Apoc1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Apoc1
Entrez Gene ID	11812
Full Name	apolipoprotein C-I
Synonyms	Apo-CIB,ApoC-IB,apo-CI,apoC-I
General protein information	Preferred Names apolipoprotein C-I Names apolipoprotein C-I apolipoprotein C1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7 A3\|7 9.94 cM
Summary	This gene encodes a precursor plasma protein that is cleaved to yield a signal peptide and two alternatively processed mature peptides. The encoded protein, which is a component of chylomicrons, very low density lipoproteins and high density lipoproteins, transports lipids from the intestines to other locations in the body. This protein binds to free fatty acids preventing their uptake by cells. This protein is a cofactor for lecithin cholesterol acyltransferase, an enzyme that catalyzes the conversion of free cholesterol to cholesteryl esters. The encoded protein inhibits the activity of the cholesteryl ester transfer protein which promotes the exchange of neutral lipids between lipoproteins. In humans this gene is associated with risk of coronary artery disease and age-associated memory impairment. Mice lacking this gene demonstrate impaired memory. This gene is clustered with three other apolipoprotein genes on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013].

mRNA and Protein(s)

mRNA	Protein	Name
NM_007469.5	NP_031495.1	apolipoprotein C-I precursor
NM_001110009.2	NP_001103479.1	apolipoprotein C-I precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	APOC1	NP_001183977.1
Rattus norvegicus (Norway rat)	LOC100910181	XP_003752261.1
Mus musculus (house mouse)	Apoc1	NP_031495.1

Gene Ontology
Bibliography

Related articles in PubMed

Loss of Rearranged L-Myc Fusion (RLF) results in defects in heart development in the mouse.
Bourke LM, Del Monte-Nieto G, Outhwaite JE, Bharti V, Pollock PM, Simmons DG, Adam A, Hur SS, Maghzal GJ, Whitelaw E, Stocker R, Suter CM, Harvey RP, Harten SK
Differentiation; research in biological diversity948-20(2017 Mar - Apr)

Apolipoprotein C-I plays a role in the pathogenesis of glomerulosclerosis.
Bus P, Pierneef L, Bor R, Wolterbeek R, van Es LA, Rensen PC, de Heer E, Havekes LM, Bruijn JA, Berb?e JF, Baelde HJ
The Journal of pathology241(5)589-599(2017 Apr)

Secretome-derived isotope tags (SDIT) reveal adipocyte-derived apolipoprotein C-I as a predictive marker for cardiovascular disease.
Li RX, Ding YB, Zhao SL, Xiao YY, Li QR, Xia FY, Sun L, Lin X, Wu JR, Liao K, Zeng R
Journal of proteome research11(5)2851-62(2012 May)

Apolipoprotein CI knock-out mice display impaired memory functions.
Berb?e JF, Vanmierlo T, Abildayeva K, Blokland A, Jansen PJ, L?tjohann D, Gautier T, Sijbrands E, Prickaerts J, Hadfoune M, Ramaekers FC, Kuipers F, Rensen PC, Mulder M
Journal of Alzheimer's disease : JAD23(4)737-47(2011)

Apolipoprotein C-I binds free fatty acids and reduces their intracellular esterification.
Westerterp M, Berb?e JF, Delsing DJ, Jong MC, Gijbels MJ, Dahlmans VE, Offerman EH, Romijn JA, Havekes LM, Rensen PC
Journal of lipid research48(6)1353-61(2007 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

APOC1 expression induces glomerulosclerosis, potentially by increasing the cytokine response in macrophages.
Title: Apolipoprotein C-I plays a role in the pathogenesis of glomerulosclerosis.

Apolipoprotein C-I was significantly increased in obese mice plasma.
Title: Secretome-derived isotope tags (SDIT) reveal adipocyte-derived apolipoprotein C-I as a predictive marker for cardiovascular disease.

The absence of ApoC-I results in impaired memory functions, which is, together with previous data, suggestive of an important, bell-shaped gene-dose dependent role for ApoC-I in appropriate brain functioning
Title: Apolipoprotein CI knock-out mice display impaired memory functions.

Data show that the stimulating effect of apoCI on the lipopolysaccharide (LPS)response resembles that of LPS-binding protein (LBP) and depends on CD14/ Toll-like receptor 4 signaling.
Title: Apolipoprotein CI enhances the biological response to LPS via the CD14/TLR4 pathway by LPS-binding elements in both its N- and C-terminal helix.

apoCI is a novel inhibitor of the scavenger receptor BI -mediated uptake of HDL cholesterol by hepatocytes; apoCI is a determinant for the plasma levels and size of HDL in vivo.
Title: Apolipoprotein CI inhibits scavenger receptor BI and increases plasma HDL levels in vivo.

