Cd1d2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cd1d2
Entrez Gene ID	12480
Full Name	CD1d2 antigen
Synonyms	CD1.2,Cd1b,Ly-38
General protein information	Preferred Names CD1d2 antigen Names antigen-presenting glycoprotein CD1d2 T-cell surface glycoprotein CD1d2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3 F1\|3 37.88 cM
Summary	This gene encodes a MHC class I-like molecule involved in the presentation of lipid antigens to T cells, and is involved in the activation of Natural Killer T (NKT) cells. The gene is highly similar to the CD1d1 antigen gene, which is located adjacent to this gene in a tail-to-tail fashion. This gene contains a frameshift and does not produce a functional product in the C57BL/6 strain. Alternatively splice transcript variants encoding different isoforms have been found in non-C57BL/6 strains. [provided by RefSeq, Jan 2014].

mRNA and Protein(s)

mRNA	Protein	Name
NM_007640.2	NP_031666.2	antigen-presenting glycoprotein CD1d2 isoform 1 precursor
NM_001289449.1	NP_001276378.1	antigen-presenting glycoprotein CD1d2 isoform 2 precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

CD1d-mediated activation of group 3 innate lymphoid cells drives IL-22 production.
Saez de Guinoa J, Jimeno R, Farhadi N, Jervis PJ, Cox LR, Besra GS, Barral P
EMBO reports18(1)39-47(2017 01)

Interleukin-30 (IL27p28) alleviates experimental sepsis by modulating cytokine profile in NKT cells.
Yan J, Mitra A, Hu J, Cutrera JJ, Xia X, Doetschman T, Gagea M, Mishra L, Li S
Journal of hepatology64(5)1128-1136(2016 May)

NKT cells mediate the recruitment of neutrophils by stimulating epithelial chemokine secretion during colitis.
Huang E, Liu R, Lu Z, Liu J, Liu X, Zhang D, Chu Y
Biochemical and biophysical research communications474(2)252-258(2016 05)

NKT cell modulates NAFLD potentiation of metabolic oxidative stress-induced mesangial cell activation and proximal tubular toxicity.
Alhasson F, Dattaroy D, Das S, Chandrashekaran V, Seth RK, Schnellmann RG, Chatterjee S
American journal of physiology. Renal physiology310(1)F85-F101(2016 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These data demonstrate that both the developmental requirements and functions of Cd1b-autoreactive T cells resemble those of Invariant Natural Killer T-Cells cells and could in turn be manipulated for use in anti-microbial therapies.
Title: Autoreactive CD1b-restricted T cells: a new innate-like T-cell population that contributes to immunity against infection.

Crystal structures of mouse CD1d-iGb3 complex and its cognate Valpha14 T cell receptor.
Title: Crystal structures of mouse CD1d-iGb3 complex and its cognate Valpha14 T cell receptor suggest a model for dual recognition of foreign and self glycolipids.

a new allele for Cd1d2 is characterized by a point mutation, resulting in a replacement of alanine at position 176 by a valine
Title: Identification of a new mouse Cd1d2 allele.

CD1a and CD1b surface expression is independent from de novo synthesized glycosphingolipids.
Title: CD1a and CD1b surface expression is independent from de novo synthesized glycosphingolipids.

The following Cd1d2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cd1d2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu18314	NM_001289449.1 Latest version!	Mus musculus CD1d2 antigen (Cd1d2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu18020	NM_007640.2 Latest version!	Mus musculus CD1d2 antigen (Cd1d2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cd1d2 ( NM_001289449.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001276378.1 Mus musculus CD1d2 antigen (Cd1d2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu18314
Clone ID Related Accession (Same CDS sequence)	NM_001289449.1
Accession Version	NM_001289449.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 897bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	antigen-presenting glycoprotein CD1d2 isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC057149.1. Transcript Variant: This variant (2) has an alternate splice site, compared to variant 1. The reading frame is not affected and the resulting isoform (2) lacks an internal segment, compared to isoform 1. Sequence Note: This RefSeq represents the functional transcript found in 129, NMRI, AKR/J, and other strains. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC057149.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849383 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## polymorphic pseudogene :: PMID: 9531267 ##RefSeq-Attributes-END##

