Serpinb7 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Serpinb7
Entrez Gene ID	117092
Full Name	serpin family B member 7
Synonyms	Megsin
General protein information	Preferred Names serpin family B member 7 Names serpin B7 serine (or cysteine) peptidase inhibitor, clade B, member 7 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 7 serine (or cysteine) proteinase inhibitor, clade B, member 7 serpin peptidase inhibitor, clade B (ovalbumin), member 7
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 13 Map Location: 13p11
Summary	serine protease inhibitor possibly involved in modulating extracellular matrix deposition [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006249629.1	XP_006249691.1	serpin B7 isoform X1
XM_008769420.2	XP_008767642.1	serpin B7 isoform X1
NM_130404.1	NP_569088.1	serpin B7

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Serpinb7	NP_081824.1
Homo sapiens (human)	SERPINB7	NP_003775.1
Pan troglodytes (chimpanzee)	SERPINB7	XP_524011.2
Rattus norvegicus (Norway rat)	Serpinb7	NP_569088.1
	SERPINB7	XP_002801007.1
Canis lupus familiaris (dog)	SERPINB7	XP_005615395.1
Bos taurus (cattle)	SERPINB7	NP_001192689.1

Gene Ontology
Bibliography

Related articles in PubMed

Overexpression of megsin induces mesangial cell proliferation and excretion of type IV collagen in vitro.
Xia Y, Zhang Y, Shi W, Liu S, Chen Y, Liang X, Ye Z
Cellular immunology271(2)413-7(2011)

Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping.
McDonough CW, Bostrom MA, Lu L, Hicks PJ, Langefeld CD, Divers J, Mychaleckyj JC, Freedman BI, Bowden DW
Human genetics126(6)805-17(2009 Dec)

The role of megsin, a serine protease inhibitor, in diabetic mesangial matrix accumulation.
Ohtomo S, Nangaku M, Izuhara Y, Yamada N, Dan T, Mori T, Ito S, van Ypersele de Strihou C, Miyata T
Kidney international74(6)768-74(2008 Sep)

Megsin 2093T-2180C haplotype at the 3' untranslated region is associated with poor renal survival in Korean IgA nephropathy patients.
Lim CS, Kim SM, Oh YK, Joo KW, Kim YS, Han JS, Kim S
Clinical nephrology70(2)101-9(2008 Aug)

[Association of single nucleotide polymorphism of megsin gene with IgA nephropathy].
Wang ZH, Chen N, Pan XX, Ren H, Wang WM, Zhang W, Hao CL, Zhu J, Lu Y, Han B
Zhonghua yi xue za zhi86(19)1337-41(2006 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

over-expression of megsin induced incorporation of [(3)H]thymidine in mesangial cells and PDGF-BB, TGF-beta1 upregulation
Title: Overexpression of megsin induces mesangial cell proliferation and excretion of type IV collagen in vitro.

high glucose per se induces megsin expression both in vivo in a model of type II diabetic nephropathy and in vitro in cultured mesangial cells, in which it also inhibits total MMP-2 and MMP-9 activities and plasmin enzymatic activity.
Title: The role of megsin, a serine protease inhibitor, in diabetic mesangial matrix accumulation.

The following Serpinb7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Serpinb7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa00348	NM_130404.1 Latest version!	Rattus norvegicus serpin family B member 7 (Serpinb7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa35206	XM_006249629.1 Latest version!	Rattus norvegicus serpin family B member 7 (Serpinb7), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa35206	XM_008769420.2 Latest version!	Rattus norvegicus serpin family B member 7 (Serpinb7), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Serpinb7 ( NM_130404.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_569088.1 Rattus norvegicus serpin family B member 7 (Serpinb7), mRNA.

