ARHGAP11B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ARHGAP11B
Entrez Gene ID	89839
Full Name	Rho GTPase activating protein 11B
Synonyms	B'-T,FAM7B1,GAP (1-8)
General protein information	Preferred Names Rho GTPase activating protein 11B Names rho GTPase-activating protein 11B family with sequence similarity 7, member B1 rho-type GTPase-activating protein 11B
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q13.2
Disorder MIM:	616310

mRNA and Protein(s)

mRNA	Protein	Name
NM_001039841.1	NP_001034930.1	rho GTPase-activating protein 11B
NM_001039841.2	NP_001034930.1	rho GTPase-activating protein 11B

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

A single splice site mutation in human-specific
Florio M, Namba T, P??bo S, Hiller M, Huttner WB
Science advances2(12)e1601941(2016 Dec)

Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion.
Florio M, Albert M, Taverna E, Namba T, Brandl H, Lewitus E, Haffner C, Sykes A, Wong FK, Peters J, Guhr E, Klemroth S, Pr?fer K, Kelso J, Naumann R, N?sslein I, Dahl A, Lachmann R, P??bo S, Huttner WB
Science (New York, N.Y.)347(6229)1465-70(2015 Mar)

A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy.
Speed D, Hoggart C, Petrovski S, Tachmazidou I, Coffey A, Jorgensen A, Eleftherohorinou H, De Iorio M, Todaro M, De T, Smith D, Smith PE, Jackson M, Cooper P, Kellett M, Howell S, Newton M, Yerra R, Tan M, French C, Reuber M, Sills GE, Chadwick D, Pirmohamed M, Bentley D, Scheffer I, Berkovic S, Balding D, Palotie A, Marson A, O'Brien TJ, Johnson MR
Human molecular genetics23(1)247-58(2014 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ARHGAP11B may have contributed to evolutionary expansion of human neocortex.
Title: Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion.

The following ARHGAP11B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ARHGAP11B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13447	NM_001039841.2 Latest version!	Homo sapiens Rho GTPase activating protein 11B (ARHGAP11B), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
View Old Accession Versions >>
OHu13447	NM_001039841.1	Homo sapiens Rho GTPase activating protein 11B (ARHGAP11B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ARHGAP11B ( NM_001039841.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001034930.1 Homo sapiens Rho GTPase activating protein 11B (ARHGAP11B), mRNA.

Price & Availability↑

CloneID	OHu13447
Clone ID Related Accession (Same CDS sequence)	NM_001039841.1 , NM_001039841.2
Accession Version	NM_001039841.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 804bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-04-10
Organism	Homo sapiens(Human)
Product	rho GTPase-activating protein 11B
Comment	PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC105788.1. On or before Mar 17, 2006 this sequence version replaced XM_931017.1, XM_931023.1, XM_931028.1, XM_926156.1, XM_931039.1, XM_931045.1, XM_931050.1. ##Evidence-Data-START## Transcript exon combination :: BC105788.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGTGGGATC AGAGGCTGGT GAAGTTGGCC CTGTTGCAGC ATCTGCGGGC CTTCTATGGT 
ATTAAGGTGA AGGGTGTCCG TGGGCAGTGC GATCGCAGGA GACATGAAAC AGCAGCCACG 
GAAATAGGGG GTAAAATATT TGGAGTACCT TTTAATGCAC TGCCCCATTC TGCTGTACCA 
GAATATGGAC ACATTCCAAG CTTTCTTGTC GATGCTTGCA CATCTTTAGA AGAACATATT 
CATACCGAAG GGCTTTTTCG GAAATCAGGA TCTGTGATTC GCCTAAAAGC ACTAAAGAAT 
AAAGTGGATC ATGGTGAAGG TTGCCTATCT TCTGCACCTC CTTGTGATAT TGCGGGACTT 
CTTAAGCAGT TTTTTAGGGA ACTGCCAGAG CCCATTCTCC CAGCTGATTT GCATGAAGCA 
CTTTTGAAAG CTCAACAGTT AGGCACAGAG GAAAAGAATA AAGCTATACT GTTGCTCTCC 
TGTCTTCTGG CTGACCACAC AGTTCATGTA TTAAGATACT TCTTTAACTT TCTCAGGAAT 
GTTTCTCTTA GATCCAGTGA GAATAAGATG GATAGCAGCA ATCTTGCAGT AATATTTGCA 
CCAAATCTTC TTCAGACAAG TGAAGGACAT GAAAAGATGT CTTCTAACGC AGAAAAGAAG 
GGCGTGTACC AGACTTTATC CTGGAAAAGA TACCAGCCAT GTTGGGTATT GATGGTCTCT 
GTGCTACTCC ATCACTGGAA GGCTTTGAAG AAGGTGAATA TGAAACTCCT GGTGAATATA 
AGAGAAAGAG AAGACAACGT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001034930.1
CDS	146..949
Translation	MWDQRLVKLALLQHLRAFYGIKVKGVRGQCDRRRHETAATEIGGKIFGVPFNALPHSAVPEYGHIPSFLVDACTSLEEHIHTEGLFRKSGSVIRLKALKNKVDHGEGCLSSAPPCDIAGLLKQFFRELPEPILPADLHEALLKAQQLGTEEKNKAILLLSCLLADHTVHVLRYFFNFLRNVSLRSSENKMDSSNLAVIFAPNLLQTSEGHEKMSSNAEKKGVYQTLSWKRYQPCWVLMVSVLLHHWKALKKVNMKLLVNIREREDNV

