Fpr3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fpr3
Entrez Gene ID	14294
Full Name	formyl peptide receptor 3
Synonyms	ALX,Fpr-rs1,Fpr-s1,Fprl1,LXA4-R,Lxa4r
General protein information	Preferred Names formyl peptide receptor 3 Names formyl peptide receptor-related sequence 1 FMLP-R-I FMLP-related receptor I LXA4 receptor N-formyl peptide receptor 2 N-formyl peptide receptor 3 N-formylpeptide receptor-like 1 formyl peptide receptor-like 1 lipoxin A4 receptor
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 17 Map Location: 17\|17 A3.2

mRNA and Protein(s)

mRNA	Protein	Name
NM_008042.2	NP_032068.2	formyl peptide receptor-related sequence 1

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Resolvin D1 protects the liver from ischemia/reperfusion injury by enhancing M2 macrophage polarization and efferocytosis.
Kang JW, Lee SM
Biochimica et biophysica acta1861(9 Pt A)1025-1035(2016 09)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

ALOX5AP Overexpression in Adipose Tissue Leads to LXA4 Production and Protection Against Diet-Induced Obesity and Insulin Resistance.
Elias I, Ferr? T, Vil? L, Mu?oz S, Casellas A, Garcia M, Molas M, Agudo J, Roca C, Ruberte J, Bosch F, Franckhauser S
Diabetes65(8)2139-50(2016 08)

Strain-specific Loss of Formyl Peptide Receptor 3 in the Murine Vomeronasal and Immune Systems.
Stempel H, Jung M, P?rez-G?mez A, Leinders-Zufall T, Zufall F, Bufe B
The Journal of biological chemistry291(18)9762-75(2016 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

antagonist pretreatment or gene silencing of the RvD1 receptor, ALX/FPR2, abrogated the anti-inflammatory and pro-resolving actions of RvD1. These data indicate that RvD1 ameliorates IR-induced liver injury, and this protection is associated with enhancement of M2 polarization and efferocytosis via ALX/FPR2 activation
Title: Resolvin D1 protects the liver from ischemia/reperfusion injury by enhancing M2 macrophage polarization and efferocytosis.

ALOX5AP Overexpression in Adipose Tissue Leads to LXA4 Production and Protection Against Diet-Induced Obesity and Insulin Resistance
Title: ALOX5AP Overexpression in Adipose Tissue Leads to LXA4 Production and Protection Against Diet-Induced Obesity and Insulin Resistance.

The genome of at least 19 strains encodes a non-functional Fpr3 variant, whereas at least 13 other strains express an intact receptor. These results provide a foundation for understanding the in vivo function of Fpr3.
Title: Strain-specific Loss of Formyl Peptide Receptor 3 in the Murine Vomeronasal and Immune Systems.

Compared with wild-type mice, Fpr2/3(-/-) animals exhibited exacerbation of disease severity, including hypothermia and cardiac dysfunction.
Title: Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis.

During ischemia, neutrophil Fpr2/3 controls platelet/neutrophil aggregates with the rapid generation of circulating LXA4, which in turn modulates downstream vascular inflammatory responses evident during the reperfusion phase.
Title: A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation.

The following Fpr3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fpr3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu58266	NM_008042.2 Latest version!	Mus musculus formyl peptide receptor 3 (Fpr3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fpr3 ( NM_008042.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032068.2 Mus musculus formyl peptide receptor 3 (Fpr3), mRNA.

Price & Availability↑

CloneID	OMu58266
Clone ID Related Accession (Same CDS sequence)	NM_008042.2
Accession Version	NM_008042.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1056bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	formyl peptide receptor-related sequence 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC171405.1. On Feb 1, 2007 this sequence version replaced NM_008042.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: U78299.1 [ECO:0000345] ##Evidence-Data-END##

