OR51E2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	OR51E2
Entrez Gene ID	81285
Full Name	olfactory receptor family 51 subfamily E member 2
Synonyms	OR51E3P,OR52A2,PSGR
General protein information	Preferred Names olfactory receptor family 51 subfamily E member 2 Names olfactory receptor 51E2 HPRAJ olfactory receptor OR11-16 olfactory receptor, family 51, subfamily E, member 3 pseudogene olfactory receptor, family 52, subfamily A, member 2 prostate-specific G-protein coupled receptor
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11p15.4
Summary	Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008].
Disorder MIM:	611268

mRNA and Protein(s)

mRNA	Protein	Name
NM_030774.3	NP_110401.1	olfactory receptor 51E2
NM_030774.4	NP_110401.1	olfactory receptor 51E2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	LOC466344	XP_003951855.1
	OR51E2	XP_001112401.2
Canis lupus familiaris (dog)	LOC100856052	XP_005633640.1
Mus musculus (house mouse)	Olfr78	NP_570936.1
Homo sapiens (human)	OR51E2	NP_110401.1
Rattus norvegicus (Norway rat)	Olr59	NP_775415.1
Xenopus tropicalis (tropical clawed frog)	or51e1	NP_001120273.1
Bos taurus (cattle)	OR51E2	XP_005216211.1

Gene Ontology
Bibliography

Related articles in PubMed

Functional expression of olfactory receptors in human primary melanoma and melanoma metastasis.
Gelis L, Jovancevic N, Bechara FG, Neuhaus EM, Hatt H
Experimental dermatology26(7)569-576(2017 Jul)

Odorant Receptor 51E2 Agonist ?-ionone Regulates RPE Cell Migration and Proliferation.
Jovancevic N, Khalfaoui S, Weinrich M, Weidinger D, Simon A, Kalbe B, Kernt M, Kampik A, Gisselmann G, Gelis L, Hatt H
Frontiers in physiology8888(2017)

Circulating mRNAs and miRNAs as candidate markers for the diagnosis and prognosis of prostate cancer.
Souza MF, Kuasne H, Barros-Filho MC, Cili?o HL, Marchi FA, Fuganti PE, Paschoal AR, Rogatto SR, C?lus IMS
PloS one12(9)e0184094(2017)

Defining an olfactory receptor function in airway smooth muscle cells.
Aisenberg WH, Huang J, Zhu W, Rajkumar P, Cruz R, Santhanam L, Natarajan N, Yong HM, De Santiago B, Oh JJ, Yoon AR, Panettieri RA, Homann O, Sullivan JK, Liggett SB, Pluznick JL, An SS
Scientific reports638231(2016 Dec)

Functional Characterization of the Odorant Receptor 51E2 in Human Melanocytes.
Gelis L, Jovancevic N, Veitinger S, Mandal B, Arndt HD, Neuhaus EM, Hatt H
The Journal of biological chemistry291(34)17772-86(2016 08)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Two genes, OR51E2 and SIM2, and two miRNAs, miR-200c and miR-200b, showed significant association with prostate cancer.
Title: Circulating mRNAs and miRNAs as candidate markers for the diagnosis and prognosis of prostate cancer.

Plasma membrane preparations showed that OR51E2 protein is present at the melanocyte cell surface.
Title: Functional Characterization of the Odorant Receptor 51E2 in Human Melanocytes.

PSGR overexpression synergizes with loss of PTEN to accelerate prostate cancer development, and present a novel bigenic mouse model that mimics the human condition
Title: Prostate-specific G-protein-coupled receptor collaborates with loss of PTEN to promote prostate cancer progression.

Pyk2-NDRG1 axis is possibly involved in conveying the anti-proliferative effect of beta-ionone in prostate cancer cells.
Title: Quantitative phosphoproteomics reveals the protein tyrosine kinase Pyk2 as a central effector of olfactory receptor signaling in prostate cancer cells.

We identified androstenone derivatives as ligands for the recombinant receptor PSGR
Title: Activation of an olfactory receptor inhibits proliferation of prostate cancer cells.

The following OR51E2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OR51E2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu04500	NM_030774.4 Latest version!	Homo sapiens olfactory receptor family 51 subfamily E member 2 (OR51E2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu04500	NM_030774.3	Homo sapiens olfactory receptor family 51 subfamily E member 2 (OR51E2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

OR51E2 ( NM_030774.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_110401.1 Homo sapiens olfactory receptor family 51 subfamily E member 2 (OR51E2), mRNA.