Target ORF information:

RefSeq Version	NM_001039841.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens Rho GTPase activating protein 11B (ARHGAP11B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001039841.1

ORF Insert Sequence:

ATGTGGGATC AGAGGCTGGT GAAGTTGGCC CTGTTGCAGC ATCTGCGGGC CTTCTATGGT 
ATTAAGGTGA AGGGTGTCCG TGGGCAGTGC GATCGCAGGA GACATGAAAC AGCAGCCACG 
GAAATAGGGG GTAAAATATT TGGAGTACCT TTTAATGCAC TGCCCCATTC TGCTGTACCA 
GAATATGGAC ACATTCCAAG CTTTCTTGTC GATGCTTGCA CATCTTTAGA AGAACATATT 
CATACCGAAG GGCTTTTTCG GAAATCAGGA TCTGTGATTC GCCTAAAAGC ACTAAAGAAT 
AAAGTGGATC ATGGTGAAGG TTGCCTATCT TCTGCACCTC CTTGTGATAT TGCGGGACTT 
CTTAAGCAGT TTTTTAGGGA ACTGCCAGAG CCCATTCTCC CAGCTGATTT GCATGAAGCA 
CTTTTGAAAG CTCAACAGTT AGGCACAGAG GAAAAGAATA AAGCTATACT GTTGCTCTCC 
TGTCTTCTGG CTGACCACAC AGTTCATGTA TTAAGATACT TCTTTAACTT TCTCAGGAAT 
GTTTCTCTTA GATCCAGTGA GAATAAGATG GATAGCAGCA ATCTTGCAGT AATATTTGCA 
CCAAATCTTC TTCAGACAAG TGAAGGACAT GAAAAGATGT CTTCTAACGC AGAAAAGAAG 
GGCGTGTACC AGACTTTATC CTGGAAAAGA TACCAGCCAT GTTGGGTATT GATGGTCTCT 
GTGCTACTCC ATCACTGGAA GGCTTTGAAG AAGGTGAATA TGAAACTCCT GGTGAATATA 
AGAGAAAGAG AAGACAACGT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ARHGAP11B ( NM_001039841.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001034930.1 Homo sapiens Rho GTPase activating protein 11B (ARHGAP11B), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu13447
Clone ID Related Accession (Same CDS sequence)	NM_001039841.1 , NM_001039841.2
Accession Version	NM_001039841.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 804bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-30
Organism	Homo sapiens(human)
Product	rho GTPase-activating protein 11B
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL556699.3, AC091057.6 and BC105788.1. On Jul 12, 2017 this sequence version replaced NM_001039841.1. Transcript Variant: This variant (1) represents the protein-coding transcript. ##Evidence-Data-START## Transcript exon combination :: BC105788.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTGGGATC AGAGGCTGGT GAAGTTGGCC CTGTTGCAGC ATCTGCGGGC CTTCTATGGT 
ATTAAGGTGA AGGGTGTCCG TGGGCAGTGC GATCGCAGGA GACATGAAAC AGCAGCCACG 
GAAATAGGGG GTAAAATATT TGGAGTACCT TTTAATGCAC TGCCCCATTC TGCTGTACCA 
GAATATGGAC ACATTCCAAG CTTTCTTGTC GATGCTTGCA CATCTTTAGA AGAACATATT 
CATACCGAAG GGCTTTTTCG GAAATCAGGA TCTGTGATTC GCCTAAAAGC ACTAAAGAAT 
AAAGTGGATC ATGGTGAAGG TTGCCTATCT TCTGCACCTC CTTGTGATAT TGCGGGACTT 
CTTAAGCAGT TTTTTAGGGA ACTGCCAGAG CCCATTCTCC CAGCTGATTT GCATGAAGCA 
CTTTTGAAAG CTCAACAGTT AGGCACAGAG GAAAAGAATA AAGCTATACT GTTGCTCTCC 
TGTCTTCTGG CTGACCACAC AGTTCATGTA TTAAGATACT TCTTTAACTT TCTCAGGAAT 
GTTTCTCTTA GATCCAGTGA GAATAAGATG GATAGCAGCA ATCTTGCAGT AATATTTGCA 
CCAAATCTTC TTCAGACAAG TGAAGGACAT GAAAAGATGT CTTCTAACGC AGAAAAGAAG 
GGCGTGTACC AGACTTTATC CTGGAAAAGA TACCAGCCAT GTTGGGTATT GATGGTCTCT 
GTGCTACTCC ATCACTGGAA GGCTTTGAAG AAGGTGAATA TGAAACTCCT GGTGAATATA 
AGAGAAAGAG AAGACAACGT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001034930.1
CDS	674..1477
Translation	MWDQRLVKLALLQHLRAFYGIKVKGVRGQCDRRRHETAATEIGGKIFGVPFNALPHSAVPEYGHIPSFLVDACTSLEEHIHTEGLFRKSGSVIRLKALKNKVDHGEGCLSSAPPCDIAGLLKQFFRELPEPILPADLHEALLKAQQLGTEEKNKAILLLSCLLADHTVHVLRYFFNFLRNVSLRSSENKMDSSNLAVIFAPNLLQTSEGHEKMSSNAEKKGVYQTLSWKRYQPCWVLMVSVLLHHWKALKKVNMKLLVNIREREDNV

