TNFRSF10C cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TNFRSF10C
Entrez Gene ID	8794
Full Name	TNF receptor superfamily member 10c
Synonyms	CD263,DCR1,DCR1-TNFR,LIT,TRAIL-R3,TRAILR3,TRID
General protein information	Preferred Names TNF receptor superfamily member 10c Names tumor necrosis factor receptor superfamily member 10C TNF-related apoptosis-inducing ligand receptor 3 antagonist decoy receptor for TRAIL/Apo-2L cytotoxic TRAIL receptor-3 decoy TRAIL receptor without death domain decoy receptor 1 lymphocyte inhibitor of TRAIL tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8p21.3
Summary	The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008].
Disorder MIM:	603613

mRNA and Protein(s)

mRNA	Protein	Name
NM_003841.4	NP_003832.2	tumor necrosis factor receptor superfamily member 10C precursor
NM_003841.5	NP_003832.3	tumor necrosis factor receptor superfamily member 10C precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	TNFRSF10C	XP_528085.1
Homo sapiens (human)	TNFRSF10C	NP_003832.2

Gene Ontology
Bibliography

Related articles in PubMed

Prognostic significance of TRAIL-R3 and CCR-2 expression in tumor epithelial cells of patients with early breast cancer.
Labovsky V, Martinez LM, Davies KM, de Luj?n Calcagno M, Garc?a-Rivello H, Wernicke A, Feldman L, Matas A, Giorello MB, Borzone FR, Choi H, Howard SC, Chasseing NA
BMC cancer17(1)280(2017 04)

Decoy receptors block TRAIL sensitivity at a supracellular level: the role of stromal cells in controlling tumour TRAIL sensitivity.
O'Leary L, van der Sloot AM, Reis CR, Deegan S, Ryan AE, Dhami SP, Murillo LS, Cool RH, Correa de Sampaio P, Thompson K, Murphy G, Quax WJ, Serrano L, Samali A, Szegezdi E
Oncogene35(10)1261-70(2016 Mar)

Epigenetic inactivation of TRAIL decoy receptors at 8p12-21.3 commonly deleted region confers sensitivity to Apo2L/trail-Cisplatin combination therapy in cervical cancer.
Narayan G, Xie D, Ishdorj G, Scotto L, Mansukhani M, Pothuri B, Wright JD, Kaufmann AM, Schneider A, Arias-Pulido H, Murty VV
Genes, chromosomes & cancer55(2)177-89(2016 Feb)

Decoy Receptor DcR1 Is Induced in a p50/Bcl3-Dependent Manner and Attenuates the Efficacy of Temozolomide.
Mansour NM, Bernal GM, Wu L, Crawley CD, Cahill KE, Voce DJ, Balyasnikova IV, Zhang W, Spretz R, Nunez L, Larsen GF, Weichselbaum RR, Yamini B
Cancer research75(10)2039-48(2015 May)

Signal peptide prediction based on analysis of experimentally verified cleavage sites.
Zhang Z, Henzel WJ
Protein science : a publication of the Protein Society13(10)2819-24(2004 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

High levels of TRAIL-R3 and CCR-2 expression in tumor epithelial cells identified patients with early breast cancer with poor outcomes.
Title: Prognostic significance of TRAIL-R3 and CCR-2 expression in tumor epithelial cells of patients with early breast cancer.

DcRs regulate TRAIL sensitivity at a supracellular level
Title: Decoy receptors block TRAIL sensitivity at a supracellular level: the role of stromal cells in controlling tumour TRAIL sensitivity.

Results identified epigenetic inactivation of TNFRSF10C and TNFRSF10D in majority of cervical cancer cases.
Title: Epigenetic inactivation of TRAIL decoy receptors at 8p12-21.3 commonly deleted region confers sensitivity to Apo2L/trail-Cisplatin combination therapy in cervical cancer.

DcR1 upregulation mediates temozolomide resistance.
Title: Decoy Receptor DcR1 Is Induced in a p50/Bcl3-Dependent Manner and Attenuates the Efficacy of Temozolomide.

membrane expression more common in endometrioid endometrial cancer than in normal endometrium
Title: Membrane expression of trail receptors DcR1 and DcR2 in the normal endometrium, endometrial atypical hyperplasia and endometrioid endometrial cancer.

The following TNFRSF10C gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TNFRSF10C cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu26632	NM_003841.4 Latest version!	Homo sapiens TNF receptor superfamily member 10c (TNFRSF10C), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu109348	NM_003841.5 Latest version!	Homo sapiens TNF receptor superfamily member 10c (TNFRSF10C), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TNFRSF10C ( NM_003841.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003832.2 Homo sapiens TNF receptor superfamily member 10c (TNFRSF10C), mRNA.

