Olfr78 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Olfr78
Entrez Gene ID	170639
Full Name	olfactory receptor 78
Synonyms	4633402A21Rik,MOL2.3,MOR18-2,Or51e2,PSGR,RA1c
General protein information	Preferred Names olfactory receptor 78 Names olfactory receptor 51E2 GA_x6K02T2PBJ9-5459657-5458695 olfactory receptor MOR18-2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7\|7 E3
Summary	Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001168503.1	NP_001161975.1	olfactory receptor 51E2
NM_130866.4	NP_570936.1	olfactory receptor 51E2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	LOC466344	XP_003951855.1
	OR51E2	XP_001112401.2
Canis lupus familiaris (dog)	LOC100856052	XP_005633640.1
Mus musculus (house mouse)	Olfr78	NP_570936.1
Homo sapiens (human)	OR51E2	NP_110401.1
Rattus norvegicus (Norway rat)	Olr59	NP_775415.1
Xenopus tropicalis (tropical clawed frog)	or51e1	NP_001120273.1
Bos taurus (cattle)	OR51E2	XP_005216211.1

Gene Ontology
Bibliography

Related articles in PubMed

Prostate-Specific G-Protein Coupled Receptor, an Emerging Biomarker Regulating Inflammation and Prostate Cancer Invasion.
Rodriguez M, Siwko S, Liu M
Current molecular medicine16(6)526-32(2016)

Oxygen regulation of breathing through an olfactory receptor activated by lactate.
Chang AJ, Ortega FE, Riegler J, Madison DV, Krasnow MA
Nature527(7577)240-4(2015 Nov)

Expression of odorant receptor Olfr78 in enteroendocrine cells of the colon.
Fleischer J, Bumbalo R, Bautze V, Strotmann J, Breer H
Cell and tissue research361(3)697-710(2015 Sep)

Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation.
Pluznick JL, Protzko RJ, Gevorgyan H, Peterlin Z, Sipos A, Han J, Brunet I, Wan LX, Rey F, Wang T, Firestein SJ, Yanagisawa M, Gordon JI, Eichmann A, Peti-Peterdi J, Caplan MJ
Proceedings of the National Academy of Sciences of the United States of America110(11)4410-5(2013 Mar)

Retinoic acid receptor and CNGA2 channel signaling are part of a regulatory feedback loop controlling axonal convergence and survival of olfactory sensory neurons.
?ztokatli H, H?rnberg M, Berghard A, Bohm S
FASEB journal : official publication of the Federation of American Societies for Experimental Biology26(2)617-27(2012 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Transgenic mice overexpressing PSGR in the prostate were reported to develop an acute inflammatory response followed by emergence of low grade prostatic intraepithelial neoplasia, whereas mice with compound PSGR overexpression and loss of PTEN exhibited accelerated formation of invasive prostate adenocarcinoma. (Review)
Title: Prostate-Specific G-Protein Coupled Receptor, an Emerging Biomarker Regulating Inflammation and Prostate Cancer Invasion.

in addition to its role in olfaction, Olfr78 acts as a hypoxia sensor in the breathing circuit by sensing lactate produced when oxygen levels decline
Title: Oxygen regulation of breathing through an olfactory receptor activated by lactate.

Olfr78 is involved in the regulation of hormone secretion from such cells, as evoked by nutritional compounds
Title: Expression of odorant receptor Olfr78 in enteroendocrine cells of the colon.

SCFAs produced by the gut microbiota modulate blood pressure via Olfr78 and Gpr41.
Title: Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation.

