TTC1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TTC1
Entrez Gene ID	7265
Full Name	tetratricopeptide repeat domain 1
Synonyms	TPR1
General protein information	Preferred Names tetratricopeptide repeat domain 1 Names tetratricopeptide repeat protein 1 TPR repeat protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q33.3
Summary	This gene encodes a protein that belongs to the tetratrico peptide repeat superfamily of proteins. The encoded protein plays a role in protein-protein interactions, and binds to the Galpha subunit of G protein-coupled receptors to activate the Ras signaling pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].
Disorder MIM:	601963

mRNA and Protein(s)

mRNA	Protein	Name
NM_003314.3	NP_003305.1	tetratricopeptide repeat protein 1
NM_003314.2	NP_003305.1	tetratricopeptide repeat protein 1
NM_001282500.1	NP_001269429.1	tetratricopeptide repeat protein 1

Pathways from BioSystems

Homologies

	TTC1	XP_001083639.1
Rattus norvegicus (Norway rat)	Ttc1	NP_001005529.1
Gallus gallus (chicken)	TTC1	XP_004944871.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003336	XP_314232.5
Mus musculus (house mouse)	Ttc1	NP_598556.1
Danio rerio (zebrafish)	ttc1	NP_001007383.1
Canis lupus familiaris (dog)	TTC1	XP_546270.2
Arabidopsis thaliana (thale cress)	AT4G30480	NP_194777.3
Oryza sativa (rice)	Os10g0486900	NP_001064904.1
Homo sapiens (human)	TTC1	NP_003305.1
Pan troglodytes (chimpanzee)	TTC1	XP_001140840.2
Bos taurus (cattle)	TTC1	NP_001029389.1
Drosophila melanogaster (fruit fly)	CG14894	NP_650543.1
Xenopus tropicalis (tropical clawed frog)	LOC100487316	XP_002940222.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

An inter-species protein-protein interaction network across vast evolutionary distance.
Zhong Q, Pevzner SJ, Hao T, Wang Y, Mosca R, Menche J, Taipale M, Ta?an M, Fan C, Yang X, Haley P, Murray RR, Mer F, Gebreab F, Tam S, MacWilliams A, Dricot A, Reichert P, Santhanam B, Ghamsari L, Calderwood MA, Rolland T, Charloteaux B, Lindquist S, Barab?si AL, Hill DE, Aloy P, Cusick ME, Xia Y, Roth FP, Vidal M
Molecular systems biology12(4)865(2016 Apr)

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T, Richardson A, Sun S, Yang F, Shen YA, Murray RR, Spirohn K, Begg BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Trigg SA, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K, Charloteaux B, Chen AA, Calderwood MA, Aloy P, Roth FP, Hill DE, Iakoucheva LM, Xia Y, Vidal M
Cell164(4)805-17(2016 Feb)

A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.
Taipale M, Tucker G, Peng J, Krykbaeva I, Lin ZY, Larsen B, Choi H, Berger B, Gingras AC, Lindquist S
Cell158(2)434-448(2014 Jul)

Activation of Ras-dependent signaling pathways by G(14) -coupled receptors requires the adaptor protein TPR1.
Kwan DH, Yung LY, Ye RD, Wong YH
Journal of cellular biochemistry113(11)3486-97(2012 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The crystal structure of monopolar spindle 1 (Mps1) N-terminal region TPR domain has been determined.
Title: Structural and functional insights into the role of the N-terminal Mps1 TPR domain in the SAC (spindle assembly checkpoint).

TPR1 is required for Galpha14 to stimulate Ras-dependent signaling pathways, but not for the propagation of signals along Ras-independent pathways.
Title: Activation of Ras-dependent signaling pathways by G(14) -coupled receptors requires the adaptor protein TPR1.

beta3 region of Galpha16 is essential for interaction with TPR1 and the subsequent activation of Ras
Title: G?16 interacts with tetratricopeptide repeat 1 (TPR1) through its ?3 region to activate Ras independently of phospholipase C? signaling.

