PAGE4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PAGE4
Entrez Gene ID	9506
Full Name	PAGE family member 4
Synonyms	CT16.7,GAGE-9,GAGEC1,JM-27,JM27,PAGE-1,PAGE-4
General protein information	Preferred Names PAGE family member 4 Names P antigen family member 4 P antigen family, member 4 (prostate associated) g antigen family C member 1 prostate-associated gene protein 4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xp11.23
Summary	This gene is a member of the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in prostate and prostate cancer. It is also expressed in other male and female reproductive tissues including testis, fallopian tube, uterus, and placenta, as well as in testicular cancer and uterine cancer. The protein encoded by this gene shares sequence similarity with other GAGE/PAGE proteins, and also belongs to a family of CT (cancer-testis) antigens. The protein may play a role in benign and malignant prostate diseases. A related pseudogene is located on chromosome 7. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].
Disorder MIM:	300287

mRNA and Protein(s)

mRNA	Protein	Name
XM_005272740.2	XP_005272797.1	P antigen family member 4 isoform X1
NM_007003.3	NP_008934.1	P antigen family member 4
NM_001318877.1	NP_001305806.1	P antigen family member 4
NM_007003.4	NP_008934.1	P antigen family member 4

Pathways from BioSystems

Homologies

	PAGE4	XP_002806288.1
Homo sapiens (human)	PAGE4	NP_008934.1
Pan troglodytes (chimpanzee)	PAGE4	XP_001142671.1

Gene Ontology
Bibliography

Related articles in PubMed

Phosphorylation-induced conformational dynamics in an intrinsically disordered protein and potential role in phenotypic heterogeneity.
Kulkarni P, Jolly MK, Jia D, Mooney SM, Bhargava A, Kagohara LT, Chen Y, Hao P, He Y, Veltri RW, Grishaev A, Weninger K, Levine H, Orban J
Proceedings of the National Academy of Sciences of the United States of America114(13)E2644-E2653(2017 Mar)

Phosphorylation-induced Conformational Ensemble Switching in an Intrinsically Disordered Cancer/Testis Antigen.
He Y, Chen Y, Mooney SM, Rajagopalan K, Bhargava A, Sacho E, Weninger K, Bryan PN, Kulkarni P, Orban J
The Journal of biological chemistry290(41)25090-102(2015 Oct)

The Stress-response protein prostate-associated gene 4, interacts with c-Jun and potentiates its transactivation.
Rajagopalan K, Qiu R, Mooney SM, Rao S, Shiraishi T, Sacho E, Huang H, Shapiro E, Weninger KR, Kulkarni P
Biochimica et biophysica acta1842(2)154-63(2014 Feb)

Prostate-associated gene 4 (PAGE4) protects cells against stress by elevating p21 and suppressing reactive oxygen species production.
Zeng Y, Gao D, Kim JJ, Shiraishi T, Terada N, Kakehi Y, Kong C, Getzenberg RH, Kulkarni P
American journal of clinical and experimental urology1(1)39-52(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

phosphorylation of PAGE4 leads to conformational shifts
Title: Phosphorylation-induced Conformational Ensemble Switching in an Intrinsically Disordered Cancer/Testis Antigen.

PAGE4, a regulator of c-Jun transactivation, is phosphorylated by homeodomain-interacting protein kinase 1.
Title: Cancer/testis antigen PAGE4, a regulator of c-Jun transactivation, is phosphorylated by homeodomain-interacting protein kinase 1, a component of the stress-response pathway.

Data suggest that disrupting prostate-associated gene 4 (PAGE4)/c-Jun interaction using small molecules could be a novel strategy to treat prostate cancer.
Title: The Stress-response protein prostate-associated gene 4, interacts with c-Jun and potentiates its transactivation.

Dysregulation of epithelial PAGE4 modulates AR signaling.
Title: PAGE4 positivity is associated with attenuated AR signaling and predicts patient survival in hormone-naive prostate cancer.

