Gene Symbol | APH1B |
Entrez Gene ID | 83464 |
Full Name | aph-1 homolog B, gamma-secretase subunit |
Synonyms | APH-1B,PRO1328,PSFL,TAAV688 |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptors and beta-amyloid precursor protein. [provided by RefSeq, Sep 2011]. |
Disorder MIM: |