The following Olfr78 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Olfr78 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu12911	NM_001168503.1 Latest version!	Mus musculus olfactory receptor 78 (Olfr78), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
OMu12911	NM_130866.4 Latest version!	Mus musculus olfactory receptor 78 (Olfr78), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Olfr78 ( NM_001168503.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001161975.1 Mus musculus olfactory receptor 78 (Olfr78), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu12911
Clone ID Related Accession (Same CDS sequence)	NM_001168503.1 , NM_130866.4
Accession Version	NM_001168503.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 963bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-21
Organism	Mus musculus(house mouse)
Product	olfactory receptor 51E2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK036356.1 and AC162175.10. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK036356.1, BB629223.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGTTCCT GCAACTTCAC CCATGCCACC TTCCTGCTTA TTGGTATTCC AGGACTGGAG 
GAAGCTCACT TTTGGTTTGG CTTCCCCCTG CTTTCCATGT ATGCTGTAGC ATTGTTTGGA 
AACTGCATTG TGGTCTTCAT AGTGAGAACA GAGCGGAGCC TGCATGCACC CATGTACCTT 
TTTCTCTGCA TGCTGGCAGC TATTGATCTG GCTTTGTCCA CATCCACAAT GCCCAAGATT 
CTCGCCCTCT TTTGGTTTGA CTCCCGGGAG ATTACTTTTG ATGCCTGTCT TGCCCAGATG 
TTTTTCATTC ATACTCTCTC AGCAATTGAA TCTACTATCC TGCTGGCCAT GGCCTTTGAC 
CGGTACGTGG CTATCTGCCA CCCACTGCGT CACGCTGCTG TCCTCAACAA TACAGTAACA 
GTCCAAATAG GCATGGTGGC TCTGGTCCGG GGATCCCTAT TCTTTTTCCC ACTCCCACTA 
CTGATCAAGC GACTGGCTTT CTGTCACTCC AATGTGCTCT CCCACTCCTA TTGTGTCCAC 
CAGGATGTGA TGAAGTTGGC CTATACAGAC ACATTACCCA ATGTAGTCTA TGGTCTAACT 
GCCATTCTGC TAGTCATGGG TGTAGATGTC ATGTTCATCT CCTTGTCCTA CTTCCTGATC 
ATACGAACGG TTCTGCAACT GCCTTCCAAG TCTGAGCGAG CTAAGGCATT TGGGACTTGT 
GTGTCACACA TTAGTGTGGT CCTGGCTTTC TATGTACCAC TCATTGGTCT GTCAGTGGTG 
CACCGTTTTG GAAACAGCCT GGATCCCATT GTGCATGTTC TAATGGGGGA TGTCTACCTG 
CTGCTGCCTC CTGTGATCAA TCCCATCATC TACGGTGCTA AGACCAAACA GATCAGAACA 
CGGGTTCTGG CTATGTTCAA GATCAGCTGT GACAAGGACA TTGAAGCTGG GGGAAACACG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001161975.1
CDS	347..1309
Translation	MSSCNFTHATFLLIGIPGLEEAHFWFGFPLLSMYAVALFGNCIVVFIVRTERSLHAPMYLFLCMLAAIDLALSTSTMPKILALFWFDSREITFDACLAQMFFIHTLSAIESTILLAMAFDRYVAICHPLRHAAVLNNTVTVQIGMVALVRGSLFFFPLPLLIKRLAFCHSNVLSHSYCVHQDVMKLAYTDTLPNVVYGLTAILLVMGVDVMFISLSYFLIIRTVLQLPSKSERAKAFGTCVSHISVVLAFYVPLIGLSVVHRFGNSLDPIVHVLMGDVYLLLPPVINPIIYGAKTKQIRTRVLAMFKISCDKDIEAGGNT

Target ORF information:

RefSeq Version	NM_001168503.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus olfactory receptor 78 (Olfr78), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001168503.1

ORF Insert Sequence:

ATGAGTTCCT GCAACTTCAC CCATGCCACC TTCCTGCTTA TTGGTATTCC AGGACTGGAG 
GAAGCTCACT TTTGGTTTGG CTTCCCCCTG CTTTCCATGT ATGCTGTAGC ATTGTTTGGA 
AACTGCATTG TGGTCTTCAT AGTGAGAACA GAGCGGAGCC TGCATGCACC CATGTACCTT 
TTTCTCTGCA TGCTGGCAGC TATTGATCTG GCTTTGTCCA CATCCACAAT GCCCAAGATT 
CTCGCCCTCT TTTGGTTTGA CTCCCGGGAG ATTACTTTTG ATGCCTGTCT TGCCCAGATG 
TTTTTCATTC ATACTCTCTC AGCAATTGAA TCTACTATCC TGCTGGCCAT GGCCTTTGAC 
CGGTACGTGG CTATCTGCCA CCCACTGCGT CACGCTGCTG TCCTCAACAA TACAGTAACA 
GTCCAAATAG GCATGGTGGC TCTGGTCCGG GGATCCCTAT TCTTTTTCCC ACTCCCACTA 
CTGATCAAGC GACTGGCTTT CTGTCACTCC AATGTGCTCT CCCACTCCTA TTGTGTCCAC 
CAGGATGTGA TGAAGTTGGC CTATACAGAC ACATTACCCA ATGTAGTCTA TGGTCTAACT 
GCCATTCTGC TAGTCATGGG TGTAGATGTC ATGTTCATCT CCTTGTCCTA CTTCCTGATC 
ATACGAACGG TTCTGCAACT GCCTTCCAAG TCTGAGCGAG CTAAGGCATT TGGGACTTGT 
GTGTCACACA TTAGTGTGGT CCTGGCTTTC TATGTACCAC TCATTGGTCT GTCAGTGGTG 
CACCGTTTTG GAAACAGCCT GGATCCCATT GTGCATGTTC TAATGGGGGA TGTCTACCTG 
CTGCTGCCTC CTGTGATCAA TCCCATCATC TACGGTGCTA AGACCAAACA GATCAGAACA 
CGGGTTCTGG CTATGTTCAA GATCAGCTGT GACAAGGACA TTGAAGCTGG GGGAAACACG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Olfr78 ( NM_130866.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_570936.1 Mus musculus olfactory receptor 78 (Olfr78), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu12911
Clone ID Related Accession (Same CDS sequence)	NM_001168503.1 , NM_130866.4
Accession Version	NM_130866.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 963bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-21
Organism	Mus musculus(house mouse)
Product	olfactory receptor 51E2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK036356.1, AK028467.1 and AC162175.10. On Dec 9, 2009 this sequence version replaced NM_130866.3. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK028467.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGTTCCT GCAACTTCAC CCATGCCACC TTCCTGCTTA TTGGTATTCC AGGACTGGAG 
GAAGCTCACT TTTGGTTTGG CTTCCCCCTG CTTTCCATGT ATGCTGTAGC ATTGTTTGGA 
AACTGCATTG TGGTCTTCAT AGTGAGAACA GAGCGGAGCC TGCATGCACC CATGTACCTT 
TTTCTCTGCA TGCTGGCAGC TATTGATCTG GCTTTGTCCA CATCCACAAT GCCCAAGATT 
CTCGCCCTCT TTTGGTTTGA CTCCCGGGAG ATTACTTTTG ATGCCTGTCT TGCCCAGATG 
TTTTTCATTC ATACTCTCTC AGCAATTGAA TCTACTATCC TGCTGGCCAT GGCCTTTGAC 
CGGTACGTGG CTATCTGCCA CCCACTGCGT CACGCTGCTG TCCTCAACAA TACAGTAACA 
GTCCAAATAG GCATGGTGGC TCTGGTCCGG GGATCCCTAT TCTTTTTCCC ACTCCCACTA 
CTGATCAAGC GACTGGCTTT CTGTCACTCC AATGTGCTCT CCCACTCCTA TTGTGTCCAC 
CAGGATGTGA TGAAGTTGGC CTATACAGAC ACATTACCCA ATGTAGTCTA TGGTCTAACT 
GCCATTCTGC TAGTCATGGG TGTAGATGTC ATGTTCATCT CCTTGTCCTA CTTCCTGATC 
ATACGAACGG TTCTGCAACT GCCTTCCAAG TCTGAGCGAG CTAAGGCATT TGGGACTTGT 
GTGTCACACA TTAGTGTGGT CCTGGCTTTC TATGTACCAC TCATTGGTCT GTCAGTGGTG 
CACCGTTTTG GAAACAGCCT GGATCCCATT GTGCATGTTC TAATGGGGGA TGTCTACCTG 
CTGCTGCCTC CTGTGATCAA TCCCATCATC TACGGTGCTA AGACCAAACA GATCAGAACA 
CGGGTTCTGG CTATGTTCAA GATCAGCTGT GACAAGGACA TTGAAGCTGG GGGAAACACG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_570936.1
CDS	1216..2178
Translation	MSSCNFTHATFLLIGIPGLEEAHFWFGFPLLSMYAVALFGNCIVVFIVRTERSLHAPMYLFLCMLAAIDLALSTSTMPKILALFWFDSREITFDACLAQMFFIHTLSAIESTILLAMAFDRYVAICHPLRHAAVLNNTVTVQIGMVALVRGSLFFFPLPLLIKRLAFCHSNVLSHSYCVHQDVMKLAYTDTLPNVVYGLTAILLVMGVDVMFISLSYFLIIRTVLQLPSKSERAKAFGTCVSHISVVLAFYVPLIGLSVVHRFGNSLDPIVHVLMGDVYLLLPPVINPIIYGAKTKQIRTRVLAMFKISCDKDIEAGGNT

