BPY2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	BPY2
Entrez Gene ID	9083
Full Name	basic charge, Y-linked, 2
Synonyms	BPY2A,VCY2,VCY2A
General protein information	Preferred Names basic charge, Y-linked, 2 Names testis-specific basic protein Y 2 basic protein on Y chromosome 2 testis-specific basic protein on Y, 2 variable charge, Y-linked, 2 variably charged protein Y 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: Y Map Location: Yq11.223
Summary	This gene is located in the nonrecombining portion of the Y chromosome, and expressed specifically in testis. The encoded protein interacts with ubiquitin protein ligase E3A and may be involved in male germ cell development and male infertility. Three nearly identical copies of this gene exist on chromosome Y; two copies are part of a palindromic region. This record represents the copy outside of the palidromic region. [provided by RefSeq, Jul 2008].
Disorder MIM:	400013

mRNA and Protein(s)

mRNA	Protein	Name
NM_004678.2	NP_004669.2	testis-specific basic protein Y 2
NM_004678.3	NP_004669.2	testis-specific basic protein Y 2

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Isoform-Level Gene Expression Profiles of Human Y Chromosome Azoospermia Factor Genes and Their X Chromosome Paralogs in the Testicular Tissue of Non-Obstructive Azoospermia Patients.
Ahmadi Rastegar D, Sharifi Tabar M, Alikhani M, Parsamatin P, Sahraneshin Samani F, Sabbaghian M, Sadighi Gilani MA, Mohammad Ahadi A, Mohseni Meybodi A, Piryaei A, Ansari-Pour N, Gourabi H, Baharvand H, Salekdeh GH
Journal of proteome research14(9)3595-605(2015 Sep)

Gene copy number alterations in the azoospermia-associated AZFc region and their effect on spermatogenic impairment.
Lu C, Jiang J, Zhang R, Wang Y, Xu M, Qin Y, Lin Y, Guo X, Ni B, Zhao Y, Diao N, Chen F, Shen H, Sha J, Xia Y, Hu Z, Wang X
Molecular human reproduction20(9)836-43(2014 Sep)

Differential effect of specific gr/gr deletion subtypes on spermatogenesis in the Chinese Han population.
Yang Y, Ma M, Li L, Su D, Chen P, Ma Y, Liu Y, Tao D, Lin L, Zhang S
International journal of andrology33(5)745-54(2010 Oct)

Alu sequence variants of the BPY2 gene in proven fertile and infertile men with Sertoli cell-only phenotype.
Choi J, Koh E, Suzuki H, Maeda Y, Yoshida A, Namiki M
International journal of urology : official journal of the Japanese Urological Association14(5)431-5(2007 May)

A family of human Y chromosomes has dispersed throughout northern Eurasia despite a 1.8-Mb deletion in the azoospermia factor c region.
Repping S, van Daalen SK, Korver CM, Brown LG, Marszalek JD, Gianotten J, Oates RD, Silber S, van der Veen F, Page DC, Rozen S
Genomics83(6)1046-52(2004 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

genetic association study in Chinese population: Data suggest that combined patterns of copy number abnormality in BPY2 (basic charge Y-linked protein 2) and/or DAZ1 (deleted in azoospermia 1) are associated with spermatogenic impairment/azoospermia.
Title: Gene copy number alterations in the azoospermia-associated AZFc region and their effect on spermatogenic impairment.

Observational study of gene-disease association. (HuGE Navigator)
Title: Differential effect of specific gr/gr deletion subtypes on spermatogenesis in the Chinese Han population.

Observational study of gene-disease association. (HuGE Navigator)
Title: Alu sequence variants of the BPY2 gene in proven fertile and infertile men with Sertoli cell-only phenotype.

VCY2 was weakly expressed at the spermatogonia and immunonegative in spermatocytes and round spermatids in testicular biopsy specimens with maturation arrest or hypospermatogenesis.
Title: Specific expression of VCY2 in human male germ cells and its involvement in the pathogenesis of male infertility.

VCY2 protein interacts with the HECT domain of ubiquitin-protein ligase E3A
Title: VCY2 protein interacts with the HECT domain of ubiquitin-protein ligase E3A.

