Gene Symbol | XRCC1 |
Entrez Gene ID | 7515 |
Full Name | X-ray repair cross complementing 1 |
Synonyms | RCC,SCAR26 |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]. |
Disorder MIM: | |
Disorder Html: | ?Spinocerebellar ataxia, autosomal recessive 26, 617633 (3) |