Myzap cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Myzap
Entrez Gene ID	102371
Full Name	myocardial zonula adherens protein
Synonyms	AA407270,AV006038,Gcom1,Gm640,Grinl1a7,Myozap
General protein information	Preferred Names myocardial zonula adherens protein Names myocardial zonula adherens protein GRINL1A complex locus protein 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9\|9 D

mRNA and Protein(s)

mRNA	Protein	Name
NM_001033208.4	NP_001028380.1	myocardial zonula adherens protein precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Gcom1	NP_001014233.1
Mus musculus (house mouse)	Myzap	NP_001028380.1
Pan troglodytes (chimpanzee)	GCOM1	XP_003952711.1
Homo sapiens (human)	MYZAP	NP_001018110.1
Canis lupus familiaris (dog)	MYZAP	XP_005638514.1

Gene Ontology
Bibliography

Related articles in PubMed

Myozap Deficiency Promotes Adverse Cardiac Remodeling via Differential Regulation of Mitogen-activated Protein Kinase/Serum-response Factor and ?-Catenin/GSK-3? Protein Signaling.
Rangrez AY, Eden M, Poyanmehr R, Kuhn C, Stiebeling K, Dierck F, Bernt A, L?llmann-Rauch R, Weiler H, Kirchof P, Frank D, Frey N
The Journal of biological chemistry291(8)4128-43(2016 Feb)

Mice with cardiac-restricted overexpression of Myozap are sensitized to biomechanical stress and develop a protein-aggregate-associated cardiomyopathy.
Frank D, Rangrez AY, Poyanmehr R, Seeger TS, Kuhn C, Eden M, Stiebeling K, Bernt A, Grund C, Franke WW, Frey N
Journal of molecular and cellular cardiology72196-207(2014 Jul)

Genome-wide identification of endothelial cell-enriched genes in the mouse embryo.
Takase H, Matsumoto K, Yamadera R, Kubota Y, Otsu A, Suzuki R, Ishitobi H, Mochizuki H, Kojima T, Takano S, Uchida K, Takahashi S, Ema M
Blood120(4)914-23(2012 Jul)

Myozap, a novel intercalated disc protein, activates serum response factor-dependent signaling and is required to maintain cardiac function in vivo.
Seeger TS, Frank D, Rohr C, Will R, Just S, Grund C, Lyon R, Luedde M, Koegl M, Sheikh F, Rottbauer W, Franke WW, Katus HA, Olson EN, Frey N
Circulation research106(5)880-90(2010 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Cardiac overexpression of Myozap results in cardiomyopathy with hypertrophy and left ventricular dilation.
Title: Mice with cardiac-restricted overexpression of Myozap are sensitized to biomechanical stress and develop a protein-aggregate-associated cardiomyopathy.

Reveal myozap as a previously unrecognized component of a Rho-dependent signaling pathway that links the intercalated disc to cardiac gene regulation.
Title: Myozap, a novel intercalated disc protein, activates serum response factor-dependent signaling and is required to maintain cardiac function in vivo.

The following Myzap gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Myzap cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu12409	NM_001033208.4 Latest version!	Mus musculus myocardial zonula adherens protein (Myzap), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Myzap ( NM_001033208.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001028380.1 Mus musculus myocardial zonula adherens protein (Myzap), mRNA.

