Gene Symbol | TNFRSF4 |
Entrez Gene ID | 7293 |
Full Name | TNF receptor superfamily member 4 |
Synonyms | ACT35,CD134,IMD16,OX40,TXGP1L |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008]. |
Disorder MIM: | |
Disorder Html: | ?Immunodeficiency 16, 615593 (3) |