ADORA3 cDNA ORF clone, Macaca mulatta(Rhesus monkey)

Gene
Clones
gRNAs

Summary

Gene Symbol	ADORA3
Entrez Gene ID	704295
Full Name	adenosine A3 receptor
Gene Type	protein-coding
Organism	Macaca mulatta(Rhesus monkey)
Summary	This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors involved in a variety of intracellular signaling pathways and physiological functions. Studies of orthologous proteins suggest that the receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it may have neuroprotective and neurodegenerative effects, and it may also mediate cell proliferation and cell death. This gene shares its 5' terminal exon with some transcripts from overlapping GeneID:104564310, which encodes a transmembrane and immunoglobulin domain-containing protein. [provided by RefSeq, Nov 2014].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001302782.1	NP_001289711.1	adenosine A3 receptor

Pathways from BioSystems

Homologies

	ADORA3	XP_001105876.1
Rattus norvegicus (Norway rat)	LOC100363178	XP_002729146.1

Gene Ontology
Bibliography

Related articles in PubMed

A new rhesus macaque assembly and annotation for next-generation sequencing analyses.
Zimin AV, Cornish AS, Maudhoo MD, Gibbs RM, Zhang X, Pandey S, Meehan DT, Wipfler K, Bosinger SE, Johnson ZP, Tharp GK, Mar?ais G, Roberts M, Ferguson B, Fox HS, Treangen T, Salzberg SL, Yorke JA, Norgren RB Jr
Biology direct9(1)20(2014 Oct)

G protein-coupled receptors and adipogenesis: a focus on adenosine receptors.
Eisenstein A, Ravid K
Journal of cellular physiology229(4)414-21(2014 Apr)

Allosteric interactions at adenosine A(1) and A(3) receptors: new insights into the role of small molecules and receptor dimerization.
Hill SJ, May LT, Kellam B, Woolard J
British journal of pharmacology171(5)1102-13(2014 Mar)

A3 receptor ligands: past, present and future trends.
Taliani S, Pugliesi I, Bellandi M, La Motta C, Da Settimo F
Current topics in medicinal chemistry10(10)942-75(2010)

Differential expression of adenosine A3 receptors controls adenosine A2A receptor-mediated inhibition of TLR responses in microglia.
van der Putten C, Zuiderwijk-Sick EA, van Straalen L, de Geus ED, Boven LA, Kondova I, IJzerman AP, Bajramovic JJ
Journal of immunology (Baltimore, Md. : 1950)182(12)7603-12(2009 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

report a differential, activation state-specific expression of ADORA in microglia and uncover a role for A(3)R as dynamically regulated suppressors of A(2A)R-mediated inhibition of TLR-induced responses
Title: Differential expression of adenosine A3 receptors controls adenosine A2A receptor-mediated inhibition of TLR responses in microglia.

The following ADORA3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ADORA3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMb24170	NM_001302782.1 Latest version!	Macaca mulatta adenosine A3 receptor (ADORA3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ADORA3 ( NM_001302782.1 ) cDNA ORF clone, Macaca mulatta(Rhesus monkey) -> NP_001289711.1 Macaca mulatta adenosine A3 receptor (ADORA3), mRNA.

Price & Availability↑

CloneID	OMb24170
Clone ID Related Accession (Same CDS sequence)	NM_001302782.1
Accession Version	NM_001302782.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 957bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-11
Organism	Macaca mulatta(Rhesus monkey)
Product	adenosine A3 receptor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from QNVO02000012.1 and CB553482.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR5038768.319979.1, SRR5038768.427306.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4688315, SAMEA4688316 [ECO:0000348] ##Evidence-Data-END##

ATGCCCAACA ACAGCACTGC TCCGTCATTG ACCGATGTTA CCTACATCAC CATGGAGATT 
TTCATTGGAC TCTGCGCCAT AGTGGGCAAC GTGCTGGTCA TCTGGGTGGT CAAGCTGAAC 
CCCAGCCTGC AGACCACCAC CTTCTATTTC ATTGTCTCTC TAGCCCTGGC TGACATTGCT 
GTTGGGGTGC TGGTCATGCC TTTGGCCGTT GTCGTCAGTC TGGGCATCAC AATCCACTTC 
TACAGCTGCC TTTTTATGGC CTGCCTACTG CTGATCTTTA CCCACGCCTC CATCATGTCC 
TTGCTGGCCA TCGCTGTGGA CCGATACTTG CGGGTCAAGC TTACCGTCAG ATACAAGAGG 
GTCACAACTC ACAGAAGAAT ATGGCTGGCC CTGGGCCTTT GCTGGCTGGT GTCATTCCTG 
GTGGGACTGA CCCCCATGTT TGGCTGGAAC ATGAAACTGA CCTCAGAGTA CCACAGAAAT 
GTCACCTTCC TTTCATGCCA ATTCCTTTCT GTCATGAGAA TGGACTACAT GGTATACTTC 
AGCTTCTTCA CCTGGATTTT CATCCCCCTG GTAGTCATGT GTGCCATCTA TCTTGACATC 
TTTTACATCA TCCGGAACAA ACTCAGTCAG AACTTCTCTA ACTCCAAAGA GACAGGTGCA 
TTTTATGGAC GGGAGTTCAA GACAGCTAAG TCCTTGTTTC TGGTTCTTTT CTTGTTTGCT 
CTGTCATGGC TGCCTTTATC CATCATCAAC TGCATCATCC ACTTTAATGG TGAGGTACCA 
CAGCTTGTGC TGTACATGGG CATCCTGCTG TCCCATGCCA ATTCCATGAT GAACCCTATC 
GTCTACGCCT ATAAAATAAA GAAGTTCAAG GAAACCTACC TTTTGATCCT CAAAGCCTGT 
GTGGTCTGCC ATCCCTCTGA TTCTTTGGAC ACAAGCATTG AGAAGAATTC TGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001289711.1
CDS	365..1321
Translation	MPNNSTAPSLTDVTYITMEIFIGLCAIVGNVLVIWVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAVVVSLGITIHFYSCLFMACLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFLSVMRMDYMVYFSFFTWIFIPLVVMCAIYLDIFYIIRNKLSQNFSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIHFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE

Target ORF information:

RefSeq Version	NM_001302782.1
Organism	Macaca mulatta(Rhesus monkey)
Definition	Macaca mulatta adenosine A3 receptor (ADORA3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001302782.1

ORF Insert Sequence:

ATGCCCAACA ACAGCACTGC TCCGTCATTG ACCGATGTTA CCTACATCAC CATGGAGATT 
TTCATTGGAC TCTGCGCCAT AGTGGGCAAC GTGCTGGTCA TCTGGGTGGT CAAGCTGAAC 
CCCAGCCTGC AGACCACCAC CTTCTATTTC ATTGTCTCTC TAGCCCTGGC TGACATTGCT 
GTTGGGGTGC TGGTCATGCC TTTGGCCGTT GTCGTCAGTC TGGGCATCAC AATCCACTTC 
TACAGCTGCC TTTTTATGGC CTGCCTACTG CTGATCTTTA CCCACGCCTC CATCATGTCC 
TTGCTGGCCA TCGCTGTGGA CCGATACTTG CGGGTCAAGC TTACCGTCAG ATACAAGAGG 
GTCACAACTC ACAGAAGAAT ATGGCTGGCC CTGGGCCTTT GCTGGCTGGT GTCATTCCTG 
GTGGGACTGA CCCCCATGTT TGGCTGGAAC ATGAAACTGA CCTCAGAGTA CCACAGAAAT 
GTCACCTTCC TTTCATGCCA ATTCCTTTCT GTCATGAGAA TGGACTACAT GGTATACTTC 
AGCTTCTTCA CCTGGATTTT CATCCCCCTG GTAGTCATGT GTGCCATCTA TCTTGACATC 
TTTTACATCA TCCGGAACAA ACTCAGTCAG AACTTCTCTA ACTCCAAAGA GACAGGTGCA 
TTTTATGGAC GGGAGTTCAA GACAGCTAAG TCCTTGTTTC TGGTTCTTTT CTTGTTTGCT 
CTGTCATGGC TGCCTTTATC CATCATCAAC TGCATCATCC ACTTTAATGG TGAGGTACCA 
CAGCTTGTGC TGTACATGGG CATCCTGCTG TCCCATGCCA ATTCCATGAT GAACCCTATC 
GTCTACGCCT ATAAAATAAA GAAGTTCAAG GAAACCTACC TTTTGATCCT CAAAGCCTGT 
GTGGTCTGCC ATCCCTCTGA TTCTTTGGAC ACAAGCATTG AGAAGAATTC TGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A new rhesus macaque assembly and annotation for next-generation sequencing analyses.
Biology direct9(1)20(2014 Oct)
Zimin AV,Cornish AS,Maudhoo MD,Gibbs RM,Zhang X,Pandey S,Meehan DT,Wipfler K,Bosinger SE,Johnson ZP,Tharp GK,Mar?ais G,Roberts M,Ferguson B,Fox HS,Treangen T,Salzberg SL,Yorke JA,Norgren RB Jr

G protein-coupled receptors and adipogenesis: a focus on adenosine receptors.
Journal of cellular physiology229(4)414-21(2014 Apr)
Eisenstein A,Ravid K

Allosteric interactions at adenosine A(1) and A(3) receptors: new insights into the role of small molecules and receptor dimerization.
British journal of pharmacology171(5)1102-13(2014 Mar)
Hill SJ,May LT,Kellam B,Woolard J

A3 receptor ligands: past, present and future trends.
Current topics in medicinal chemistry10(10)942-75(2010)
Taliani S,Pugliesi I,Bellandi M,La Motta C,Da Settimo F

Differential expression of adenosine A3 receptors controls adenosine A2A receptor-mediated inhibition of TLR responses in microglia.
Journal of immunology (Baltimore, Md. : 1950)182(12)7603-12(2009 Jun)
van der Putten C,Zuiderwijk-Sick EA,van Straalen L,de Geus ED,Boven LA,Kondova I,IJzerman AP,Bajramovic JJ

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ADORA3 cDNA ORF clone, Macaca mulatta(Rhesus monkey)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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