Price & Availability↑

CloneID	OHu26632
Clone ID Related Accession (Same CDS sequence)	NM_003841.4
Accession Version	NM_003841.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 780bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-22
Organism	Homo sapiens(human)
Product	tumor necrosis factor receptor superfamily member 10C precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC107959.8 and BC125041.1. This sequence is a reference standard in the RefSeqGene project. On Nov 30, 2016 this sequence version replaced NM_003841.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. CCDS Note: This CCDS representation uses a downstream AUG start codon. This start codon has a strong Kozak signal and is restricted to human. An upstream start codon, which has a weak Kozak signal and is conserved in some other primates, is also present. The use of the upstream start codon would result in a protein that is 40 aa longer at the N-terminus. However, this would eliminate a signal peptide that is predicted for the shorter but not the longer N-terminus. PMID:9242611 shows experimental evidence for cleavage of a signal peptide following aa 25 from the downstream start, and this is also confirmed in PMID:15340161. Therefore, the downstream start codon is represented for this CCDS. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF033854.1, AF016267.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCCGGA TCCCCAAGAC CCTAAAGTTC GTCGTCGTCA TCGTCGCGGT CCTGCTGCCA 
GTCCTAGCTT ACTCTGCCAC CACTGCCCGG CAGGAGGAAG TTCCCCAGCA GACAGTGGCC 
CCACAGCAAC AGAGGCACAG CTTCAAGGGG GAGGAGTGTC CAGCAGGATC TCATAGATCA 
GAACATACTG GAGCCTGTAA CCCGTGCACA GAGGGTGTGG ATTACACCAA CGCTTCCAAC 
AATGAACCTT CTTGCTTCCC ATGTACAGTT TGTAAATCAG ATCAAAAACA TAAAAGTTCC 
TGCACCATGA CCAGAGACAC AGTGTGTCAG TGTAAAGAAG GCACCTTCCG GAATGAAAAC 
TCCCCAGAGA TGTGCCGGAA GTGTAGCAGG TGCCCTAGTG GGGAAGTCCA AGTCAGTAAT 
TGTACGTCCT GGGATGATAT CCAGTGTGTT GAAGAATTTG GTGCCAATGC CACTGTGGAA 
ACCCCAGCTG CTGAAGAGAC AATGAACACC AGCCCGGGGA CTCCTGCCCC AGCTGCTGAA 
GAGACAATGA ACACCAGCCC AGGGACTCCT GCCCCAGCTG CTGAAGAGAC AATGACCACC 
AGCCCGGGGA CTCCTGCCCC AGCTGCTGAA GAGACAATGA CCACCAGCCC GGGGACTCCT 
GCCCCAGCTG CTGAAGAGAC AATGACCACC AGCCCGGGGA CTCCTGCCTC TTCTCATTAC 
CTCTCATGCA CCATCGTAGG GATCATAGTT CTAATTGTGC TTCTGATTGT GTTTGTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003832.2
CDS	309..1088
Translation	MARIPKTLKFVVVIVAVLLPVLAYSATTARQEEVPQQTVAPQQQRHSFKGEECPAGSHRSEHTGACNPCTEGVDYTNASNNEPSCFPCTVCKSDQKHKSSCTMTRDTVCQCKEGTFRNENSPEMCRKCSRCPSGEVQVSNCTSWDDIQCVEEFGANATVETPAAEETMNTSPGTPAPAAEETMNTSPGTPAPAAEETMTTSPGTPAPAAEETMTTSPGTPAPAAEETMTTSPGTPASSHYLSCTIVGIIVLIVLLIVFV

Target ORF information:

RefSeq Version	NM_003841.4
Organism	Homo sapiens(human)
Definition	Homo sapiens TNF receptor superfamily member 10c (TNFRSF10C), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003841.4

ORF Insert Sequence:

ATGGCCCGGA TCCCCAAGAC CCTAAAGTTC GTCGTCGTCA TCGTCGCGGT CCTGCTGCCA 
GTCCTAGCTT ACTCTGCCAC CACTGCCCGG CAGGAGGAAG TTCCCCAGCA GACAGTGGCC 
CCACAGCAAC AGAGGCACAG CTTCAAGGGG GAGGAGTGTC CAGCAGGATC TCATAGATCA 
GAACATACTG GAGCCTGTAA CCCGTGCACA GAGGGTGTGG ATTACACCAA CGCTTCCAAC 
AATGAACCTT CTTGCTTCCC ATGTACAGTT TGTAAATCAG ATCAAAAACA TAAAAGTTCC 
TGCACCATGA CCAGAGACAC AGTGTGTCAG TGTAAAGAAG GCACCTTCCG GAATGAAAAC 
TCCCCAGAGA TGTGCCGGAA GTGTAGCAGG TGCCCTAGTG GGGAAGTCCA AGTCAGTAAT 
TGTACGTCCT GGGATGATAT CCAGTGTGTT GAAGAATTTG GTGCCAATGC CACTGTGGAA 
ACCCCAGCTG CTGAAGAGAC AATGAACACC AGCCCGGGGA CTCCTGCCCC AGCTGCTGAA 
GAGACAATGA ACACCAGCCC AGGGACTCCT GCCCCAGCTG CTGAAGAGAC AATGACCACC 
AGCCCGGGGA CTCCTGCCCC AGCTGCTGAA GAGACAATGA CCACCAGCCC GGGGACTCCT 
GCCCCAGCTG CTGAAGAGAC AATGACCACC AGCCCGGGGA CTCCTGCCTC TTCTCATTAC 
CTCTCATGCA CCATCGTAGG GATCATAGTT CTAATTGTGC TTCTGATTGT GTTTGTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TNFRSF10C ( NM_003841.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_003832.3 Homo sapiens TNF receptor superfamily member 10c (TNFRSF10C), mRNA.

Price & Availability↑

CloneID	OHu109348
Clone ID Related Accession (Same CDS sequence)	NM_003841.5
Accession Version	NM_003841.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 780bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Homo sapiens(human)
Product	tumor necrosis factor receptor superfamily member 10C precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC107959.8. On Nov 30, 2019 this sequence version replaced NM_003841.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. CCDS Note: This CCDS representation uses a downstream AUG start codon. This start codon has a strong Kozak signal and is restricted to human. An upstream start codon, which has a weak Kozak signal and is conserved in some other primates, is also present. The use of the upstream start codon would result in a protein that is 40 aa longer at the N-terminus. However, this would eliminate a signal peptide that is predicted for the shorter but not the longer N-terminus. PMID:9242611 shows experimental evidence for cleavage of a signal peptide following aa 25 from the downstream start, and this is also confirmed in PMID:15340161. Therefore, the downstream start codon is represented for this CCDS. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC017852.1, AF014794.2 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCCGGA TCCCCAAGAC CCTAAAGTTC GTCGTCGTCA TCGTCGCGGT CCTGCTGCCA 
GTCCTAGCTT ACTCTGCCAC CACTGCCCGG CAGGAGGAAG TTCCCCAGCA GACAGTGGCC 
CCACAGCAAC AGAGGCACAG CTTCAAGGGG GAGGAGTGTC CAGCAGGATC TCATAGATCA 
GAACATACTG GAGCCTGTAA CCCGTGCACA GAGGGTGTGG ATTACACCAA CGCTTCCAAC 
AATGAACCTT CTTGCTTCCC ATGTACAGTT TGTAAATCAG ATCAAAAACA TAAAAGTTCC 
TGCACCATGA CCAGAGACAC AGTGTGTCAG TGTAAAGAAG GCACCTTCCG GAATGAAAAC 
TCCCCAGAGA TGTGCCGGAA GTGTAGCAGG TGCCCTAGTG GGGAAGTCCA AGTCAGTAAT 
TGTACGTCCT GGGATGATAT CCAGTGTGTT GAAGAATTTG GTGCCAATGC CACTGTGGAA 
ACCCCAGCTG CTGAAGAGAC AATGAACACC AGCCCGGGGA CTCCTGCCCC AGCTGCTGAA 
GAGACAATGA ACACCAGCCC GGGGACTCCT GCCCCAGCTG CTGAAGAGAC AATGACCACC 
AGCCCGGGGA CTCCTGCCCC AGCTGCTGAA GAGACAATGA CCACCAGCCC GGGGACTCCT 
GCCCCAGCTG CTGAAGAGAC AATGATCACC AGCCCGGGGA CTCCTGCCTC TTCTCATTAC 
CTCTCATGCA CCATCGTAGG GATCATAGTT CTAATTGTGC TTCTGATTGT GTTTGTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003832.3
CDS	202..981
Translation	MARIPKTLKFVVVIVAVLLPVLAYSATTARQEEVPQQTVAPQQQRHSFKGEECPAGSHRSEHTGACNPCTEGVDYTNASNNEPSCFPCTVCKSDQKHKSSCTMTRDTVCQCKEGTFRNENSPEMCRKCSRCPSGEVQVSNCTSWDDIQCVEEFGANATVETPAAEETMNTSPGTPAPAAEETMNTSPGTPAPAAEETMTTSPGTPAPAAEETMTTSPGTPAPAAEETMITSPGTPASSHYLSCTIVGIIVLIVLLIVFV

