Plk3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Plk3
Entrez Gene ID	12795
Full Name	polo like kinase 3
Synonyms	Cnk,Fnk,PLK-3,PRK
General protein information	Preferred Names polo like kinase 3 Names serine/threonine-protein kinase PLK3 FGF-inducible kinase cytokine-inducible serine/threonine-protein kinase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4\|4 D1
Summary	This gene encodes a member of the highly conserved polo-like kinase family of serine/threonine kinases. Members of this family are characterized by an amino-terminal catalytic domain and a carboxy-terminal bipartite polo box domain that functions as a substrate-binding motif and a cellular localization signal. Polo-like kinases have primarily been implicated in cell cycle regulation. In mouse, this protein that has been reported to localize to the nucleolus during interphase but is undetectable during mitosis, following nucleolus dissociation during prophase. The protein relocalizes to the nucleolus just prior to cytokinesis and peak levels are detected during G1 of interphase. This gene has been implicated in regulation of entry into S phase, with RNAi-induced depletion resulting in failure to re-enter the cell cycle. Mice deficient for this gene exhibit increased weight and tumor development at advanced age. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_013807.3	NP_038835.2	serine/threonine-protein kinase PLK3 isoform 1
NM_001313916.1	NP_001300845.1	serine/threonine-protein kinase PLK3 isoform 2

Pathways from BioSystems

Homologies

	PLK3	XP_001099497.1
Mus musculus (house mouse)	Plk3	NP_038835.2
Gallus gallus (chicken)	PLK3	XP_004936781.1
Homo sapiens (human)	PLK3	NP_004064.2
Canis lupus familiaris (dog)	PLK3	XP_532604.2
Bos taurus (cattle)	PLK3	NP_001068621.1
Xenopus tropicalis (tropical clawed frog)	plk3	NP_001006766.1
Rattus norvegicus (Norway rat)	Plk3	NP_071523.1
Danio rerio (zebrafish)	plk3	NP_958465.1

Gene Ontology
Bibliography

Related articles in PubMed

Polo-Like Kinase 3 Appears Dispensable for Normal Retinal Development Despite Robust Embryonic Expression.
Goetz JJ, Laboissonniere LA, Wester AK, Lynch MR, Trimarchi JM
PloS one11(3)e0150878(2016)

Osmotic stress-induced phosphorylation of H2AX by polo-like kinase 3 affects cell cycle progression in human corneal epithelial cells.
Wang L, Dai W, Lu L
The Journal of biological chemistry289(43)29827-35(2014 Oct)

Polo-like kinase 3 regulates CtIP during DNA double-strand break repair in G1.
Barton O, Naumann SC, Diemer-Biehs R, K?nzel J, Steinlage M, Conrad S, Makharashvili N, Wang J, Feng L, Lopez BS, Paull TT, Chen J, Jeggo PA, L?brich M
The Journal of cell biology206(7)877-94(2014 Sep)

Absence of polo-like kinase 3 in mice stabilizes Cdc25A after DNA damage but is not sufficient to produce tumors.
Myer DL, Robbins SB, Yin M, Boivin GP, Liu Y, Greis KD, Bahassi el M, Stambrook PJ
Mutation research714(1-2)1-10(2011 Sep)

Regulation of PTEN stability and activity by Plk3.
Xu D, Yao Y, Jiang X, Lu L, Dai W
The Journal of biological chemistry285(51)39935-42(2010 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Polo-Like Kinase 3 Appears Dispensable for Normal Retinal Development Despite Robust Embryonic Expression
Title: Polo-Like Kinase 3 Appears Dispensable for Normal Retinal Development Despite Robust Embryonic Expression.

Calcium- and integrin-binding protein 1 is involved in regulating endomitosis, perhaps through its interaction with Plk3
Title: Calcium- and integrin-binding protein 1 regulates endomitosis and its interaction with Polo-like kinase 3 is enhanced in endomitotic Dami cells.