PAGE4 is a highly intrinsically disordered protein with an anti-apoptotic function
Title: The cancer/testis antigen prostate-associated gene 4 (PAGE4) is a highly intrinsically disordered protein.

The following PAGE4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PAGE4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu16681	NM_007003.4 Latest version!	Homo sapiens PAGE family member 4 (PAGE4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu16681	NM_001318877.1 Latest version!	Homo sapiens PAGE family member 4 (PAGE4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu16681	XM_005272740.2 Latest version!	Homo sapiens P antigen family, member 4 (prostate associated) (PAGE4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu16681	NM_007003.3	Homo sapiens P antigen family, member 4 (prostate associated) (PAGE4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PAGE4 ( NM_007003.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_008934.1 Homo sapiens P antigen family, member 4 (prostate associated) (PAGE4), mRNA.

Price & Availability↑

CloneID	OHu16681
Clone ID Related Accession (Same CDS sequence)	XM_005272740.2 , NM_007003.3 , NM_001318877.1 , NM_007003.4
Accession Version	NM_007003.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 309bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	P antigen family member 4
Comment

ATGAGTGCAC GAGTGAGATC AAGATCCAGA GGAAGAGGAG ATGGTCAGGA GGCTCCCGAT 
GTGGTTGCAT TCGTGGCTCC CGGTGAATCT CAGCAAGAGG AACCACCAAC TGACAATCAG 
GATATTGAAC CTGGACAAGA GAGAGAAGGA ACACCTCCGA TCGAAGAACG TAAAGTAGAA 
GGTGATTGCC AGGAAATGGA TCTGGAAAAG ACTCGGAGTG AGCGTGGAGA TGGCTCTGAT 
GTAAAAGAGA AGACTCCACC TAATCCTAAG CATGCTAAGA CTAAAGAAGC AGGAGATGGG 
CAGCCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_008934.1
Translation	MSARVRSRSRGRGDGQEAPDVVAFVAPGESQQEEPPTDNQDIEPGQEREGTPPIEERKVEGDCQEMDLEKTRSERGDGSDVKEKTPPNPKHAKTKEAGDGQP

Target ORF information:

RefSeq Version	NM_007003.3
Organism	Homo sapiens(Human)
Definition	Homo sapiens P antigen family, member 4 (prostate associated) (PAGE4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007003.3

ORF Insert Sequence:

ATGAGTGCAC GAGTGAGATC AAGATCCAGA GGAAGAGGAG ATGGTCAGGA GGCTCCCGAT 
GTGGTTGCAT TCGTGGCTCC CGGTGAATCT CAGCAAGAGG AACCACCAAC TGACAATCAG 
GATATTGAAC CTGGACAAGA GAGAGAAGGA ACACCTCCGA TCGAAGAACG TAAAGTAGAA 
GGTGATTGCC AGGAAATGGA TCTGGAAAAG ACTCGGAGTG AGCGTGGAGA TGGCTCTGAT 
GTAAAAGAGA AGACTCCACC TAATCCTAAG CATGCTAAGA CTAAAGAAGC AGGAGATGGG 
CAGCCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PAGE4 ( NM_001318877.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001305806.1 Homo sapiens PAGE family member 4 (PAGE4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu16681
Clone ID Related Accession (Same CDS sequence)	XM_005272740.2 , NM_007003.3 , NM_001318877.1 , NM_007003.4
Accession Version	NM_001318877.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 309bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Homo sapiens(human)
Product	P antigen family member 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC231644.3, AI093155.1 and AL548759.3. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AI093155.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGTGCAC GAGTGAGATC AAGATCCAGA GGAAGAGGAG ATGGTCAGGA GGCTCCCGAT 
GTGGTTGCAT TCGTGGCTCC CGGTGAATCT CAGCAAGAGG AACCACCAAC TGACAATCAG 
GATATTGAAC CTGGACAAGA GAGAGAAGGA ACACCTCCGA TCGAAGAACG TAAAGTAGAA 
GGTGATTGCC AGGAAATGGA TCTGGAAAAG ACTCGGAGTG AGCGTGGAGA TGGCTCTGAT 
GTAAAAGAGA AGACTCCACC TAATCCTAAG CATGCTAAGA CTAAAGAAGC AGGAGATGGG 
CAGCCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001305806.1
CDS	68..376
Translation	MSARVRSRSRGRGDGQEAPDVVAFVAPGESQQEEPPTDNQDIEPGQEREGTPPIEERKVEGDCQEMDLEKTRSERGDGSDVKEKTPPNPKHAKTKEAGDGQP

