Cygb cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cygb
Entrez Gene ID	114886
Full Name	cytoglobin
Synonyms	3110001K20Rik,HGb,Staap
General protein information	Preferred Names cytoglobin Names cytoglobin histoglobin stellate cell activation associated protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11\|11 E2

mRNA and Protein(s)

mRNA	Protein	Name
NM_030206.4	NP_084482.1	cytoglobin
XM_011248674.3	XP_011246976.1	cytoglobin isoform X1
XM_011248674.2	XP_011246976.1	cytoglobin isoform X1

Pathways from BioSystems

Homologies

	CYGB	XP_001104888.1
Canis lupus familiaris (dog)	CYGB	NP_001071055.1
Mus musculus (house mouse)	Cygb	NP_084482.1
Danio rerio (zebrafish)	LOC100150453	XP_001923665.2
Xenopus tropicalis (tropical clawed frog)	cygb	NP_001006870.1
Homo sapiens (human)	CYGB	NP_599030.1
Bos taurus (cattle)	CYGB	NP_001193649.1
Gallus gallus (chicken)	CYGB	NP_001008789.1
Rattus norvegicus (Norway rat)	Cygb	NP_570100.1
Pan troglodytes (chimpanzee)	CYGB	XP_003953243.1
Danio rerio (zebrafish)	cygb2	NP_001019395.1

Gene Ontology
Bibliography

Related articles in PubMed

Cytoglobin inhibits migration through PI3K/AKT/mTOR pathway in fibroblast cells.
Demirci S, Do?an A, Apdik H, Tuysuz EC, Gulluoglu S, Bayrak OF, ?ahin F
Molecular and cellular biochemistry437(1-2)133-142(2018 Jan)

The Hemoglobin Homolog Cytoglobin in Smooth Muscle Inhibits Apoptosis and Regulates Vascular Remodeling.
Jourd'heuil FL, Xu H, Reilly T, McKellar K, El Alaoui C, Steppich J, Liu YF, Zhao W, Ginnan R, Conti D, Lopez-Soler R, Asif A, Keller RK, Schwarz JJ, Thanh Thuy LT, Kawada N, Long X, Singer HA, Jourd'heuil D
Arteriosclerosis, thrombosis, and vascular biology37(10)1944-1955(2017 Oct)

Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall.
Liu X, El-Mahdy MA, Boslett J, Varadharaj S, Hemann C, Abdelghany TM, Ismail RS, Little SC, Zhou D, Thuy LT, Kawada N, Zweier JL
Nature communications814807(2017 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Findings provide evidence for the loss of globin-linked neuroprotection to be linked to Alzheimer's disease angiopathogenesis, while raising the possibility of REST/ NRSF being an upstream regulator.
Title: Impaired hypoxic tolerance in APP23 mice: a dysregulation of neuroprotective globin levels.

Thus, the absence of Cygb in pericytes provokes organ abnormalities, possibly via derangement of the nitric oxide and antioxidant defence system and through accelerated cellular senescence.
Title: Absence of cytoglobin promotes multiple organ abnormalities in aged mice.

Studied hepatic stellate cell cytoglobin involvement in acetaminophen induced hepatotoxicity through the regulation of CYP2E1.
Title: Involvement of hepatic stellate cell cytoglobin in acute hepatocyte damage through the regulation of CYP2E1-mediated xenobiotic metabolism.

Cygb, expressed in hepatic stellate cells during liver fibrosis, plays role in cancer development with nonalcoholic steatohepatitis.
Title: Cytoglobin deficiency promotes liver cancer development from hepatosteatosis through activation of the oxidative stress pathway.

cytoglobin serves an important role in muscle repair and regeneration
Title: Cytoglobin modulates myogenic progenitor cell viability and muscle regeneration.

The following Cygb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cygb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu14223	NM_030206.4 Latest version!	Mus musculus cytoglobin (Cygb), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu72401	XM_011248674.3 Latest version!	Mus musculus cytoglobin (Cygb), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OMu72401	XM_011248674.2	Mus musculus cytoglobin (Cygb), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cygb ( NM_030206.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_084482.1 Mus musculus cytoglobin (Cygb), mRNA.

