HRK cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HRK
Entrez Gene ID	8739
Full Name	harakiri, BCL2 interacting protein
Synonyms	DP5,HARAKIRI
General protein information	Preferred Names harakiri, BCL2 interacting protein Names activator of apoptosis harakiri BH3-interacting domain-containing protein 3 activator of apoptosis Hrk death protein 5 harakiri, BCL2 interacting protein (contains only BH3 domain) neuronal death protein DP5
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q24.22
Summary	This gene encodes a member of the BCL-2 protein family. Members of this family are involved in activating or inhibiting apoptosis. The encoded protein localizes to intracellular membranes. This protein promotes apoptosis by interacting with the apoptotic inhibitors BCL-2 and BCL-X(L) via its BH3 domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012].
Disorder MIM:	603447

mRNA and Protein(s)

mRNA	Protein	Name
NM_003806.2	NP_003797.1	activator of apoptosis harakiri
XM_017020146.1	XP_016875635.1	activator of apoptosis harakiri isoform X1
NM_003806.3	NP_003797.1	activator of apoptosis harakiri
NM_003806.4	NP_003797.1	activator of apoptosis harakiri

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	HRK	XP_001145194.2
Bos taurus (cattle)	HRK	NP_001178170.1
Homo sapiens (human)	HRK	NP_003797.1

Gene Ontology
Bibliography

Related articles in PubMed

KDM2B, an H3K36-specific demethylase, regulates apoptotic response of GBM cells to TRAIL.
Kurt IC, Sur I, Kaya E, Cingoz A, Kazancioglu S, Kahya Z, Toparlak OD, Senbabaoglu F, Kaya Z, Ozyerli E, Karah?seyinoglu S, Lack NA, G?m?s ZH, Onder TT, Bagci-Onder T
Cell death & disease8(6)e2897(2017 Jun)

MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic ?-Cells.
Grieco FA, Sebastiani G, Juan-Mateu J, Villate O, Marroqui L, Ladri?re L, Tugay K, Regazzi R, Bugliani M, Marchetti P, Dotta F, Eizirik DL
Diabetes66(1)100-112(2017 Jan)

Hrk mediates 2-methoxyestradiol-induced mitochondrial apoptotic signaling in prostate cancer cells.
Chang I, Majid S, Saini S, Zaman MS, Yamamura S, Chiyomaru T, Shahryari V, Fukuhara S, Deng G, Dahiya R, Tanaka Y
Molecular cancer therapeutics12(6)1049-59(2013 Jun)

ATF4 orchestrates a program of BH3-only protein expression in severe hypoxia.
Pike LR, Phadwal K, Simon AK, Harris AL
Molecular biology reports39(12)10811-22(2012 Dec)

Nuclear magnetic resonance study of protein-protein interactions involving apoptosis regulator Diva (Boo) and the BH3 domain of proapoptotic Bcl-2 members.
Santiveri CM, Sborgi L, de Alba E
Journal of molecular recognition : JMR25(12)665-73(2012 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

miR-23a-3p, miR-23b-3p, and miR-149-5p, were downregulated by cytokines and selected for further studies. These miRNAs were found to regulate the expression of the proapoptotic Bcl-2 proteins DP5 and PUMA and consequent human beta-cell apoptosis.
Title: MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic ?-Cells.

our findings suggest that induction of the BH3-only protein Hrk is a critical step in 2-ME activation of the JNK-induced apoptotic pathway, targeting mitochondria by liberating proapoptotic protein Bak.
Title: Hrk mediates 2-methoxyestradiol-induced mitochondrial apoptotic signaling in prostate cancer cells.

The BH3-only protein harakiri (HRK) is transactivated by ATF4 in severe hypoxia through direct binding of ATF4 to the promoter region.
Title: ATF4 orchestrates a program of BH3-only protein expression in severe hypoxia.

Diva binds peptides derived from the BH3 domain of several other proapoptotic Bcl-2 proteins, including mouse Harakiri, Bid, Bak and Bmf.
Title: Nuclear magnetic resonance study of protein-protein interactions involving apoptosis regulator Diva (Boo) and the BH3 domain of proapoptotic Bcl-2 members.

SUZ12 promotes the proliferation of human EOC cells by inhibiting apoptosis and HRK is a novel SUZ12 target gene whose upregulation contributes to apoptosis induced by SUZ12 knockdown.
Title: SUZ12 promotes human epithelial ovarian cancer by suppressing apoptosis via silencing HRK.

