Inhbc cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Inhbc
Entrez Gene ID	16325
Full Name	inhibin beta-C
General protein information	Preferred Names inhibin beta-C Names inhibin beta C chain activin beta-C chain
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 10 Map Location: 10 D3\|10 74.5 cM
Summary	This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of homodimeric and heterodimeric activin complexes. The heterodimeric complex may function in the inhibition of activin A signaling. Transgenic mice overexpressing this gene exhibit defects in testis, liver and prostate. [provided by RefSeq, Aug 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_010565.4	NP_034695.1	inhibin beta C chain preproprotein

Pathways from BioSystems

Homologies

Homo sapiens (human)	INHBC	NP_005529.1
Canis lupus familiaris (dog)	INHBC	XP_849169.2
Rattus norvegicus (Norway rat)	Inhbc	NP_072136.1
	INHBC	XP_001115940.1
Xenopus tropicalis (tropical clawed frog)	LOC100493888	XP_002939470.1
Bos taurus (cattle)	INHBC	NP_001192912.1
Pan troglodytes (chimpanzee)	INHBC	XP_522443.1
Mus musculus (house mouse)	Inhbc	NP_034695.1

Gene Ontology
Bibliography

Related articles in PubMed

Regional localization of activin-?
Gold E, Zellhuber-McMillan S, Risbridger G, Marino FE
Gene expression patterns : GEP23-2470-79(2017 Jan)

Activin-?C modulates gonadal, but not adrenal tumorigenesis in the inhibin deficient mice.
Marino FE, Risbridger G, Gold E
Molecular and cellular endocrinology40941-50(2015 Jul)

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A, Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR
Neuron83(2)309-323(2014 Jul)

The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification.
Boroviak T, Loos R, Bertone P, Smith A, Nichols J
Nature cell biology16(6)516-28(2014 Jun)

Transforming growth factor-? superfamily ligand trap ACE-536 corrects anemia by promoting late-stage erythropoiesis.
Suragani RN, Cadena SM, Cawley SM, Sako D, Mitchell D, Li R, Davies MV, Alexander MJ, Devine M, Loveday KS, Underwood KW, Grinberg AV, Quisel JD, Chopra R, Pearsall RS, Seehra J, Kumar R
Nature medicine20(4)408-14(2014 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results showed activin-C and follistatin are differentially expressed during prostate development and suggested that the antagonistic property of follistatin is secondary to the action of activin-C. Study provides evidence to support a role of activin-C in prostate development and provides new insights in the spatiotemporal localization of activins and their antagonists during mouse prostate development.
Title: Regional localization of activin-?

Data reinforces the importance of activin-betaC in reproductive biology and suggests that activin-betaC is a tumor modulator with gonadal specificity.
Title: Activin-?C modulates gonadal, but not adrenal tumorigenesis in the inhibin deficient mice.

results indicate that the beta(C) and beta(E) subunits of activin form homo- and heterodimers, and that the functions of the two subunits are quite different
Title: Comparison of the function of the beta(C) and beta(E) subunits of activin in AML12 hepatocytes.

Data support the conclusion that activin inhibits adrenal tumor growth promoted by luteinizing hormone by inducing adrenal x-zone regression.
Title: Activin induces x-zone apoptosis that inhibits luteinizing hormone-dependent adrenocortical tumor formation in inhibin-deficient mice.

The following Inhbc gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Inhbc cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu06358	NM_010565.4 Latest version!	Mus musculus inhibin beta-C (Inhbc), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Inhbc ( NM_010565.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034695.1 Mus musculus inhibin beta-C (Inhbc), mRNA.