ATGGAAACCA ACTACTCTAT CCCTTTGAAT GGATCAGATG TGGTGATCTA TGATTCTACC 
ATCTCCAGGG TTCTGTGGAT CCTCTCAATG GTGGTTGTCT CCATCACTTT CTTCCTTGGT 
GTGCTGGGAA ATGGACTAGT GATCTGGGTA GCTGGATTCC GGATGCCACA CACTGTCACC 
ACTATCTGGT ATCTGAATCT AGCATTGGCT GACTTCTCTT TCACAGCAAC TCTACCATTC 
CTTCTTGTTG AAATGGCTAT GAAAGAAAAA TGGCCTTTTG GCTGGTTCCT GTGTAAATTA 
GTTCACATTG CAGTAGATGT AAACCTATTT GGAAGTGTCT TCTTGATTGC TGTCATTGCC 
TTGGACCGCT GTATTTGTGT CCTGCATCCA GTCTGGGCTC AGAACCACCG CACTGTGAGC 
CTGGCTAGAA ATGTGGTTGT TGGGTCCTGG ATTTTTGCTC TCATTCTCAC TTTGCCCCTT 
TTCCTCTTCT TGACTACAGT TAGAGATGCT AGAGGGGATG TGCACTGTAG ATTGAGCTTT 
GTATCCTGGG GCAACTCTGT TGAGGAAAGG TTGAACACAG CTATCACGTT TGTAACAACT 
AGAGGGATCA TCAGGTTCAT TGTTAGCTTC AGCTTGCCCA TGTCCTTTGT TGCCATCTGC 
TATGGACTCA TCACTACAAA GATTCACAAA AAAGCCTTTG TTAATTCCAG CCGTCCTTTC 
CGAGTTCTTA CAGGAGTTGT GGCTTCCTTC TTTATCTGTT GGTTTCCTTT CCAATTGGTG 
GCCCTTTTAG GCACAGTCTG GCTCAAAGAG ATGCAGTTTA GTGGTAGTTA TAAAATTATT 
GGCAGGTTGG TTAATCCAAC CAGTTCATTG GCCTTTTTCA ATAGCTGCCT CAATCCAATT 
CTCTATGTTT TCATGGGCCA GGACTTTCAA GAAAGACTGA TTCATTCCCT GTCTTCTCGT 
CTGCAGAGAG CCCTGAGTGA GGACTCTGGT CATATCAGTG ATACAAGAAC CAATTTGGCT 
TCACTTCCTG AAGACATTGA AATAAAGGCA ATATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032068.2
CDS	12..1067
Translation	METNYSIPLNGSDVVIYDSTISRVLWILSMVVVSITFFLGVLGNGLVIWVAGFRMPHTVTTIWYLNLALADFSFTATLPFLLVEMAMKEKWPFGWFLCKLVHIAVDVNLFGSVFLIAVIALDRCICVLHPVWAQNHRTVSLARNVVVGSWIFALILTLPLFLFLTTVRDARGDVHCRLSFVSWGNSVEERLNTAITFVTTRGIIRFIVSFSLPMSFVAICYGLITTKIHKKAFVNSSRPFRVLTGVVASFFICWFPFQLVALLGTVWLKEMQFSGSYKIIGRLVNPTSSLAFFNSCLNPILYVFMGQDFQERLIHSLSSRLQRALSEDSGHISDTRTNLASLPEDIEIKAI

Target ORF information:

RefSeq Version	NM_008042.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus formyl peptide receptor 3 (Fpr3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008042.2

ORF Insert Sequence:

ATGGAAACCA ACTACTCTAT CCCTTTGAAT GGATCAGATG TGGTGATCTA TGATTCTACC 
ATCTCCAGGG TTCTGTGGAT CCTCTCAATG GTGGTTGTCT CCATCACTTT CTTCCTTGGT 
GTGCTGGGAA ATGGACTAGT GATCTGGGTA GCTGGATTCC GGATGCCACA CACTGTCACC 
ACTATCTGGT ATCTGAATCT AGCATTGGCT GACTTCTCTT TCACAGCAAC TCTACCATTC 
CTTCTTGTTG AAATGGCTAT GAAAGAAAAA TGGCCTTTTG GCTGGTTCCT GTGTAAATTA 
GTTCACATTG CAGTAGATGT AAACCTATTT GGAAGTGTCT TCTTGATTGC TGTCATTGCC 
TTGGACCGCT GTATTTGTGT CCTGCATCCA GTCTGGGCTC AGAACCACCG CACTGTGAGC 
CTGGCTAGAA ATGTGGTTGT TGGGTCCTGG ATTTTTGCTC TCATTCTCAC TTTGCCCCTT 
TTCCTCTTCT TGACTACAGT TAGAGATGCT AGAGGGGATG TGCACTGTAG ATTGAGCTTT 
GTATCCTGGG GCAACTCTGT TGAGGAAAGG TTGAACACAG CTATCACGTT TGTAACAACT 
AGAGGGATCA TCAGGTTCAT TGTTAGCTTC AGCTTGCCCA TGTCCTTTGT TGCCATCTGC 
TATGGACTCA TCACTACAAA GATTCACAAA AAAGCCTTTG TTAATTCCAG CCGTCCTTTC 
CGAGTTCTTA CAGGAGTTGT GGCTTCCTTC TTTATCTGTT GGTTTCCTTT CCAATTGGTG 
GCCCTTTTAG GCACAGTCTG GCTCAAAGAG ATGCAGTTTA GTGGTAGTTA TAAAATTATT 
GGCAGGTTGG TTAATCCAAC CAGTTCATTG GCCTTTTTCA ATAGCTGCCT CAATCCAATT 
CTCTATGTTT TCATGGGCCA GGACTTTCAA GAAAGACTGA TTCATTCCCT GTCTTCTCGT 
CTGCAGAGAG CCCTGAGTGA GGACTCTGGT CATATCAGTG ATACAAGAAC CAATTTGGCT 
TCACTTCCTG AAGACATTGA AATAAAGGCA ATATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Resolvin D1 protects the liver from ischemia/reperfusion injury by enhancing M2 macrophage polarization and efferocytosis.
Biochimica et biophysica acta1861(9 Pt A)1025-1035(2016 09)
Kang JW,Lee SM

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

ALOX5AP Overexpression in Adipose Tissue Leads to LXA4 Production and Protection Against Diet-Induced Obesity and Insulin Resistance.
Diabetes65(8)2139-50(2016 08)
Elias I,Ferr? T,Vil? L,Mu?oz S,Casellas A,Garcia M,Molas M,Agudo J,Roca C,Ruberte J,Bosch F,Franckhauser S

Strain-specific Loss of Formyl Peptide Receptor 3 in the Murine Vomeronasal and Immune Systems.
The Journal of biological chemistry291(18)9762-75(2016 Apr)
Stempel H,Jung M,P?rez-G?mez A,Leinders-Zufall T,Zufall F,Bufe B

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Fpr3 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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