INHBC cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	INHBC
Entrez Gene ID	3626
Full Name	inhibin beta C subunit
Synonyms	IHBC
General protein information	Preferred Names inhibin beta C subunit Names inhibin beta C chain activin beta-C chain
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q13.3
Summary	This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of homodimeric and heterodimeric activin complexes. The heterodimeric complex may function in the inhibition of activin A signaling. Transgenic mice overexpressing this gene exhibit defects in testis, liver and prostate. [provided by RefSeq, Aug 2016].
Disorder MIM:	601233

mRNA and Protein(s)

mRNA	Protein	Name
NM_005538.4	NP_005529.1	inhibin beta C chain preproprotein
NM_005538.3	NP_005529.1	inhibin beta C chain preproprotein

Pathways from BioSystems

Homologies

Homo sapiens (human)	INHBC	NP_005529.1
Canis lupus familiaris (dog)	INHBC	XP_849169.2
Rattus norvegicus (Norway rat)	Inhbc	NP_072136.1
	INHBC	XP_001115940.1
Xenopus tropicalis (tropical clawed frog)	LOC100493888	XP_002939470.1
Bos taurus (cattle)	INHBC	NP_001192912.1
Pan troglodytes (chimpanzee)	INHBC	XP_522443.1
Mus musculus (house mouse)	Inhbc	NP_034695.1

Gene Ontology
Bibliography

Related articles in PubMed

Over-Expression of Activin-?
Ottley EC, Reader KL, Lee K, Marino FE, Nicholson HD, Risbridger GP, Gold E
Hormones & cancer8(2)100-107(2017 Apr)

Effects of recombinant activins on steroidogenesis in human granulosa-lutein cells.
Chang HM, Cheng JC, Klausen C, Taylor EL, Leung PC
The Journal of clinical endocrinology and metabolism99(10)E1922-32(2014 Oct)

Serum inhibin A and inhibin B levels in epithelial ovarian cancer patients.
Walentowicz P, Krintus M, Sadlecki P, Grabiec M, Mankowska-Cyl A, Sokup A, Walentowicz-Sadlecka M
PloS one9(3)e90575(2014)

The inhibin-?C subunit is down-regulated, while inhibin-?E is up-regulated by interferon-?1a in Ishikawa carcinoma cell line.
J?ckstock J, Kimmich T, Mylonas I, Friese K, Dian D
Archives of gynecology and obstetrics288(4)883-8(2013 Oct)

SNPs in the TGF-? signaling pathway are associated with increased risk of brain metastasis in patients with non-small-cell lung cancer.
Li Q, Wu H, Chen B, Hu G, Huang L, Qin K, Chen Y, Yuan X, Liao Z
PloS one7(12)e51713(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study shows an up-regulation of activin-C in aggressive prostate cancer only, suggesting that activin-C may play a role in the advanced stages of the disease.
Title: Over-Expression of Activin-?

Activin A, B, and AB have similar effects on steroidogenesis in human granulosa cells; in contrast, activin AC is not biologically active and does not act as a competitive antagonist.
Title: Effects of recombinant activins on steroidogenesis in human granulosa-lutein cells.

Serum inhibin levels correlate with clinical characteristics and mortality in epithelial ovarian cancer patients.
Title: Serum inhibin A and inhibin B levels in epithelial ovarian cancer patients.

The inhibin-betaC subunit is down-regulated, while inhibin-betaE is up-regulated by interferon-beta1a in Ishikawa carcinoma cell line.
Title: The inhibin-?C subunit is down-regulated, while inhibin-?E is up-regulated by interferon-?1a in Ishikawa carcinoma cell line.

Single Nucleotide Polymorphisms in INHBC gene is associated with brain metastasis in non-small-cell lung cancer
Title: SNPs in the TGF-? signaling pathway are associated with increased risk of brain metastasis in patients with non-small-cell lung cancer.

The following INHBC gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the INHBC cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu27493	NM_005538.4 Latest version!	Homo sapiens inhibin subunit beta C (INHBC), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu27493	NM_005538.3	Homo sapiens inhibin beta C subunit (INHBC), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

INHBC ( NM_005538.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005529.1 Homo sapiens inhibin subunit beta C (INHBC), mRNA.