The following BPY2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BPY2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19235	NM_004678.3 Latest version!	Homo sapiens basic charge Y-linked 2 (BPY2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu19235	NM_004678.2	Homo sapiens basic charge Y-linked 2 (BPY2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

BPY2 ( NM_004678.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_004669.2 Homo sapiens basic charge Y-linked 2 (BPY2), mRNA.

Price & Availability↑

CloneID	OHu19235
Clone ID Related Accession (Same CDS sequence)	NM_004678.2 , NM_004678.3
Accession Version	NM_004678.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 321bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-20
Organism	Homo sapiens(human)
Product	testis-specific basic protein Y 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF000980.1 and AC006366.4. This sequence is a reference standard in the RefSeqGene project. On Sep 6, 2007 this sequence version replaced NM_004678.1. CCDS Note: This CCDS ID represents the protein described in PMIDs: 12724276 and 12207887. It should be noted this transcript is predicted to undergo nonsense-mediated mRNA decay (NMD). However, the protein is represented because it was detected endogenously in PMID: 12724276. Three identical copies of this gene exist on chromosome Y; two copies are part of a palindromic region. This record represents the copy outside of the palidromic region. ##Evidence-Data-START## Transcript exon combination :: AF000980.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148874 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## NMD candidate :: PMID: 12207887, 12724276 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGATGACGC TTGTCCCCAG AGCCAGGACA CGTGCAGGAC AGGATCATTA CTCTCATCCC 
TGCCCCAGAT TTTCACAGGT GCTGCTTACA GAGGGCATCA TGACATATTG CTTGACAAAG 
AACCTAAGTG ATGTTAATAT TCTGCATAGG TTGCTAAAAA ATGGGAATGT GAGAAATACC 
TTGCTTCAGT CCAAAGTGGG CTTGCTGACA TATTATGTGA AACTGTACCC GGGTGAAGTG 
ACTCTTCTGA CTAGGCCCAG CATACAAATG AGATTATGCT GTATCACTGG CTCAGTGTCG 
AGGCCCAGAT CACAGAAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004669.2
CDS	333..653
Translation	MMTLVPRARTRAGQDHYSHPCPRFSQVLLTEGIMTYCLTKNLSDVNILHRLLKNGNVRNTLLQSKVGLLTYYVKLYPGEVTLLTRPSIQMRLCCITGSVSRPRSQK

Target ORF information:

RefSeq Version	NM_004678.2
Organism	Homo sapiens(human)
Definition	Homo sapiens basic charge Y-linked 2 (BPY2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004678.2

ORF Insert Sequence:

ATGATGACGC TTGTCCCCAG AGCCAGGACA CGTGCAGGAC AGGATCATTA CTCTCATCCC 
TGCCCCAGAT TTTCACAGGT GCTGCTTACA GAGGGCATCA TGACATATTG CTTGACAAAG 
AACCTAAGTG ATGTTAATAT TCTGCATAGG TTGCTAAAAA ATGGGAATGT GAGAAATACC 
TTGCTTCAGT CCAAAGTGGG CTTGCTGACA TATTATGTGA AACTGTACCC GGGTGAAGTG 
ACTCTTCTGA CTAGGCCCAG CATACAAATG AGATTATGCT GTATCACTGG CTCAGTGTCG 
AGGCCCAGAT CACAGAAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BPY2 ( NM_004678.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004669.2 Homo sapiens basic charge Y-linked 2 (BPY2), mRNA.