Plk3 functions as an essential component of the hypoxia regulatory pathway by direct phosphorylation of HIF-1alpha
Title: Plk3 functions as an essential component of the hypoxia regulatory pathway by direct phosphorylation of HIF-1alpha.

Plk3 as a new player in the regulation of the PI3K/PDK1/Akt signaling axis by phosphorylation and stabilization of PTEN.
Title: Regulation of PTEN stability and activity by Plk3.

The specificity of TTP for promoting the degradation of Plk3 was demonstrated by the unaltered decay of Plk3 mRNA in cell
Title: Stimulation of polo-like kinase 3 mRNA decay by tristetraprolin.

The following Plk3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Plk3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu15011	NM_013807.3 Latest version!	Mus musculus polo like kinase 3 (Plk3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00
OMu76881	NM_001313916.1 Latest version!	Mus musculus polo like kinase 3 (Plk3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Plk3 ( NM_013807.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_038835.2 Mus musculus polo like kinase 3 (Plk3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu15011
Clone ID Related Accession (Same CDS sequence)	NM_013807.3
Accession Version	NM_013807.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1947bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Mus musculus(house mouse)
Product	serine/threonine-protein kinase PLK3 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL671866.8 and BC063051.1. On Sep 11, 2015 this sequence version replaced NM_013807.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC063051.1, AK156754.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164139 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCCCG CCGCCGGCTT CTTGTCTCCG CGCCCCTTCC CGCGCGCGGC TGCCCCGTCC 
GCGCCCCCCG CCGGCCCGGG GCCGCCTGCC AATGCCTCCC CGCGATCGGA ACCTGAGGTG 
CTGGCCGGGC CACGGGCGCC GGATCCTCCT GGTCGCCTCA TCACCGACCC TCTCAGCGGC 
CGTACCTACA CCAAGGGTCG CTTGTTGGGC AAGGGGGGCT TCGCACGCTG CTATGAAGCC 
ACTGACACCG AGTCTGGTAT AGCCTACGCG GTCAAAGTCA TCCCACAGAG TCGCGTCGCC 
AAGCCGCATC AGCGCGAGAA GATCCTAAAT GAGATAGAGT TGCACCGAGA CCTACAGCAC 
CGCCATATCG TTCGCTTTTC ACATCATTTC GAGGATGCTG ACAACATATA CATTTTCCTG 
GAGCTCTGTA GCCGAAAGTC CCTGGCCCAC ATCTGGAAGG CCCGACACAC CCTGTTGGAA 