Results report cooperative interactions involving Hsp70, Hsp40, and TPR1 that enhance Hsp70-dependent folding of chemically denatured substrates.
Title: Cooperative interaction of Hsp40 and TPR1 with Hsp70 reverses Hsp70-HspBp1 complex formation.

Data show that tetratricopeptide repeat 1 is a novel adaptor protein for Ras and selected Galpha proteins that may be involved in protein-protein interaction relating to G-protein signaling.
Title: Identification of tetratricopeptide repeat 1 as an adaptor protein that interacts with heterotrimeric G proteins and the small GTPase Ras.

The following TTC1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TTC1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu00658	NM_001282500.1 Latest version!	Homo sapiens tetratricopeptide repeat domain 1 (TTC1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu00658	NM_003314.3 Latest version!	Homo sapiens tetratricopeptide repeat domain 1 (TTC1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu00658	NM_003314.2	Homo sapiens tetratricopeptide repeat domain 1 (TTC1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TTC1 ( NM_003314.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003305.1 Homo sapiens tetratricopeptide repeat domain 1 (TTC1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu00658
Clone ID Related Accession (Same CDS sequence)	NM_003314.3 , NM_003314.2 , NM_001282500.1
Accession Version	NM_003314.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 879bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	tetratricopeptide repeat protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP245572.1 and U46570.1. On Nov 23, 2018 this sequence version replaced NM_003314.2. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.1063557.1, SRR3476690.281072.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000231238.10/ ENSP00000231238.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGGGAGA AGTCAGAGAA CTGTGGGGTT CCAGAGGATC TGTTAAATGG TTTGAAGGTT 
ACAGATACTC AGGAAGCCGA GTGTGCTGGC CCTCCAGTTC CTGATCCCAA AAATCAGCAT 
TCCCAGAGTA AGCTGCTCAG GGATGATGAG GCCCATCTCC AGGAGGACCA GGGAGAAGAG 
GAGTGTTTTC ATGACTGCAG TGCCTCATTT GAGGAGGAGC CAGGAGCGGA CAAGGTTGAG 
AACAAATCTA ATGAAGATGT GAATTCCTCT GAACTAGATG AAGAATACCT AATAGAACTG 
GAAAAAAACA TGTCGGATGA AGAGAAACAG AAAAGAAGAG AAGAGAGCAC TAGACTAAAG 
GAGGAGGGAA ATGAACAGTT TAAGAAAGGA GATTATATAG AAGCTGAAAG TTCTTATAGT 
CGAGCCCTCG AAATGTGCCC ATCCTGCTTC CAAAAGGAGA GGTCGATTCT ATTTTCAAAT 
AGAGCTGCAG CAAGGATGAA ACAGGACAAG AAAGAAATGG CCATCAATGA CTGCAGCAAA 
GCAATTCAAT TAAACCCCAG CTATATCAGG GCAATATTGA GGAGAGCAGA GTTGTATGAG 
AAGACGGACA AGCTAGATGA AGCCCTGGAA GACTATAAAT CTATATTAGA AAAAGATCCA 
TCAATACATC AAGCAAGAGA AGCTTGTATG AGATTACCTA AGCAAATTGA AGAACGTAAT 
GAAAGACTAA AAGAAGAGAT GTTAGGTAAA TTAAAAGATC TTGGGAACTT GGTTCTCCGA 
CCTTTTGGGC TCTCCACGGA AAATTTCCAG ATCAAACAGG ATTCCTCTAC CGGCTCGTAC 
TCCATCAATT TCGTTCAAAA TCCAAATAAT AACAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003305.1
CDS	85..963
Translation	MGEKSENCGVPEDLLNGLKVTDTQEAECAGPPVPDPKNQHSQSKLLRDDEAHLQEDQGEEECFHDCSASFEEEPGADKVENKSNEDVNSSELDEEYLIELEKNMSDEEKQKRREESTRLKEEGNEQFKKGDYIEAESSYSRALEMCPSCFQKERSILFSNRAAARMKQDKKEMAINDCSKAIQLNPSYIRAILRRAELYEKTDKLDEALEDYKSILEKDPSIHQAREACMRLPKQIEERNERLKEEMLGKLKDLGNLVLRPFGLSTENFQIKQDSSTGSYSINFVQNPNNNR