The following HRK gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HRK cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09532	NM_003806.4 Latest version!	Homo sapiens harakiri, BCL2 interacting protein (HRK), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
OHu09532	XM_017020146.1 Latest version!	Homo sapiens harakiri, BCL2 interacting protein (HRK), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
View Old Accession Versions >>
OHu09532	NM_003806.2	Homo sapiens harakiri, BCL2 interacting protein (HRK), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
OHu09532	NM_003806.3	Homo sapiens harakiri, BCL2 interacting protein (HRK), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HRK ( NM_003806.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_003797.1 Homo sapiens harakiri, BCL2 interacting protein (HRK), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu09532
Clone ID Related Accession (Same CDS sequence)	NM_003806.2 , XM_017020146.1 , NM_003806.3 , NM_003806.4
Accession Version	NM_003806.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 276bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	activator of apoptosis harakiri
Comment	REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U76376.1 and AC083806.16. On Oct 20, 2012 this sequence version replaced NM_003806.1. Transcript Variant: This variant (1) encodes the functional protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. CCDS Note: This CCDS ID represents the protein described in PMID: 9130713 and 9228060. This transcript is supported by BF510077.1. It should be noted this transcript is predicted to undergo nonsense-mediated mRNA decay (NMD). However, the protein is represented because it was detected endogenously PMID: 18008329. It is likely that the majority of transcripts representing this variant will undergo NMD, while some low level of NMD escape may allow for the expression of this protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D83699.1, HY075247.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## NMD candidate :: translation inferred from conservation ##RefSeq-Attributes-END##

ATGTGCCCGT GCCCCCTGCA CCGCGGCCGC GGCCCCCCGG CCGTGTGCGC CTGCAGCGCG 
GGTCGCCTGG GGCTGCGCTC GTCCGCCGCG CAGCTCACCG CCGCCCGGCT CAAGGCGCTA 
GGCGACGAGC TGCACCAGCG CACCATGTGG CGGCGCCGCG CGCGGAGCCG GAGGGCGCCG 
GCGCCCGGCG CGCTCCCCAC CTACTGGCCT TGGCTGTGCG CGGCCGCGCA GGTGGCGGCG 
CTGGCGGCCT GGCTGCTCGG CAGGCGGAAC TTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003797.1
CDS	121..396
Translation	MCPCPLHRGRGPPAVCACSAGRLGLRSSAAQLTAARLKALGDELHQRTMWRRRARSRRAPAPGALPTYWPWLCAAAQVAALAAWLLGRRNL

Target ORF information:

RefSeq Version	NM_003806.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens harakiri, BCL2 interacting protein (HRK), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003806.2

ORF Insert Sequence:

ATGTGCCCGT GCCCCCTGCA CCGCGGCCGC GGCCCCCCGG CCGTGTGCGC CTGCAGCGCG 
GGTCGCCTGG GGCTGCGCTC GTCCGCCGCG CAGCTCACCG CCGCCCGGCT CAAGGCGCTA 
GGCGACGAGC TGCACCAGCG CACCATGTGG CGGCGCCGCG CGCGGAGCCG GAGGGCGCCG 
GCGCCCGGCG CGCTCCCCAC CTACTGGCCT TGGCTGTGCG CGGCCGCGCA GGTGGCGGCG 
CTGGCGGCCT GGCTGCTCGG CAGGCGGAAC TTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HRK ( NM_003806.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003797.1 Homo sapiens harakiri, BCL2 interacting protein (HRK), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu09532
Clone ID Related Accession (Same CDS sequence)	NM_003806.2 , XM_017020146.1 , NM_003806.3 , NM_003806.4
Accession Version	NM_003806.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 276bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-30
Organism	Homo sapiens(human)
Product	activator of apoptosis harakiri
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U76376.1, D83699.1, AC083806.16, AK094730.1 and BU623308.1. On Jun 27, 2017 this sequence version replaced NM_003806.2. Transcript Variant: This variant (1) encodes the functional protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. CCDS Note: This CCDS ID represents the protein described in PMID: 9130713 and 9228060. This transcript is supported by BF510077.1. It should be noted this transcript is predicted to undergo nonsense-mediated mRNA decay (NMD). However, the protein is represented because it was detected endogenously PMID: 18008329. It is likely that the majority of transcripts representing this variant will undergo NMD, while some low level of NMD escape may allow for the expression of this protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U76376.1, SRR1660809.12764.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## NMD candidate :: translation inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTGCCCGT GCCCCCTGCA CCGCGGCCGC GGCCCCCCGG CCGTGTGCGC CTGCAGCGCG 
GGTCGCCTGG GGCTGCGCTC GTCCGCCGCG CAGCTCACCG CCGCCCGGCT CAAGGCGCTA 
GGCGACGAGC TGCACCAGCG CACCATGTGG CGGCGCCGCG CGCGGAGCCG GAGGGCGCCG 
GCGCCCGGCG CGCTCCCCAC CTACTGGCCT TGGCTGTGCG CGGCCGCGCA GGTGGCGGCG 
CTGGCGGCCT GGCTGCTCGG CAGGCGGAAC TTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003797.1
CDS	121..396
Translation	MCPCPLHRGRGPPAVCACSAGRLGLRSSAAQLTAARLKALGDELHQRTMWRRRARSRRAPAPGALPTYWPWLCAAAQVAALAAWLLGRRNL