The following Apoc1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Apoc1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu16384	NM_001110009.2 Latest version!	Mus musculus apolipoprotein C-I (Apoc1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu16384	NM_007469.5 Latest version!	Mus musculus apolipoprotein C-I (Apoc1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Apoc1 ( NM_007469.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031495.1 Mus musculus apolipoprotein C-I (Apoc1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu16384
Clone ID Related Accession (Same CDS sequence)	NM_007469.5 , NM_001110009.2
Accession Version	NM_007469.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 267bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	apolipoprotein C-I precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC149282.2 and AK011358.1. On Dec 6, 2013 this sequence version replaced NM_007469.4. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BF383631.1, CB947285.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGAGGCTCT TCATCGCTCT TCCTGTCCTG ATTGTGGTCG TAGCCATGAC CTTGGAAGGC 
CCAGCCCCCG CCCAGGCGGC CCCGGATTTG TCCGGAACAT TGGAGAGCAT ACCGGATAAA 
CTGAAGGAGT TTGGGAACAC TTTGGAAGAC AAGGCCCGGG CAGCCATTGA ACATATCAAA 
CAGAAGGAAA TTTTGACCAA GACCCGGGCC TGGTTCTCAG AGGCATTTGG CAAAGTGAAG 
GAGAAGTTGA AGACCACGTT CTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031495.1
CDS	192..458
Translation	MRLFIALPVLIVVVAMTLEGPAPAQAAPDLSGTLESIPDKLKEFGNTLEDKARAAIEHIKQKEILTKTRAWFSEAFGKVKEKLKTTFS

Target ORF information:

RefSeq Version	NM_007469.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus apolipoprotein C-I (Apoc1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007469.5

ORF Insert Sequence:

ATGAGGCTCT TCATCGCTCT TCCTGTCCTG ATTGTGGTCG TAGCCATGAC CTTGGAAGGC 
CCAGCCCCCG CCCAGGCGGC CCCGGATTTG TCCGGAACAT TGGAGAGCAT ACCGGATAAA 
CTGAAGGAGT TTGGGAACAC TTTGGAAGAC AAGGCCCGGG CAGCCATTGA ACATATCAAA 
CAGAAGGAAA TTTTGACCAA GACCCGGGCC TGGTTCTCAG AGGCATTTGG CAAAGTGAAG 
GAGAAGTTGA AGACCACGTT CTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Apoc1 ( NM_001110009.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001103479.1 Mus musculus apolipoprotein C-I (Apoc1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu16384
Clone ID Related Accession (Same CDS sequence)	NM_007469.5 , NM_001110009.2
Accession Version	NM_001110009.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 267bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	apolipoprotein C-I precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC149282.2 and BC094638.1. On Dec 6, 2013 this sequence version replaced NM_001110009.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BY453222.1, AA049273.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGAGGCTCT TCATCGCTCT TCCTGTCCTG ATTGTGGTCG TAGCCATGAC CTTGGAAGGC 
CCAGCCCCCG CCCAGGCGGC CCCGGATTTG TCCGGAACAT TGGAGAGCAT ACCGGATAAA 
CTGAAGGAGT TTGGGAACAC TTTGGAAGAC AAGGCCCGGG CAGCCATTGA ACATATCAAA 
CAGAAGGAAA TTTTGACCAA GACCCGGGCC TGGTTCTCAG AGGCATTTGG CAAAGTGAAG 
GAGAAGTTGA AGACCACGTT CTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001103479.1
CDS	70..336
Translation	MRLFIALPVLIVVVAMTLEGPAPAQAAPDLSGTLESIPDKLKEFGNTLEDKARAAIEHIKQKEILTKTRAWFSEAFGKVKEKLKTTFS

Target ORF information:

RefSeq Version	NM_001110009.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus apolipoprotein C-I (Apoc1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001110009.2

ORF Insert Sequence:

ATGAGGCTCT TCATCGCTCT TCCTGTCCTG ATTGTGGTCG TAGCCATGAC CTTGGAAGGC 
CCAGCCCCCG CCCAGGCGGC CCCGGATTTG TCCGGAACAT TGGAGAGCAT ACCGGATAAA 
CTGAAGGAGT TTGGGAACAC TTTGGAAGAC AAGGCCCGGG CAGCCATTGA ACATATCAAA 
CAGAAGGAAA TTTTGACCAA GACCCGGGCC TGGTTCTCAG AGGCATTTGG CAAAGTGAAG 
GAGAAGTTGA AGACCACGTT CTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Loss of Rearranged L-Myc Fusion (RLF) results in defects in heart development in the mouse.
Differentiation; research in biological diversity948-20(2017 Mar - Apr)
Bourke LM,Del Monte-Nieto G,Outhwaite JE,Bharti V,Pollock PM,Simmons DG,Adam A,Hur SS,Maghzal GJ,Whitelaw E,Stocker R,Suter CM,Harvey RP,Harten SK

Apolipoprotein C-I plays a role in the pathogenesis of glomerulosclerosis.
The Journal of pathology241(5)589-599(2017 Apr)
Bus P,Pierneef L,Bor R,Wolterbeek R,van Es LA,Rensen PC,de Heer E,Havekes LM,Bruijn JA,Berb?e JF,Baelde HJ

Secretome-derived isotope tags (SDIT) reveal adipocyte-derived apolipoprotein C-I as a predictive marker for cardiovascular disease.
Journal of proteome research11(5)2851-62(2012 May)
Li RX,Ding YB,Zhao SL,Xiao YY,Li QR,Xia FY,Sun L,Lin X,Wu JR,Liao K,Zeng R

Apolipoprotein CI knock-out mice display impaired memory functions.
Journal of Alzheimer's disease : JAD23(4)737-47(2011)
Berb?e JF,Vanmierlo T,Abildayeva K,Blokland A,Jansen PJ,L?tjohann D,Gautier T,Sijbrands E,Prickaerts J,Hadfoune M,Ramaekers FC,Kuipers F,Rensen PC,Mulder M

Apolipoprotein C-I binds free fatty acids and reduces their intracellular esterification.
Journal of lipid research48(6)1353-61(2007 Jun)
Westerterp M,Berb?e JF,Delsing DJ,Jong MC,Gijbels MJ,Dahlmans VE,Offerman EH,Romijn JA,Havekes LM,Rensen PC

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Apoc1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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