Price & Availability↑

CloneID	ORa00348
Clone ID Related Accession (Same CDS sequence)	NM_130404.1
Accession Version	NM_130404.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1143bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-26
Organism	Rattus norvegicus(Norway rat)
Product	serpin B7
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF105329.1. ##Evidence-Data-START## Transcript exon combination :: AF105329.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689602 [ECO:0000348] ##Evidence-Data-END##

ATGGCCTCCC TTGCTGCAGC AAATGCAGAA TTTGGCTTCG ACTTATTCAG AGAGATGGAT 
AGTAGTCAAG GAAACGGAAA TGTATTCTTC TCTTCCCTGA GCATCTTCAC TGCCCTGAGC 
CTAATCCGTT TGGGTGCTCG AGGTGACTGT GCACGTCAGA TTGACAAGGC CCTGCACTTT 
ATCTCCCCAT CAAGACAAGG GAATTCATCG AACAGTCAGC TAGGACTGCA ATATCAATTG 
AAAAGAGTTC TTGCTGACAT AAACTCATCT CATAAGGATT ATGAACTCAG CATTGCCAAT 
GGAGTTTTTG CAGAGAAAGT ATTTGATTTT CATAAGAGCT ATATGGAGTG TGCTGAAAAC 
TTATACAATG CTAAAGTGGA AAGAGTTGAT TTTACAAATG ATATACAAGA AACCAGATTT 
AAAATTAATA AATGGATTGA AAATGAAACA CATGGCAAAA TCAAGAAGGT GTTGGGGGAC 
AGCAGCCTCA GCTCATCAGC TGTCATGGTG CTAGTGAATG CTGTTTACTT CAAAGGCAAG 
TGGAAATCGG CCTTCACCAA GAGTGATACC CTCAGTTGCC ATTTCAGGTC TCCCAGCGGT 
CCTGGAAAAG CAGTTAATAT GATGCATCAA GAACGGAGGT TCAATTTGTC TACCATTCAG 
GAGCCACCAA TGCAGATTCT TGAGCTACAA TATCATGGTG GCATAAGCAT GTACATCATG 
TTGCCCGAGG ATGACCTATC CGAAATTGAA AGCAAGCTGA GTTTCCAGAA TCTAATGGAC 
TGGACAAATA GCAGGAAGAT GAAATCTCAG TATGTGAATG TGTTTCTCCC CCAGTTCAAG 
ATAGAGAAAG ATTATGAAAT GAGGAGCCAC TTGAAATCTG TAGGCTTGGA AGACATCTTT 
GTTGAGTCCA GGGCTGATCT GTCTGGAATT GCCTCTGGAG GTCGTCTCTA TGTATCAAAG 
CTAATGCACA AGTCCCTCAT AGAGGTCTCA GAAGAAGGCA CCGAGGCAAC TGCTGCCACA 
GAAAGTAACA TCGTTGAAAA GCTACTTCCT GAATCCACGG TGTTCAGAGC TGACCGCCCC 
TTTCTGTTTG TCATTAGGAA GAATGGCATC ATCTTATTTA CTGGCAAAGT CTCGTGTCCT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_569088.1
CDS	1..1143
Translation	MASLAAANAEFGFDLFREMDSSQGNGNVFFSSLSIFTALSLIRLGARGDCARQIDKALHFISPSRQGNSSNSQLGLQYQLKRVLADINSSHKDYELSIANGVFAEKVFDFHKSYMECAENLYNAKVERVDFTNDIQETRFKINKWIENETHGKIKKVLGDSSLSSSAVMVLVNAVYFKGKWKSAFTKSDTLSCHFRSPSGPGKAVNMMHQERRFNLSTIQEPPMQILELQYHGGISMYIMLPEDDLSEIESKLSFQNLMDWTNSRKMKSQYVNVFLPQFKIEKDYEMRSHLKSVGLEDIFVESRADLSGIASGGRLYVSKLMHKSLIEVSEEGTEATAATESNIVEKLLPESTVFRADRPFLFVIRKNGIILFTGKVSCP

Target ORF information:

RefSeq Version	NM_130404.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus serpin family B member 7 (Serpinb7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_130404.1

ORF Insert Sequence:

ATGGCCTCCC TTGCTGCAGC AAATGCAGAA TTTGGCTTCG ACTTATTCAG AGAGATGGAT 
AGTAGTCAAG GAAACGGAAA TGTATTCTTC TCTTCCCTGA GCATCTTCAC TGCCCTGAGC 
CTAATCCGTT TGGGTGCTCG AGGTGACTGT GCACGTCAGA TTGACAAGGC CCTGCACTTT 
ATCTCCCCAT CAAGACAAGG GAATTCATCG AACAGTCAGC TAGGACTGCA ATATCAATTG 
AAAAGAGTTC TTGCTGACAT AAACTCATCT CATAAGGATT ATGAACTCAG CATTGCCAAT 
GGAGTTTTTG CAGAGAAAGT ATTTGATTTT CATAAGAGCT ATATGGAGTG TGCTGAAAAC 
TTATACAATG CTAAAGTGGA AAGAGTTGAT TTTACAAATG ATATACAAGA AACCAGATTT 
AAAATTAATA AATGGATTGA AAATGAAACA CATGGCAAAA TCAAGAAGGT GTTGGGGGAC 
AGCAGCCTCA GCTCATCAGC TGTCATGGTG CTAGTGAATG CTGTTTACTT CAAAGGCAAG 
TGGAAATCGG CCTTCACCAA GAGTGATACC CTCAGTTGCC ATTTCAGGTC TCCCAGCGGT 
CCTGGAAAAG CAGTTAATAT GATGCATCAA GAACGGAGGT TCAATTTGTC TACCATTCAG 
GAGCCACCAA TGCAGATTCT TGAGCTACAA TATCATGGTG GCATAAGCAT GTACATCATG 
TTGCCCGAGG ATGACCTATC CGAAATTGAA AGCAAGCTGA GTTTCCAGAA TCTAATGGAC 
TGGACAAATA GCAGGAAGAT GAAATCTCAG TATGTGAATG TGTTTCTCCC CCAGTTCAAG 
ATAGAGAAAG ATTATGAAAT GAGGAGCCAC TTGAAATCTG TAGGCTTGGA AGACATCTTT 
GTTGAGTCCA GGGCTGATCT GTCTGGAATT GCCTCTGGAG GTCGTCTCTA TGTATCAAAG 
CTAATGCACA AGTCCCTCAT AGAGGTCTCA GAAGAAGGCA CCGAGGCAAC TGCTGCCACA 
GAAAGTAACA TCGTTGAAAA GCTACTTCCT GAATCCACGG TGTTCAGAGC TGACCGCCCC 
TTTCTGTTTG TCATTAGGAA GAATGGCATC ATCTTATTTA CTGGCAAAGT CTCGTGTCCT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Serpinb7 ( XM_006249629.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006249691.1 Rattus norvegicus serpin family B member 7 (Serpinb7), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa35206
Clone ID Related Accession (Same CDS sequence)	XM_006249629.1 , XM_008769420.2
Accession Version	XM_006249629.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1143bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	serpin B7 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005112.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCTCCC TTGCTGCAGC AAATGCAGAA TTTGGCTTCG ACTTATTCAG AGAGATGGAT 
AGTAGTCAAG GAAACGGAAA TGTATTCTTC TCTTCCCTGA GCATCTTCAC TGCCCTGAGC 
CTAATCCGTT TGGGTGCTCG AGGTGACTGT GCACGTCAGA TTGACAAGGC CCTGCACTTT 
ATCTCCCCAT CAAGACAAGG GAATTCATCG AACAGTCAGC TAGGACTGCA ATATCAATTG 
AAAAGAGTTC TTGCTGACAT AAACTCATCT CATAAGGATT ATGAACTCAG CATTGCCAAT 
GGAGTTTTTG CAGAGAAAGT ATTTGATTTT CATAAGAGCT ATATGGAGTG TGCTGAAAAC 
TTATACAATG CTAAAGTGGA AAGAGTTGAC TTTACAAATG ATATACAAGA AACCAGATTT 
AAAATTAATA AATGGATTGA AAATGAAACA CATGGCAAAA TCAAGAAGGT GTTGGGGGAC 
AGCAGCCTCA GCTCATCAGC TGTCATGGTG CTAGTGAATG CTGTTTACTT CAAAGGCAAG 
TGGAAATCGG CCTTCACCAA GAGTGATACC CTCAGTTGCC ATTTCAGGTC TCCCACGTGT 
CCTGGAAAAG CAGTTAATAT GATGCATCAA GAACGGAGGT TCAATTTGTC TACCATTCAG 
GAGCCACCAA TGCAGATTCT TGAGCTACAA TATCATGGTG GCATAAGCAT GTACATCATG 
TTGCCCGAGG ATGACCTATC CGAAATTGAA AGCAAGCTGA GTTTCCAGAA TCTAATGGAC 
TGGACAAATA GCAGGAAGAT GAAATCTCAG TATGTGAATG TGTTTCTCCC CCAGTTCAAG 
ATAGAGAAAG ATTATGAAAT GAGGAGCCAC TTGAAATCTG TAGGCTTGGA AGACATCTTT 
GTTGAGTCCA GGGCTGATCT GTCTGGAATT GCCTCTGGAG GTCGTCTCTA TGTATCAAAG 
CTAATGCACA AGTCCCTCAT AGAGGTCTCA GAAGAAGGCA CCGAGGCAAC TGCTGCCACA 
GAAAGTAACA TCGTTGAAAA GCTACTTCCT GAATCCACGG TGTTCAGAGC TGACCGCCCC 
TTTCTGTTTG TCATTAGGAA GAATGGCATC ATCTTATTTA CTGGCAAAGT CTCGTGTCCT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006249691.1
CDS	81..1223
Translation	MASLAAANAEFGFDLFREMDSSQGNGNVFFSSLSIFTALSLIRLGARGDCARQIDKALHFISPSRQGNSSNSQLGLQYQLKRVLADINSSHKDYELSIANGVFAEKVFDFHKSYMECAENLYNAKVERVDFTNDIQETRFKINKWIENETHGKIKKVLGDSSLSSSAVMVLVNAVYFKGKWKSAFTKSDTLSCHFRSPTCPGKAVNMMHQERRFNLSTIQEPPMQILELQYHGGISMYIMLPEDDLSEIESKLSFQNLMDWTNSRKMKSQYVNVFLPQFKIEKDYEMRSHLKSVGLEDIFVESRADLSGIASGGRLYVSKLMHKSLIEVSEEGTEATAATESNIVEKLLPESTVFRADRPFLFVIRKNGIILFTGKVSCP

