Defa-rs2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Defa-rs2
Entrez Gene ID	13222
Full Name	defensin, alpha, related sequence 2
Synonyms	CRS4C,CRS4C-1,CRS4C1d,CRS4C1e,CRS4C1f,CRS4C1g,CRS4C1h,CRS4C1i,CRS4C1j,Defcr-rs2,Defcr-rs3
General protein information	Preferred Names defensin, alpha, related sequence 2 Names alpha-defensin-related sequence 2 cryptdin related sequence peptide cryptdin-related protein 4C-1 defensin related cryptdin, related sequence 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)

mRNA and Protein(s)

mRNA	Protein	Name
NM_007847.1	NP_031873.1	alpha-defensin-related sequence 2 precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord.
Tamplin OJ, Cox BJ, Rossant J
Developmental biology360(2)415-25(2011 Dec)

Elevated expression of Paneth cell CRS4C in ileitis-prone SAMP1/YitFc mice: regional distribution, subcellular localization, and mechanism of action.
Shanahan MT, Vidrich A, Shirafuji Y, Dubois CL, Henschen-Edman A, Hagen SJ, Cohn SM, Ouellette AJ
The Journal of biological chemistry285(10)7493-504(2010 Mar)

Increased diversity of intestinal antimicrobial peptides by covalent dimer formation.
Hornef MW, P?tsep K, Karlsson J, Refai E, Andersson M
Nature immunology5(8)836-43(2004 Aug)

A family of defensin-like genes codes for diverse cysteine-rich peptides in mouse Paneth cells.
Huttner KM, Ouellette AJ
Genomics24(1)99-109(1994 Nov)

A novel gene family coding for cationic, cysteine-rich peptides. Regulation in mouse small intestine and cells of myeloid origin.
Ouellette AJ, Lauldi JC
The Journal of biological chemistry269(28)18702(1994 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that in ileitis-prone mice, Paneth cell levels of CRS4C mRNAs and peptides are induced more than a 1000-fold relative to non-prone strains as early as 4 weeks of age.
Title: Elevated expression of Paneth cell CRS4C in ileitis-prone SAMP1/YitFc mice: regional distribution, subcellular localization, and mechanism of action.

The following Defa-rs2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Defa-rs2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu00909	NM_007847.1 Latest version!	Mus musculus defensin, alpha, related sequence 2 (Defa-rs2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Defa-rs2 ( NM_007847.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031873.1 Mus musculus defensin, alpha, related sequence 2 (Defa-rs2), mRNA.

Price & Availability↑

CloneID	OMu00909
Clone ID Related Accession (Same CDS sequence)	NM_007847.1
Accession Version	NM_007847.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 276bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	alpha-defensin-related sequence 2 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M33227.1. ##Evidence-Data-START## Transcript exon combination :: M33227.1 [ECO:0000332] ##Evidence-Data-END##

ATGAAGAAAC TTGTCCTCCT CTTTGCCCTT GTCCTGCTTG CATTCCAGGT CCAGGCTGAT 
TCTATCCAAA ACACAGATGA AGAGACTAAA ACTGAGGAGC AGCCAGGGGA AAAGGACCAG 
GCTGTGTCTG TCTCTTTTGG AGACCCACAA GGCTCTGCTC TTCAAGATGC AGCCCTAGGA 
TGGGGTCGGC GGTGCCCACA ATGCCCTAGA TGCCCGTCAT GCCCATCTTG CCCGAGATGC 
CCGAGGTGCC CGAGGTGCAA ATGCAATCCA AAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031873.1
CDS	46..321
Translation	MKKLVLLFALVLLAFQVQADSIQNTDEETKTEEQPGEKDQAVSVSFGDPQGSALQDAALGWGRRCPQCPRCPSCPSCPRCPRCPRCKCNPK

Target ORF information:

RefSeq Version	NM_007847.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus defensin, alpha, related sequence 2 (Defa-rs2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007847.1

ORF Insert Sequence:

ATGAAGAAAC TTGTCCTCCT CTTTGCCCTT GTCCTGCTTG CATTCCAGGT CCAGGCTGAT 
TCTATCCAAA ACACAGATGA AGAGACTAAA ACTGAGGAGC AGCCAGGGGA AAAGGACCAG 
GCTGTGTCTG TCTCTTTTGG AGACCCACAA GGCTCTGCTC TTCAAGATGC AGCCCTAGGA 
TGGGGTCGGC GGTGCCCACA ATGCCCTAGA TGCCCGTCAT GCCCATCTTG CCCGAGATGC 
CCGAGGTGCC CGAGGTGCAA ATGCAATCCA AAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord.
Developmental biology360(2)415-25(2011 Dec)
Tamplin OJ,Cox BJ,Rossant J

Elevated expression of Paneth cell CRS4C in ileitis-prone SAMP1/YitFc mice: regional distribution, subcellular localization, and mechanism of action.
The Journal of biological chemistry285(10)7493-504(2010 Mar)
Shanahan MT,Vidrich A,Shirafuji Y,Dubois CL,Henschen-Edman A,Hagen SJ,Cohn SM,Ouellette AJ

Increased diversity of intestinal antimicrobial peptides by covalent dimer formation.
Nature immunology5(8)836-43(2004 Aug)
Hornef MW,P?tsep K,Karlsson J,Refai E,Andersson M

A family of defensin-like genes codes for diverse cysteine-rich peptides in mouse Paneth cells.
Genomics24(1)99-109(1994 Nov)
Huttner KM,Ouellette AJ

A novel gene family coding for cationic, cysteine-rich peptides. Regulation in mouse small intestine and cells of myeloid origin.
The Journal of biological chemistry269(28)18702(1994 Jul)
Ouellette AJ,Lauldi JC