Price & Availability↑

CloneID	OMu06358
Clone ID Related Accession (Same CDS sequence)	NM_010565.4
Accession Version	NM_010565.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1059bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Mus musculus(house mouse)
Product	inhibin beta C chain preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC114678.20 and AK131946.1. On Aug 4, 2016 this sequence version replaced NM_010565.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC026140.1, SRR1660821.98489.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849383, SAMN00849386 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCTCCT CCTTGCTCCT GGCTCTTCTG TTCCTGACTC CAACCACAGT AGTGAACCCC 
AAAACTGAGG GTCCATGCCC AGCATGTTGG GGTGCCATCT TTGACCTGGA GAGCCAGCGG 
GAGCTGCTTC TCGATTTGGC CAAGAAAAGT ATCCTGGACA AGCTGCACCT CAGCCAGCGC 
CCCATACTCA GTCGGCCAGT GTCCAGAGGG GCTCTCAAGA CCGCGCTGCA GCGCCTCCGC 
GGGCCTCGAC GGGAAACCCT GTTGGAGCAT GACCAGAGAC AAGAAGAATA TGAGATCATC 
AGCTTTGCTG ACACAGACCT CTCCAGCATC AACCAGACCC GGCTCGAGTT CCACTTCTCT 
GGTAGAATGG CCAGCGGCAT GGAGGTCCGG CAGACCCGCT TCATGTTCTT CGTACAGTTC 
CCCCACAATG CCACCCAGAC CATGAATATA AGAGTTCTTG TGCTAAGACC ATATGACACC 
AACCTCACCT TGACAAGTCA GTACGTGGTG CAGGTGAATG CCAGTGGCTG GTACCAGCTT 
CTCCTGGGAC CTGAAGCTCA AGCTGCTTGC AGCCAGGGAC ACCTTACTCT GGAGCTGGTA 
CCAGAAAGCC AGGTGGCCCA CAGTTCCTTG ATCCTGGGCT GGTTTTCCCA CAGGCCTTTT 
GTGGCAGCCC AGGTAAGGGT TGAGGGCAAG CATCGGGTTC GCCGGCGAGG TATCGATTGC 
CAGGGGGCGT CCAGGATGTG CTGTCGACAA GAGTTCTTCG TAGACTTCCG TGAGATTGGC 
TGGAATGACT GGATCATCCA GCCTGAAGGC TATGCCATGA ACTTCTGCAC TGGGCAGTGC 
CCACTACATG TGGCAGGCAT GCCTGGCATC TCTGCCTCCT TTCACACTGC AGTGCTGAAT 
CTGCTCAAAG CCAACGCAGC TGCTGGCACC ACTGGCAGGG GCTCGTGCTG CGTGCCTACA 
TCTCGGCGCC CTCTGTCTTT GCTCTACTAT GACAGGGACA GCAACATTGT CAAGACGGAT 
ATACCTGACA TGGTGGTCGA GGCCTGCGGG TGTAGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034695.1
CDS	153..1211
Translation	MASSLLLALLFLTPTTVVNPKTEGPCPACWGAIFDLESQRELLLDLAKKSILDKLHLSQRPILSRPVSRGALKTALQRLRGPRRETLLEHDQRQEEYEIISFADTDLSSINQTRLEFHFSGRMASGMEVRQTRFMFFVQFPHNATQTMNIRVLVLRPYDTNLTLTSQYVVQVNASGWYQLLLGPEAQAACSQGHLTLELVPESQVAHSSLILGWFSHRPFVAAQVRVEGKHRVRRRGIDCQGASRMCCRQEFFVDFREIGWNDWIIQPEGYAMNFCTGQCPLHVAGMPGISASFHTAVLNLLKANAAAGTTGRGSCCVPTSRRPLSLLYYDRDSNIVKTDIPDMVVEACGCS

Target ORF information:

RefSeq Version	NM_010565.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus inhibin beta-C (Inhbc), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010565.4

ORF Insert Sequence:

ATGGCCTCCT CCTTGCTCCT GGCTCTTCTG TTCCTGACTC CAACCACAGT AGTGAACCCC 
AAAACTGAGG GTCCATGCCC AGCATGTTGG GGTGCCATCT TTGACCTGGA GAGCCAGCGG 
GAGCTGCTTC TCGATTTGGC CAAGAAAAGT ATCCTGGACA AGCTGCACCT CAGCCAGCGC 
CCCATACTCA GTCGGCCAGT GTCCAGAGGG GCTCTCAAGA CCGCGCTGCA GCGCCTCCGC 
GGGCCTCGAC GGGAAACCCT GTTGGAGCAT GACCAGAGAC AAGAAGAATA TGAGATCATC 
AGCTTTGCTG ACACAGACCT CTCCAGCATC AACCAGACCC GGCTCGAGTT CCACTTCTCT 
GGTAGAATGG CCAGCGGCAT GGAGGTCCGG CAGACCCGCT TCATGTTCTT CGTACAGTTC 
CCCCACAATG CCACCCAGAC CATGAATATA AGAGTTCTTG TGCTAAGACC ATATGACACC 
AACCTCACCT TGACAAGTCA GTACGTGGTG CAGGTGAATG CCAGTGGCTG GTACCAGCTT 
CTCCTGGGAC CTGAAGCTCA AGCTGCTTGC AGCCAGGGAC ACCTTACTCT GGAGCTGGTA 
CCAGAAAGCC AGGTGGCCCA CAGTTCCTTG ATCCTGGGCT GGTTTTCCCA CAGGCCTTTT 
GTGGCAGCCC AGGTAAGGGT TGAGGGCAAG CATCGGGTTC GCCGGCGAGG TATCGATTGC 
CAGGGGGCGT CCAGGATGTG CTGTCGACAA GAGTTCTTCG TAGACTTCCG TGAGATTGGC 
TGGAATGACT GGATCATCCA GCCTGAAGGC TATGCCATGA ACTTCTGCAC TGGGCAGTGC 
CCACTACATG TGGCAGGCAT GCCTGGCATC TCTGCCTCCT TTCACACTGC AGTGCTGAAT 
CTGCTCAAAG CCAACGCAGC TGCTGGCACC ACTGGCAGGG GCTCGTGCTG CGTGCCTACA 
TCTCGGCGCC CTCTGTCTTT GCTCTACTAT GACAGGGACA GCAACATTGT CAAGACGGAT 
ATACCTGACA TGGTGGTCGA GGCCTGCGGG TGTAGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Regional localization of activin-?
Gene expression patterns : GEP23-2470-79(2017 Jan)
Gold E,Zellhuber-McMillan S,Risbridger G,Marino FE

Activin-?C modulates gonadal, but not adrenal tumorigenesis in the inhibin deficient mice.
Molecular and cellular endocrinology40941-50(2015 Jul)
Marino FE,Risbridger G,Gold E

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Neuron83(2)309-323(2014 Jul)
Thompson CL,Ng L,Menon V,Martinez S,Lee CK,Glattfelder K,Sunkin SM,Henry A,Lau C,Dang C,Garcia-Lopez R,Martinez-Ferre A,Pombero A,Rubenstein JLR,Wakeman WB,Hohmann J,Dee N,Sodt AJ,Young R,Smith K,Nguyen TN,Kidney J,Kuan L,Jeromin A,Kaykas A,Miller J,Page D,Orta G,Bernard A,Riley Z,Smith S,Wohnoutka P,Hawrylycz MJ,Puelles L,Jones AR

The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification.
Nature cell biology16(6)516-28(2014 Jun)
Boroviak T,Loos R,Bertone P,Smith A,Nichols J

Transforming growth factor-? superfamily ligand trap ACE-536 corrects anemia by promoting late-stage erythropoiesis.
Nature medicine20(4)408-14(2014 Apr)
Suragani RN,Cadena SM,Cawley SM,Sako D,Mitchell D,Li R,Davies MV,Alexander MJ,Devine M,Loveday KS,Underwood KW,Grinberg AV,Quisel JD,Chopra R,Pearsall RS,Seehra J,Kumar R

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Inhbc cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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