Price & Availability↑

CloneID	OMu12409
Clone ID Related Accession (Same CDS sequence)	NM_001033208.4
Accession Version	NM_001033208.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1401bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	myocardial zonula adherens protein precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC107662.9 and AC160560.2. On Oct 19, 2007 this sequence version replaced NM_001033208.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AK146889.1, BC139077.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGCTGCGCT CCACGTCCAC TGTCACCCTG TTCTCAGGTG GCGGCGCCAA GTCGCCTGGA 
ACGCCCAGTA GAAGGGCAAA TGTCTGCAGA CTGCGGCTGA CTGTGCCCCC TGAGAATCCA 
GTGCCACAGC AAACAGAAAA GAAGATCGAA AGGAAAGATC AGCCTCCAGA ACTAAGCAAT 
GGAGAATCTA CCAAGAGGCT CCCTCAGGGT GTTGTCTATG GTGTGGTGCG AAGATCAGAT 
CCCAACCAGC AGAAGGAAAT GGTCGTGTAT GGCTGGTCCA CCAATCAGCT GAAAGAAGAG 
ATGAATTACA TCAAAGACGT GAGGGCCACA CTGGAGAAAG TGAGGAAGCG GATGTATGGA 
GACTATGATG AGATGAGACA GAAGATCCGA CAGCTCACCC AGGACCTGTC GGTGTCCCAT 
GCTCAGCAGG ACTATCTAGA CAGTCACATC CAAGCCCAGG CATCGGCCCT GGATAGCTTC 
AATGCCATGA ATGCGGCATT GGCATCAGAC TCTGTTGGCT TACAGAAAAC CCTTGTGGAC 
GTGACTTTGG AAAATAGCCA TATCAAGGAT CAAATCCGAC ATCTGCAACA GACCTATGAA 
GCATCCATGG ACAAGCTGCG GGAGAAGCAG AGGCAGTTAG AGGCTGCTCA GATGGAAAAC 
CAGCTCCTAA AGATGAGGGT GGAGTCATCG CAAGAAGCCA ATGCTGAGGT GATGCGGGAG 
ATGACGAGAA AGCTGTACAG CCAGTATGAG GAGAAACTGC AGGAGGCACA GCGCAAGCAC 
AGTGCGGAGA AGGAGGTGCT CCTGGAAGAA ACCAATAGCT TTCTGAAGGC CATCGAAGAG 
GCCAATAAGA AGATGGAGGC AGCTGAGCTC AGCCTGGAGG AGAAAGACCA GAAGATCGGG 
GAACTGGACA GGCTGATTGA ACGCATGGAG AAGGAACGGC ATCAGCTCCA GCTCCAGCTC 
CTTGAGCATG AGACAGAAAT GTCAGGGGAG ATGGCAGATT CTGACAAGAA CAGGTACCAG 
CAGCTGGAGG AGGCGTCGGC CAGCCTCCGG GAGCGGATCA GACACCTGGA TGACATGGTG 
CACTGCCAGC AGAAGAAAGT CAAGCAGATG GTTGAGGAGA TTGAGTCATT AAAGAAAAAA 
GTGCAACAGA AGCAGCTCCT GATACTGCAG CTTTTAGAAA AAATCTCTTT CCTGGAAGGA 
GAGAATAATG AACTACAAAG CAGGTTGGAC TATTTGACAG AAACCCAGCC CAAGACTGAA 
GTGGAAACAA GAGAAATTGG AGTGGGGTGT GATCTTCTTC CCAGCCCAAC AGGCAGGACT 
CGTGAAATCA CAATGCCTTC CAGGAGTTAC ACCCCGTACA CGAGAGTCCT GGAGTTATCC 
TCAAAGAAAA CGCTGACTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001028380.1
CDS	97..1497
Translation	MLRSTSTVTLFSGGGAKSPGTPSRRANVCRLRLTVPPENPVPQQTEKKIERKDQPPELSNGESTKRLPQGVVYGVVRRSDPNQQKEMVVYGWSTNQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQDLSVSHAQQDYLDSHIQAQASALDSFNAMNAALASDSVGLQKTLVDVTLENSHIKDQIRHLQQTYEASMDKLREKQRQLEAAQMENQLLKMRVESSQEANAEVMREMTRKLYSQYEEKLQEAQRKHSAEKEVLLEETNSFLKAIEEANKKMEAAELSLEEKDQKIGELDRLIERMEKERHQLQLQLLEHETEMSGEMADSDKNRYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKVQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQPKTEVETREIGVGCDLLPSPTGRTREITMPSRSYTPYTRVLELSSKKTLT

Target ORF information:

RefSeq Version	NM_001033208.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus myocardial zonula adherens protein (Myzap), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001033208.4

ORF Insert Sequence:

ATGCTGCGCT CCACGTCCAC TGTCACCCTG TTCTCAGGTG GCGGCGCCAA GTCGCCTGGA 
ACGCCCAGTA GAAGGGCAAA TGTCTGCAGA CTGCGGCTGA CTGTGCCCCC TGAGAATCCA 
GTGCCACAGC AAACAGAAAA GAAGATCGAA AGGAAAGATC AGCCTCCAGA ACTAAGCAAT 
GGAGAATCTA CCAAGAGGCT CCCTCAGGGT GTTGTCTATG GTGTGGTGCG AAGATCAGAT 
CCCAACCAGC AGAAGGAAAT GGTCGTGTAT GGCTGGTCCA CCAATCAGCT GAAAGAAGAG 
ATGAATTACA TCAAAGACGT GAGGGCCACA CTGGAGAAAG TGAGGAAGCG GATGTATGGA 
GACTATGATG AGATGAGACA GAAGATCCGA CAGCTCACCC AGGACCTGTC GGTGTCCCAT 
GCTCAGCAGG ACTATCTAGA CAGTCACATC CAAGCCCAGG CATCGGCCCT GGATAGCTTC 
AATGCCATGA ATGCGGCATT GGCATCAGAC TCTGTTGGCT TACAGAAAAC CCTTGTGGAC 
GTGACTTTGG AAAATAGCCA TATCAAGGAT CAAATCCGAC ATCTGCAACA GACCTATGAA 
GCATCCATGG ACAAGCTGCG GGAGAAGCAG AGGCAGTTAG AGGCTGCTCA GATGGAAAAC 
CAGCTCCTAA AGATGAGGGT GGAGTCATCG CAAGAAGCCA ATGCTGAGGT GATGCGGGAG 
ATGACGAGAA AGCTGTACAG CCAGTATGAG GAGAAACTGC AGGAGGCACA GCGCAAGCAC 
AGTGCGGAGA AGGAGGTGCT CCTGGAAGAA ACCAATAGCT TTCTGAAGGC CATCGAAGAG 
GCCAATAAGA AGATGGAGGC AGCTGAGCTC AGCCTGGAGG AGAAAGACCA GAAGATCGGG 
GAACTGGACA GGCTGATTGA ACGCATGGAG AAGGAACGGC ATCAGCTCCA GCTCCAGCTC 
CTTGAGCATG AGACAGAAAT GTCAGGGGAG ATGGCAGATT CTGACAAGAA CAGGTACCAG 
CAGCTGGAGG AGGCGTCGGC CAGCCTCCGG GAGCGGATCA GACACCTGGA TGACATGGTG 
CACTGCCAGC AGAAGAAAGT CAAGCAGATG GTTGAGGAGA TTGAGTCATT AAAGAAAAAA 
GTGCAACAGA AGCAGCTCCT GATACTGCAG CTTTTAGAAA AAATCTCTTT CCTGGAAGGA 
GAGAATAATG AACTACAAAG CAGGTTGGAC TATTTGACAG AAACCCAGCC CAAGACTGAA 
GTGGAAACAA GAGAAATTGG AGTGGGGTGT GATCTTCTTC CCAGCCCAAC AGGCAGGACT 
CGTGAAATCA CAATGCCTTC CAGGAGTTAC ACCCCGTACA CGAGAGTCCT GGAGTTATCC 
TCAAAGAAAA CGCTGACTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Myozap Deficiency Promotes Adverse Cardiac Remodeling via Differential Regulation of Mitogen-activated Protein Kinase/Serum-response Factor and ?-Catenin/GSK-3? Protein Signaling.
The Journal of biological chemistry291(8)4128-43(2016 Feb)
Rangrez AY,Eden M,Poyanmehr R,Kuhn C,Stiebeling K,Dierck F,Bernt A,L?llmann-Rauch R,Weiler H,Kirchof P,Frank D,Frey N

Mice with cardiac-restricted overexpression of Myozap are sensitized to biomechanical stress and develop a protein-aggregate-associated cardiomyopathy.
Journal of molecular and cellular cardiology72196-207(2014 Jul)
Frank D,Rangrez AY,Poyanmehr R,Seeger TS,Kuhn C,Eden M,Stiebeling K,Bernt A,Grund C,Franke WW,Frey N

Genome-wide identification of endothelial cell-enriched genes in the mouse embryo.
Blood120(4)914-23(2012 Jul)
Takase H,Matsumoto K,Yamadera R,Kubota Y,Otsu A,Suzuki R,Ishitobi H,Mochizuki H,Kojima T,Takano S,Uchida K,Takahashi S,Ema M

Myozap, a novel intercalated disc protein, activates serum response factor-dependent signaling and is required to maintain cardiac function in vivo.
Circulation research106(5)880-90(2010 Mar)
Seeger TS,Frank D,Rohr C,Will R,Just S,Grund C,Lyon R,Luedde M,Koegl M,Sheikh F,Rottbauer W,Franke WW,Katus HA,Olson EN,Frey N

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Myzap cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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