Gzma cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gzma
Entrez Gene ID	14938
Full Name	granzyme A
Synonyms	AW494114,Ctla-3,Ctla3,Hf,Hf1,SE1,TSP-1,TSP1
General protein information	Preferred Names granzyme A Names granzyme A BLT esterase H factor Hanukah factor autocrine thymic lymphoma granzyme-like serine protease fragmentin-1 serine esterase 1 t cell-specific serine protease 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 13 Map Location: 13 D2.2\|13 63.93 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_010370.3	NP_034500.1	granzyme A precursor
NM_010370.2	NP_034500.1	granzyme A precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	GZMA	NP_006135.1
Canis lupus familiaris (dog)	GZMA	XP_544335.3
Bos taurus (cattle)	GZMA	NP_001092565.1
Rattus norvegicus (Norway rat)	Gzma	NP_703198.1
Xenopus tropicalis (tropical clawed frog)	LOC100497188	XP_002941159.1
Gallus gallus (chicken)	GZMA	NP_989788.1
Pan troglodytes (chimpanzee)	GZMA	XP_001148261.1
Mus musculus (house mouse)	Gzma	NP_034500.1
	GZMA	XP_001097639.1

Gene Ontology
Bibliography

Related articles in PubMed

Granzyme A Deficiency Breaks Immune Tolerance and Promotes Autoimmune Diabetes Through a Type I Interferon-Dependent Pathway.
Mollah ZUA, Quah HS, Graham KL, Jhala G, Krishnamurthy B, Dharma JFM, Chee J, Trivedi PM, Pappas EG, Mackin L, Chu EPF, Akazawa S, Fynch S, Hodson C, Deans AJ, Trapani JA, Chong MMW, Bird PI, Brodnicki TC, Thomas HE, Kay TWH
Diabetes66(12)3041-3050(2017 12)

RNA-Seq analysis of chikungunya virus infection and identification of granzyme A as a major promoter of arthritic inflammation.
Wilson JA, Prow NA, Schroder WA, Ellis JJ, Cumming HE, Gearing LJ, Poo YS, Taylor A, Hertzog PJ, Di Giallonardo F, Hueston L, Le Grand R, Tang B, Le TT, Gardner J, Mahalingam S, Roques P, Bird PI, Suhrbier A
PLoS pathogens13(2)e1006155(2017 Feb)

Expression and Function of Granzymes A and B in
Garc?a-Laorden MI, Stroo I, Terpstra S, Florquin S, Medema JP, van T Veer C, de Vos AF, van der Poll T
Mediators of inflammation20174137563(2017)

Interleukin-15-Dependent T-Cell-like Innate Intraepithelial Lymphocytes Develop in the Intestine and Transform into Lymphomas in Celiac Disease.
Ettersperger J, Montcuquet N, Malamut G, Guegan N, Lopez-Lastra S, Gayraud S, Reimann C, Vidal E, Cagnard N, Villarese P, Andre-Schmutz I, Gomes Domingues R, Godinho-Silva C, Veiga-Fernandes H, Lhermitte L, Asnafi V, Macintyre E, Cellier C, Beldjord K, Di Santo JP, Cerf-Bensussan N, Meresse B
Immunity45(3)610-625(2016 09)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

a novel endogenous trigger for autoimmune diabetes and an in vivo role for granzyme A in maintaining immune tolerance.
Title: Granzyme A Deficiency Breaks Immune Tolerance and Promotes Autoimmune Diabetes Through a Type I Interferon-Dependent Pathway.

Granzyme A does not have a crucial role in vivo in the protective response to tuberculosis.
Title: Granzyme A Is Expressed in Mouse Lungs during Mycobacterium tuberculosis Infection but Does Not Contribute to Protection In Vivo.

this study shows that gzmA and gzmB partly regulate local inflammation during early pneumonia but eventually play an insignificant role during pneumosepsis by the common human pathogen Klebsiella pneumoniae
Title: Granzymes A and B Regulate the Local Inflammatory Response during Klebsiella pneumoniae Pneumonia.