CCAGAGGTTC GCTACTACCT GCGCCAGATC CTTTCTGGCC TCAAGTACTT GCACCAGAGG 
GGTATCTTAC ACAGAGATCT CAAGCTGGGA AATTTTTTCA TCACGGATAA CATGGAACTG 
AAGGTGGGGG ATTTTGGGCT GGCAGCTCGA TTAGAGCCCC CAGAGCAGAG GAAAAAGACC 
ATCTGTGGCA CTCCCAACTA CGTGGCTCCA GAAGTGCTGC TGAGACAGGG CCATGGCCCC 
GAGGCAGATG TGTGGTCGCT TGGTTGTGTC ATGTACACGC TCCTGTGTGG GAGCCCCCCA 
TTTGAGACTG CTGACCTGAA GGAGACATAC CGCTGCATCA AGCAGGTTCA TTACACGCTA 
CCTGCCAGCC TCTCCCTGCC TGCCCGGCAG CTCCTGGCTG CCATCCTCCG AGCTTCACCC 
AGAGACCGCC CTTCCATTGA ACAGATTTTA CGCCATGACT TCTTTACGAA GGGCTACACC 
CCTGATCGGC TCCCGGTCAG CAGCTGTGTG ACAGTCCCAG ATCTGACACC CCCCAACCCT 
GCGAGGAGTC TGTTTGCCAA AGTTACCAAG AGCCTGTTTG GCAGGAAAAA GAACAAGAAT 
AAGAACCATT CTGAGGACCA GGATAATGTC TCCTGCTTGG TGAGTGGCCT CATGCGCACA 
TCCATCGGTC ATCCAGATGT CAGGCCGGAG GCTCCTGTAG TTTCAGGCCA GGCCCCTGCC 
AGCTTGGTAG AGACAGCTGC CGAGGACAGC TCGCCCCGTG GGACACTGGC CAGCAGTGGA 
GATGGGTTTG AAGAAGGTTT GACTGTGGCC ACAGTGGTAG AGTCTGCCCT CTGTGCACTG 
AGAAACTGTG TGGCCTTCAT GCCCCCAGCC GAACAGAACC CAGCCCCGCT GGCACAGCCA 
GAGCCTCTGG TGTGGGTCAG CAAGTGGGTT GACTACTCCA ACAAGTTTGG CTTTGGCTAT 
CAGCTGTCCA GCCGCCGTGT AGCCGTGCTC TTCAATGATG GCACACACAT GGCCCTGTCA 
GCCAATAGGA AGACGGTGCA CTACAACCCC ACCAGCACGA AGCACTTCTC CTTCTCCATG 
GGTTCTGTGC CCCGAGCTCT GCAGCCTCAG CTGGGCATCC TGCGGTATTT TGCGTCCTAC 
ATGGAACAGC ACCTCATGAA GGGTGGAGAT CTGCCCAGTG TGGAAGAGGC GGAGGTGCCT 
GCCCCACCCT TGCTGCTGCA GTGGGTCAAG ACTGACCAGG CCCTCCTCAT GCTGTTCAGT 
GATGGCACTG TCCAGGTGAA CTTCTACGGG GACCACACGA AGCTGATCCT CAGTGGCTGG 
GAGCCTCTCC TTGTGACCTT CGTGGCCCGC AATCGCAGTG CTTGTACTTA CCTCGCTTCC 
CACCTCCGGC AGCTGGGCTG CTCCCCAGAC TTGCGGCAGC GACTGCGCTA CGCTCTGCGC 
CTGCTCAGGG ACCAAAGCCC TGCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_038835.2
CDS	100..2046
Translation	MEPAAGFLSPRPFPRAAAPSAPPAGPGPPANASPRSEPEVLAGPRAPDPPGRLITDPLSGRTYTKGRLLGKGGFARCYEATDTESGIAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITDNMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIEQILRHDFFTKGYTPDRLPVSSCVTVPDLTPPNPARSLFAKVTKSLFGRKKNKNKNHSEDQDNVSCLVSGLMRTSIGHPDVRPEAPVVSGQAPASLVETAAEDSSPRGTLASSGDGFEEGLTVATVVESALCALRNCVAFMPPAEQNPAPLAQPEPLVWVSKWVDYSNKFGFGYQLSSRRVAVLFNDGTHMALSANRKTVHYNPTSTKHFSFSMGSVPRALQPQLGILRYFASYMEQHLMKGGDLPSVEEAEVPAPPLLLQWVKTDQALLMLFSDGTVQVNFYGDHTKLILSGWEPLLVTFVARNRSACTYLASHLRQLGCSPDLRQRLRYALRLLRDQSPA

