H4C12 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	H4C12
Entrez Gene ID	8362
Full Name	histone cluster 1 H4 family member k
Synonyms	H4/d,H4F2iii,H4FD,dJ160A22.1
General protein information	Preferred Names histone cluster 1 H4 family member k Names histone H4 H4 histone family, member D histone 1, H4k histone cluster 1, H4k
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p22.1
Summary	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015].
Disorder MIM:	602825

mRNA and Protein(s)

mRNA	Protein	Name
NM_003541.2	NP_003532.1	histone H4
NM_003541.3	NP_003532.1	histone H4

Pathways from BioSystems

Homologies

	LOC705352	XP_001097005.1
Bos taurus (cattle)	LOC518961	XP_002697556.1
Mus musculus (house mouse)	Hist1h4j	NP_835582.1
Rattus norvegicus (Norway rat)	LOC102551184	XP_006254044.1
Homo sapiens (human)	HIST1H4K	NP_003532.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012558	XP_305995.3
Caenorhabditis elegans (roundworm)	his-18	NP_505298.1
Xenopus tropicalis (tropical clawed frog)	LOC100492878	XP_002945478.1
Pan troglodytes (chimpanzee)	LOC462494	XP_003311107.1
Drosophila melanogaster (fruit fly)	His4:CG33895	NP_001027317.1
Danio rerio (zebrafish)	si:ch211-113a14.21	XP_005163254.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation.
Jacquet K, Fradet-Turcotte A, Avvakumov N, Lambert JP, Roques C, Pandita RK, Paquet E, Herst P, Gingras AC, Pandita TK, Legube G, Doyon Y, Durocher D, C?t? J
Molecular cell62(3)409-421(2016 05)

Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5.
Mavrakis KJ, McDonald ER 3rd, Schlabach MR, Billy E, Hoffman GR, deWeck A, Ruddy DA, Venkatesan K, Yu J, McAllister G, Stump M, deBeaumont R, Ho S, Yue Y, Liu Y, Yan-Neale Y, Yang G, Lin F, Yin H, Gao H, Kipp DR, Zhao S, McNamara JT, Sprague ER, Zheng B, Lin Y, Cho YS, Gu J, Crawford K, Ciccone D, Vitari AC, Lai A, Capka V, Hurov K, Porter JA, Tallarico J, Mickanin C, Lees E, Pagliarini R, Keen N, Schmelzle T, Hofmann F, Stegmeier F, Sellers WR
Science (New York, N.Y.)351(6278)1208-13(2016 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Promoter hypermethylation of HIST1H4K is associated with prostate carcinogenesis
Title: Evaluation of the clinical value of the newly identified urine biomarker HIST1H4K for diagnosis and prognosis of prostate cancer in Bulgarian patients.

The following H4C12 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the H4C12 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu00917	NM_003541.3 Latest version!	Homo sapiens H4 clustered histone 12 (H4C12), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu00917	NM_003541.2	Homo sapiens histone cluster 1 H4 family member k (HIST1H4K), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

H4C12 ( NM_003541.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_003532.1 Homo sapiens histone cluster 1 H4 family member k (HIST1H4K), mRNA.

Price & Availability↑

CloneID	OHu00917
Clone ID Related Accession (Same CDS sequence)	NM_003541.2 , NM_003541.3
Accession Version	NM_003541.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 312bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-04
Organism	Homo sapiens(human)
Product	histone H4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X60483.1. On Sep 21, 2001 this sequence version replaced NM_003541.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC111093.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCTGGCC GCGGCAAAGG CGGGAAGGGT CTTGGCAAAG GCGGCGCTAA GCGCCACCGT 
AAAGTACTGC GCGACAATAT CCAGGGCATC ACCAAGCCGG CCATCCGGCG CCTTGCTCGC 
CGCGGCGGCG TGAAGCGCAT CTCCGGCCTC ATCTACGAGG AGACTCGCGG GGTGCTGAAG 
GTGTTCCTGG AGAACGTGAT CCGGGACGCC GTGACCTATA CAGAGCACGC CAAGCGCAAG 
ACGGTCACCG CCATGGATGT GGTCTACGCG CTCAAGCGCC AGGGCCGCAC CCTCTACGGT 
TTCGGTGGTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003532.1
CDS	1..312
Translation	MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG

Target ORF information:

RefSeq Version	NM_003541.2
Organism	Homo sapiens(human)
Definition	Homo sapiens histone cluster 1 H4 family member k (HIST1H4K), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003541.2

ORF Insert Sequence:

ATGTCTGGCC GCGGCAAAGG CGGGAAGGGT CTTGGCAAAG GCGGCGCTAA GCGCCACCGT 
AAAGTACTGC GCGACAATAT CCAGGGCATC ACCAAGCCGG CCATCCGGCG CCTTGCTCGC 
CGCGGCGGCG TGAAGCGCAT CTCCGGCCTC ATCTACGAGG AGACTCGCGG GGTGCTGAAG 
GTGTTCCTGG AGAACGTGAT CCGGGACGCC GTGACCTATA CAGAGCACGC CAAGCGCAAG 
ACGGTCACCG CCATGGATGT GGTCTACGCG CTCAAGCGCC AGGGCCGCAC CCTCTACGGT 
TTCGGTGGTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

H4C12 ( NM_003541.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003532.1 Homo sapiens H4 clustered histone 12 (H4C12), mRNA.

Price & Availability↑

CloneID	OHu00917
Clone ID Related Accession (Same CDS sequence)	NM_003541.2 , NM_003541.3
Accession Version	NM_003541.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 312bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Homo sapiens(human)
Product	histone H4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL049822.30. On Dec 3, 2019 this sequence version replaced NM_003541.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: DA438592.1, DA439641.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCTGGCC GCGGCAAAGG CGGGAAGGGT CTTGGCAAAG GCGGCGCTAA GCGCCACCGT 
AAAGTACTGC GCGACAATAT CCAGGGCATC ACCAAGCCGG CCATCCGGCG CCTTGCTCGC 
CGCGGCGGCG TGAAGCGCAT CTCCGGCCTC ATCTACGAGG AGACTCGCGG GGTGCTGAAG 
GTGTTCCTGG AGAACGTGAT CCGGGACGCC GTGACCTATA CAGAGCACGC CAAGCGCAAG 
ACGGTCACCG CCATGGATGT GGTCTACGCG CTCAAGCGCC AGGGCCGCAC CCTCTACGGT 
TTCGGTGGTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003532.1
CDS	34..345
Translation	MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG

Target ORF information:

RefSeq Version	NM_003541.3
Organism	Homo sapiens(human)
Definition	Homo sapiens H4 clustered histone 12 (H4C12), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003541.3

ORF Insert Sequence:

ATGTCTGGCC GCGGCAAAGG CGGGAAGGGT CTTGGCAAAG GCGGCGCTAA GCGCCACCGT 
AAAGTACTGC GCGACAATAT CCAGGGCATC ACCAAGCCGG CCATCCGGCG CCTTGCTCGC 
CGCGGCGGCG TGAAGCGCAT CTCCGGCCTC ATCTACGAGG AGACTCGCGG GGTGCTGAAG 
GTGTTCCTGG AGAACGTGAT CCGGGACGCC GTGACCTATA CAGAGCACGC CAAGCGCAAG 
ACGGTCACCG CCATGGATGT GGTCTACGCG CTCAAGCGCC AGGGCCGCAC CCTCTACGGT 
TTCGGTGGTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation.
Molecular cell62(3)409-421(2016 05)
Jacquet K,Fradet-Turcotte A,Avvakumov N,Lambert JP,Roques C,Pandita RK,Paquet E,Herst P,Gingras AC,Pandita TK,Legube G,Doyon Y,Durocher D,C?t? J

Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5.
Science (New York, N.Y.)351(6278)1208-13(2016 Mar)
Mavrakis KJ,McDonald ER 3rd,Schlabach MR,Billy E,Hoffman GR,deWeck A,Ruddy DA,Venkatesan K,Yu J,McAllister G,Stump M,deBeaumont R,Ho S,Yue Y,Liu Y,Yan-Neale Y,Yang G,Lin F,Yin H,Gao H,Kipp DR,Zhao S,McNamara JT,Sprague ER,Zheng B,Lin Y,Cho YS,Gu J,Crawford K,Ciccone D,Vitari AC,Lai A,Capka V,Hurov K,Porter JA,Tallarico J,Mickanin C,Lees E,Pagliarini R,Keen N,Schmelzle T,Hofmann F,Stegmeier F,Sellers WR

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H4C12 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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