The results, in susceptible B6 mice for GzmB and in resistant 129/Sv mice for GzmA and/or the GzmB cluster, point to granzyme-mediated host defense regulation in the liver in experimental visceral leishmaniasis.
Title: Granzyme-mediated regulation of host defense in the liver in experimental Leishmania donovani infection.

Data indicate N-terminomics on the human and mouse granzymes A and K by combined fractional diagonal chromatography (COFRADIC).
Title: Substrate specificities of the granzyme tryptases A and K.

The following Gzma gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gzma cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu23008	NM_010370.3 Latest version!	Mus musculus granzyme A (Gzma), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
View Old Accession Versions >>
OMu23008	NM_010370.2	Mus musculus granzyme A (Gzma), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gzma ( NM_010370.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034500.1 Mus musculus granzyme A (Gzma), mRNA.

Price & Availability↑

CloneID	OMu23008
Clone ID Related Accession (Same CDS sequence)	NM_010370.3 , NM_010370.2
Accession Version	NM_010370.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 783bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Mus musculus(house mouse)
Product	granzyme A precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC061146.1 and EH095037.1. On Apr 13, 2018 this sequence version replaced NM_010370.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC061146.1, X14799.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGGAACG CCTCTGGTCC CCGGGGGCCA TCTCTTGCTA CTCTCCTTTT TCTTCTGCTT 
ATTCCTGAAG GAGGCTGTGA AAGAATCATT GGAGGAGACA CGGTTGTTCC TCACTCAAGA 
CCGTATATGG CTCTACTTAA ACTTAGTTCA AATACCATCT GTGCTGGCGC TTTGATTGAA 
AAGAACTGGG TGTTGACTGC TGCCCACTGT AACGTGGGAA AGAGATCTAA GTTCATTCTT 
GGGGCTCACT CAATCAATAA GGAGCCAGAA CAACAGATAT TGACTGTTAA GAAAGCATTT 
CCCTATCCAT GCTATGATGA ATATACACGT GAGGGGGATC TACAACTTGT ACGGCTAAAG 
AAAAAAGCAA CAGTTAACAG AAATGTGGCT ATCCTTCACC TACCTAAAAA GGGAGATGAT 
GTGAAACCAG GAACCAGATG CCGAGTAGCA GGATGGGGGA GATTTGGCAA TAAGTCAGCT 
CCCTCTGAAA CTCTGAGAGA AGTCAACATC ACTGTCATAG ACAGAAAAAT CTGCAATGAT 
GAAAAACACT ATAATTTTCA TCCTGTAATT GGACTAAACA TGATTTGTGC AGGGGACCTC 
CGTGGTGGAA AGGACTCCTG CAATGGGGAT TCTGGCAGCC CTCTGCTATG TGATGGTATT 
TTGCGAGGCA TCACCTCTTT TGGTGGAGAG AAGTGTGGAG ATCGCCGATG GCCTGGTGTC 
TATACTTTCC TCTCAGATAA ACACCTCAAT TGGATAAAGA AGATTATGAA GGGTTCTGTG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034500.1
CDS	31..813
Translation	MRNASGPRGPSLATLLFLLLIPEGGCERIIGGDTVVPHSRPYMALLKLSSNTICAGALIEKNWVLTAAHCNVGKRSKFILGAHSINKEPEQQILTVKKAFPYPCYDEYTREGDLQLVRLKKKATVNRNVAILHLPKKGDDVKPGTRCRVAGWGRFGNKSAPSETLREVNITVIDRKICNDEKHYNFHPVIGLNMICAGDLRGGKDSCNGDSGSPLLCDGILRGITSFGGEKCGDRRWPGVYTFLSDKHLNWIKKIMKGSV

Target ORF information:

RefSeq Version	NM_010370.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus granzyme A (Gzma), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010370.3

ORF Insert Sequence:

ATGAGGAACG CCTCTGGTCC CCGGGGGCCA TCTCTTGCTA CTCTCCTTTT TCTTCTGCTT 
ATTCCTGAAG GAGGCTGTGA AAGAATCATT GGAGGAGACA CGGTTGTTCC TCACTCAAGA 
CCGTATATGG CTCTACTTAA ACTTAGTTCA AATACCATCT GTGCTGGCGC TTTGATTGAA 
AAGAACTGGG TGTTGACTGC TGCCCACTGT AACGTGGGAA AGAGATCTAA GTTCATTCTT 
GGGGCTCACT CAATCAATAA GGAGCCAGAA CAACAGATAT TGACTGTTAA GAAAGCATTT 
CCCTATCCAT GCTATGATGA ATATACACGT GAGGGGGATC TACAACTTGT ACGGCTAAAG 
AAAAAAGCAA CAGTTAACAG AAATGTGGCT ATCCTTCACC TACCTAAAAA GGGAGATGAT 
GTGAAACCAG GAACCAGATG CCGAGTAGCA GGATGGGGGA GATTTGGCAA TAAGTCAGCT 
CCCTCTGAAA CTCTGAGAGA AGTCAACATC ACTGTCATAG ACAGAAAAAT CTGCAATGAT 
GAAAAACACT ATAATTTTCA TCCTGTAATT GGACTAAACA TGATTTGTGC AGGGGACCTC 
CGTGGTGGAA AGGACTCCTG CAATGGGGAT TCTGGCAGCC CTCTGCTATG TGATGGTATT 
TTGCGAGGCA TCACCTCTTT TGGTGGAGAG AAGTGTGGAG ATCGCCGATG GCCTGGTGTC 
TATACTTTCC TCTCAGATAA ACACCTCAAT TGGATAAAGA AGATTATGAA GGGTTCTGTG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gzma ( NM_010370.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034500.1 Mus musculus granzyme A (Gzma), mRNA.

Price & Availability↑

CloneID	OMu23008
Clone ID Related Accession (Same CDS sequence)	NM_010370.3 , NM_010370.2
Accession Version	NM_010370.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 783bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Mus musculus(house mouse)
Product	granzyme A precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC061146.1. On Nov 3, 2006 this sequence version replaced NM_010370.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC061146.1, X14799.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849380 [ECO:0000348] ##Evidence-Data-END##

ATGAGGAACG CCTCTGGTCC CCGGGGGCCA TCTCTTGCTA CTCTCCTTTT TCTTCTGCTT 
ATTCCTGAAG GAGGCTGTGA AAGAATCATT GGAGGAGACA CGGTTGTTCC TCACTCAAGA 
CCGTATATGG CTCTACTTAA ACTTAGTTCA AATACCATCT GTGCTGGCGC TTTGATTGAA 
AAGAACTGGG TGTTGACTGC TGCCCACTGT AACGTGGGAA AGAGATCTAA GTTCATTCTT 
GGGGCTCACT CAATCAATAA GGAGCCAGAA CAACAGATAT TGACTGTTAA GAAAGCATTT 
CCCTATCCAT GCTATGATGA ATATACACGT GAGGGGGATC TACAACTTGT ACGGCTAAAG 
AAAAAAGCAA CAGTTAACAG AAATGTGGCT ATCCTTCACC TACCTAAAAA GGGAGATGAT 
GTGAAACCAG GAACCAGATG CCGAGTAGCA GGATGGGGGA GATTTGGCAA TAAGTCAGCT 
CCCTCTGAAA CTCTGAGAGA AGTCAACATC ACTGTCATAG ACAGAAAAAT CTGCAATGAT 
GAAAAACACT ATAATTTTCA TCCTGTAATT GGACTAAACA TGATTTGTGC AGGGGACCTC 
CGTGGTGGAA AGGACTCCTG CAATGGGGAT TCTGGCAGCC CTCTGCTATG TGATGGTATT 
TTGCGAGGCA TCACCTCTTT TGGTGGAGAG AAGTGTGGAG ATCGCCGATG GCCTGGTGTC 
TATACTTTCC TCTCAGATAA ACACCTCAAT TGGATAAAGA AGATTATGAA GGGTTCTGTG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034500.1
CDS	31..813
Translation	MRNASGPRGPSLATLLFLLLIPEGGCERIIGGDTVVPHSRPYMALLKLSSNTICAGALIEKNWVLTAAHCNVGKRSKFILGAHSINKEPEQQILTVKKAFPYPCYDEYTREGDLQLVRLKKKATVNRNVAILHLPKKGDDVKPGTRCRVAGWGRFGNKSAPSETLREVNITVIDRKICNDEKHYNFHPVIGLNMICAGDLRGGKDSCNGDSGSPLLCDGILRGITSFGGEKCGDRRWPGVYTFLSDKHLNWIKKIMKGSV

