 
CAGCAGATAA TGGCAGCTTT AAACTCGCAG ACTGCCGTGC AATTCCAGCA GTATGCAGCC 
CAGCAGTATC CAGGGAACTA CGAACAACAG CAGATTCTCA TCCGCCAGCT GCAGGAGCAG 
CACTATCAGC AGTATATGCA GCAGTTATAT CAAGTCCAGC TTGCACAACA ACAGGCAGCA 
TTACAGAAAC AGCAAGAAGT AGTGATGGCT GGGGCATCAT TGCCTGCATC ATCAAAGGTG 
AACACAGCTG GAGCAAGTGA TACACTGTCA GTTAATGGAC AGGCCAAAAC CCACACTGAA 
AATTCCGAAA AAGTCCTTGA GCCAGAAGCT GCAGAAGAAG CCTTGGAAAA TGGACCAAAA 
GACTCTCTTC CAGTGATTGC AGCTCCATCC ATGTGGACAA GACCACAAAT CAAAGACTTT 
AAAGAGAAGA TTCGGCAGGA TGCAGATTCT GTGATTACAG TACGTCGAGG AGAAGTCGTC 
ACCGTCCGAG TCCCGACTCA TGAGGAAGGA TCATACCTAT TTTGGGAATT TGCCACAGAC 
AGTTATGACA TTGGGTTTGG GGTTTATTTT GAATGGACAG ACTCTCCAAA TGCTGCTGTC 
AGTGTGCATG TCAGTGAGTC CAGTGACGAG GAGGAGGAGG AGGAAGAAAA TGTCACTTGT 
GAAGAAAAAG CAAAAAAGAA CGCCAACAAG CCTCTGCTGG ATGAGATTGT ACCTGTGTAC 
CGGCGGGACT GTCACGAGGA AGTATATGCA GGCAGCCACC AGTATCCAGG GAGGGGAGTC 
TATCTCCTCA AGTTTGATAA TTCCTACTCT CTGTGGAGGT CCAAGTCCGT CTACTACAGA 
GTCTATTATA CTAGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_573488.2
CDS	60..1637
Translation	MAAQLNVEQLEVSLDGLTLSPDSEERPGAEGAPPQTPPSSAPGNGLGSGASGQQREPGEAAAEGAAEEARRMEQHWGFGLEELYGLALRFYKIKDGKAFHPTYEEKLKFVALHKQVLLGPYNPDTSPEVGFFDVLGNDRRREWAALGNMSKEDAMVEFVKLLNKCCPLLSAYVASHRIEKEEEEKRRKAEEERRQREEEERERLQKEEEKRKREEEDRLRREEEERRRIEEERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQQQAALQKQQEVVMAGASLPASSKVNTAGASDTLSVNGQAKTHTENSEKVLEPEAAEEALENGPKDSLPVIAAPSMWTRPQIKDFKEKIRQDADSVITVRRGEVVTVRVPTHEEGSYLFWEFATDSYDIGFGVYFEWTDSPNAAVSVHVSESSDEEEEEEENVTCEEKAKKNANKPLLDEIVPVYRRDCHEEVYAGSHQYPGRGVYLLKFDNSYSLWRSKSVYYRVYYTR

Target ORF information:

RefSeq Version	NM_133225.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus acyl-Coenzyme A binding domain containing 3 (Acbd3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133225.3

ORF Insert Sequence:

ATGGCGGCGC AGCTGAACGT AGAGCAGCTC GAGGTGTCGC TCGACGGTCT CACGCTGAGC 
CCGGACTCGG AGGAGAGGCC CGGCGCGGAG GGGGCCCCGC CGCAGACGCC GCCGTCCTCG 
GCCCCGGGGA ATGGACTGGG CTCCGGCGCC TCGGGGCAGC AGCGGGAGCC CGGGGAGGCG 
GCGGCTGAGG GCGCGGCCGA GGAGGCGCGG CGGATGGAGC AGCACTGGGG CTTTGGCCTG 
GAGGAGCTTT ACGGCCTGGC GCTGCGCTTC TACAAAATAA AAGATGGCAA AGCCTTTCAT 
CCAACTTATG AAGAAAAACT GAAGTTCGTG GCACTGCATA AGCAAGTTCT TTTGGGCCCA 
TATAACCCAG ACACGTCCCC TGAGGTTGGA TTCTTTGATG TGTTGGGGAA TGATAGGAGG 
AGAGAATGGG CAGCTCTGGG AAACATGTCC AAGGAGGATG CCATGGTAGA GTTTGTGAAG 
CTTCTAAATA AGTGTTGTCC TCTCCTCTCG GCATATGTTG CGTCCCACAG AATAGAGAAG 
GAAGAAGAAG AGAAAAGAAG AAAGGCGGAG GAGGAGCGAA GGCAGCGTGA AGAGGAAGAA 
CGAGAGCGGC TGCAAAAGGA AGAAGAGAAG CGGAAGCGAG AGGAGGAAGA CCGGCTGAGA 
CGGGAGGAGG AAGAGAGGCG GCGGATAGAG GAAGAGAGGC TTCGGCTGGA ACAGCAAAAG 
CAGCAGATAA TGGCAGCTTT AAACTCGCAG ACTGCCGTGC AATTCCAGCA GTATGCAGCC 
CAGCAGTATC CAGGGAACTA CGAACAACAG CAGATTCTCA TCCGCCAGCT GCAGGAGCAG 
CACTATCAGC AGTATATGCA GCAGTTATAT CAAGTCCAGC TTGCACAACA ACAGGCAGCA 
TTACAGAAAC AGCAAGAAGT AGTGATGGCT GGGGCATCAT TGCCTGCATC ATCAAAGGTG 
AACACAGCTG GAGCAAGTGA TACACTGTCA GTTAATGGAC AGGCCAAAAC CCACACTGAA 
AATTCCGAAA AAGTCCTTGA GCCAGAAGCT GCAGAAGAAG CCTTGGAAAA TGGACCAAAA 
GACTCTCTTC CAGTGATTGC AGCTCCATCC ATGTGGACAA GACCACAAAT CAAAGACTTT 
AAAGAGAAGA TTCGGCAGGA TGCAGATTCT GTGATTACAG TACGTCGAGG AGAAGTCGTC 
ACCGTCCGAG TCCCGACTCA TGAGGAAGGA TCATACCTAT TTTGGGAATT TGCCACAGAC 
AGTTATGACA TTGGGTTTGG GGTTTATTTT GAATGGACAG ACTCTCCAAA TGCTGCTGTC 
AGTGTGCATG TCAGTGAGTC CAGTGACGAG GAGGAGGAGG AGGAAGAAAA TGTCACTTGT 
GAAGAAAAAG CAAAAAAGAA CGCCAACAAG CCTCTGCTGG ATGAGATTGT ACCTGTGTAC 
CGGCGGGACT GTCACGAGGA AGTATATGCA GGCAGCCACC AGTATCCAGG GAGGGGAGTC 
TATCTCCTCA AGTTTGATAA TTCCTACTCT CTGTGGAGGT CCAAGTCCGT CTACTACAGA 
GTCTATTATA CTAGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Acyl-CoA-binding domain containing 3 modulates NAD+ metabolism through activating poly(ADP-ribose) polymerase 1.
The Biochemical journal469(2)189-98(2015 Jul)
Chen Y,Bang S,Park S,Shi H,Kim SF

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Nucleic acids research42(Database issue)D802-9(2014 Jan)
Koscielny G,Yaikhom G,Iyer V,Meehan TF,Morgan H,Atienza-Herrero J,Blake A,Chen CK,Easty R,Di Fenza A,Fiegel T,Grifiths M,Horne A,Karp NA,Kurbatova N,Mason JC,Matthews P,Oakley DJ,Qazi A,Regnart J,Retha A,Santos LA,Sneddon DJ,Warren J,Westerberg H,Wilson RJ,Melvin DG,Smedley D,Brown SD,Flicek P,Skarnes WC,Mallon AM,Parkinson H

The mammalian Golgi regulates numb signaling in asymmetric cell division by releasing ACBD3 during mitosis.
Cell129(1)163-78(2007 Apr)
Zhou Y,Atkins JB,Rompani SB,Bancescu DL,Petersen PH,Tang H,Zou K,Stewart SB,Zhong W

Protein-protein interactions mediate mitochondrial cholesterol transport and steroid biosynthesis.
The Journal of biological chemistry281(50)38879-93(2006 Dec)
Liu J,Rone MB,Papadopoulos V

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Acbd3 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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