Target ORF information:

RefSeq Version	XM_006249629.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus serpin family B member 7 (Serpinb7), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006249629.1

ORF Insert Sequence:

ATGGCCTCCC TTGCTGCAGC AAATGCAGAA TTTGGCTTCG ACTTATTCAG AGAGATGGAT 
AGTAGTCAAG GAAACGGAAA TGTATTCTTC TCTTCCCTGA GCATCTTCAC TGCCCTGAGC 
CTAATCCGTT TGGGTGCTCG AGGTGACTGT GCACGTCAGA TTGACAAGGC CCTGCACTTT 
ATCTCCCCAT CAAGACAAGG GAATTCATCG AACAGTCAGC TAGGACTGCA ATATCAATTG 
AAAAGAGTTC TTGCTGACAT AAACTCATCT CATAAGGATT ATGAACTCAG CATTGCCAAT 
GGAGTTTTTG CAGAGAAAGT ATTTGATTTT CATAAGAGCT ATATGGAGTG TGCTGAAAAC 
TTATACAATG CTAAAGTGGA AAGAGTTGAC TTTACAAATG ATATACAAGA AACCAGATTT 
AAAATTAATA AATGGATTGA AAATGAAACA CATGGCAAAA TCAAGAAGGT GTTGGGGGAC 
AGCAGCCTCA GCTCATCAGC TGTCATGGTG CTAGTGAATG CTGTTTACTT CAAAGGCAAG 
TGGAAATCGG CCTTCACCAA GAGTGATACC CTCAGTTGCC ATTTCAGGTC TCCCACGTGT 
CCTGGAAAAG CAGTTAATAT GATGCATCAA GAACGGAGGT TCAATTTGTC TACCATTCAG 
GAGCCACCAA TGCAGATTCT TGAGCTACAA TATCATGGTG GCATAAGCAT GTACATCATG 
TTGCCCGAGG ATGACCTATC CGAAATTGAA AGCAAGCTGA GTTTCCAGAA TCTAATGGAC 
TGGACAAATA GCAGGAAGAT GAAATCTCAG TATGTGAATG TGTTTCTCCC CCAGTTCAAG 
ATAGAGAAAG ATTATGAAAT GAGGAGCCAC TTGAAATCTG TAGGCTTGGA AGACATCTTT 
GTTGAGTCCA GGGCTGATCT GTCTGGAATT GCCTCTGGAG GTCGTCTCTA TGTATCAAAG 
CTAATGCACA AGTCCCTCAT AGAGGTCTCA GAAGAAGGCA CCGAGGCAAC TGCTGCCACA 
GAAAGTAACA TCGTTGAAAA GCTACTTCCT GAATCCACGG TGTTCAGAGC TGACCGCCCC 
TTTCTGTTTG TCATTAGGAA GAATGGCATC ATCTTATTTA CTGGCAAAGT CTCGTGTCCT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Serpinb7 ( XM_008769420.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008767642.1 Rattus norvegicus serpin family B member 7 (Serpinb7), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa35206
Clone ID Related Accession (Same CDS sequence)	XM_006249629.1 , XM_008769420.2