Price & Availability↑

CloneID	OHu04500
Clone ID Related Accession (Same CDS sequence)	NM_030774.3 , NM_030774.4
Accession Version	NM_030774.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 963bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-20
Organism	Homo sapiens(human)
Product	olfactory receptor 51E2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK314051.1 and AC090719.8. On Dec 20, 2008 this sequence version replaced NM_030774.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY033942.1, SRR1803616.125178.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2155984 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGTTCCT GCAACTTCAC ACATGCCACC TTTGTGCTTA TTGGTATCCC AGGATTAGAG 
AAAGCCCATT TCTGGGTTGG CTTCCCCCTC CTTTCCATGT ATGTAGTGGC AATGTTTGGA 
AACTGCATCG TGGTCTTCAT CGTAAGGACG GAACGCAGCC TGCACGCTCC GATGTACCTC 
TTTCTCTGCA TGCTTGCAGC CATTGACCTG GCCTTATCCA CATCCACCAT GCCTAAGATC 
CTTGCCCTTT TCTGGTTTGA TTCCCGAGAG ATTAGCTTTG AGGCCTGTCT TACCCAGATG 
TTCTTTATTC ATGCCCTCTC AGCCATTGAA TCCACCATCC TGCTGGCCAT GGCCTTTGAC 
CGTTATGTGG CCATCTGCCA CCCACTGCGC CATGCTGCAG TGCTCAACAA TACAGTAACA 
GCCCAGATTG GCATCGTGGC TGTGGTCCGC GGATCCCTCT TTTTTTTCCC ACTGCCTCTG 
CTGATCAAGC GGCTGGCCTT CTGCCACTCC AATGTCCTCT CGCACTCCTA TTGTGTCCAC 
CAGGATGTAA TGAAGTTGGC CTATGCAGAC ACTTTGCCCA ATGTGGTATA TGGTCTTACT 
GCCATTCTGC TGGTCATGGG CGTGGACGTA ATGTTCATCT CCTTGTCCTA TTTTCTGATA 
ATACGAACGG TTCTGCAACT GCCTTCCAAG TCAGAGCGGG CCAAGGCCTT TGGAACCTGT 
GTGTCACACA TTGGTGTGGT ACTCGCCTTC TATGTGCCAC TTATTGGCCT CTCAGTGGTA 
CACCGCTTTG GAAACAGCCT TCATCCCATT GTGCGTGTTG TCATGGGTGA CATCTACCTG 
CTGCTGCCTC CTGTCATCAA TCCCATCATC TATGGTGCCA AAACCAAACA GATCAGAACA 
CGGGTGCTGG CTATGTTCAA GATCAGCTGT GACAAGGACT TGCAGGCTGT GGGAGGCAAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_110401.1
CDS	245..1207
Translation	MSSCNFTHATFVLIGIPGLEKAHFWVGFPLLSMYVVAMFGNCIVVFIVRTERSLHAPMYLFLCMLAAIDLALSTSTMPKILALFWFDSREISFEACLTQMFFIHALSAIESTILLAMAFDRYVAICHPLRHAAVLNNTVTAQIGIVAVVRGSLFFFPLPLLIKRLAFCHSNVLSHSYCVHQDVMKLAYADTLPNVVYGLTAILLVMGVDVMFISLSYFLIIRTVLQLPSKSERAKAFGTCVSHIGVVLAFYVPLIGLSVVHRFGNSLHPIVRVVMGDIYLLLPPVINPIIYGAKTKQIRTRVLAMFKISCDKDLQAVGGK

Target ORF information:

RefSeq Version	NM_030774.3
Organism	Homo sapiens(human)
Definition	Homo sapiens olfactory receptor family 51 subfamily E member 2 (OR51E2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030774.3

ORF Insert Sequence:

ATGAGTTCCT GCAACTTCAC ACATGCCACC TTTGTGCTTA TTGGTATCCC AGGATTAGAG 
AAAGCCCATT TCTGGGTTGG CTTCCCCCTC CTTTCCATGT ATGTAGTGGC AATGTTTGGA 
AACTGCATCG TGGTCTTCAT CGTAAGGACG GAACGCAGCC TGCACGCTCC GATGTACCTC 
TTTCTCTGCA TGCTTGCAGC CATTGACCTG GCCTTATCCA CATCCACCAT GCCTAAGATC 
CTTGCCCTTT TCTGGTTTGA TTCCCGAGAG ATTAGCTTTG AGGCCTGTCT TACCCAGATG 
TTCTTTATTC ATGCCCTCTC AGCCATTGAA TCCACCATCC TGCTGGCCAT GGCCTTTGAC 
CGTTATGTGG CCATCTGCCA CCCACTGCGC CATGCTGCAG TGCTCAACAA TACAGTAACA 
GCCCAGATTG GCATCGTGGC TGTGGTCCGC GGATCCCTCT TTTTTTTCCC ACTGCCTCTG 
CTGATCAAGC GGCTGGCCTT CTGCCACTCC AATGTCCTCT CGCACTCCTA TTGTGTCCAC 
CAGGATGTAA TGAAGTTGGC CTATGCAGAC ACTTTGCCCA ATGTGGTATA TGGTCTTACT 
GCCATTCTGC TGGTCATGGG CGTGGACGTA ATGTTCATCT CCTTGTCCTA TTTTCTGATA 
ATACGAACGG TTCTGCAACT GCCTTCCAAG TCAGAGCGGG CCAAGGCCTT TGGAACCTGT 
GTGTCACACA TTGGTGTGGT ACTCGCCTTC TATGTGCCAC TTATTGGCCT CTCAGTGGTA 
CACCGCTTTG GAAACAGCCT TCATCCCATT GTGCGTGTTG TCATGGGTGA CATCTACCTG 
CTGCTGCCTC CTGTCATCAA TCCCATCATC TATGGTGCCA AAACCAAACA GATCAGAACA 
CGGGTGCTGG CTATGTTCAA GATCAGCTGT GACAAGGACT TGCAGGCTGT GGGAGGCAAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OR51E2 ( NM_030774.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_110401.1 Homo sapiens olfactory receptor family 51 subfamily E member 2 (OR51E2), mRNA.

Price & Availability↑

CloneID	OHu04500
Clone ID Related Accession (Same CDS sequence)	NM_030774.3 , NM_030774.4
Accession Version	NM_030774.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 963bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	olfactory receptor 51E2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC090719.8 and AK314051.1. On May 17, 2019 this sequence version replaced NM_030774.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY033942.1, SRR1803616.125178.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2155984 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000396950.4/ ENSP00000380153.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGTTCCT GCAACTTCAC ACATGCCACC TTTGTGCTTA TTGGTATCCC AGGATTAGAG 
AAAGCCCATT TCTGGGTTGG CTTCCCCCTC CTTTCCATGT ATGTAGTGGC AATGTTTGGA 
AACTGCATCG TGGTCTTCAT CGTAAGGACG GAACGCAGCC TGCACGCTCC GATGTACCTC 
TTTCTCTGCA TGCTTGCAGC CATTGACCTG GCCTTATCCA CATCCACCAT GCCTAAGATC 
CTTGCCCTTT TCTGGTTTGA TTCCCGAGAG ATTAGCTTTG AGGCCTGTCT TACCCAGATG 
TTCTTTATTC ATGCCCTCTC AGCCATTGAA TCCACCATCC TGCTGGCCAT GGCCTTTGAC 
CGTTATGTGG CCATCTGCCA CCCACTGCGC CATGCTGCAG TGCTCAACAA TACAGTAACA 
GCCCAGATTG GCATCGTGGC TGTGGTCCGC GGATCCCTCT TTTTTTTCCC ACTGCCTCTG 
CTGATCAAGC GGCTGGCCTT CTGCCACTCC AATGTCCTCT CGCACTCCTA TTGTGTCCAC 
CAGGATGTAA TGAAGTTGGC CTATGCAGAC ACTTTGCCCA ATGTGGTATA TGGTCTTACT 
GCCATTCTGC TGGTCATGGG CGTGGACGTA ATGTTCATCT CCTTGTCCTA TTTTCTGATA 
ATACGAACGG TTCTGCAACT GCCTTCCAAG TCAGAGCGGG CCAAGGCCTT TGGAACCTGT 
GTGTCACACA TTGGTGTGGT ACTCGCCTTC TATGTGCCAC TTATTGGCCT CTCAGTGGTA 
CACCGCTTTG GAAACAGCCT TCATCCCATT GTGCGTGTTG TCATGGGTGA CATCTACCTG 
CTGCTGCCTC CTGTCATCAA TCCCATCATC TATGGTGCCA AAACCAAACA GATCAGAACA 
CGGGTGCTGG CTATGTTCAA GATCAGCTGT GACAAGGACT TGCAGGCTGT GGGAGGCAAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_110401.1
CDS	252..1214
Translation	MSSCNFTHATFVLIGIPGLEKAHFWVGFPLLSMYVVAMFGNCIVVFIVRTERSLHAPMYLFLCMLAAIDLALSTSTMPKILALFWFDSREISFEACLTQMFFIHALSAIESTILLAMAFDRYVAICHPLRHAAVLNNTVTAQIGIVAVVRGSLFFFPLPLLIKRLAFCHSNVLSHSYCVHQDVMKLAYADTLPNVVYGLTAILLVMGVDVMFISLSYFLIIRTVLQLPSKSERAKAFGTCVSHIGVVLAFYVPLIGLSVVHRFGNSLHPIVRVVMGDIYLLLPPVINPIIYGAKTKQIRTRVLAMFKISCDKDLQAVGGK