Target ORF information:

RefSeq Version	NM_001318877.1
Organism	Homo sapiens(human)
Definition	Homo sapiens PAGE family member 4 (PAGE4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001318877.1

ORF Insert Sequence:

ATGAGTGCAC GAGTGAGATC AAGATCCAGA GGAAGAGGAG ATGGTCAGGA GGCTCCCGAT 
GTGGTTGCAT TCGTGGCTCC CGGTGAATCT CAGCAAGAGG AACCACCAAC TGACAATCAG 
GATATTGAAC CTGGACAAGA GAGAGAAGGA ACACCTCCGA TCGAAGAACG TAAAGTAGAA 
GGTGATTGCC AGGAAATGGA TCTGGAAAAG ACTCGGAGTG AGCGTGGAGA TGGCTCTGAT 
GTAAAAGAGA AGACTCCACC TAATCCTAAG CATGCTAAGA CTAAAGAAGC AGGAGATGGG 
CAGCCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PAGE4 ( NM_007003.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_008934.1 Homo sapiens PAGE family member 4 (PAGE4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu16681
Clone ID Related Accession (Same CDS sequence)	XM_005272740.2 , NM_007003.3 , NM_001318877.1 , NM_007003.4
Accession Version	NM_007003.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 309bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	P antigen family member 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG435968.1, DA841276.1, AC231644.3 and AL548759.3. On Jan 15, 2016 this sequence version replaced NM_007003.3. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA838759.1, DA841276.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000218068.7/ ENSP00000218068.6 RefSeq Select criteria :: based on expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGTGCAC GAGTGAGATC AAGATCCAGA GGAAGAGGAG ATGGTCAGGA GGCTCCCGAT 
GTGGTTGCAT TCGTGGCTCC CGGTGAATCT CAGCAAGAGG AACCACCAAC TGACAATCAG 
GATATTGAAC CTGGACAAGA GAGAGAAGGA ACACCTCCGA TCGAAGAACG TAAAGTAGAA 
GGTGATTGCC AGGAAATGGA TCTGGAAAAG ACTCGGAGTG AGCGTGGAGA TGGCTCTGAT 
GTAAAAGAGA AGACTCCACC TAATCCTAAG CATGCTAAGA CTAAAGAAGC AGGAGATGGG 
CAGCCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_008934.1
CDS	80..388
Translation	MSARVRSRSRGRGDGQEAPDVVAFVAPGESQQEEPPTDNQDIEPGQEREGTPPIEERKVEGDCQEMDLEKTRSERGDGSDVKEKTPPNPKHAKTKEAGDGQP

Target ORF information:

RefSeq Version	NM_007003.4
Organism	Homo sapiens(human)
Definition	Homo sapiens PAGE family member 4 (PAGE4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007003.4

ORF Insert Sequence:

ATGAGTGCAC GAGTGAGATC AAGATCCAGA GGAAGAGGAG ATGGTCAGGA GGCTCCCGAT 
GTGGTTGCAT TCGTGGCTCC CGGTGAATCT CAGCAAGAGG AACCACCAAC TGACAATCAG 
GATATTGAAC CTGGACAAGA GAGAGAAGGA ACACCTCCGA TCGAAGAACG TAAAGTAGAA 
GGTGATTGCC AGGAAATGGA TCTGGAAAAG ACTCGGAGTG AGCGTGGAGA TGGCTCTGAT 
GTAAAAGAGA AGACTCCACC TAATCCTAAG CATGCTAAGA CTAAAGAAGC AGGAGATGGG 
CAGCCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PAGE4 ( XM_005272740.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_005272797.1 Homo sapiens P antigen family, member 4 (prostate associated) (PAGE4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu16681
Clone ID Related Accession (Same CDS sequence)	XM_005272740.2 , NM_007003.3 , NM_001318877.1 , NM_007003.4
Accession Version	XM_005272740.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 309bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	P antigen family member 4 isoform X1
Comment