Accession Version	XM_008769420.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1143bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	serpin B7 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005112.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008769420.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCTCCC TTGCTGCAGC AAATGCAGAA TTTGGCTTCG ACTTATTCAG AGAGATGGAT 
AGTAGTCAAG GAAACGGAAA TGTATTCTTC TCTTCCCTGA GCATCTTCAC TGCCCTGAGC 
CTAATCCGTT TGGGTGCTCG AGGTGACTGT GCACGTCAGA TTGACAAGGC CCTGCACTTT 
ATCTCCCCAT CAAGACAAGG GAATTCATCG AACAGTCAGC TAGGACTGCA ATATCAATTG 
AAAAGAGTTC TTGCTGACAT AAACTCATCT CATAAGGATT ATGAACTCAG CATTGCCAAT 
GGAGTTTTTG CAGAGAAAGT ATTTGATTTT CATAAGAGCT ATATGGAGTG TGCTGAAAAC 
TTATACAATG CTAAAGTGGA AAGAGTTGAC TTTACAAATG ATATACAAGA AACCAGATTT 
AAAATTAATA AATGGATTGA AAATGAAACA CATGGCAAAA TCAAGAAGGT GTTGGGGGAC 
AGCAGCCTCA GCTCATCAGC TGTCATGGTG CTAGTGAATG CTGTTTACTT CAAAGGCAAG 
TGGAAATCGG CCTTCACCAA GAGTGATACC CTCAGTTGCC ATTTCAGGTC TCCCACGTGT 
CCTGGAAAAG CAGTTAATAT GATGCATCAA GAACGGAGGT TCAATTTGTC TACCATTCAG 
GAGCCACCAA TGCAGATTCT TGAGCTACAA TATCATGGTG GCATAAGCAT GTACATCATG 
TTGCCCGAGG ATGACCTATC CGAAATTGAA AGCAAGCTGA GTTTCCAGAA TCTAATGGAC 
TGGACAAATA GCAGGAAGAT GAAATCTCAG TATGTGAATG TGTTTCTCCC CCAGTTCAAG 
ATAGAGAAAG ATTATGAAAT GAGGAGCCAC TTGAAATCTG TAGGCTTGGA AGACATCTTT 
GTTGAGTCCA GGGCTGATCT GTCTGGAATT GCCTCTGGAG GTCGTCTCTA TGTATCAAAG 
CTAATGCACA AGTCCCTCAT AGAGGTCTCA GAAGAAGGCA CCGAGGCAAC TGCTGCCACA 
GAAAGTAACA TCGTTGAAAA GCTACTTCCT GAATCCACGG TGTTCAGAGC TGACCGCCCC 
TTTCTGTTTG TCATTAGGAA GAATGGCATC ATCTTATTTA CTGGCAAAGT CTCGTGTCCT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008767642.1
CDS	128..1270
Translation	MASLAAANAEFGFDLFREMDSSQGNGNVFFSSLSIFTALSLIRLGARGDCARQIDKALHFISPSRQGNSSNSQLGLQYQLKRVLADINSSHKDYELSIANGVFAEKVFDFHKSYMECAENLYNAKVERVDFTNDIQETRFKINKWIENETHGKIKKVLGDSSLSSSAVMVLVNAVYFKGKWKSAFTKSDTLSCHFRSPTCPGKAVNMMHQERRFNLSTIQEPPMQILELQYHGGISMYIMLPEDDLSEIESKLSFQNLMDWTNSRKMKSQYVNVFLPQFKIEKDYEMRSHLKSVGLEDIFVESRADLSGIASGGRLYVSKLMHKSLIEVSEEGTEATAATESNIVEKLLPESTVFRADRPFLFVIRKNGIILFTGKVSCP

