Vsx1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Vsx1
Entrez Gene ID	114889
Full Name	visual system homeobox 1
Synonyms	CHX10-like
General protein information	Preferred Names visual system homeobox 1 Names visual system homeobox 1 homeodomain protein RINX retinal inner nuclear layer homeobox protein transcription factor VSX1 visual system homeobox 1 homolog
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 2 Map Location: 2 G3\|2 74.74 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_054068.2	NP_473409.1	visual system homeobox 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	VSX1	XP_001149985.1
Canis lupus familiaris (dog)	VSX1	XP_850138.1
Rattus norvegicus (Norway rat)	Vsx1	NP_001103016.1
Gallus gallus (chicken)	VSX1	NP_990100.1
	LOC715973	XP_002798304.1
Bos taurus (cattle)	VSX1	NP_777192.1
Mus musculus (house mouse)	Vsx1	NP_473409.1
Homo sapiens (human)	VSX1	NP_055403.2

Gene Ontology
Bibliography

Related articles in PubMed

Gsg1, Trnp1, and Tmem215 Mark Subpopulations of Bipolar Interneurons in the Mouse Retina.
Park KU, Randazzo G, Jones KL, Brzezinski JA 4th
Investigative ophthalmology & visual science58(2)1137-1150(2017 02)

Chx10 Consolidates V2a Interneuron Identity through Two Distinct Gene Repression Modes.
Clovis YM, Seo SY, Kwon JS, Rhee JC, Yeo S, Lee JW, Lee S, Lee SK
Cell reports16(6)1642-1652(2016 08)

Vsx1 Transiently Defines an Early Intermediate V2 Interneuron Precursor Compartment in the Mouse Developing Spinal Cord.
Francius C, Hidalgo-Figueroa M, Debrulle S, Pelosi B, Rucchin V, Ronellenfitch K, Panayiotou E, Makrides N, Misra K, Harris A, Hassani H, Schakman O, Parras C, Xiang M, Malas S, Chow RL, Clotman F
Frontiers in molecular neuroscience9145(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These findings reveal a role for Vsx1 in type 3a bipolar cells and suggest that Vsx1 function is required transiently in this cell type during the postnatal period.
Title: Requirement for the paired-like homeodomain transcription factor VSX1 in type 3a mouse retinal bipolar cell terminal differentiation.

findings indicate that Vsx1 regulates terminal gene expression in Type 7 bipolar cells and is necessary for proper ON visual signaling within a directionally selective circuit.
Title: Vsx1 regulates terminal differentiation of type 7 ON bipolar cells.

Transcription factor visual system homeobox 1 homolog (Vsx1) controls specific aspects of visual function in the neural circuitry of the mammalian retina.
Title: Genetic control of circuit function: Vsx1 and Irx5 transcription factors regulate contrast adaptation in the mouse retina.

Although Vsx1 mRNA is upregulated in Chx10/Vsx2 deficient RPCs, Vsx1 does not genetically compensate for loss of Chx10/Vsx2, demonstrating that Prd-L:CVC genes, although important, are not absolutely required to initiate retinal development.
Title: Negative regulation of Vsx1 by its paralog Chx10/Vsx2 is conserved in the vertebrate retina.

Vsx1 is required for cone bipolar cell differentiation and regulates photopic vision perception.
Title: Regulation of retinal cone bipolar cell differentiation and photopic vision by the CVC homeobox gene Vsx1.

The following Vsx1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Vsx1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu09548	NM_054068.2 Latest version!	Mus musculus visual system homeobox 1 (Vsx1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Vsx1 ( NM_054068.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_473409.1 Mus musculus visual system homeobox 1 (Vsx1), mRNA.

Price & Availability↑

CloneID	OMu09548
Clone ID Related Accession (Same CDS sequence)	NM_054068.2
Accession Version	NM_054068.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1092bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Mus musculus(house mouse)
Product	visual system homeobox 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC057647.1. On Dec 20, 2003 this sequence version replaced NM_054068.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC057647.1, AK044393.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164132 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACTGGAC GGGATGGGCT TTCGGATGCG CGCTCCAGGA GTAGAGCCCT GGCGCCAGGC 
TGTCCTCCCA CCGGCTCTCG CCTTCGAAGC TTTGCCATCA ATGACCTGCT GGGATTGGAG 
GCAGACCTGC CAACTCCGGC GGAGCCTGGG CTAAGATCCA ACAGCGGAGA TCCAGCGGAG 
GCAATAGGGT CGGGACCGGG ACCGGGGCCA GGACTCTGCG GCTCCTGCCC TGCTCGCGGG 
GCTCTCCCGC TGGGCCTGGG GCTCCTCTGC GGCTTCGGGG CGCAGCCCCC TTCCGCTGCC 
GCCGCCGCTC GTGCGCGCTG CCTGCTCCTC GCCGACCTGC GGCTTCTGCC ATCTGCAGGA 
CCCGAGCCTG CTGTCGCCCA GGGCCCGGTC CACCCGCCGC CTGCGCTCGG CAGCCAGCAG 
CGCAGCGAGA GCGTCTCCAC GTCGGATGGG GACAGTCCAT CTGAAGAAAA GAATGACCCG 
AAGATGTCCC TTATCCTGGG CAAAAGGAAG AAGCGGAGGC ACAGGACGGT TTTCACTGCC 
CATCAACTCG AAGAACTGGA GAAGGCCTTT GGTGAGGCCC ACTACCCTGA CGTGTACGCT 
CGGGAAATGC TGGCTGCGAA AACAGAGCTC CCGGAAGACC GAATACAGGT CTGGTTCCAG 
AACCGGAGGG CCAAGTGGCG TAAGCGAGAG AAGCGCTGGG GTGGCAGCAG TGTGATGGCT 
GAGTACGGGC TCTACGGAGC CATGGTGCGC CACTGCATTC CACTGCCGGA CAGCGTGCTC 
AACTCTGCAG ATAGCCTGCA GGGCTCCTGT GCACCCTGGC TTCTGGGGAT GCATAAAAAG 
TCCACAGGGA TGAGAAAACC AGAAAGTGAA GACAAGTTGG CAGGACTCTG GGAGTTTGAC 
CATCTCAAAA AGGGTGCTAA TAAGGATGAG GATGGACCTG AGAGGGGGCC AGACGAAACA 
ACCCAGAACC CTGAGAATAG CTTGGAGGAT GTGGCCATTG ACCTGTCCAG CTCTTCCAGG 
CAGGAGACTA AGAAAATGCC CCCAGGGTCC AGTACTCAGC TGCCCCAGCC CCCACAGGTG 
GGAGCCTCAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_473409.1
CDS	178..1269
Translation	MTGRDGLSDARSRSRALAPGCPPTGSRLRSFAINDLLGLEADLPTPAEPGLRSNSGDPAEAIGSGPGPGPGLCGSCPARGALPLGLGLLCGFGAQPPSAAAAARARCLLLADLRLLPSAGPEPAVAQGPVHPPPALGSQQRSESVSTSDGDSPSEEKNDPKMSLILGKRKKRRHRTVFTAHQLEELEKAFGEAHYPDVYAREMLAAKTELPEDRIQVWFQNRRAKWRKREKRWGGSSVMAEYGLYGAMVRHCIPLPDSVLNSADSLQGSCAPWLLGMHKKSTGMRKPESEDKLAGLWEFDHLKKGANKDEDGPERGPDETTQNPENSLEDVAIDLSSSSRQETKKMPPGSSTQLPQPPQVGAS

