SELENOW cDNA ORF clone, Macaca mulatta(Rhesus monkey)

Gene
Clones
gRNAs

Summary

Gene Symbol	SELENOW
Entrez Gene ID	718370
Full Name	selenoprotein W
Synonyms	SEPW1
Gene Type	protein-coding
Organism	Macaca mulatta(Rhesus monkey)
Summary	This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is highly expressed in skeletal muscle, heart and brain. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Studies in mouse show that this selenoprotein is involved in muscle growth and differentiation, and in the protection of neurons from oxidative stress during neuronal development. A pseudogene of this locus has been identified on chromosome 1. [provided by RefSeq, Aug 2017].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001042737.2	NP_001036202.1	selenoprotein W

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Sepw1	NP_037159.4
Pan troglodytes (chimpanzee)	SEPW1	NP_001148049.1
Gallus gallus (chicken)	SEPW1	NP_001159799.1
Danio rerio (zebrafish)	sepw1	NP_840072.3
Homo sapiens (human)	SEPW1	NP_003000.1
Bos taurus (cattle)	SEPW1	NP_001156697.1
	SEPW1	NP_001036202.1
Canis lupus familiaris (dog)	SEPW1	NP_001108484.1
Mus musculus (house mouse)	Sepw1	NP_033182.1

Gene Ontology
Bibliography

Related articles in PubMed

Selenoprotein Gene Nomenclature.
Gladyshev VN, Arn?r ES, Berry MJ, Brigelius-Floh? R, Bruford EA, Burk RF, Carlson BA, Castellano S, Chavatte L, Conrad M, Copeland PR, Diamond AM, Driscoll DM, Ferreiro A, Floh? L, Green FR, Guig? R, Handy DE, Hatfield DL, Hesketh J, Hoffmann PR, Holmgren A, Hondal RJ, Howard MT, Huang K, Kim HY, Kim IY, K?hrle J, Krol A, Kryukov GV, Lee BJ, Lee BC, Lei XG, Liu Q, Lescure A, Lobanov AV, Loscalzo J, Maiorino M, Mariotti M, Sandeep Prabhu K, Rayman MP, Rozovsky S, Salinas G, Schmidt EE, Schomburg L, Schweizer U, Simonovi? M, Sunde RA, Tsuji PA, Tweedie S, Ursini F, Whanger PD, Zhang Y
The Journal of biological chemistry291(46)24036-24040(2016 Nov)

A new rhesus macaque assembly and annotation for next-generation sequencing analyses.
Zimin AV, Cornish AS, Maudhoo MD, Gibbs RM, Zhang X, Pandey S, Meehan DT, Wipfler K, Bosinger SE, Johnson ZP, Tharp GK, Mar?ais G, Roberts M, Ferguson B, Fox HS, Treangen T, Salzberg SL, Yorke JA, Norgren RB Jr
Biology direct9(1)20(2014 Oct)

Composition and evolution of the vertebrate and mammalian selenoproteomes.
Mariotti M, Ridge PG, Zhang Y, Lobanov AV, Pringle TH, Guigo R, Hatfield DL, Gladyshev VN
PloS one7(3)e33066(2012)

Selenoprotein W: a review.
Whanger PD
Cellular and molecular life sciences : CMLS57(13-14)1846-52(2000 Dec)

Purification, characterization, and glutathione binding to selenoprotein W from monkey muscle.
Gu QP, Beilstein MA, Barofsky E, Ream W, Whanger PD
Archives of biochemistry and biophysics361(1)25-33(1999 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following SELENOW gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SELENOW cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMb04729	NM_001042737.2 Latest version!	Macaca mulatta selenoprotein W (SELENOW), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SELENOW ( NM_001042737.2 ) cDNA ORF clone, Macaca mulatta(Rhesus monkey) -> NP_001036202.1 Macaca mulatta selenoprotein W (SELENOW), mRNA.

