LCE3D cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LCE3D
Entrez Gene ID	84648
Full Name	late cornified envelope 3D
Synonyms	LEP16,SPRL6A,SPRL6B
General protein information	Preferred Names late cornified envelope 3D Names late cornified envelope protein 3D late envelope protein 16 small proline rich-like (epidermal differentiation complex) 6A small proline rich-like (epidermal differentiation complex) 6B small proline-rich-like epidermal differentiation complex protein 6A small proline-rich-like epidermal differentiation complex protein 6B
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q21.3
Disorder MIM:	612616

mRNA and Protein(s)

mRNA	Protein	Name
NM_032563.1	NP_115952.1	late cornified envelope protein 3D
NM_032563.2	NP_115952.1	late cornified envelope protein 3D

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Variants in MHC, LCE and IL12B have epistatic effects on psoriasis risk in Chinese population.
Zheng HF, Zuo XB, Lu WS, Li Y, Cheng H, Zhu KJ, Yin XY, Zhang C, Ren YQ, Wang WJ, Sun LD, Cui Y, Yang S, Zhang FY, Zhang XJ
Journal of dermatological science61(2)124-8(2011 Feb)

A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.
, Strange A, Capon F, Spencer CC, Knight J, Weale ME, Allen MH, Barton A, Band G, Bellenguez C, Bergboer JG, Blackwell JM, Bramon E, Bumpstead SJ, Casas JP, Cork MJ, Corvin A, Deloukas P, Dilthey A, Duncanson A, Edkins S, Estivill X, Fitzgerald O, Freeman C, Giardina E, Gray E, Hofer A, H?ffmeier U, Hunt SE, Irvine AD, Jankowski J, Kirby B, Langford C, Lascorz J, Leman J, Leslie S, Mallbris L, Markus HS, Mathew CG, McLean WH, McManus R, M?ssner R, Moutsianas L, Naluai AT, Nestle FO, Novelli G, Onoufriadis A, Palmer CN, Perricone C, Pirinen M, Plomin R, Potter SC, Pujol RM, Rautanen A, Riveira-Munoz E, Ryan AW, Salmhofer W, Samuelsson L, Sawcer SJ, Schalkwijk J, Smith CH, St?hle M, Su Z, Tazi-Ahnini R, Traupe H, Viswanathan AC, Warren RB, Weger W, Wolk K, Wood N, Worthington J, Young HS, Zeeuwen PL, Hayday A, Burden AD, Griffiths CE, Kere J, Reis A, McVean G, Evans DM, Brown MA, Barker JN, Peltonen L, Donnelly P, Trembath RC
Nature genetics42(11)985-90(2010 Nov)

Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21.
Zhang XJ, Huang W, Yang S, Sun LD, Zhang FY, Zhu QX, Zhang FR, Zhang C, Du WH, Pu XM, Li H, Xiao FL, Wang ZX, Cui Y, Hao F, Zheng J, Yang XQ, Cheng H, He CD, Liu XM, Xu LM, Zheng HF, Zhang SM, Zhang JZ, Wang HY, Cheng YL, Ji BH, Fang QY, Li YZ, Zhou FS, Han JW, Quan C, Chen B, Liu JL, Lin D, Fan L, Zhang AP, Liu SX, Yang CJ, Wang PG, Zhou WM, Lin GS, Wu WD, Fan X, Gao M, Yang BQ, Lu WS, Zhang Z, Zhu KJ, Shen SK, Li M, Zhang XY, Cao TT, Ren W, Zhang X, He J, Tang XF, Lu S, Yang JQ, Zhang L, Wang DN, Yuan F, Yin XY, Huang HJ, Wang HF, Lin XY, Liu JJ
Nature genetics41(2)205-10(2009 Feb)

Late cornified envelope family in differentiating epithelia--response to calcium and ultraviolet irradiation.
Jackson B, Tilli CM, Hardman MJ, Avilion AA, MacLeod MC, Ashcroft GS, Byrne C
The Journal of investigative dermatology124(5)1062-70(2005 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We identified significant combined effects between MHC and LCE, MHC and IL12B on the risk of psoriasis in Chinese population.
Title: Variants in MHC, LCE and IL12B have epistatic effects on psoriasis risk in Chinese population.

Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21.

paper describing nomenclature changes and expression in range of tissues and in response to UV
Title: Late cornified envelope family in differentiating epithelia--response to calcium and ultraviolet irradiation.