Target ORF information:

RefSeq Version	NM_054068.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus visual system homeobox 1 (Vsx1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_054068.2

ORF Insert Sequence:

ATGACTGGAC GGGATGGGCT TTCGGATGCG CGCTCCAGGA GTAGAGCCCT GGCGCCAGGC 
TGTCCTCCCA CCGGCTCTCG CCTTCGAAGC TTTGCCATCA ATGACCTGCT GGGATTGGAG 
GCAGACCTGC CAACTCCGGC GGAGCCTGGG CTAAGATCCA ACAGCGGAGA TCCAGCGGAG 
GCAATAGGGT CGGGACCGGG ACCGGGGCCA GGACTCTGCG GCTCCTGCCC TGCTCGCGGG 
GCTCTCCCGC TGGGCCTGGG GCTCCTCTGC GGCTTCGGGG CGCAGCCCCC TTCCGCTGCC 
GCCGCCGCTC GTGCGCGCTG CCTGCTCCTC GCCGACCTGC GGCTTCTGCC ATCTGCAGGA 
CCCGAGCCTG CTGTCGCCCA GGGCCCGGTC CACCCGCCGC CTGCGCTCGG CAGCCAGCAG 
CGCAGCGAGA GCGTCTCCAC GTCGGATGGG GACAGTCCAT CTGAAGAAAA GAATGACCCG 
AAGATGTCCC TTATCCTGGG CAAAAGGAAG AAGCGGAGGC ACAGGACGGT TTTCACTGCC 
CATCAACTCG AAGAACTGGA GAAGGCCTTT GGTGAGGCCC ACTACCCTGA CGTGTACGCT 
CGGGAAATGC TGGCTGCGAA AACAGAGCTC CCGGAAGACC GAATACAGGT CTGGTTCCAG 
AACCGGAGGG CCAAGTGGCG TAAGCGAGAG AAGCGCTGGG GTGGCAGCAG TGTGATGGCT 
GAGTACGGGC TCTACGGAGC CATGGTGCGC CACTGCATTC CACTGCCGGA CAGCGTGCTC 
AACTCTGCAG ATAGCCTGCA GGGCTCCTGT GCACCCTGGC TTCTGGGGAT GCATAAAAAG 
TCCACAGGGA TGAGAAAACC AGAAAGTGAA GACAAGTTGG CAGGACTCTG GGAGTTTGAC 
CATCTCAAAA AGGGTGCTAA TAAGGATGAG GATGGACCTG AGAGGGGGCC AGACGAAACA 
ACCCAGAACC CTGAGAATAG CTTGGAGGAT GTGGCCATTG ACCTGTCCAG CTCTTCCAGG 
CAGGAGACTA AGAAAATGCC CCCAGGGTCC AGTACTCAGC TGCCCCAGCC CCCACAGGTG 
GGAGCCTCAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gsg1, Trnp1, and Tmem215 Mark Subpopulations of Bipolar Interneurons in the Mouse Retina.
Investigative ophthalmology & visual science58(2)1137-1150(2017 02)
Park KU,Randazzo G,Jones KL,Brzezinski JA 4th

Chx10 Consolidates V2a Interneuron Identity through Two Distinct Gene Repression Modes.
Cell reports16(6)1642-1652(2016 08)
Clovis YM,Seo SY,Kwon JS,Rhee JC,Yeo S,Lee JW,Lee S,Lee SK

Vsx1 Transiently Defines an Early Intermediate V2 Interneuron Precursor Compartment in the Mouse Developing Spinal Cord.
Frontiers in molecular neuroscience9145(2016)
Francius C,Hidalgo-Figueroa M,Debrulle S,Pelosi B,Rucchin V,Ronellenfitch K,Panayiotou E,Makrides N,Misra K,Harris A,Hassani H,Schakman O,Parras C,Xiang M,Malas S,Chow RL,Clotman F

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Vsx1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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