ATGCGGTACC TACCGTGCCT GTTGCTGTGG GCATTCCTAC AGGTCTGGGG ACAATCTGAA 
GTCCAGCAAA AGAATTACAC CTTCCGCTGC CTGCAGACTT CTTCCTTTGC TAACATAAGC 
TGGTCCCGCA CAGACAGCCT GATCTTGCTG GGGGATCTGC AGACACACCG TTGGAGTAAT 
GACTCAGCCA TCATCAGCTT CACGAAGCCA TGGTCCCAGG ATCCCATTGA GATCCAGTTG 
TCTACCGGCT GTGAAATGTA CCCTGGGAAT GCTTCGGAAA GCTTTTTTCA TGTAGCATTT 
CAAGGAAAAT ATGCCGTGAG ATTCCGGGGA ACATCTTGGC AGAGGGTCCT AGGGGCCCCA 
TCTTGGTTAG ACTTGCCCAT CAAAGTGCTC AACGCTGATC AAGGGACAAG TGCAACCGTG 
CAGACGCTCC TGAATGACAC CTGGCCCCAG TTTGCCCGTG GTCTCCTAGA GGCAGGGAAG 
TCAGACCTAG AGAAGCAAGA GAAGCCAGTG GCCTGGTTGT CCAGTGTCCC CAGCTCTGCA 
CATGGCCATC TGCAGCTGGT GTGTCATGTC TCTGGCTTCT ACCCAAAACC TGTGTGGGTG 
ATGTGGATGC GGGGTGACCA GGAGCAACAG GGTACTCACA GAGGTGATTT CCTGCCAAAT 
GCTGATGAGA CATGGTATCT TCAAGCAACC CTGGATGTGG AGGCTGGAGA GGAAGCTGGC 
CTGGCCTGCA GGGTGAAGCA CAGCAGCCTA GGAGGACAGG ATATCATCCT CTACTGGGAT 
GCCAGGCAAG CACCCGTGGG CCTGATCGTC TTCATAGTAC TAATCATGCT AGTGGTGGTG 
GGTGCTGTAG TCTACTATAT CTGGAGAAGG AGAAGCGCTT ATCAAGACAT CCGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001276378.1
CDS	60..956
Translation	MRYLPCLLLWAFLQVWGQSEVQQKNYTFRCLQTSSFANISWSRTDSLILLGDLQTHRWSNDSAIISFTKPWSQDPIEIQLSTGCEMYPGNASESFFHVAFQGKYAVRFRGTSWQRVLGAPSWLDLPIKVLNADQGTSATVQTLLNDTWPQFARGLLEAGKSDLEKQEKPVAWLSSVPSSAHGHLQLVCHVSGFYPKPVWVMWMRGDQEQQGTHRGDFLPNADETWYLQATLDVEAGEEAGLACRVKHSSLGGQDIILYWDARQAPVGLIVFIVLIMLVVVGAVVYYIWRRRSAYQDIR

Target ORF information:

RefSeq Version	NM_001289449.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus CD1d2 antigen (Cd1d2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001289449.1

ORF Insert Sequence:

ATGCGGTACC TACCGTGCCT GTTGCTGTGG GCATTCCTAC AGGTCTGGGG ACAATCTGAA 
GTCCAGCAAA AGAATTACAC CTTCCGCTGC CTGCAGACTT CTTCCTTTGC TAACATAAGC 
TGGTCCCGCA CAGACAGCCT GATCTTGCTG GGGGATCTGC AGACACACCG TTGGAGTAAT 
GACTCAGCCA TCATCAGCTT CACGAAGCCA TGGTCCCAGG ATCCCATTGA GATCCAGTTG 
TCTACCGGCT GTGAAATGTA CCCTGGGAAT GCTTCGGAAA GCTTTTTTCA TGTAGCATTT 
CAAGGAAAAT ATGCCGTGAG ATTCCGGGGA ACATCTTGGC AGAGGGTCCT AGGGGCCCCA 
TCTTGGTTAG ACTTGCCCAT CAAAGTGCTC AACGCTGATC AAGGGACAAG TGCAACCGTG 
CAGACGCTCC TGAATGACAC CTGGCCCCAG TTTGCCCGTG GTCTCCTAGA GGCAGGGAAG 
TCAGACCTAG AGAAGCAAGA GAAGCCAGTG GCCTGGTTGT CCAGTGTCCC CAGCTCTGCA 
CATGGCCATC TGCAGCTGGT GTGTCATGTC TCTGGCTTCT ACCCAAAACC TGTGTGGGTG 
ATGTGGATGC GGGGTGACCA GGAGCAACAG GGTACTCACA GAGGTGATTT CCTGCCAAAT 
GCTGATGAGA CATGGTATCT TCAAGCAACC CTGGATGTGG AGGCTGGAGA GGAAGCTGGC 
CTGGCCTGCA GGGTGAAGCA CAGCAGCCTA GGAGGACAGG ATATCATCCT CTACTGGGAT 
GCCAGGCAAG CACCCGTGGG CCTGATCGTC TTCATAGTAC TAATCATGCT AGTGGTGGTG 
GGTGCTGTAG TCTACTATAT CTGGAGAAGG AGAAGCGCTT ATCAAGACAT CCGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cd1d2 ( NM_007640.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031666.2 Mus musculus CD1d2 antigen (Cd1d2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu18020
Clone ID Related Accession (Same CDS sequence)	NM_007640.2
Accession Version	NM_007640.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1011bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	antigen-presenting glycoprotein CD1d2 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M63697.1 and X15036.1. On Jul 25, 2006 this sequence version replaced NM_007640.1. Transcript Variant: This variant (1) encodes a functional protein in 129, NMRI, AKR/J, and other strains, but not in C57BL/6. Sequence Note: This RefSeq represents the functional transcript found in 129, NMRI, AKR/J, and other strains. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849379 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## polymorphic pseudogene :: PMID: 9531267 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCGGTACC TACCGTGCCT GTTGCTGTGG GCATTCCTAC AGGTCTGGGG ACAATCTGAA 
GTCCAGCAAA AGAATTACAC CTTCCGCTGC CTGCAGACTT CTTCCTTTGC TAACATAAGC 
TGGTCCCGCA CAGACAGCCT GATCTTGCTG GGGGATCTGC AGACACACCG TTGGAGTAAT 
GACTCAGCCA TCATCAGCTT CACGAAGCCA TGGTCCCAGG GCAAGTTGAG TAACCAGCAG 
TGGGAGAAGT TGCAGCATAT GTTTCAAGTC TATCGAGTCA GCTTTACCAG GGACATACAG 
GAATTAGTCA AAATGATGTC ACCTAAAGAA GACTATCCCA TTGAGATCCA GTTGTCTACC 
GGCTGTGAAA TGTACCCTGG GAATGCTTCG GAAAGCTTTT TTCATGTAGC ATTTCAAGGA 
AAATATGCCG TGAGATTCCG GGGAACATCT TGGCAGAGGG TCCTAGGGGC CCCATCTTGG 
TTAGACTTGC CCATCAAAGT GCTCAACGCT GATCAAGGGA CAAGTGCAAC CGTGCAGACG 
CTCCTGAATG ACACCTGGCC CCAGTTTGCC CGTGGTCTCC TAGAGGCAGG GAAGTCAGAC 
CTAGAGAAGC AAGAGAAGCC AGTGGCCTGG TTGTCCAGTG TCCCCAGCTC TGCACATGGC 
CATCTGCAGC TGGTGTGTCA TGTCTCTGGC TTCTACCCAA AACCTGTGTG GGTGATGTGG 
ATGCGGGGTG ACCAGGAGCA ACAGGGTACT CACAGAGGTG ATTTCCTGCC AAATGCTGAT 
GAGACATGGT ATCTTCAAGC AACCCTGGAT GTGGAGGCTG GAGAGGAAGC TGGCCTGGCC 
TGCAGGGTGA AGCACAGCAG CCTAGGAGGA CAGGATATCA TCCTCTACTG GGATGCCAGG 
CAAGCACCCG TGGGCCTGAT CGTCTTCATA GTACTAATCA TGCTAGTGGT GGTGGGTGCT 
GTAGTCTACT ATATCTGGAG AAGGAGAAGC GCTTATCAAG ACATCCGGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031666.2
CDS	60..1070
Translation	MRYLPCLLLWAFLQVWGQSEVQQKNYTFRCLQTSSFANISWSRTDSLILLGDLQTHRWSNDSAIISFTKPWSQGKLSNQQWEKLQHMFQVYRVSFTRDIQELVKMMSPKEDYPIEIQLSTGCEMYPGNASESFFHVAFQGKYAVRFRGTSWQRVLGAPSWLDLPIKVLNADQGTSATVQTLLNDTWPQFARGLLEAGKSDLEKQEKPVAWLSSVPSSAHGHLQLVCHVSGFYPKPVWVMWMRGDQEQQGTHRGDFLPNADETWYLQATLDVEAGEEAGLACRVKHSSLGGQDIILYWDARQAPVGLIVFIVLIMLVVVGAVVYYIWRRRSAYQDIR