Target ORF information:

RefSeq Version	NM_003314.3
Organism	Homo sapiens(human)
Definition	Homo sapiens tetratricopeptide repeat domain 1 (TTC1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003314.3

ORF Insert Sequence:

ATGGGGGAGA AGTCAGAGAA CTGTGGGGTT CCAGAGGATC TGTTAAATGG TTTGAAGGTT 
ACAGATACTC AGGAAGCCGA GTGTGCTGGC CCTCCAGTTC CTGATCCCAA AAATCAGCAT 
TCCCAGAGTA AGCTGCTCAG GGATGATGAG GCCCATCTCC AGGAGGACCA GGGAGAAGAG 
GAGTGTTTTC ATGACTGCAG TGCCTCATTT GAGGAGGAGC CAGGAGCGGA CAAGGTTGAG 
AACAAATCTA ATGAAGATGT GAATTCCTCT GAACTAGATG AAGAATACCT AATAGAACTG 
GAAAAAAACA TGTCGGATGA AGAGAAACAG AAAAGAAGAG AAGAGAGCAC TAGACTAAAG 
GAGGAGGGAA ATGAACAGTT TAAGAAAGGA GATTATATAG AAGCTGAAAG TTCTTATAGT 
CGAGCCCTCG AAATGTGCCC ATCCTGCTTC CAAAAGGAGA GGTCGATTCT ATTTTCAAAT 
AGAGCTGCAG CAAGGATGAA ACAGGACAAG AAAGAAATGG CCATCAATGA CTGCAGCAAA 
GCAATTCAAT TAAACCCCAG CTATATCAGG GCAATATTGA GGAGAGCAGA GTTGTATGAG 
AAGACGGACA AGCTAGATGA AGCCCTGGAA GACTATAAAT CTATATTAGA AAAAGATCCA 
TCAATACATC AAGCAAGAGA AGCTTGTATG AGATTACCTA AGCAAATTGA AGAACGTAAT 
GAAAGACTAA AAGAAGAGAT GTTAGGTAAA TTAAAAGATC TTGGGAACTT GGTTCTCCGA 
CCTTTTGGGC TCTCCACGGA AAATTTCCAG ATCAAACAGG ATTCCTCTAC CGGCTCGTAC 
TCCATCAATT TCGTTCAAAA TCCAAATAAT AACAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TTC1 ( NM_003314.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_003305.1 Homo sapiens tetratricopeptide repeat domain 1 (TTC1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu00658
Clone ID Related Accession (Same CDS sequence)	NM_003314.3 , NM_003314.2 , NM_001282500.1
Accession Version	NM_003314.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 879bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-27
Organism	Homo sapiens(human)
Product	tetratricopeptide repeat protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP245572.1, U46570.1 and BQ017702.1. On Sep 13, 2013 this sequence version replaced NM_003314.1. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.125921.1, SRR1163657.106179.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGGAGA AGTCAGAGAA CTGTGGGGTT CCAGAGGATC TGTTAAATGG TTTGAAGGTT 
ACAGATACTC AGGAAGCCGA GTGTGCTGGC CCTCCAGTTC CTGATCCCAA AAATCAGCAT 
TCCCAGAGTA AGCTGCTCAG GGATGATGAG GCCCATCTCC AGGAGGACCA GGGAGAAGAG 
GAGTGTTTTC ATGACTGCAG TGCCTCATTT GAGGAGGAGC CAGGAGCGGA CAAGGTTGAG 
AACAAATCTA ATGAAGATGT GAATTCCTCT GAACTAGATG AAGAATACCT AATAGAACTG 
GAAAAAAACA TGTCGGATGA AGAGAAACAG AAAAGAAGAG AAGAGAGCAC TAGACTAAAG 
GAGGAGGGAA ATGAACAGTT TAAGAAAGGA GATTATATAG AAGCTGAAAG TTCTTATAGT 
CGAGCCCTCG AAATGTGCCC ATCCTGCTTC CAAAAGGAGA GGTCGATTCT ATTTTCAAAT 
AGAGCTGCAG CAAGGATGAA ACAGGACAAG AAAGAAATGG CCATCAATGA CTGCAGCAAA 
GCAATTCAAT TAAACCCCAG CTATATCAGG GCAATATTGA GGAGAGCAGA GTTGTATGAG 
AAGACGGACA AGCTAGATGA AGCCCTGGAA GACTATAAAT CTATATTAGA AAAAGATCCA 
TCAATACATC AAGCAAGAGA AGCTTGTATG AGATTACCTA AGCAAATTGA AGAACGTAAT 
GAAAGACTAA AAGAAGAGAT GTTAGGTAAA TTAAAAGATC TTGGGAACTT GGTTCTCCGA 
CCTTTTGGGC TCTCCACGGA AAATTTCCAG ATCAAACAGG ATTCCTCTAC CGGCTCGTAC 
TCCATCAATT TCGTTCAAAA TCCAAATAAT AACAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003305.1
CDS	124..1002
Translation	MGEKSENCGVPEDLLNGLKVTDTQEAECAGPPVPDPKNQHSQSKLLRDDEAHLQEDQGEEECFHDCSASFEEEPGADKVENKSNEDVNSSELDEEYLIELEKNMSDEEKQKRREESTRLKEEGNEQFKKGDYIEAESSYSRALEMCPSCFQKERSILFSNRAAARMKQDKKEMAINDCSKAIQLNPSYIRAILRRAELYEKTDKLDEALEDYKSILEKDPSIHQAREACMRLPKQIEERNERLKEEMLGKLKDLGNLVLRPFGLSTENFQIKQDSSTGSYSINFVQNPNNNR

