Serpinb7 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Serpinb7
Entrez Gene ID	116872
Full Name	serine (or cysteine) peptidase inhibitor, clade B, member 7
Synonyms	4631416M05Rik,megsin,ovalbumin
General protein information	Preferred Names serine (or cysteine) peptidase inhibitor, clade B, member 7 Names serpin B7 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 7 serine (or cysteine) proteinase inhibitor, clade B, member 7
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1\|1 E2.1

mRNA and Protein(s)

mRNA	Protein	Name
NM_027548.3	NP_081824.1	serpin B7

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Serpinb7	NP_081824.1
Homo sapiens (human)	SERPINB7	NP_003775.1
Pan troglodytes (chimpanzee)	SERPINB7	XP_524011.2
Rattus norvegicus (Norway rat)	Serpinb7	NP_569088.1
	SERPINB7	XP_002801007.1
Canis lupus familiaris (dog)	SERPINB7	XP_005615395.1
Bos taurus (cattle)	SERPINB7	NP_001192689.1

Gene Ontology
Bibliography

Related articles in PubMed

Update of the human and mouse SERPIN gene superfamily.
Heit C, Jackson BC, McAndrews M, Wright MW, Thompson DC, Silverman GA, Nebert DW, Vasiliou V
Human genomics722(2013 Oct)

Delivery of megsin siRNA plasmid reveals therapeutic potential against diabetic nephropathy by down-regulating p27(kip1) level.
Liu M, Zhang Y, Chi Y, Zhai S, Wang B, Shi Y, Li Y
Journal of nephrology25(3)418-25(2012 May-Jun)

A severe diabetic nephropathy model with early development of nodule-like lesions induced by megsin overexpression in RAGE/iNOS transgenic mice.
Inagi R, Yamamoto Y, Nangaku M, Usuda N, Okamato H, Kurokawa K, van Ypersele de Strihou C, Yamamoto H, Miyata T
Diabetes55(2)356-66(2006 Feb)

Comparative genomic analysis of the clade B serpin cluster at human chromosome 18q21: amplification within the mouse squamous cell carcinoma antigen gene locus.
Askew DJ, Askew YS, Kato Y, Turner RF, Dewar K, Lehoczky J, Silverman GA
Genomics84(1)176-84(2004 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Suggest that the down-regulation of megsin might exert beneficial effects on the diabetic kidney partly through down-regulation of p27(kip1).
Title: Delivery of megsin siRNA plasmid reveals therapeutic potential against diabetic nephropathy by down-regulating p27(kip1) level.

diabetic nephropathy model in triple transgenic mice overexpressing RAGE, iNOS & megsin; triple-hit damage develops severe diabetic nephropathy at early age with mesangial expansion, nodule-like lesion & tubulointerstitial damage with oxidative stress
Title: A severe diabetic nephropathy model with early development of nodule-like lesions induced by megsin overexpression in RAGE/iNOS transgenic mice.

The following Serpinb7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Serpinb7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu04338	NM_027548.3 Latest version!	Mus musculus serine (or cysteine) peptidase inhibitor, clade B, member 7 (Serpinb7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Serpinb7 ( NM_027548.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_081824.1 Mus musculus serine (or cysteine) peptidase inhibitor, clade B, member 7 (Serpinb7), mRNA.

Price & Availability↑

CloneID	OMu04338
Clone ID Related Accession (Same CDS sequence)	NM_027548.3
Accession Version	NM_027548.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1143bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-27
Organism	Mus musculus(house mouse)
Product	serpin B7
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK014524.1 and BC064004.1. On May 15, 2009 this sequence version replaced NM_027548.2. ##Evidence-Data-START## Transcript exon combination :: BC064004.1, AK014524.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164137 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCTCCC TTGCTGCAGC AAATGCAGAA TTTGGCTTCG ACTTATTCAG AGAGATGGAT 
AGTAGCCAAG GAAATGGAAA TGTATTCTTC TCTTCCCTGA GCATCTTCAC TGCCCTGACC 
CTAATCCGTC TGGGTGCTCG AGGTGACTGT GCACGTCAGA TTGACAAGGC ACTGCACTTT 
AACATACCAT CAAGACAAGG AAACTCATCT AATAATCAGC CAGGACTTCA GTATCAATTG 
AAAAGAGTTC TTGCTGACAT AAACTCATCT CATAAGGATT ATGAACTCAG CATTGCCACT 
GGAGTTTTTG CAGAAAAAGT CTATGACTTT CATAAGAACT ACATTGAGTG TGCTGAAAAC 
TTATACAATG CTAAAGTGGA AAGAGTTGAC TTCACAAATG ATGTACAAGA TACCAGATTT 
AAAATTAATA AATGGATTGA AAATGAGACA CATGGAAAGA TCAAGAAGGT GTTGGGCGAC 
AGCAGCCTCA GCTCGTCGGC TGTCATGGTG CTGGTGAACG CTGTTTACTT CAAAGGCAAA 
TGGAAATCGG CCTTCACCAA GACTGATACC CTCAGTTGCC GTTTTAGGTC TCCCACGTGT 
CCTGGAAAAG TAGTTAATAT GATGCATCAA GAACGGCGGT TCAATTTGTC TACCATTCAG 
CAGCCACCAA TGCAGGTTCT TGAGCTCCAA TATCATGGTG GCATAAGCAT GTACATTATG 
CTGCCTGAGG ATGGCCTATG TGAAATTGAA AGCAAGCTGA GTTTCCAGAA TCTGATGGAC 
TGGACCAATA GGAGGAAAAT GAAATCTCAG TATGTGAACG TGTTTCTCCC CCAGTTCAAG 
ATAGAGAAGA ATTATGAAAT GACGCACCAC TTGAAATCCT TAGGCTTGAA AGATATCTTT 
GATGAGTCCA GTGCAGATCT CTCTGGAATT GCCTCTGGAG GTCGTCTCTA CGTATCAAAG 
CTAATGCACA AGTCATTCAT AGAGGTCTCA GAGGAGGGCA CTGAAGCCAC TGCTGCCACA 
GAAAATAACA TTGTTGAAAA GCAGCTTCCT GAGTCCACAG TGTTCAGAGC CGACCGCCCC 
TTTCTGTTTG TCATCAAGAA GAATGACATC ATCTTATTTA CTGGCAAAGT CTCTTGTCCT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_081824.1
CDS	63..1205
Translation	MASLAAANAEFGFDLFREMDSSQGNGNVFFSSLSIFTALTLIRLGARGDCARQIDKALHFNIPSRQGNSSNNQPGLQYQLKRVLADINSSHKDYELSIATGVFAEKVYDFHKNYIECAENLYNAKVERVDFTNDVQDTRFKINKWIENETHGKIKKVLGDSSLSSSAVMVLVNAVYFKGKWKSAFTKTDTLSCRFRSPTCPGKVVNMMHQERRFNLSTIQQPPMQVLELQYHGGISMYIMLPEDGLCEIESKLSFQNLMDWTNRRKMKSQYVNVFLPQFKIEKNYEMTHHLKSLGLKDIFDESSADLSGIASGGRLYVSKLMHKSFIEVSEEGTEATAATENNIVEKQLPESTVFRADRPFLFVIKKNDIILFTGKVSCP