Target ORF information:

RefSeq Version	NM_010370.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus granzyme A (Gzma), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010370.2

ORF Insert Sequence:

ATGAGGAACG CCTCTGGTCC CCGGGGGCCA TCTCTTGCTA CTCTCCTTTT TCTTCTGCTT 
ATTCCTGAAG GAGGCTGTGA AAGAATCATT GGAGGAGACA CGGTTGTTCC TCACTCAAGA 
CCGTATATGG CTCTACTTAA ACTTAGTTCA AATACCATCT GTGCTGGCGC TTTGATTGAA 
AAGAACTGGG TGTTGACTGC TGCCCACTGT AACGTGGGAA AGAGATCTAA GTTCATTCTT 
GGGGCTCACT CAATCAATAA GGAGCCAGAA CAACAGATAT TGACTGTTAA GAAAGCATTT 
CCCTATCCAT GCTATGATGA ATATACACGT GAGGGGGATC TACAACTTGT ACGGCTAAAG 
AAAAAAGCAA CAGTTAACAG AAATGTGGCT ATCCTTCACC TACCTAAAAA GGGAGATGAT 
GTGAAACCAG GAACCAGATG CCGAGTAGCA GGATGGGGGA GATTTGGCAA TAAGTCAGCT 
CCCTCTGAAA CTCTGAGAGA AGTCAACATC ACTGTCATAG ACAGAAAAAT CTGCAATGAT 
GAAAAACACT ATAATTTTCA TCCTGTAATT GGACTAAACA TGATTTGTGC AGGGGACCTC 
CGTGGTGGAA AGGACTCCTG CAATGGGGAT TCTGGCAGCC CTCTGCTATG TGATGGTATT 
TTGCGAGGCA TCACCTCTTT TGGTGGAGAG AAGTGTGGAG ATCGCCGATG GCCTGGTGTC 
TATACTTTCC TCTCAGATAA ACACCTCAAT TGGATAAAGA AGATTATGAA GGGTTCTGTG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Granzyme A Deficiency Breaks Immune Tolerance and Promotes Autoimmune Diabetes Through a Type I Interferon-Dependent Pathway.
Diabetes66(12)3041-3050(2017 12)
Mollah ZUA,Quah HS,Graham KL,Jhala G,Krishnamurthy B,Dharma JFM,Chee J,Trivedi PM,Pappas EG,Mackin L,Chu EPF,Akazawa S,Fynch S,Hodson C,Deans AJ,Trapani JA,Chong MMW,Bird PI,Brodnicki TC,Thomas HE,Kay TWH

RNA-Seq analysis of chikungunya virus infection and identification of granzyme A as a major promoter of arthritic inflammation.
PLoS pathogens13(2)e1006155(2017 Feb)
Wilson JA,Prow NA,Schroder WA,Ellis JJ,Cumming HE,Gearing LJ,Poo YS,Taylor A,Hertzog PJ,Di Giallonardo F,Hueston L,Le Grand R,Tang B,Le TT,Gardner J,Mahalingam S,Roques P,Bird PI,Suhrbier A

Expression and Function of Granzymes A and B in
Mediators of inflammation20174137563(2017)
Garc?a-Laorden MI,Stroo I,Terpstra S,Florquin S,Medema JP,van T Veer C,de Vos AF,van der Poll T

Interleukin-15-Dependent T-Cell-like Innate Intraepithelial Lymphocytes Develop in the Intestine and Transform into Lymphomas in Celiac Disease.
Immunity45(3)610-625(2016 09)
Ettersperger J,Montcuquet N,Malamut G,Guegan N,Lopez-Lastra S,Gayraud S,Reimann C,Vidal E,Cagnard N,Villarese P,Andre-Schmutz I,Gomes Domingues R,Godinho-Silva C,Veiga-Fernandes H,Lhermitte L,Asnafi V,Macintyre E,Cellier C,Beldjord K,Di Santo JP,Cerf-Bensussan N,Meresse B

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Gzma cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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