Price & Availability↑

CloneID	OMu14223
Clone ID Related Accession (Same CDS sequence)	NM_030206.4
Accession Version	NM_030206.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 573bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	cytoglobin
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AL607039.25. On Oct 19, 2007 this sequence version replaced NM_030206.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK172475.1, AK019410.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN01164131 [ECO:0000348] ##Evidence-Data-END##

ATGGAGAAAG TGCCGGGCGA CATGGAGATA GAGCGTAGGG AGAGGAGCGA GGAGCTGTCC 
GAGGCGGAGA GGAAGGCGGT TCAGGCTACG TGGGCCCGGC TGTATGCCAA CTGCGAGGAC 
GTGGGGGTGG CCATCCTGGT GAGGTTCTTT GTGAACTTCC CTTCGGCCAA GCAGTACTTC 
AGCCAGTTTA GACACATGGA GGATCCCTTG GAGATGGAGA GGAGTCCCCA GCTGCGGAAG 
CACGCCTGCC GGGTCATGGG GGCCCTCAAC ACTGTCGTGG AGAACCTGCA TGACCCAGAC 
AAGGTATCCT CTGTGCTCGC CCTGGTCGGC AAGGCCCACG CCCTCAAGCA CAAGGTGGAA 
CCTATGTACT TTAAGATTCT CTCTGGGGTC ATTCTGGAGG TGATCGCCGA GGAATTTGCC 
AATGACTTCC CTGTGGAGAC GCAGAAAGCC TGGGCCAAGC TGCGGGGTCT CATCTACAGC 
CACGTGACCG CAGCCTACAA GGAAGTGGGC TGGGTACAGC AGGTCCCCAA CACCACCACC 
CCACCAGCCA CTCTGCCCTC TTCAGGGCCG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_084482.1
CDS	395..967
Translation	MEKVPGDMEIERRERSEELSEAERKAVQATWARLYANCEDVGVAILVRFFVNFPSAKQYFSQFRHMEDPLEMERSPQLRKHACRVMGALNTVVENLHDPDKVSSVLALVGKAHALKHKVEPMYFKILSGVILEVIAEEFANDFPVETQKAWAKLRGLIYSHVTAAYKEVGWVQQVPNTTTPPATLPSSGP

Target ORF information:

RefSeq Version	NM_030206.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus cytoglobin (Cygb), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030206.4

ORF Insert Sequence:

ATGGAGAAAG TGCCGGGCGA CATGGAGATA GAGCGTAGGG AGAGGAGCGA GGAGCTGTCC 
GAGGCGGAGA GGAAGGCGGT TCAGGCTACG TGGGCCCGGC TGTATGCCAA CTGCGAGGAC 
GTGGGGGTGG CCATCCTGGT GAGGTTCTTT GTGAACTTCC CTTCGGCCAA GCAGTACTTC 
AGCCAGTTTA GACACATGGA GGATCCCTTG GAGATGGAGA GGAGTCCCCA GCTGCGGAAG 
CACGCCTGCC GGGTCATGGG GGCCCTCAAC ACTGTCGTGG AGAACCTGCA TGACCCAGAC 
AAGGTATCCT CTGTGCTCGC CCTGGTCGGC AAGGCCCACG CCCTCAAGCA CAAGGTGGAA 
CCTATGTACT TTAAGATTCT CTCTGGGGTC ATTCTGGAGG TGATCGCCGA GGAATTTGCC 
AATGACTTCC CTGTGGAGAC GCAGAAAGCC TGGGCCAAGC TGCGGGGTCT CATCTACAGC 
CACGTGACCG CAGCCTACAA GGAAGTGGGC TGGGTACAGC AGGTCCCCAA CACCACCACC 
CCACCAGCCA CTCTGCCCTC TTCAGGGCCG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cygb ( XM_011248674.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011246976.1 Mus musculus cytoglobin (Cygb), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu72401
Clone ID Related Accession (Same CDS sequence)	XM_011248674.3 , XM_011248674.2
Accession Version	XM_011248674.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 543bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	cytoglobin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_011248674.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGAAAG TGCCGGGCGA CATGGAGATA GAGCGTAGGG AGAGGAGCGA GGAGCTGTCC 
GAGGCGGAGA GGAAGGCGGT TCAGGCTACG TGGGCCCGGC TGTATGCCAA CTGCGAGGAC 
GTGGGGGTGG CCATCCTGGT GAGGTTCTTT GTGAACTTCC CTTCGGCCAA GCAGTACTTC 
AGCCAGTTTA GACACATGGA GGATCCCTTG GAGATGGAGA GGAGTCCCCA GCTGCGGAAG 
CACGCCTGCC GGGTCATGGG GGCCCTCAAC ACTGTCGTGG AGAACCTGCA TGACCCAGAC 
AAGGTATCCT CTGTGCTCGC CCTGGTCGGC AAGGCCCACG CCCTCAAGCA CAAGGTGGAA 
CCTATGTACT TTAAGATTCT CTCTGGGGTC ATTCTGGAGG TGATCGCCGA GGAATTTGCC 
AATGACTTCC CTGTGGAGAC GCAGAAAGCC TGGGCCAAGC TGCGGGGTCT CATCTACAGC 
CACGTGACCG CAGCCTACAA GGAAGTGGGC TGGGTACAGC AGGTCCCCAA CACCACCACG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011246976.1
CDS	586..1128
Translation	MEKVPGDMEIERRERSEELSEAERKAVQATWARLYANCEDVGVAILVRFFVNFPSAKQYFSQFRHMEDPLEMERSPQLRKHACRVMGALNTVVENLHDPDKVSSVLALVGKAHALKHKVEPMYFKILSGVILEVIAEEFANDFPVETQKAWAKLRGLIYSHVTAAYKEVGWVQQVPNTTT

Target ORF information:

RefSeq Version	XM_011248674.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus cytoglobin (Cygb), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011248674.3

ORF Insert Sequence:

ATGGAGAAAG TGCCGGGCGA CATGGAGATA GAGCGTAGGG AGAGGAGCGA GGAGCTGTCC 
GAGGCGGAGA GGAAGGCGGT TCAGGCTACG TGGGCCCGGC TGTATGCCAA CTGCGAGGAC 
GTGGGGGTGG CCATCCTGGT GAGGTTCTTT GTGAACTTCC CTTCGGCCAA GCAGTACTTC 
AGCCAGTTTA GACACATGGA GGATCCCTTG GAGATGGAGA GGAGTCCCCA GCTGCGGAAG 
CACGCCTGCC GGGTCATGGG GGCCCTCAAC ACTGTCGTGG AGAACCTGCA TGACCCAGAC 
AAGGTATCCT CTGTGCTCGC CCTGGTCGGC AAGGCCCACG CCCTCAAGCA CAAGGTGGAA 
CCTATGTACT TTAAGATTCT CTCTGGGGTC ATTCTGGAGG TGATCGCCGA GGAATTTGCC 
AATGACTTCC CTGTGGAGAC GCAGAAAGCC TGGGCCAAGC TGCGGGGTCT CATCTACAGC 
CACGTGACCG CAGCCTACAA GGAAGTGGGC TGGGTACAGC AGGTCCCCAA CACCACCACG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cygb ( XM_011248674.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011246976.1 Mus musculus cytoglobin (Cygb), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu72401
Clone ID Related Accession (Same CDS sequence)	XM_011248674.3 , XM_011248674.2
Accession Version	XM_011248674.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 543bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	cytoglobin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_011248674.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGAAAG TGCCGGGCGA CATGGAGATA GAGCGTAGGG AGAGGAGCGA GGAGCTGTCC 
GAGGCGGAGA GGAAGGCGGT TCAGGCTACG TGGGCCCGGC TGTATGCCAA CTGCGAGGAC 
GTGGGGGTGG CCATCCTGGT GAGGTTCTTT GTGAACTTCC CTTCGGCCAA GCAGTACTTC 
AGCCAGTTTA GACACATGGA GGATCCCTTG GAGATGGAGA GGAGTCCCCA GCTGCGGAAG 
CACGCCTGCC GGGTCATGGG GGCCCTCAAC ACTGTCGTGG AGAACCTGCA TGACCCAGAC 
AAGGTATCCT CTGTGCTCGC CCTGGTCGGC AAGGCCCACG CCCTCAAGCA CAAGGTGGAA 
CCTATGTACT TTAAGATTCT CTCTGGGGTC ATTCTGGAGG TGATCGCCGA GGAATTTGCC 
AATGACTTCC CTGTGGAGAC GCAGAAAGCC TGGGCCAAGC TGCGGGGTCT CATCTACAGC 
CACGTGACCG CAGCCTACAA GGAAGTGGGC TGGGTACAGC AGGTCCCCAA CACCACCACG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011246976.1
CDS	243..785
Translation	MEKVPGDMEIERRERSEELSEAERKAVQATWARLYANCEDVGVAILVRFFVNFPSAKQYFSQFRHMEDPLEMERSPQLRKHACRVMGALNTVVENLHDPDKVSSVLALVGKAHALKHKVEPMYFKILSGVILEVIAEEFANDFPVETQKAWAKLRGLIYSHVTAAYKEVGWVQQVPNTTT