LEP16 is one of a cluster of 16-20 related genes at 1q21 which includes XP5. Proteins incorporate into the cornified envelope of stratified, terminally differentiating epithelia. LEP16 transcripts detected in heart, skin and esophagus.
Title: Differentially expressed late constituents of the epidermal cornified envelope.

The following LCE3D gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LCE3D cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29874	NM_032563.2 Latest version!	Homo sapiens late cornified envelope 3D (LCE3D), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu29874	NM_032563.1	Homo sapiens late cornified envelope 3D (LCE3D), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LCE3D ( NM_032563.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_115952.1 Homo sapiens late cornified envelope 3D (LCE3D), mRNA.

Price & Availability↑

CloneID	OHu29874
Clone ID Related Accession (Same CDS sequence)	NM_032563.1 , NM_032563.2
Accession Version	NM_032563.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 279bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	late cornified envelope protein 3D
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AB048288.1. ##Evidence-Data-START## Transcript exon combination :: AB048288.1, BC101784.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2147596 [ECO:0000348] ##Evidence-Data-END##

ATGTCCTGCC AGCAGAACCA GCAGCAGTGC CAACCCCCAC CCAAGTGTCC CTCACCCAAG 
TGTCCCCCAA AGAGCCCAGT ACAGTGTCTG CCTCCAGCTT CCTCTGGCTG TGCCCCAAGC 
TCTGGGGGCT GTGGCCCTAG CTCCGAGGGC GGCTGCTTCC TGAACCACCA CAGGCGCCAC 
CACCGATGCC GGCGCCAGAG GCCCAACTCC TGTGACAGGG GCAGTGGTCA GCAAGGCGGG 
GGCTCTGGCT GCGGCCATGG CTCTGGAGGC TGCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115952.1
CDS	58..336
Translation	MSCQQNQQQCQPPPKCPSPKCPPKSPVQCLPPASSGCAPSSGGCGPSSEGGCFLNHHRRHHRCRRQRPNSCDRGSGQQGGGSGCGHGSGGCC

Target ORF information:

RefSeq Version	NM_032563.1
Organism	Homo sapiens(human)
Definition	Homo sapiens late cornified envelope 3D (LCE3D), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032563.1

ORF Insert Sequence:

ATGTCCTGCC AGCAGAACCA GCAGCAGTGC CAACCCCCAC CCAAGTGTCC CTCACCCAAG 
TGTCCCCCAA AGAGCCCAGT ACAGTGTCTG CCTCCAGCTT CCTCTGGCTG TGCCCCAAGC 
TCTGGGGGCT GTGGCCCTAG CTCCGAGGGC GGCTGCTTCC TGAACCACCA CAGGCGCCAC 
CACCGATGCC GGCGCCAGAG GCCCAACTCC TGTGACAGGG GCAGTGGTCA GCAAGGCGGG 
GGCTCTGGCT GCGGCCATGG CTCTGGAGGC TGCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LCE3D ( NM_032563.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_115952.1 Homo sapiens late cornified envelope 3D (LCE3D), mRNA.

Price & Availability↑

CloneID	OHu29874
Clone ID Related Accession (Same CDS sequence)	NM_032563.1 , NM_032563.2
Accession Version	NM_032563.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 279bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-01
Organism	Homo sapiens(human)
Product	late cornified envelope protein 3D
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL356426.11 and AB048288.1. On Nov 22, 2018 this sequence version replaced NM_032563.1. ##Evidence-Data-START## Transcript exon combination :: AB048288.1, BC101784.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2147596 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000368787.4/ ENSP00000357776.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCCTGCC AGCAGAACCA GCAGCAGTGC CAACCCCCAC CCAAGTGTCC CTCACCCAAG 
TGTCCCCCAA AGAGCCCAGT ACAGTGTCTG CCTCCAGCTT CCTCTGGCTG TGCCCCAAGC 
TCTGGGGGCT GTGGCCCTAG CTCCGAGGGC GGCTGCTTCC TGAACCACCA CAGGCGCCAC 
CACCGATGCC GGCGCCAGAG GCCCAACTCC TGTGACAGGG GCAGTGGTCA GCAAGGCGGG 
GGCTCTGGCT GCGGCCATGG CTCTGGAGGC TGCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115952.1
CDS	70..348
Translation	MSCQQNQQQCQPPPKCPSPKCPPKSPVQCLPPASSGCAPSSGGCGPSSEGGCFLNHHRRHHRCRRQRPNSCDRGSGQQGGGSGCGHGSGGCC

