Lgals2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lgals2
Entrez Gene ID	107753
Full Name	lectin, galactose-binding, soluble 2
Synonyms	2200008F12Rik,AI324147
General protein information	Preferred Names lectin, galactose-binding, soluble 2 Names galectin-2 gal-2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 15 Map Location: 15\|15 E1

mRNA and Protein(s)

mRNA	Protein	Name
NM_025622.3	NP_079898.2	galectin-2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	LGALS2	XP_525588.2
Homo sapiens (human)	LGALS2	NP_006489.1
Bos taurus (cattle)	LGALS2	NP_001244020.1
Rattus norvegicus (Norway rat)	Lgals2	NP_598283.1
Gallus gallus (chicken)	LGALS2	XP_001234400.2
Canis lupus familiaris (dog)	LGALS2	XP_531742.1
Mus musculus (house mouse)	Lgals2	NP_079898.2
Xenopus tropicalis (tropical clawed frog)	lgals2	NP_001116913.1

Gene Ontology
Bibliography

Related articles in PubMed

Identification of the cysteine residue responsible for oxidative inactivation of mouse galectin-2.
Tamura M, Sasai A, Ozawa R, Saito M, Yamamoto K, Takeuchi T, Ohtake K, Tateno H, Hirabayashi J, Kobayashi J, Arata Y
Journal of biochemistry160(4)233-241(2016 Oct)

Galectin expression in healing wounded skin treated with low-temperature plasma: Comparison with treatment by electronical coagulation.
Akimoto Y, Ikehara S, Yamaguchi T, Kim J, Kawakami H, Shimizu N, Hori M, Sakakita H, Ikehara Y
Archives of biochemistry and biophysics60586-94(2016 Sep)

S-nitrosylation of mouse galectin-2 prevents oxidative inactivation by hydrogen peroxide.
Tamura M, Saito M, Yamamoto K, Takeuchi T, Ohtake K, Tateno H, Hirabayashi J, Kobayashi J, Arata Y
Biochemical and biophysical research communications457(4)712-7(2015 Feb)

Galectin-2 induces a proinflammatory, anti-arteriogenic phenotype in monocytes and macrophages.
Y?ld?r?m C, Vogel DY, Hollander MR, Baggen JM, Fontijn RD, Nieuwenhuis S, Haverkamp A, de Vries MR, Quax PH, Garcia-Vallejo JJ, van der Laan AM, Dijkstra CD, van der Pouw Kraan TC, van Royen N, Horrevoets AJ
PloS one10(4)e0124347(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Therefore, Cys(57) is suggested to be responsible for oxidative inactivation of the mGal-2 protein, and protection of the sulfhydryl group of the Cys(57) in mGal-2 by S-nitrosylation is likely important for maintaining mGal-2 protein function in an oxidative environment such as the gastrointestinal tract.
Title: Identification of the cysteine residue responsible for oxidative inactivation of mouse galectin-2.

analysis of the effect of low-temperature plasma on the expression of galectin-1, -2, and -3 in the healing skin compared with those of electrocoagulation conducted with a high-frequency electrical coagulator
Title: Galectin expression in healing wounded skin treated with low-temperature plasma: Comparison with treatment by electronical coagulation.

Gal-2 oxidation by H2O2 resulted in the loss of sugar-binding ability, while S-nitrosylation prevented H2O2-inducted inactivation, presumably by protecting the Cys residue(s) in the protein.
Title: S-nitrosylation of mouse galectin-2 prevents oxidative inactivation by hydrogen peroxide.

Studies of specific knock-out mice show that galectin-2 acts through the CD14/toll-like receptor (TLR)-4 pathway. It leads to increased CD40-positive and reduced CD206-positive macrophages around remodeling collateral arteries.
Title: Galectin-2 induces a proinflammatory, anti-arteriogenic phenotype in monocytes and macrophages.

In normal murine skin, low levels of galectin-2 messenger RNA are detected.
Title: Galectin-2 suppresses contact allergy by inducing apoptosis in activated CD8+ T cells.

The following Lgals2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lgals2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu00783	NM_025622.3 Latest version!	Mus musculus lectin, galactose-binding, soluble 2 (Lgals2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lgals2 ( NM_025622.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_079898.2 Mus musculus lectin, galactose-binding, soluble 2 (Lgals2), mRNA.