Price & Availability↑

CloneID	OMb04729
Clone ID Related Accession (Same CDS sequence)	NM_001042737.2
Accession Version	NM_001042737.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 264bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-25
Organism	Macaca mulatta(Rhesus monkey)
Product	selenoprotein W
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from JV704030.1 and JV625537.1. On May 3, 2017 this sequence version replaced NM_001042737.1. ##Evidence-Data-START## Transcript exon combination :: JV625537.1, CN805251.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4688315, SAMEA4688316 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: experimental evidence (PMID:9882425) protein contains selenocysteine :: PMID: 9315310 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTCTCG CCGTGCGAGT CGTTTATTGT GGCGCTTGAG GCTACAAGTC CAAGTATCTT 
CAGCTCAAGA AGAAGTTAGA AGATGAGTTC CCCGGCCGCC TGGACATCTG CGGCGAGGGA 
ACTCCCCAGG CCACCGGGTT CTTTGAAGTA ATGGTAGCCG GGAAGTTGAT TCACTCTAAG 
AAGAAAGGCG ATGGCTACGT GGACACAGAA AGCAAGTTTC TGAAGCTGGT GGCCGCCATC 
AAAGCCGCCT TGGCCCAGGG CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001036202.1
CDS	198..461
Translation	MALAVRVVYCGA*GYKSKYLQLKKKLEDEFPGRLDICGEGTPQATGFFEVMVAGKLIHSKKKGDGYVDTESKFLKLVAAIKAALAQG

Target ORF information:

RefSeq Version	NM_001042737.2
Organism	Macaca mulatta(Rhesus monkey)
Definition	Macaca mulatta selenoprotein W (SELENOW), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001042737.2

ORF Insert Sequence:

ATGGCTCTCG CCGTGCGAGT CGTTTATTGT GGCGCTTGAG GCTACAAGTC CAAGTATCTT 
CAGCTCAAGA AGAAGTTAGA AGATGAGTTC CCCGGCCGCC TGGACATCTG CGGCGAGGGA 
ACTCCCCAGG CCACCGGGTT CTTTGAAGTA ATGGTAGCCG GGAAGTTGAT TCACTCTAAG 
AAGAAAGGCG ATGGCTACGT GGACACAGAA AGCAAGTTTC TGAAGCTGGT GGCCGCCATC 
AAAGCCGCCT TGGCCCAGGG CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Selenoprotein Gene Nomenclature.
The Journal of biological chemistry291(46)24036-24040(2016 Nov)
Gladyshev VN,Arn?r ES,Berry MJ,Brigelius-Floh? R,Bruford EA,Burk RF,Carlson BA,Castellano S,Chavatte L,Conrad M,Copeland PR,Diamond AM,Driscoll DM,Ferreiro A,Floh? L,Green FR,Guig? R,Handy DE,Hatfield DL,Hesketh J,Hoffmann PR,Holmgren A,Hondal RJ,Howard MT,Huang K,Kim HY,Kim IY,K?hrle J,Krol A,Kryukov GV,Lee BJ,Lee BC,Lei XG,Liu Q,Lescure A,Lobanov AV,Loscalzo J,Maiorino M,Mariotti M,Sandeep Prabhu K,Rayman MP,Rozovsky S,Salinas G,Schmidt EE,Schomburg L,Schweizer U,Simonovi? M,Sunde RA,Tsuji PA,Tweedie S,Ursini F,Whanger PD,Zhang Y

A new rhesus macaque assembly and annotation for next-generation sequencing analyses.
Biology direct9(1)20(2014 Oct)
Zimin AV,Cornish AS,Maudhoo MD,Gibbs RM,Zhang X,Pandey S,Meehan DT,Wipfler K,Bosinger SE,Johnson ZP,Tharp GK,Mar?ais G,Roberts M,Ferguson B,Fox HS,Treangen T,Salzberg SL,Yorke JA,Norgren RB Jr

Composition and evolution of the vertebrate and mammalian selenoproteomes.
PloS one7(3)e33066(2012)
Mariotti M,Ridge PG,Zhang Y,Lobanov AV,Pringle TH,Guigo R,Hatfield DL,Gladyshev VN

Selenoprotein W: a review.
Cellular and molecular life sciences : CMLS57(13-14)1846-52(2000 Dec)
Whanger PD

Purification, characterization, and glutathione binding to selenoprotein W from monkey muscle.
Archives of biochemistry and biophysics361(1)25-33(1999 Jan)
Gu QP,Beilstein MA,Barofsky E,Ream W,Whanger PD

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SELENOW cDNA ORF clone, Macaca mulatta(Rhesus monkey)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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