Price & Availability↑

CloneID	OHu27493
Clone ID Related Accession (Same CDS sequence)	NM_005538.4 , NM_005538.3
Accession Version	NM_005538.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1059bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	inhibin beta C chain preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP237373.1, BC130324.1, AC022506.38 and BX105206.1. On Nov 22, 2018 this sequence version replaced NM_005538.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.261333.1, BC130324.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2144120 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000309668.3/ ENSP00000308716.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGACCTCCT CATTGCTTCT GGCCTTTCTC CTCCTGGCTC CAACCACAGT GGCCACTCCC 
AGAGCTGGCG GTCAGTGTCC AGCATGTGGG GGGCCCACCT TGGAACTGGA GAGCCAGCGG 
GAGCTGCTTC TTGATCTGGC CAAGAGAAGC ATCTTGGACA AGCTGCACCT CACCCAGCGC 
CCAACACTGA ACCGCCCTGT GTCCAGAGCT GCTTTGAGGA CTGCACTGCA GCACCTCCAC 
GGGGTCCCAC AGGGGGCACT TCTAGAGGAC AACAGGGAAC AGGAATGTGA AATCATCAGC 
TTTGCTGAGA CAGGCCTCTC CACCATCAAC CAGACTCGTC TTGATTTTCA CTTCTCCTCT 
GATAGAACTG CTGGTGACAG GGAGGTCCAG CAGGCCAGTC TCATGTTCTT TGTGCAGCTC 
CCTTCCAATA CCACTTGGAC CTTGAAAGTG AGAGTCCTTG TGCTGGGTCC ACATAATACC 
AACCTCACCT TGGCTACTCA GTACCTGCTG GAGGTGGATG CCAGTGGCTG GCATCAACTC 
CCCCTAGGGC CTGAAGCTCA AGCTGCCTGC AGCCAGGGGC ACCTGACCCT GGAGCTGGTA 
CTTGAAGGCC AGGTAGCCCA GAGCTCAGTC ATCCTGGGTG GAGCTGCCCA TAGGCCTTTT 
GTGGCAGCCC GGGTGAGAGT TGGGGGCAAA CACCAGATTC ACCGACGAGG CATCGACTGC 
CAAGGAGGGT CCAGGATGTG CTGTCGACAA GAGTTTTTTG TGGACTTCCG TGAGATTGGC 
TGGCACGACT GGATCATCCA GCCTGAGGGC TACGCCATGA ACTTCTGCAT AGGGCAGTGC 
CCACTACACA TAGCAGGCAT GCCTGGTATT GCTGCCTCCT TTCACACTGC AGTGCTCAAT 
CTTCTCAAGG CCAACACAGC TGCAGGCACC ACTGGAGGGG GCTCATGCTG TGTACCCACG 
GCCCGGCGCC CCCTGTCTCT GCTCTATTAT GACAGGGACA GCAACATTGT CAAGACTGAC 
ATACCTGACA TGGTAGTAGA GGCCTGTGGG TGCAGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005529.1
CDS	104..1162
Translation	MTSSLLLAFLLLAPTTVATPRAGGQCPACGGPTLELESQRELLLDLAKRSILDKLHLTQRPTLNRPVSRAALRTALQHLHGVPQGALLEDNREQECEIISFAETGLSTINQTRLDFHFSSDRTAGDREVQQASLMFFVQLPSNTTWTLKVRVLVLGPHNTNLTLATQYLLEVDASGWHQLPLGPEAQAACSQGHLTLELVLEGQVAQSSVILGGAAHRPFVAARVRVGGKHQIHRRGIDCQGGSRMCCRQEFFVDFREIGWHDWIIQPEGYAMNFCIGQCPLHIAGMPGIAASFHTAVLNLLKANTAAGTTGGGSCCVPTARRPLSLLYYDRDSNIVKTDIPDMVVEACGCS

Target ORF information:

RefSeq Version	NM_005538.4
Organism	Homo sapiens(human)
Definition	Homo sapiens inhibin subunit beta C (INHBC), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005538.4

ORF Insert Sequence:

ATGACCTCCT CATTGCTTCT GGCCTTTCTC CTCCTGGCTC CAACCACAGT GGCCACTCCC 
AGAGCTGGCG GTCAGTGTCC AGCATGTGGG GGGCCCACCT TGGAACTGGA GAGCCAGCGG 
GAGCTGCTTC TTGATCTGGC CAAGAGAAGC ATCTTGGACA AGCTGCACCT CACCCAGCGC 
CCAACACTGA ACCGCCCTGT GTCCAGAGCT GCTTTGAGGA CTGCACTGCA GCACCTCCAC 
GGGGTCCCAC AGGGGGCACT TCTAGAGGAC AACAGGGAAC AGGAATGTGA AATCATCAGC 
TTTGCTGAGA CAGGCCTCTC CACCATCAAC CAGACTCGTC TTGATTTTCA CTTCTCCTCT 
GATAGAACTG CTGGTGACAG GGAGGTCCAG CAGGCCAGTC TCATGTTCTT TGTGCAGCTC 
CCTTCCAATA CCACTTGGAC CTTGAAAGTG AGAGTCCTTG TGCTGGGTCC ACATAATACC 
AACCTCACCT TGGCTACTCA GTACCTGCTG GAGGTGGATG CCAGTGGCTG GCATCAACTC 
CCCCTAGGGC CTGAAGCTCA AGCTGCCTGC AGCCAGGGGC ACCTGACCCT GGAGCTGGTA 
CTTGAAGGCC AGGTAGCCCA GAGCTCAGTC ATCCTGGGTG GAGCTGCCCA TAGGCCTTTT 
GTGGCAGCCC GGGTGAGAGT TGGGGGCAAA CACCAGATTC ACCGACGAGG CATCGACTGC 
CAAGGAGGGT CCAGGATGTG CTGTCGACAA GAGTTTTTTG TGGACTTCCG TGAGATTGGC 
TGGCACGACT GGATCATCCA GCCTGAGGGC TACGCCATGA ACTTCTGCAT AGGGCAGTGC 
CCACTACACA TAGCAGGCAT GCCTGGTATT GCTGCCTCCT TTCACACTGC AGTGCTCAAT 
CTTCTCAAGG CCAACACAGC TGCAGGCACC ACTGGAGGGG GCTCATGCTG TGTACCCACG 
GCCCGGCGCC CCCTGTCTCT GCTCTATTAT GACAGGGACA GCAACATTGT CAAGACTGAC 
ATACCTGACA TGGTAGTAGA GGCCTGTGGG TGCAGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

INHBC ( NM_005538.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005529.1 Homo sapiens inhibin beta C subunit (INHBC), mRNA.

Price & Availability↑

CloneID	OHu27493
Clone ID Related Accession (Same CDS sequence)	NM_005538.4 , NM_005538.3
Accession Version	NM_005538.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1059bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-02
Organism	Homo sapiens(human)
Product	inhibin beta C chain preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP237373.1, BC130324.1, AC022506.38 and BX105206.1. On Sep 7, 2013 this sequence version replaced NM_005538.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BP237373.1, SRR1660807.261333.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2144120 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACCTCCT CATTGCTTCT GGCCTTTCTC CTCCTGGCTC CAACCACAGT GGCCACTCCC 
AGAGCTGGCG GTCAGTGTCC AGCATGTGGG GGGCCCACCT TGGAACTGGA GAGCCAGCGG 
GAGCTGCTTC TTGATCTGGC CAAGAGAAGC ATCTTGGACA AGCTGCACCT CACCCAGCGC 
CCAACACTGA ACCGCCCTGT GTCCAGAGCT GCTTTGAGGA CTGCACTGCA GCACCTCCAC 
GGGGTCCCAC AGGGGGCACT TCTAGAGGAC AACAGGGAAC AGGAATGTGA AATCATCAGC 
TTTGCTGAGA CAGGCCTCTC CACCATCAAC CAGACTCGTC TTGATTTTCA CTTCTCCTCT 
GATAGAACTG CTGGTGACAG GGAGGTCCAG CAGGCCAGTC TCATGTTCTT TGTGCAGCTC 
CCTTCCAATA CCACTTGGAC CTTGAAAGTG AGAGTCCTTG TGCTGGGTCC ACATAATACC 
AACCTCACCT TGGCTACTCA GTACCTGCTG GAGGTGGATG CCAGTGGCTG GCATCAACTC 
CCCCTAGGGC CTGAAGCTCA AGCTGCCTGC AGCCAGGGGC ACCTGACCCT GGAGCTGGTA 
CTTGAAGGCC AGGTAGCCCA GAGCTCAGTC ATCCTGGGTG GAGCTGCCCA TAGGCCTTTT 
GTGGCAGCCC GGGTGAGAGT TGGGGGCAAA CACCAGATTC ACCGACGAGG CATCGACTGC 
CAAGGAGGGT CCAGGATGTG CTGTCGACAA GAGTTTTTTG TGGACTTCCG TGAGATTGGC 
TGGCACGACT GGATCATCCA GCCTGAGGGC TACGCCATGA ACTTCTGCAT AGGGCAGTGC 
CCACTACACA TAGCAGGCAT GCCTGGTATT GCTGCCTCCT TTCACACTGC AGTGCTCAAT 
CTTCTCAAGG CCAACACAGC TGCAGGCACC ACTGGAGGGG GCTCATGCTG TGTACCCACG 
GCCCGGCGCC CCCTGTCTCT GCTCTATTAT GACAGGGACA GCAACATTGT CAAGACTGAC 
ATACCTGACA TGGTAGTAGA GGCCTGTGGG TGCAGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005529.1
CDS	203..1261
Translation	MTSSLLLAFLLLAPTTVATPRAGGQCPACGGPTLELESQRELLLDLAKRSILDKLHLTQRPTLNRPVSRAALRTALQHLHGVPQGALLEDNREQECEIISFAETGLSTINQTRLDFHFSSDRTAGDREVQQASLMFFVQLPSNTTWTLKVRVLVLGPHNTNLTLATQYLLEVDASGWHQLPLGPEAQAACSQGHLTLELVLEGQVAQSSVILGGAAHRPFVAARVRVGGKHQIHRRGIDCQGGSRMCCRQEFFVDFREIGWHDWIIQPEGYAMNFCIGQCPLHIAGMPGIAASFHTAVLNLLKANTAAGTTGGGSCCVPTARRPLSLLYYDRDSNIVKTDIPDMVVEACGCS