Target ORF information:

RefSeq Version	NM_013807.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus polo like kinase 3 (Plk3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013807.3

ORF Insert Sequence:

ATGGAGCCCG CCGCCGGCTT CTTGTCTCCG CGCCCCTTCC CGCGCGCGGC TGCCCCGTCC 
GCGCCCCCCG CCGGCCCGGG GCCGCCTGCC AATGCCTCCC CGCGATCGGA ACCTGAGGTG 
CTGGCCGGGC CACGGGCGCC GGATCCTCCT GGTCGCCTCA TCACCGACCC TCTCAGCGGC 
CGTACCTACA CCAAGGGTCG CTTGTTGGGC AAGGGGGGCT TCGCACGCTG CTATGAAGCC 
ACTGACACCG AGTCTGGTAT AGCCTACGCG GTCAAAGTCA TCCCACAGAG TCGCGTCGCC 
AAGCCGCATC AGCGCGAGAA GATCCTAAAT GAGATAGAGT TGCACCGAGA CCTACAGCAC 
CGCCATATCG TTCGCTTTTC ACATCATTTC GAGGATGCTG ACAACATATA CATTTTCCTG 
GAGCTCTGTA GCCGAAAGTC CCTGGCCCAC ATCTGGAAGG CCCGACACAC CCTGTTGGAA 
CCAGAGGTTC GCTACTACCT GCGCCAGATC CTTTCTGGCC TCAAGTACTT GCACCAGAGG 
GGTATCTTAC ACAGAGATCT CAAGCTGGGA AATTTTTTCA TCACGGATAA CATGGAACTG 
AAGGTGGGGG ATTTTGGGCT GGCAGCTCGA TTAGAGCCCC CAGAGCAGAG GAAAAAGACC 
ATCTGTGGCA CTCCCAACTA CGTGGCTCCA GAAGTGCTGC TGAGACAGGG CCATGGCCCC 
GAGGCAGATG TGTGGTCGCT TGGTTGTGTC ATGTACACGC TCCTGTGTGG GAGCCCCCCA 
TTTGAGACTG CTGACCTGAA GGAGACATAC CGCTGCATCA AGCAGGTTCA TTACACGCTA 
CCTGCCAGCC TCTCCCTGCC TGCCCGGCAG CTCCTGGCTG CCATCCTCCG AGCTTCACCC 
AGAGACCGCC CTTCCATTGA ACAGATTTTA CGCCATGACT TCTTTACGAA GGGCTACACC 
CCTGATCGGC TCCCGGTCAG CAGCTGTGTG ACAGTCCCAG ATCTGACACC CCCCAACCCT 
GCGAGGAGTC TGTTTGCCAA AGTTACCAAG AGCCTGTTTG GCAGGAAAAA GAACAAGAAT 
AAGAACCATT CTGAGGACCA GGATAATGTC TCCTGCTTGG TGAGTGGCCT CATGCGCACA 
TCCATCGGTC ATCCAGATGT CAGGCCGGAG GCTCCTGTAG TTTCAGGCCA GGCCCCTGCC 
AGCTTGGTAG AGACAGCTGC CGAGGACAGC TCGCCCCGTG GGACACTGGC CAGCAGTGGA 
GATGGGTTTG AAGAAGGTTT GACTGTGGCC ACAGTGGTAG AGTCTGCCCT CTGTGCACTG 
AGAAACTGTG TGGCCTTCAT GCCCCCAGCC GAACAGAACC CAGCCCCGCT GGCACAGCCA 
GAGCCTCTGG TGTGGGTCAG CAAGTGGGTT GACTACTCCA ACAAGTTTGG CTTTGGCTAT 
CAGCTGTCCA GCCGCCGTGT AGCCGTGCTC TTCAATGATG GCACACACAT GGCCCTGTCA 
GCCAATAGGA AGACGGTGCA CTACAACCCC ACCAGCACGA AGCACTTCTC CTTCTCCATG 