Target ORF information:

RefSeq Version	NM_030774.4
Organism	Homo sapiens(human)
Definition	Homo sapiens olfactory receptor family 51 subfamily E member 2 (OR51E2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030774.4

ORF Insert Sequence:

ATGAGTTCCT GCAACTTCAC ACATGCCACC TTTGTGCTTA TTGGTATCCC AGGATTAGAG 
AAAGCCCATT TCTGGGTTGG CTTCCCCCTC CTTTCCATGT ATGTAGTGGC AATGTTTGGA 
AACTGCATCG TGGTCTTCAT CGTAAGGACG GAACGCAGCC TGCACGCTCC GATGTACCTC 
TTTCTCTGCA TGCTTGCAGC CATTGACCTG GCCTTATCCA CATCCACCAT GCCTAAGATC 
CTTGCCCTTT TCTGGTTTGA TTCCCGAGAG ATTAGCTTTG AGGCCTGTCT TACCCAGATG 
TTCTTTATTC ATGCCCTCTC AGCCATTGAA TCCACCATCC TGCTGGCCAT GGCCTTTGAC 
CGTTATGTGG CCATCTGCCA CCCACTGCGC CATGCTGCAG TGCTCAACAA TACAGTAACA 
GCCCAGATTG GCATCGTGGC TGTGGTCCGC GGATCCCTCT TTTTTTTCCC ACTGCCTCTG 
CTGATCAAGC GGCTGGCCTT CTGCCACTCC AATGTCCTCT CGCACTCCTA TTGTGTCCAC 
CAGGATGTAA TGAAGTTGGC CTATGCAGAC ACTTTGCCCA ATGTGGTATA TGGTCTTACT 
GCCATTCTGC TGGTCATGGG CGTGGACGTA ATGTTCATCT CCTTGTCCTA TTTTCTGATA 
ATACGAACGG TTCTGCAACT GCCTTCCAAG TCAGAGCGGG CCAAGGCCTT TGGAACCTGT 
GTGTCACACA TTGGTGTGGT ACTCGCCTTC TATGTGCCAC TTATTGGCCT CTCAGTGGTA 
CACCGCTTTG GAAACAGCCT TCATCCCATT GTGCGTGTTG TCATGGGTGA CATCTACCTG 
CTGCTGCCTC CTGTCATCAA TCCCATCATC TATGGTGCCA AAACCAAACA GATCAGAACA 
CGGGTGCTGG CTATGTTCAA GATCAGCTGT GACAAGGACT TGCAGGCTGT GGGAGGCAAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Functional expression of olfactory receptors in human primary melanoma and melanoma metastasis.
Experimental dermatology26(7)569-576(2017 Jul)
Gelis L,Jovancevic N,Bechara FG,Neuhaus EM,Hatt H

Odorant Receptor 51E2 Agonist ?-ionone Regulates RPE Cell Migration and Proliferation.
Frontiers in physiology8888(2017)
Jovancevic N,Khalfaoui S,Weinrich M,Weidinger D,Simon A,Kalbe B,Kernt M,Kampik A,Gisselmann G,Gelis L,Hatt H

Circulating mRNAs and miRNAs as candidate markers for the diagnosis and prognosis of prostate cancer.
PloS one12(9)e0184094(2017)
Souza MF,Kuasne H,Barros-Filho MC,Cili?o HL,Marchi FA,Fuganti PE,Paschoal AR,Rogatto SR,C?lus IMS

Defining an olfactory receptor function in airway smooth muscle cells.
Scientific reports638231(2016 Dec)
Aisenberg WH,Huang J,Zhu W,Rajkumar P,Cruz R,Santhanam L,Natarajan N,Yong HM,De Santiago B,Oh JJ,Yoon AR,Panettieri RA,Homann O,Sullivan JK,Liggett SB,Pluznick JL,An SS

Functional Characterization of the Odorant Receptor 51E2 in Human Melanocytes.
The Journal of biological chemistry291(34)17772-86(2016 08)
Gelis L,Jovancevic N,Veitinger S,Mandal B,Arndt HD,Neuhaus EM,Hatt H

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OR51E2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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