Target ORF information:

RefSeq Version	NM_005538.3
Organism	Homo sapiens(human)
Definition	Homo sapiens inhibin beta C subunit (INHBC), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005538.3

ORF Insert Sequence:

ATGACCTCCT CATTGCTTCT GGCCTTTCTC CTCCTGGCTC CAACCACAGT GGCCACTCCC 
AGAGCTGGCG GTCAGTGTCC AGCATGTGGG GGGCCCACCT TGGAACTGGA GAGCCAGCGG 
GAGCTGCTTC TTGATCTGGC CAAGAGAAGC ATCTTGGACA AGCTGCACCT CACCCAGCGC 
CCAACACTGA ACCGCCCTGT GTCCAGAGCT GCTTTGAGGA CTGCACTGCA GCACCTCCAC 
GGGGTCCCAC AGGGGGCACT TCTAGAGGAC AACAGGGAAC AGGAATGTGA AATCATCAGC 
TTTGCTGAGA CAGGCCTCTC CACCATCAAC CAGACTCGTC TTGATTTTCA CTTCTCCTCT 
GATAGAACTG CTGGTGACAG GGAGGTCCAG CAGGCCAGTC TCATGTTCTT TGTGCAGCTC 
CCTTCCAATA CCACTTGGAC CTTGAAAGTG AGAGTCCTTG TGCTGGGTCC ACATAATACC 
AACCTCACCT TGGCTACTCA GTACCTGCTG GAGGTGGATG CCAGTGGCTG GCATCAACTC 
CCCCTAGGGC CTGAAGCTCA AGCTGCCTGC AGCCAGGGGC ACCTGACCCT GGAGCTGGTA 
CTTGAAGGCC AGGTAGCCCA GAGCTCAGTC ATCCTGGGTG GAGCTGCCCA TAGGCCTTTT 
GTGGCAGCCC GGGTGAGAGT TGGGGGCAAA CACCAGATTC ACCGACGAGG CATCGACTGC 
CAAGGAGGGT CCAGGATGTG CTGTCGACAA GAGTTTTTTG TGGACTTCCG TGAGATTGGC 
TGGCACGACT GGATCATCCA GCCTGAGGGC TACGCCATGA ACTTCTGCAT AGGGCAGTGC 
CCACTACACA TAGCAGGCAT GCCTGGTATT GCTGCCTCCT TTCACACTGC AGTGCTCAAT 
CTTCTCAAGG CCAACACAGC TGCAGGCACC ACTGGAGGGG GCTCATGCTG TGTACCCACG 
GCCCGGCGCC CCCTGTCTCT GCTCTATTAT GACAGGGACA GCAACATTGT CAAGACTGAC 
ATACCTGACA TGGTAGTAGA GGCCTGTGGG TGCAGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Over-Expression of Activin-?
Hormones & cancer8(2)100-107(2017 Apr)
Ottley EC,Reader KL,Lee K,Marino FE,Nicholson HD,Risbridger GP,Gold E

Effects of recombinant activins on steroidogenesis in human granulosa-lutein cells.
The Journal of clinical endocrinology and metabolism99(10)E1922-32(2014 Oct)
Chang HM,Cheng JC,Klausen C,Taylor EL,Leung PC

Serum inhibin A and inhibin B levels in epithelial ovarian cancer patients.
PloS one9(3)e90575(2014)
Walentowicz P,Krintus M,Sadlecki P,Grabiec M,Mankowska-Cyl A,Sokup A,Walentowicz-Sadlecka M

The inhibin-?C subunit is down-regulated, while inhibin-?E is up-regulated by interferon-?1a in Ishikawa carcinoma cell line.
Archives of gynecology and obstetrics288(4)883-8(2013 Oct)
J?ckstock J,Kimmich T,Mylonas I,Friese K,Dian D

SNPs in the TGF-? signaling pathway are associated with increased risk of brain metastasis in patients with non-small-cell lung cancer.
PloS one7(12)e51713(2012)
Li Q,Wu H,Chen B,Hu G,Huang L,Qin K,Chen Y,Yuan X,Liao Z