Target ORF information:

RefSeq Version	NM_007640.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus CD1d2 antigen (Cd1d2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007640.2

ORF Insert Sequence:

ATGCGGTACC TACCGTGCCT GTTGCTGTGG GCATTCCTAC AGGTCTGGGG ACAATCTGAA 
GTCCAGCAAA AGAATTACAC CTTCCGCTGC CTGCAGACTT CTTCCTTTGC TAACATAAGC 
TGGTCCCGCA CAGACAGCCT GATCTTGCTG GGGGATCTGC AGACACACCG TTGGAGTAAT 
GACTCAGCCA TCATCAGCTT CACGAAGCCA TGGTCCCAGG GCAAGTTGAG TAACCAGCAG 
TGGGAGAAGT TGCAGCATAT GTTTCAAGTC TATCGAGTCA GCTTTACCAG GGACATACAG 
GAATTAGTCA AAATGATGTC ACCTAAAGAA GACTATCCCA TTGAGATCCA GTTGTCTACC 
GGCTGTGAAA TGTACCCTGG GAATGCTTCG GAAAGCTTTT TTCATGTAGC ATTTCAAGGA 
AAATATGCCG TGAGATTCCG GGGAACATCT TGGCAGAGGG TCCTAGGGGC CCCATCTTGG 
TTAGACTTGC CCATCAAAGT GCTCAACGCT GATCAAGGGA CAAGTGCAAC CGTGCAGACG 
CTCCTGAATG ACACCTGGCC CCAGTTTGCC CGTGGTCTCC TAGAGGCAGG GAAGTCAGAC 
CTAGAGAAGC AAGAGAAGCC AGTGGCCTGG TTGTCCAGTG TCCCCAGCTC TGCACATGGC 
CATCTGCAGC TGGTGTGTCA TGTCTCTGGC TTCTACCCAA AACCTGTGTG GGTGATGTGG 
ATGCGGGGTG ACCAGGAGCA ACAGGGTACT CACAGAGGTG ATTTCCTGCC AAATGCTGAT 
GAGACATGGT ATCTTCAAGC AACCCTGGAT GTGGAGGCTG GAGAGGAAGC TGGCCTGGCC 
TGCAGGGTGA AGCACAGCAG CCTAGGAGGA CAGGATATCA TCCTCTACTG GGATGCCAGG 
CAAGCACCCG TGGGCCTGAT CGTCTTCATA GTACTAATCA TGCTAGTGGT GGTGGGTGCT 
GTAGTCTACT ATATCTGGAG AAGGAGAAGC GCTTATCAAG ACATCCGGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CD1d-mediated activation of group 3 innate lymphoid cells drives IL-22 production.
EMBO reports18(1)39-47(2017 01)
Saez de Guinoa J,Jimeno R,Farhadi N,Jervis PJ,Cox LR,Besra GS,Barral P

Interleukin-30 (IL27p28) alleviates experimental sepsis by modulating cytokine profile in NKT cells.
Journal of hepatology64(5)1128-1136(2016 May)
Yan J,Mitra A,Hu J,Cutrera JJ,Xia X,Doetschman T,Gagea M,Mishra L,Li S

NKT cells mediate the recruitment of neutrophils by stimulating epithelial chemokine secretion during colitis.
Biochemical and biophysical research communications474(2)252-258(2016 05)
Huang E,Liu R,Lu Z,Liu J,Liu X,Zhang D,Chu Y

NKT cell modulates NAFLD potentiation of metabolic oxidative stress-induced mesangial cell activation and proximal tubular toxicity.
American journal of physiology. Renal physiology310(1)F85-F101(2016 Jan)
Alhasson F,Dattaroy D,Das S,Chandrashekaran V,Seth RK,Schnellmann RG,Chatterjee S

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Cd1d2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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