Price & Availability↑

CloneID	OMu00783
Clone ID Related Accession (Same CDS sequence)	NM_025622.3
Accession Version	NM_025622.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 393bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Mus musculus(house mouse)
Product	galectin-2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK008636.1 and AW456488.1. On Nov 25, 2009 this sequence version replaced NM_025622.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK008423.1, AK008636.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849376, SAMN00849377 [ECO:0000348] ##Evidence-Data-END##

ATGTCGGAGA AATTTGAGGT CAAAGACCTG AACATGAAAC CAGGGATGTC CCTGAAGATT 
AAAGGCAAGA TCCACAATGA TGTGGACCGC TTCCTCATTA ACCTGGGCCA GGGGAAAGAA 
ACCCTCAACC TGCATTTTAA CCCTCGCTTC GATGAATCCA CCATTGTCTG TAACACCAGT 
GAAGGTGGCC GCTGGGGACA AGAGCAACGA GAAAATCACA TGTGCTTCAG TCCAGGGTCA 
GAGGTCAAGA TCACCATCAC CTTCCAAGAT AAAGACTTCA AGGTGACGTT GCCTGACGGA 
CACCAGCTGA CCTTCCCCAA CAGGCTGGGC CACAACCAAC TGCACTACTT GAGCATGGGT 
GGGCTCCAGA TCTCCTCCTT CAAACTGGAG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_079898.2
CDS	53..445
Translation	MSEKFEVKDLNMKPGMSLKIKGKIHNDVDRFLINLGQGKETLNLHFNPRFDESTIVCNTSEGGRWGQEQRENHMCFSPGSEVKITITFQDKDFKVTLPDGHQLTFPNRLGHNQLHYLSMGGLQISSFKLE

Target ORF information:

RefSeq Version	NM_025622.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus lectin, galactose-binding, soluble 2 (Lgals2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_025622.3

ORF Insert Sequence:

ATGTCGGAGA AATTTGAGGT CAAAGACCTG AACATGAAAC CAGGGATGTC CCTGAAGATT 
AAAGGCAAGA TCCACAATGA TGTGGACCGC TTCCTCATTA ACCTGGGCCA GGGGAAAGAA 
ACCCTCAACC TGCATTTTAA CCCTCGCTTC GATGAATCCA CCATTGTCTG TAACACCAGT 
GAAGGTGGCC GCTGGGGACA AGAGCAACGA GAAAATCACA TGTGCTTCAG TCCAGGGTCA 
GAGGTCAAGA TCACCATCAC CTTCCAAGAT AAAGACTTCA AGGTGACGTT GCCTGACGGA 
CACCAGCTGA CCTTCCCCAA CAGGCTGGGC CACAACCAAC TGCACTACTT GAGCATGGGT 
GGGCTCCAGA TCTCCTCCTT CAAACTGGAG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Identification of the cysteine residue responsible for oxidative inactivation of mouse galectin-2.
Journal of biochemistry160(4)233-241(2016 Oct)
Tamura M,Sasai A,Ozawa R,Saito M,Yamamoto K,Takeuchi T,Ohtake K,Tateno H,Hirabayashi J,Kobayashi J,Arata Y

Galectin expression in healing wounded skin treated with low-temperature plasma: Comparison with treatment by electronical coagulation.
Archives of biochemistry and biophysics60586-94(2016 Sep)
Akimoto Y,Ikehara S,Yamaguchi T,Kim J,Kawakami H,Shimizu N,Hori M,Sakakita H,Ikehara Y

S-nitrosylation of mouse galectin-2 prevents oxidative inactivation by hydrogen peroxide.
Biochemical and biophysical research communications457(4)712-7(2015 Feb)
Tamura M,Saito M,Yamamoto K,Takeuchi T,Ohtake K,Tateno H,Hirabayashi J,Kobayashi J,Arata Y

Galectin-2 induces a proinflammatory, anti-arteriogenic phenotype in monocytes and macrophages.
PloS one10(4)e0124347(2015)
Y?ld?r?m C,Vogel DY,Hollander MR,Baggen JM,Fontijn RD,Nieuwenhuis S,Haverkamp A,de Vries MR,Quax PH,Garcia-Vallejo JJ,van der Laan AM,Dijkstra CD,van der Pouw Kraan TC,van Royen N,Horrevoets AJ

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Lgals2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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