Target ORF information:

RefSeq Version	NM_027548.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus serine (or cysteine) peptidase inhibitor, clade B, member 7 (Serpinb7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_027548.3

ORF Insert Sequence:

ATGGCCTCCC TTGCTGCAGC AAATGCAGAA TTTGGCTTCG ACTTATTCAG AGAGATGGAT 
AGTAGCCAAG GAAATGGAAA TGTATTCTTC TCTTCCCTGA GCATCTTCAC TGCCCTGACC 
CTAATCCGTC TGGGTGCTCG AGGTGACTGT GCACGTCAGA TTGACAAGGC ACTGCACTTT 
AACATACCAT CAAGACAAGG AAACTCATCT AATAATCAGC CAGGACTTCA GTATCAATTG 
AAAAGAGTTC TTGCTGACAT AAACTCATCT CATAAGGATT ATGAACTCAG CATTGCCACT 
GGAGTTTTTG CAGAAAAAGT CTATGACTTT CATAAGAACT ACATTGAGTG TGCTGAAAAC 
TTATACAATG CTAAAGTGGA AAGAGTTGAC TTCACAAATG ATGTACAAGA TACCAGATTT 
AAAATTAATA AATGGATTGA AAATGAGACA CATGGAAAGA TCAAGAAGGT GTTGGGCGAC 
AGCAGCCTCA GCTCGTCGGC TGTCATGGTG CTGGTGAACG CTGTTTACTT CAAAGGCAAA 
TGGAAATCGG CCTTCACCAA GACTGATACC CTCAGTTGCC GTTTTAGGTC TCCCACGTGT 
CCTGGAAAAG TAGTTAATAT GATGCATCAA GAACGGCGGT TCAATTTGTC TACCATTCAG 
CAGCCACCAA TGCAGGTTCT TGAGCTCCAA TATCATGGTG GCATAAGCAT GTACATTATG 
CTGCCTGAGG ATGGCCTATG TGAAATTGAA AGCAAGCTGA GTTTCCAGAA TCTGATGGAC 
TGGACCAATA GGAGGAAAAT GAAATCTCAG TATGTGAACG TGTTTCTCCC CCAGTTCAAG 
ATAGAGAAGA ATTATGAAAT GACGCACCAC TTGAAATCCT TAGGCTTGAA AGATATCTTT 
GATGAGTCCA GTGCAGATCT CTCTGGAATT GCCTCTGGAG GTCGTCTCTA CGTATCAAAG 
CTAATGCACA AGTCATTCAT AGAGGTCTCA GAGGAGGGCA CTGAAGCCAC TGCTGCCACA 
GAAAATAACA TTGTTGAAAA GCAGCTTCCT GAGTCCACAG TGTTCAGAGC CGACCGCCCC 
TTTCTGTTTG TCATCAAGAA GAATGACATC ATCTTATTTA CTGGCAAAGT CTCTTGTCCT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Update of the human and mouse SERPIN gene superfamily.
Human genomics722(2013 Oct)
Heit C,Jackson BC,McAndrews M,Wright MW,Thompson DC,Silverman GA,Nebert DW,Vasiliou V

Delivery of megsin siRNA plasmid reveals therapeutic potential against diabetic nephropathy by down-regulating p27(kip1) level.
Journal of nephrology25(3)418-25(2012 May-Jun)
Liu M,Zhang Y,Chi Y,Zhai S,Wang B,Shi Y,Li Y

A severe diabetic nephropathy model with early development of nodule-like lesions induced by megsin overexpression in RAGE/iNOS transgenic mice.
Diabetes55(2)356-66(2006 Feb)
Inagi R,Yamamoto Y,Nangaku M,Usuda N,Okamato H,Kurokawa K,van Ypersele de Strihou C,Yamamoto H,Miyata T

Comparative genomic analysis of the clade B serpin cluster at human chromosome 18q21: amplification within the mouse squamous cell carcinoma antigen gene locus.
Genomics84(1)176-84(2004 Jul)
Askew DJ,Askew YS,Kato Y,Turner RF,Dewar K,Lehoczky J,Silverman GA