Target ORF information:

RefSeq Version	NM_003841.5
Organism	Homo sapiens(human)
Definition	Homo sapiens TNF receptor superfamily member 10c (TNFRSF10C), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003841.5

ORF Insert Sequence:

ATGGCCCGGA TCCCCAAGAC CCTAAAGTTC GTCGTCGTCA TCGTCGCGGT CCTGCTGCCA 
GTCCTAGCTT ACTCTGCCAC CACTGCCCGG CAGGAGGAAG TTCCCCAGCA GACAGTGGCC 
CCACAGCAAC AGAGGCACAG CTTCAAGGGG GAGGAGTGTC CAGCAGGATC TCATAGATCA 
GAACATACTG GAGCCTGTAA CCCGTGCACA GAGGGTGTGG ATTACACCAA CGCTTCCAAC 
AATGAACCTT CTTGCTTCCC ATGTACAGTT TGTAAATCAG ATCAAAAACA TAAAAGTTCC 
TGCACCATGA CCAGAGACAC AGTGTGTCAG TGTAAAGAAG GCACCTTCCG GAATGAAAAC 
TCCCCAGAGA TGTGCCGGAA GTGTAGCAGG TGCCCTAGTG GGGAAGTCCA AGTCAGTAAT 
TGTACGTCCT GGGATGATAT CCAGTGTGTT GAAGAATTTG GTGCCAATGC CACTGTGGAA 
ACCCCAGCTG CTGAAGAGAC AATGAACACC AGCCCGGGGA CTCCTGCCCC AGCTGCTGAA 
GAGACAATGA ACACCAGCCC GGGGACTCCT GCCCCAGCTG CTGAAGAGAC AATGACCACC 
AGCCCGGGGA CTCCTGCCCC AGCTGCTGAA GAGACAATGA CCACCAGCCC GGGGACTCCT 
GCCCCAGCTG CTGAAGAGAC AATGATCACC AGCCCGGGGA CTCCTGCCTC TTCTCATTAC 
CTCTCATGCA CCATCGTAGG GATCATAGTT CTAATTGTGC TTCTGATTGT GTTTGTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Prognostic significance of TRAIL-R3 and CCR-2 expression in tumor epithelial cells of patients with early breast cancer.
BMC cancer17(1)280(2017 04)
Labovsky V,Martinez LM,Davies KM,de Luj?n Calcagno M,Garc?a-Rivello H,Wernicke A,Feldman L,Matas A,Giorello MB,Borzone FR,Choi H,Howard SC,Chasseing NA

Decoy receptors block TRAIL sensitivity at a supracellular level: the role of stromal cells in controlling tumour TRAIL sensitivity.
Oncogene35(10)1261-70(2016 Mar)
O'Leary L,van der Sloot AM,Reis CR,Deegan S,Ryan AE,Dhami SP,Murillo LS,Cool RH,Correa de Sampaio P,Thompson K,Murphy G,Quax WJ,Serrano L,Samali A,Szegezdi E

Epigenetic inactivation of TRAIL decoy receptors at 8p12-21.3 commonly deleted region confers sensitivity to Apo2L/trail-Cisplatin combination therapy in cervical cancer.
Genes, chromosomes & cancer55(2)177-89(2016 Feb)
Narayan G,Xie D,Ishdorj G,Scotto L,Mansukhani M,Pothuri B,Wright JD,Kaufmann AM,Schneider A,Arias-Pulido H,Murty VV

Decoy Receptor DcR1 Is Induced in a p50/Bcl3-Dependent Manner and Attenuates the Efficacy of Temozolomide.
Cancer research75(10)2039-48(2015 May)
Mansour NM,Bernal GM,Wu L,Crawley CD,Cahill KE,Voce DJ,Balyasnikova IV,Zhang W,Spretz R,Nunez L,Larsen GF,Weichselbaum RR,Yamini B

Signal peptide prediction based on analysis of experimentally verified cleavage sites.
Protein science : a publication of the Protein Society13(10)2819-24(2004 Oct)
Zhang Z,Henzel WJ

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TNFRSF10C cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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