GGTTCTGTGC CCCGAGCTCT GCAGCCTCAG CTGGGCATCC TGCGGTATTT TGCGTCCTAC 
ATGGAACAGC ACCTCATGAA GGGTGGAGAT CTGCCCAGTG TGGAAGAGGC GGAGGTGCCT 
GCCCCACCCT TGCTGCTGCA GTGGGTCAAG ACTGACCAGG CCCTCCTCAT GCTGTTCAGT 
GATGGCACTG TCCAGGTGAA CTTCTACGGG GACCACACGA AGCTGATCCT CAGTGGCTGG 
GAGCCTCTCC TTGTGACCTT CGTGGCCCGC AATCGCAGTG CTTGTACTTA CCTCGCTTCC 
CACCTCCGGC AGCTGGGCTG CTCCCCAGAC TTGCGGCAGC GACTGCGCTA CGCTCTGCGC 
CTGCTCAGGG ACCAAAGCCC TGCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Plk3 ( NM_001313916.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001300845.1 Mus musculus polo like kinase 3 (Plk3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu76881
Clone ID Related Accession (Same CDS sequence)	NM_001313916.1
Accession Version	NM_001313916.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1896bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Mus musculus(house mouse)
Product	serine/threonine-protein kinase PLK3 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL671866.8 and BC063051.1. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U21392.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164139 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCCCG CCGCCGGCTT CTTGTCTCCG CGCCCCTTCC CGCGCGCGGC TGCCCCGTCC 
GCGCCCCCCG CCGGCCCGGG GCCGCCTGCC AATGCCTCCC CGCGATCGGA ACCTGAGGTG 
CTGGCCGGGC CACGGGCGCC GGATCCTCCT GGTCGCCTCA TCACCGACCC TCTCAGCGGC 
CGTACCTACA CCAAGGGTCG CTTGTTGGGC AAGGGGGGCT TCGCACGCTG CTATGAAGCC 
ACTGACACCG AGTCTGGTAT AGCCTACGCG GTCAAAGTCA TCCCACAGAG TCGCGTCGCC 
AAGCCGCATC AGCGCGAGAA GATCCTAAAT GAGATAGAGT TGCACCGAGA CCTACAGCAC 
CGCCATATCG TTCGCTTTTC ACATCATTTC GAGGATGCTG ACAACATATA CATTTTCCTG 
GAGCTCTGTA GCCGAAAGTC CCTGGCCCAC ATCTGGAAGG CCCGACACAC CCTGTTGGAA 
CCAGAGGTTC GCTACTACCT GCGCCAGATC CTTTCTGGCC TCAAGTACTT GCACCAGAGG 
GGTATCTTAC ACAGAGATCT CAAGCTGGGA AATTTTTTCA TCACGGATAA CATGGAACTG 
AAGGTGGGGG ATTTTGGGCT GGCAGCTCGA TTAGAGCCCC CAGAGCAGAG GAAAAAGACC 
ATCTGTGGCA CTCCCAACTA CGTGGCTCCA GAAGTGCTGC TGAGACAGGG CCATGGCCCC 