Target ORF information:

RefSeq Version	NM_001039841.2
Organism	Homo sapiens(human)
Definition	Homo sapiens Rho GTPase activating protein 11B (ARHGAP11B), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001039841.2

ORF Insert Sequence:

ATGTGGGATC AGAGGCTGGT GAAGTTGGCC CTGTTGCAGC ATCTGCGGGC CTTCTATGGT 
ATTAAGGTGA AGGGTGTCCG TGGGCAGTGC GATCGCAGGA GACATGAAAC AGCAGCCACG 
GAAATAGGGG GTAAAATATT TGGAGTACCT TTTAATGCAC TGCCCCATTC TGCTGTACCA 
GAATATGGAC ACATTCCAAG CTTTCTTGTC GATGCTTGCA CATCTTTAGA AGAACATATT 
CATACCGAAG GGCTTTTTCG GAAATCAGGA TCTGTGATTC GCCTAAAAGC ACTAAAGAAT 
AAAGTGGATC ATGGTGAAGG TTGCCTATCT TCTGCACCTC CTTGTGATAT TGCGGGACTT 
CTTAAGCAGT TTTTTAGGGA ACTGCCAGAG CCCATTCTCC CAGCTGATTT GCATGAAGCA 
CTTTTGAAAG CTCAACAGTT AGGCACAGAG GAAAAGAATA AAGCTATACT GTTGCTCTCC 
TGTCTTCTGG CTGACCACAC AGTTCATGTA TTAAGATACT TCTTTAACTT TCTCAGGAAT 
GTTTCTCTTA GATCCAGTGA GAATAAGATG GATAGCAGCA ATCTTGCAGT AATATTTGCA 
CCAAATCTTC TTCAGACAAG TGAAGGACAT GAAAAGATGT CTTCTAACGC AGAAAAGAAG 
GGCGTGTACC AGACTTTATC CTGGAAAAGA TACCAGCCAT GTTGGGTATT GATGGTCTCT 
GTGCTACTCC ATCACTGGAA GGCTTTGAAG AAGGTGAATA TGAAACTCCT GGTGAATATA 
AGAGAAAGAG AAGACAACGT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A single splice site mutation in human-specific
Science advances2(12)e1601941(2016 Dec)
Florio M,Namba T,P??bo S,Hiller M,Huttner WB

Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion.
Science (New York, N.Y.)347(6229)1465-70(2015 Mar)
Florio M,Albert M,Taverna E,Namba T,Brandl H,Lewitus E,Haffner C,Sykes A,Wong FK,Peters J,Guhr E,Klemroth S,Pr?fer K,Kelso J,Naumann R,N?sslein I,Dahl A,Lachmann R,P??bo S,Huttner WB

A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy.
Human molecular genetics23(1)247-58(2014 Jan)
Speed D,Hoggart C,Petrovski S,Tachmazidou I,Coffey A,Jorgensen A,Eleftherohorinou H,De Iorio M,Todaro M,De T,Smith D,Smith PE,Jackson M,Cooper P,Kellett M,Howell S,Newton M,Yerra R,Tan M,French C,Reuber M,Sills GE,Chadwick D,Pirmohamed M,Bentley D,Scheffer I,Berkovic S,Balding D,Palotie A,Marson A,O'Brien TJ,Johnson MR

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ARHGAP11B cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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