Target ORF information:

RefSeq Version	XM_011248674.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus cytoglobin (Cygb), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011248674.2

ORF Insert Sequence:

ATGGAGAAAG TGCCGGGCGA CATGGAGATA GAGCGTAGGG AGAGGAGCGA GGAGCTGTCC 
GAGGCGGAGA GGAAGGCGGT TCAGGCTACG TGGGCCCGGC TGTATGCCAA CTGCGAGGAC 
GTGGGGGTGG CCATCCTGGT GAGGTTCTTT GTGAACTTCC CTTCGGCCAA GCAGTACTTC 
AGCCAGTTTA GACACATGGA GGATCCCTTG GAGATGGAGA GGAGTCCCCA GCTGCGGAAG 
CACGCCTGCC GGGTCATGGG GGCCCTCAAC ACTGTCGTGG AGAACCTGCA TGACCCAGAC 
AAGGTATCCT CTGTGCTCGC CCTGGTCGGC AAGGCCCACG CCCTCAAGCA CAAGGTGGAA 
CCTATGTACT TTAAGATTCT CTCTGGGGTC ATTCTGGAGG TGATCGCCGA GGAATTTGCC 
AATGACTTCC CTGTGGAGAC GCAGAAAGCC TGGGCCAAGC TGCGGGGTCT CATCTACAGC 
CACGTGACCG CAGCCTACAA GGAAGTGGGC TGGGTACAGC AGGTCCCCAA CACCACCACG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cytoglobin inhibits migration through PI3K/AKT/mTOR pathway in fibroblast cells.
Molecular and cellular biochemistry437(1-2)133-142(2018 Jan)
Demirci S,Do?an A,Apdik H,Tuysuz EC,Gulluoglu S,Bayrak OF,?ahin F

The Hemoglobin Homolog Cytoglobin in Smooth Muscle Inhibits Apoptosis and Regulates Vascular Remodeling.
Arteriosclerosis, thrombosis, and vascular biology37(10)1944-1955(2017 Oct)
Jourd'heuil FL,Xu H,Reilly T,McKellar K,El Alaoui C,Steppich J,Liu YF,Zhao W,Ginnan R,Conti D,Lopez-Soler R,Asif A,Keller RK,Schwarz JJ,Thanh Thuy LT,Kawada N,Long X,Singer HA,Jourd'heuil D

Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall.
Nature communications814807(2017 Apr)
Liu X,El-Mahdy MA,Boslett J,Varadharaj S,Hemann C,Abdelghany TM,Ismail RS,Little SC,Zhou D,Thuy LT,Kawada N,Zweier JL

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Cygb cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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