GAGGCAGATG TGTGGTCGCT TGGTTGTGTC ATGTACACGC TCCTGTGTGG GAGCCCCCCA 
TTTGAGACTG CTGACCTGAA GGAGACATAC CGCTGCATCA AGCAGGTTCA TTACACGCTA 
CCTGCCAGCC TCTCCCTGCC TGCCCGGCAG CTCCTGGCTG CCATCCTCCG AGCTTCACCC 
AGAGACCGCC CTTCCATTGA ACAGATTTTA CGCCATGACT TCTTTACGAA GGGCTACACC 
CCTGATCGGC TCCCGGTCAG CAGCTGTGTG ACAGTCCCAG ATCTGACACC CCCCAACCCT 
GCGAGGAGTC TGTTTGCCAA AGTTACCAAG AGCCTGTTTG GCAGGAAAAA GAACAAGAAT 
AAGAACCATT CTGAGGACCA GGATAATGTC TCCTGCTTGG CTCCTGTAGT TTCAGGCCAG 
GCCCCTGCCA GCTTGGTAGA GACAGCTGCC GAGGACAGCT CGCCCCGTGG GACACTGGCC 
AGCAGTGGAG ATGGGTTTGA AGAAGGTTTG ACTGTGGCCA CAGTGGTAGA GTCTGCCCTC 
TGTGCACTGA GAAACTGTGT GGCCTTCATG CCCCCAGCCG AACAGAACCC AGCCCCGCTG 
GCACAGCCAG AGCCTCTGGT GTGGGTCAGC AAGTGGGTTG ACTACTCCAA CAAGTTTGGC 
TTTGGCTATC AGCTGTCCAG CCGCCGTGTA GCCGTGCTCT TCAATGATGG CACACACATG 
GCCCTGTCAG CCAATAGGAA GACGGTGCAC TACAACCCCA CCAGCACGAA GCACTTCTCC 
TTCTCCATGG GTTCTGTGCC CCGAGCTCTG CAGCCTCAGC TGGGCATCCT GCGGTATTTT 
GCGTCCTACA TGGAACAGCA CCTCATGAAG GGTGGAGATC TGCCCAGTGT GGAAGAGGCG 
GAGGTGCCTG CCCCACCCTT GCTGCTGCAG TGGGTCAAGA CTGACCAGGC CCTCCTCATG 
CTGTTCAGTG ATGGCACTGT CCAGGTGAAC TTCTACGGGG ACCACACGAA GCTGATCCTC 
AGTGGCTGGG AGCCTCTCCT TGTGACCTTC GTGGCCCGCA ATCGCAGTGC TTGTACTTAC 
CTCGCTTCCC ACCTCCGGCA GCTGGGCTGC TCCCCAGACT TGCGGCAGCG ACTGCGCTAC 
GCTCTGCGCC TGCTCAGGGA CCAAAGCCCT GCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001300845.1
CDS	100..1995
Translation	MEPAAGFLSPRPFPRAAAPSAPPAGPGPPANASPRSEPEVLAGPRAPDPPGRLITDPLSGRTYTKGRLLGKGGFARCYEATDTESGIAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITDNMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIEQILRHDFFTKGYTPDRLPVSSCVTVPDLTPPNPARSLFAKVTKSLFGRKKNKNKNHSEDQDNVSCLAPVVSGQAPASLVETAAEDSSPRGTLASSGDGFEEGLTVATVVESALCALRNCVAFMPPAEQNPAPLAQPEPLVWVSKWVDYSNKFGFGYQLSSRRVAVLFNDGTHMALSANRKTVHYNPTSTKHFSFSMGSVPRALQPQLGILRYFASYMEQHLMKGGDLPSVEEAEVPAPPLLLQWVKTDQALLMLFSDGTVQVNFYGDHTKLILSGWEPLLVTFVARNRSACTYLASHLRQLGCSPDLRQRLRYALRLLRDQSPA