Target ORF information:

RefSeq Version	NM_003806.3
Organism	Homo sapiens(human)
Definition	Homo sapiens harakiri, BCL2 interacting protein (HRK), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003806.3

ORF Insert Sequence:

ATGTGCCCGT GCCCCCTGCA CCGCGGCCGC GGCCCCCCGG CCGTGTGCGC CTGCAGCGCG 
GGTCGCCTGG GGCTGCGCTC GTCCGCCGCG CAGCTCACCG CCGCCCGGCT CAAGGCGCTA 
GGCGACGAGC TGCACCAGCG CACCATGTGG CGGCGCCGCG CGCGGAGCCG GAGGGCGCCG 
GCGCCCGGCG CGCTCCCCAC CTACTGGCCT TGGCTGTGCG CGGCCGCGCA GGTGGCGGCG 
CTGGCGGCCT GGCTGCTCGG CAGGCGGAAC TTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HRK ( NM_003806.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003797.1 Homo sapiens harakiri, BCL2 interacting protein (HRK), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu09532
Clone ID Related Accession (Same CDS sequence)	NM_003806.2 , XM_017020146.1 , NM_003806.3 , NM_003806.4
Accession Version	NM_003806.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 276bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	activator of apoptosis harakiri
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC083806.16, U76376.1, D83699.1, AK094730.1 and BU623308.1. On May 17, 2019 this sequence version replaced NM_003806.3. Transcript Variant: This variant (1) encodes the functional protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. CCDS Note: This CCDS ID represents the protein described in PMID: 9130713 and 9228060. This transcript is supported by BF510077.1. It should be noted this transcript is predicted to undergo nonsense-mediated mRNA decay (NMD). However, the protein is represented because it was detected endogenously PMID: 18008329. It is likely that the majority of transcripts representing this variant will undergo NMD, while some low level of NMD escape may allow for the expression of this protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.12764.1, SRR1803612.229509.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000257572.5/ ENSP00000257572.4 NMD candidate :: translation inferred from conservation RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTGCCCGT GCCCCCTGCA CCGCGGCCGC GGCCCCCCGG CCGTGTGCGC CTGCAGCGCG 
GGTCGCCTGG GGCTGCGCTC GTCCGCCGCG CAGCTCACCG CCGCCCGGCT CAAGGCGCTA 
GGCGACGAGC TGCACCAGCG CACCATGTGG CGGCGCCGCG CGCGGAGCCG GAGGGCGCCG 
GCGCCCGGCG CGCTCCCCAC CTACTGGCCT TGGCTGTGCG CGGCCGCGCA GGTGGCGGCG 
CTGGCGGCCT GGCTGCTCGG CAGGCGGAAC TTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003797.1
CDS	135..410
Translation	MCPCPLHRGRGPPAVCACSAGRLGLRSSAAQLTAARLKALGDELHQRTMWRRRARSRRAPAPGALPTYWPWLCAAAQVAALAAWLLGRRNL

Target ORF information:

RefSeq Version	NM_003806.4
Organism	Homo sapiens(human)
Definition	Homo sapiens harakiri, BCL2 interacting protein (HRK), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003806.4

ORF Insert Sequence:

ATGTGCCCGT GCCCCCTGCA CCGCGGCCGC GGCCCCCCGG CCGTGTGCGC CTGCAGCGCG 
GGTCGCCTGG GGCTGCGCTC GTCCGCCGCG CAGCTCACCG CCGCCCGGCT CAAGGCGCTA 
GGCGACGAGC TGCACCAGCG CACCATGTGG CGGCGCCGCG CGCGGAGCCG GAGGGCGCCG 
GCGCCCGGCG CGCTCCCCAC CTACTGGCCT TGGCTGTGCG CGGCCGCGCA GGTGGCGGCG 
CTGGCGGCCT GGCTGCTCGG CAGGCGGAAC TTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HRK ( XM_017020146.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016875635.1 Homo sapiens harakiri, BCL2 interacting protein (HRK), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu09532
Clone ID Related Accession (Same CDS sequence)	NM_003806.2 , XM_017020146.1 , NM_003806.3 , NM_003806.4
Accession Version	XM_017020146.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 276bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	activator of apoptosis harakiri isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGCCCGT GCCCCCTGCA CCGCGGCCGC GGCCCCCCGG CCGTGTGCGC CTGCAGCGCG 
GGTCGCCTGG GGCTGCGCTC GTCCGCCGCG CAGCTCACCG CCGCCCGGCT CAAGGCGCTA 
GGCGACGAGC TGCACCAGCG CACCATGTGG CGGCGCCGCG CGCGGAGCCG GAGGGCGCCG 
GCGCCCGGCG CGCTCCCCAC CTACTGGCCT TGGCTGTGCG CGGCCGCGCA GGTGGCGGCG 
CTGGCGGCCT GGCTGCTCGG CAGGCGGAAC TTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016875635.1
CDS	117..392
Translation	MCPCPLHRGRGPPAVCACSAGRLGLRSSAAQLTAARLKALGDELHQRTMWRRRARSRRAPAPGALPTYWPWLCAAAQVAALAAWLLGRRNL

Target ORF information:

RefSeq Version	XM_017020146.1
Organism	Homo sapiens(human)
Definition	Homo sapiens harakiri, BCL2 interacting protein (HRK), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017020146.1

ORF Insert Sequence:

ATGTGCCCGT GCCCCCTGCA CCGCGGCCGC GGCCCCCCGG CCGTGTGCGC CTGCAGCGCG 
GGTCGCCTGG GGCTGCGCTC GTCCGCCGCG CAGCTCACCG CCGCCCGGCT CAAGGCGCTA 
GGCGACGAGC TGCACCAGCG CACCATGTGG CGGCGCCGCG CGCGGAGCCG GAGGGCGCCG 
GCGCCCGGCG CGCTCCCCAC CTACTGGCCT TGGCTGTGCG CGGCCGCGCA GGTGGCGGCG 
CTGGCGGCCT GGCTGCTCGG CAGGCGGAAC TTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

KDM2B, an H3K36-specific demethylase, regulates apoptotic response of GBM cells to TRAIL.
Cell death & disease8(6)e2897(2017 Jun)
Kurt IC,Sur I,Kaya E,Cingoz A,Kazancioglu S,Kahya Z,Toparlak OD,Senbabaoglu F,Kaya Z,Ozyerli E,Karah?seyinoglu S,Lack NA,G?m?s ZH,Onder TT,Bagci-Onder T

MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic ?-Cells.
Diabetes66(1)100-112(2017 Jan)
Grieco FA,Sebastiani G,Juan-Mateu J,Villate O,Marroqui L,Ladri?re L,Tugay K,Regazzi R,Bugliani M,Marchetti P,Dotta F,Eizirik DL

Hrk mediates 2-methoxyestradiol-induced mitochondrial apoptotic signaling in prostate cancer cells.
Molecular cancer therapeutics12(6)1049-59(2013 Jun)
Chang I,Majid S,Saini S,Zaman MS,Yamamura S,Chiyomaru T,Shahryari V,Fukuhara S,Deng G,Dahiya R,Tanaka Y

ATF4 orchestrates a program of BH3-only protein expression in severe hypoxia.
Molecular biology reports39(12)10811-22(2012 Dec)
Pike LR,Phadwal K,Simon AK,Harris AL

Nuclear magnetic resonance study of protein-protein interactions involving apoptosis regulator Diva (Boo) and the BH3 domain of proapoptotic Bcl-2 members.
Journal of molecular recognition : JMR25(12)665-73(2012 Dec)
Santiveri CM,Sborgi L,de Alba E

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HRK cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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