Price & Availability↑

CloneID	OHu19235
Clone ID Related Accession (Same CDS sequence)	NM_004678.2 , NM_004678.3
Accession Version	NM_004678.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 321bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	testis-specific basic protein Y 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF000980.1 and AC006366.4. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_004678.2. CCDS Note: This CCDS ID represents the protein described in PMIDs: 12724276 and 12207887. It should be noted this transcript is predicted to undergo nonsense-mediated mRNA decay (NMD). However, the protein is represented because it was detected endogenously in PMID: 12724276. Three identical copies of this gene exist on chromosome Y; two copies are part of a palindromic region. This record represents the copy outside of the palidromic region. ##Evidence-Data-START## Transcript exon combination :: AF000980.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148874 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000331070.8/ ENSP00000329106.3 NMD candidate :: PMID: 12207887, 12724276 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGATGACGC TTGTCCCCAG AGCCAGGACA CGTGCAGGAC AGGATCATTA CTCTCATCCC 
TGCCCCAGAT TTTCACAGGT GCTGCTTACA GAGGGCATCA TGACATATTG CTTGACAAAG 
AACCTAAGTG ATGTTAATAT TCTGCATAGG TTGCTAAAAA ATGGGAATGT GAGAAATACC 
TTGCTTCAGT CCAAAGTGGG CTTGCTGACA TATTATGTGA AACTGTACCC GGGTGAAGTG 
ACTCTTCTGA CTAGGCCCAG CATACAAATG AGATTATGCT GTATCACTGG CTCAGTGTCG 
AGGCCCAGAT CACAGAAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004669.2
CDS	333..653
Translation	MMTLVPRARTRAGQDHYSHPCPRFSQVLLTEGIMTYCLTKNLSDVNILHRLLKNGNVRNTLLQSKVGLLTYYVKLYPGEVTLLTRPSIQMRLCCITGSVSRPRSQK

Target ORF information:

RefSeq Version	NM_004678.3
Organism	Homo sapiens(human)
Definition	Homo sapiens basic charge Y-linked 2 (BPY2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004678.3

ORF Insert Sequence:

ATGATGACGC TTGTCCCCAG AGCCAGGACA CGTGCAGGAC AGGATCATTA CTCTCATCCC 
TGCCCCAGAT TTTCACAGGT GCTGCTTACA GAGGGCATCA TGACATATTG CTTGACAAAG 
AACCTAAGTG ATGTTAATAT TCTGCATAGG TTGCTAAAAA ATGGGAATGT GAGAAATACC 
TTGCTTCAGT CCAAAGTGGG CTTGCTGACA TATTATGTGA AACTGTACCC GGGTGAAGTG 
ACTCTTCTGA CTAGGCCCAG CATACAAATG AGATTATGCT GTATCACTGG CTCAGTGTCG 
AGGCCCAGAT CACAGAAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Isoform-Level Gene Expression Profiles of Human Y Chromosome Azoospermia Factor Genes and Their X Chromosome Paralogs in the Testicular Tissue of Non-Obstructive Azoospermia Patients.
Journal of proteome research14(9)3595-605(2015 Sep)
Ahmadi Rastegar D,Sharifi Tabar M,Alikhani M,Parsamatin P,Sahraneshin Samani F,Sabbaghian M,Sadighi Gilani MA,Mohammad Ahadi A,Mohseni Meybodi A,Piryaei A,Ansari-Pour N,Gourabi H,Baharvand H,Salekdeh GH

Gene copy number alterations in the azoospermia-associated AZFc region and their effect on spermatogenic impairment.
Molecular human reproduction20(9)836-43(2014 Sep)
Lu C,Jiang J,Zhang R,Wang Y,Xu M,Qin Y,Lin Y,Guo X,Ni B,Zhao Y,Diao N,Chen F,Shen H,Sha J,Xia Y,Hu Z,Wang X

Differential effect of specific gr/gr deletion subtypes on spermatogenesis in the Chinese Han population.
International journal of andrology33(5)745-54(2010 Oct)
Yang Y,Ma M,Li L,Su D,Chen P,Ma Y,Liu Y,Tao D,Lin L,Zhang S

Alu sequence variants of the BPY2 gene in proven fertile and infertile men with Sertoli cell-only phenotype.
International journal of urology : official journal of the Japanese Urological Association14(5)431-5(2007 May)
Choi J,Koh E,Suzuki H,Maeda Y,Yoshida A,Namiki M

A family of human Y chromosomes has dispersed throughout northern Eurasia despite a 1.8-Mb deletion in the azoospermia factor c region.
Genomics83(6)1046-52(2004 Jun)
Repping S,van Daalen SK,Korver CM,Brown LG,Marszalek JD,Gianotten J,Oates RD,Silber S,van der Veen F,Page DC,Rozen S

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BPY2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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