Target ORF information:

RefSeq Version	NM_032563.2
Organism	Homo sapiens(human)
Definition	Homo sapiens late cornified envelope 3D (LCE3D), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032563.2

ORF Insert Sequence:

ATGTCCTGCC AGCAGAACCA GCAGCAGTGC CAACCCCCAC CCAAGTGTCC CTCACCCAAG 
TGTCCCCCAA AGAGCCCAGT ACAGTGTCTG CCTCCAGCTT CCTCTGGCTG TGCCCCAAGC 
TCTGGGGGCT GTGGCCCTAG CTCCGAGGGC GGCTGCTTCC TGAACCACCA CAGGCGCCAC 
CACCGATGCC GGCGCCAGAG GCCCAACTCC TGTGACAGGG GCAGTGGTCA GCAAGGCGGG 
GGCTCTGGCT GCGGCCATGG CTCTGGAGGC TGCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Variants in MHC, LCE and IL12B have epistatic effects on psoriasis risk in Chinese population.
Journal of dermatological science61(2)124-8(2011 Feb)
Zheng HF,Zuo XB,Lu WS,Li Y,Cheng H,Zhu KJ,Yin XY,Zhang C,Ren YQ,Wang WJ,Sun LD,Cui Y,Yang S,Zhang FY,Zhang XJ

A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.
Nature genetics42(11)985-90(2010 Nov)
,Strange A,Capon F,Spencer CC,Knight J,Weale ME,Allen MH,Barton A,Band G,Bellenguez C,Bergboer JG,Blackwell JM,Bramon E,Bumpstead SJ,Casas JP,Cork MJ,Corvin A,Deloukas P,Dilthey A,Duncanson A,Edkins S,Estivill X,Fitzgerald O,Freeman C,Giardina E,Gray E,Hofer A,H?ffmeier U,Hunt SE,Irvine AD,Jankowski J,Kirby B,Langford C,Lascorz J,Leman J,Leslie S,Mallbris L,Markus HS,Mathew CG,McLean WH,McManus R,M?ssner R,Moutsianas L,Naluai AT,Nestle FO,Novelli G,Onoufriadis A,Palmer CN,Perricone C,Pirinen M,Plomin R,Potter SC,Pujol RM,Rautanen A,Riveira-Munoz E,Ryan AW,Salmhofer W,Samuelsson L,Sawcer SJ,Schalkwijk J,Smith CH,St?hle M,Su Z,Tazi-Ahnini R,Traupe H,Viswanathan AC,Warren RB,Weger W,Wolk K,Wood N,Worthington J,Young HS,Zeeuwen PL,Hayday A,Burden AD,Griffiths CE,Kere J,Reis A,McVean G,Evans DM,Brown MA,Barker JN,Peltonen L,Donnelly P,Trembath RC

Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21.
Nature genetics41(2)205-10(2009 Feb)
Zhang XJ,Huang W,Yang S,Sun LD,Zhang FY,Zhu QX,Zhang FR,Zhang C,Du WH,Pu XM,Li H,Xiao FL,Wang ZX,Cui Y,Hao F,Zheng J,Yang XQ,Cheng H,He CD,Liu XM,Xu LM,Zheng HF,Zhang SM,Zhang JZ,Wang HY,Cheng YL,Ji BH,Fang QY,Li YZ,Zhou FS,Han JW,Quan C,Chen B,Liu JL,Lin D,Fan L,Zhang AP,Liu SX,Yang CJ,Wang PG,Zhou WM,Lin GS,Wu WD,Fan X,Gao M,Yang BQ,Lu WS,Zhang Z,Zhu KJ,Shen SK,Li M,Zhang XY,Cao TT,Ren W,Zhang X,He J,Tang XF,Lu S,Yang JQ,Zhang L,Wang DN,Yuan F,Yin XY,Huang HJ,Wang HF,Lin XY,Liu JJ

Late cornified envelope family in differentiating epithelia--response to calcium and ultraviolet irradiation.
The Journal of investigative dermatology124(5)1062-70(2005 May)
Jackson B,Tilli CM,Hardman MJ,Avilion AA,MacLeod MC,Ashcroft GS,Byrne C

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LCE3D cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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