Target ORF information:

RefSeq Version	NM_130866.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus olfactory receptor 78 (Olfr78), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_130866.4

ORF Insert Sequence:

ATGAGTTCCT GCAACTTCAC CCATGCCACC TTCCTGCTTA TTGGTATTCC AGGACTGGAG 
GAAGCTCACT TTTGGTTTGG CTTCCCCCTG CTTTCCATGT ATGCTGTAGC ATTGTTTGGA 
AACTGCATTG TGGTCTTCAT AGTGAGAACA GAGCGGAGCC TGCATGCACC CATGTACCTT 
TTTCTCTGCA TGCTGGCAGC TATTGATCTG GCTTTGTCCA CATCCACAAT GCCCAAGATT 
CTCGCCCTCT TTTGGTTTGA CTCCCGGGAG ATTACTTTTG ATGCCTGTCT TGCCCAGATG 
TTTTTCATTC ATACTCTCTC AGCAATTGAA TCTACTATCC TGCTGGCCAT GGCCTTTGAC 
CGGTACGTGG CTATCTGCCA CCCACTGCGT CACGCTGCTG TCCTCAACAA TACAGTAACA 
GTCCAAATAG GCATGGTGGC TCTGGTCCGG GGATCCCTAT TCTTTTTCCC ACTCCCACTA 
CTGATCAAGC GACTGGCTTT CTGTCACTCC AATGTGCTCT CCCACTCCTA TTGTGTCCAC 
CAGGATGTGA TGAAGTTGGC CTATACAGAC ACATTACCCA ATGTAGTCTA TGGTCTAACT 
GCCATTCTGC TAGTCATGGG TGTAGATGTC ATGTTCATCT CCTTGTCCTA CTTCCTGATC 
ATACGAACGG TTCTGCAACT GCCTTCCAAG TCTGAGCGAG CTAAGGCATT TGGGACTTGT 
GTGTCACACA TTAGTGTGGT CCTGGCTTTC TATGTACCAC TCATTGGTCT GTCAGTGGTG 
CACCGTTTTG GAAACAGCCT GGATCCCATT GTGCATGTTC TAATGGGGGA TGTCTACCTG 
CTGCTGCCTC CTGTGATCAA TCCCATCATC TACGGTGCTA AGACCAAACA GATCAGAACA 
CGGGTTCTGG CTATGTTCAA GATCAGCTGT GACAAGGACA TTGAAGCTGG GGGAAACACG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Prostate-Specific G-Protein Coupled Receptor, an Emerging Biomarker Regulating Inflammation and Prostate Cancer Invasion.
Current molecular medicine16(6)526-32(2016)
Rodriguez M,Siwko S,Liu M

Oxygen regulation of breathing through an olfactory receptor activated by lactate.
Nature527(7577)240-4(2015 Nov)
Chang AJ,Ortega FE,Riegler J,Madison DV,Krasnow MA

Expression of odorant receptor Olfr78 in enteroendocrine cells of the colon.
Cell and tissue research361(3)697-710(2015 Sep)
Fleischer J,Bumbalo R,Bautze V,Strotmann J,Breer H

Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation.
Proceedings of the National Academy of Sciences of the United States of America110(11)4410-5(2013 Mar)
Pluznick JL,Protzko RJ,Gevorgyan H,Peterlin Z,Sipos A,Han J,Brunet I,Wan LX,Rey F,Wang T,Firestein SJ,Yanagisawa M,Gordon JI,Eichmann A,Peti-Peterdi J,Caplan MJ

Retinoic acid receptor and CNGA2 channel signaling are part of a regulatory feedback loop controlling axonal convergence and survival of olfactory sensory neurons.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology26(2)617-27(2012 Feb)
?ztokatli H,H?rnberg M,Berghard A,Bohm S

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Olfr78 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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