Target ORF information:

RefSeq Version	XM_008769420.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus serpin family B member 7 (Serpinb7), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008769420.2

ORF Insert Sequence:

ATGGCCTCCC TTGCTGCAGC AAATGCAGAA TTTGGCTTCG ACTTATTCAG AGAGATGGAT 
AGTAGTCAAG GAAACGGAAA TGTATTCTTC TCTTCCCTGA GCATCTTCAC TGCCCTGAGC 
CTAATCCGTT TGGGTGCTCG AGGTGACTGT GCACGTCAGA TTGACAAGGC CCTGCACTTT 
ATCTCCCCAT CAAGACAAGG GAATTCATCG AACAGTCAGC TAGGACTGCA ATATCAATTG 
AAAAGAGTTC TTGCTGACAT AAACTCATCT CATAAGGATT ATGAACTCAG CATTGCCAAT 
GGAGTTTTTG CAGAGAAAGT ATTTGATTTT CATAAGAGCT ATATGGAGTG TGCTGAAAAC 
TTATACAATG CTAAAGTGGA AAGAGTTGAC TTTACAAATG ATATACAAGA AACCAGATTT 
AAAATTAATA AATGGATTGA AAATGAAACA CATGGCAAAA TCAAGAAGGT GTTGGGGGAC 
AGCAGCCTCA GCTCATCAGC TGTCATGGTG CTAGTGAATG CTGTTTACTT CAAAGGCAAG 
TGGAAATCGG CCTTCACCAA GAGTGATACC CTCAGTTGCC ATTTCAGGTC TCCCACGTGT 
CCTGGAAAAG CAGTTAATAT GATGCATCAA GAACGGAGGT TCAATTTGTC TACCATTCAG 
GAGCCACCAA TGCAGATTCT TGAGCTACAA TATCATGGTG GCATAAGCAT GTACATCATG 
TTGCCCGAGG ATGACCTATC CGAAATTGAA AGCAAGCTGA GTTTCCAGAA TCTAATGGAC 
TGGACAAATA GCAGGAAGAT GAAATCTCAG TATGTGAATG TGTTTCTCCC CCAGTTCAAG 
ATAGAGAAAG ATTATGAAAT GAGGAGCCAC TTGAAATCTG TAGGCTTGGA AGACATCTTT 
GTTGAGTCCA GGGCTGATCT GTCTGGAATT GCCTCTGGAG GTCGTCTCTA TGTATCAAAG 
CTAATGCACA AGTCCCTCAT AGAGGTCTCA GAAGAAGGCA CCGAGGCAAC TGCTGCCACA 
GAAAGTAACA TCGTTGAAAA GCTACTTCCT GAATCCACGG TGTTCAGAGC TGACCGCCCC 
TTTCTGTTTG TCATTAGGAA GAATGGCATC ATCTTATTTA CTGGCAAAGT CTCGTGTCCT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Overexpression of megsin induces mesangial cell proliferation and excretion of type IV collagen in vitro.
Cellular immunology271(2)413-7(2011)
Xia Y,Zhang Y,Shi W,Liu S,Chen Y,Liang X,Ye Z

Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping.
Human genetics126(6)805-17(2009 Dec)
McDonough CW,Bostrom MA,Lu L,Hicks PJ,Langefeld CD,Divers J,Mychaleckyj JC,Freedman BI,Bowden DW

The role of megsin, a serine protease inhibitor, in diabetic mesangial matrix accumulation.
Kidney international74(6)768-74(2008 Sep)
Ohtomo S,Nangaku M,Izuhara Y,Yamada N,Dan T,Mori T,Ito S,van Ypersele de Strihou C,Miyata T

Megsin 2093T-2180C haplotype at the 3' untranslated region is associated with poor renal survival in Korean IgA nephropathy patients.
Clinical nephrology70(2)101-9(2008 Aug)
Lim CS,Kim SM,Oh YK,Joo KW,Kim YS,Han JS,Kim S

[Association of single nucleotide polymorphism of megsin gene with IgA nephropathy].
Zhonghua yi xue za zhi86(19)1337-41(2006 May)
Wang ZH,Chen N,Pan XX,Ren H,Wang WM,Zhang W,Hao CL,Zhu J,Lu Y,Han B

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Serpinb7 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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