ATGAGTGCAC GAGTGAGATC AAGATCCAGA GGAAGAGGAG ATGGTCAGGA GGCTCCCGAT 
GTGGTTGCAT TCGTGGCTCC CGGTGAATCT CAGCAAGAGG AACCACCAAC TGACAATCAG 
GATATTGAAC CTGGACAAGA GAGAGAAGGA ACACCTCCGA TCGAAGAACG TAAAGTAGAA 
GGTGATTGCC AGGAAATGGA TCTGGAAAAG ACTCGGAGTG AGCGTGGAGA TGGCTCTGAT 
GTAAAAGAGA AGACTCCACC TAATCCTAAG CATGCTAAGA CTAAAGAAGC AGGAGATGGG 
CAGCCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005272797.1
Translation	MSARVRSRSRGRGDGQEAPDVVAFVAPGESQQEEPPTDNQDIEPGQEREGTPPIEERKVEGDCQEMDLEKTRSERGDGSDVKEKTPPNPKHAKTKEAGDGQP

Target ORF information:

RefSeq Version	XM_005272740.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens P antigen family, member 4 (prostate associated) (PAGE4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005272740.2

ORF Insert Sequence:

ATGAGTGCAC GAGTGAGATC AAGATCCAGA GGAAGAGGAG ATGGTCAGGA GGCTCCCGAT 
GTGGTTGCAT TCGTGGCTCC CGGTGAATCT CAGCAAGAGG AACCACCAAC TGACAATCAG 
GATATTGAAC CTGGACAAGA GAGAGAAGGA ACACCTCCGA TCGAAGAACG TAAAGTAGAA 
GGTGATTGCC AGGAAATGGA TCTGGAAAAG ACTCGGAGTG AGCGTGGAGA TGGCTCTGAT 
GTAAAAGAGA AGACTCCACC TAATCCTAAG CATGCTAAGA CTAAAGAAGC AGGAGATGGG 
CAGCCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Phosphorylation-induced conformational dynamics in an intrinsically disordered protein and potential role in phenotypic heterogeneity.
Proceedings of the National Academy of Sciences of the United States of America114(13)E2644-E2653(2017 Mar)
Kulkarni P,Jolly MK,Jia D,Mooney SM,Bhargava A,Kagohara LT,Chen Y,Hao P,He Y,Veltri RW,Grishaev A,Weninger K,Levine H,Orban J

Phosphorylation-induced Conformational Ensemble Switching in an Intrinsically Disordered Cancer/Testis Antigen.
The Journal of biological chemistry290(41)25090-102(2015 Oct)
He Y,Chen Y,Mooney SM,Rajagopalan K,Bhargava A,Sacho E,Weninger K,Bryan PN,Kulkarni P,Orban J

The Stress-response protein prostate-associated gene 4, interacts with c-Jun and potentiates its transactivation.
Biochimica et biophysica acta1842(2)154-63(2014 Feb)
Rajagopalan K,Qiu R,Mooney SM,Rao S,Shiraishi T,Sacho E,Huang H,Shapiro E,Weninger KR,Kulkarni P

Prostate-associated gene 4 (PAGE4) protects cells against stress by elevating p21 and suppressing reactive oxygen species production.
American journal of clinical and experimental urology1(1)39-52(2013)
Zeng Y,Gao D,Kim JJ,Shiraishi T,Terada N,Kakehi Y,Kong C,Getzenberg RH,Kulkarni P

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PAGE4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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