Target ORF information:

RefSeq Version	NM_001313916.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus polo like kinase 3 (Plk3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001313916.1

ORF Insert Sequence:

ATGGAGCCCG CCGCCGGCTT CTTGTCTCCG CGCCCCTTCC CGCGCGCGGC TGCCCCGTCC 
GCGCCCCCCG CCGGCCCGGG GCCGCCTGCC AATGCCTCCC CGCGATCGGA ACCTGAGGTG 
CTGGCCGGGC CACGGGCGCC GGATCCTCCT GGTCGCCTCA TCACCGACCC TCTCAGCGGC 
CGTACCTACA CCAAGGGTCG CTTGTTGGGC AAGGGGGGCT TCGCACGCTG CTATGAAGCC 
ACTGACACCG AGTCTGGTAT AGCCTACGCG GTCAAAGTCA TCCCACAGAG TCGCGTCGCC 
AAGCCGCATC AGCGCGAGAA GATCCTAAAT GAGATAGAGT TGCACCGAGA CCTACAGCAC 
CGCCATATCG TTCGCTTTTC ACATCATTTC GAGGATGCTG ACAACATATA CATTTTCCTG 
GAGCTCTGTA GCCGAAAGTC CCTGGCCCAC ATCTGGAAGG CCCGACACAC CCTGTTGGAA 
CCAGAGGTTC GCTACTACCT GCGCCAGATC CTTTCTGGCC TCAAGTACTT GCACCAGAGG 
GGTATCTTAC ACAGAGATCT CAAGCTGGGA AATTTTTTCA TCACGGATAA CATGGAACTG 
AAGGTGGGGG ATTTTGGGCT GGCAGCTCGA TTAGAGCCCC CAGAGCAGAG GAAAAAGACC 
ATCTGTGGCA CTCCCAACTA CGTGGCTCCA GAAGTGCTGC TGAGACAGGG CCATGGCCCC 
GAGGCAGATG TGTGGTCGCT TGGTTGTGTC ATGTACACGC TCCTGTGTGG GAGCCCCCCA 
TTTGAGACTG CTGACCTGAA GGAGACATAC CGCTGCATCA AGCAGGTTCA TTACACGCTA 
CCTGCCAGCC TCTCCCTGCC TGCCCGGCAG CTCCTGGCTG CCATCCTCCG AGCTTCACCC 
AGAGACCGCC CTTCCATTGA ACAGATTTTA CGCCATGACT TCTTTACGAA GGGCTACACC 
CCTGATCGGC TCCCGGTCAG CAGCTGTGTG ACAGTCCCAG ATCTGACACC CCCCAACCCT 
GCGAGGAGTC TGTTTGCCAA AGTTACCAAG AGCCTGTTTG GCAGGAAAAA GAACAAGAAT 
AAGAACCATT CTGAGGACCA GGATAATGTC TCCTGCTTGG CTCCTGTAGT TTCAGGCCAG 
GCCCCTGCCA GCTTGGTAGA GACAGCTGCC GAGGACAGCT CGCCCCGTGG GACACTGGCC 
AGCAGTGGAG ATGGGTTTGA AGAAGGTTTG ACTGTGGCCA CAGTGGTAGA GTCTGCCCTC 
TGTGCACTGA GAAACTGTGT GGCCTTCATG CCCCCAGCCG AACAGAACCC AGCCCCGCTG 
GCACAGCCAG AGCCTCTGGT GTGGGTCAGC AAGTGGGTTG ACTACTCCAA CAAGTTTGGC 
TTTGGCTATC AGCTGTCCAG CCGCCGTGTA GCCGTGCTCT TCAATGATGG CACACACATG 
GCCCTGTCAG CCAATAGGAA GACGGTGCAC TACAACCCCA CCAGCACGAA GCACTTCTCC 
TTCTCCATGG GTTCTGTGCC CCGAGCTCTG CAGCCTCAGC TGGGCATCCT GCGGTATTTT 
GCGTCCTACA TGGAACAGCA CCTCATGAAG GGTGGAGATC TGCCCAGTGT GGAAGAGGCG 
GAGGTGCCTG CCCCACCCTT GCTGCTGCAG TGGGTCAAGA CTGACCAGGC CCTCCTCATG 
CTGTTCAGTG ATGGCACTGT CCAGGTGAAC TTCTACGGGG ACCACACGAA GCTGATCCTC 
AGTGGCTGGG AGCCTCTCCT TGTGACCTTC GTGGCCCGCA ATCGCAGTGC TTGTACTTAC 
CTCGCTTCCC ACCTCCGGCA GCTGGGCTGC TCCCCAGACT TGCGGCAGCG ACTGCGCTAC 
GCTCTGCGCC TGCTCAGGGA CCAAAGCCCT GCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Polo-Like Kinase 3 Appears Dispensable for Normal Retinal Development Despite Robust Embryonic Expression.
PloS one11(3)e0150878(2016)
Goetz JJ,Laboissonniere LA,Wester AK,Lynch MR,Trimarchi JM

Osmotic stress-induced phosphorylation of H2AX by polo-like kinase 3 affects cell cycle progression in human corneal epithelial cells.
The Journal of biological chemistry289(43)29827-35(2014 Oct)
Wang L,Dai W,Lu L

Polo-like kinase 3 regulates CtIP during DNA double-strand break repair in G1.
The Journal of cell biology206(7)877-94(2014 Sep)
Barton O,Naumann SC,Diemer-Biehs R,K?nzel J,Steinlage M,Conrad S,Makharashvili N,Wang J,Feng L,Lopez BS,Paull TT,Chen J,Jeggo PA,L?brich M

Absence of polo-like kinase 3 in mice stabilizes Cdc25A after DNA damage but is not sufficient to produce tumors.
Mutation research714(1-2)1-10(2011 Sep)
Myer DL,Robbins SB,Yin M,Boivin GP,Liu Y,Greis KD,Bahassi el M,Stambrook PJ

Regulation of PTEN stability and activity by Plk3.
The Journal of biological chemistry285(51)39935-42(2010 Dec)
Xu D,Yao Y,Jiang X,Lu L,Dai W

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Plk3 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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