Target ORF information:

RefSeq Version	NM_003314.2
Organism	Homo sapiens(human)
Definition	Homo sapiens tetratricopeptide repeat domain 1 (TTC1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003314.2

ORF Insert Sequence:

ATGGGGGAGA AGTCAGAGAA CTGTGGGGTT CCAGAGGATC TGTTAAATGG TTTGAAGGTT 
ACAGATACTC AGGAAGCCGA GTGTGCTGGC CCTCCAGTTC CTGATCCCAA AAATCAGCAT 
TCCCAGAGTA AGCTGCTCAG GGATGATGAG GCCCATCTCC AGGAGGACCA GGGAGAAGAG 
GAGTGTTTTC ATGACTGCAG TGCCTCATTT GAGGAGGAGC CAGGAGCGGA CAAGGTTGAG 
AACAAATCTA ATGAAGATGT GAATTCCTCT GAACTAGATG AAGAATACCT AATAGAACTG 
GAAAAAAACA TGTCGGATGA AGAGAAACAG AAAAGAAGAG AAGAGAGCAC TAGACTAAAG 
GAGGAGGGAA ATGAACAGTT TAAGAAAGGA GATTATATAG AAGCTGAAAG TTCTTATAGT 
CGAGCCCTCG AAATGTGCCC ATCCTGCTTC CAAAAGGAGA GGTCGATTCT ATTTTCAAAT 
AGAGCTGCAG CAAGGATGAA ACAGGACAAG AAAGAAATGG CCATCAATGA CTGCAGCAAA 
GCAATTCAAT TAAACCCCAG CTATATCAGG GCAATATTGA GGAGAGCAGA GTTGTATGAG 
AAGACGGACA AGCTAGATGA AGCCCTGGAA GACTATAAAT CTATATTAGA AAAAGATCCA 
TCAATACATC AAGCAAGAGA AGCTTGTATG AGATTACCTA AGCAAATTGA AGAACGTAAT 
GAAAGACTAA AAGAAGAGAT GTTAGGTAAA TTAAAAGATC TTGGGAACTT GGTTCTCCGA 
CCTTTTGGGC TCTCCACGGA AAATTTCCAG ATCAAACAGG ATTCCTCTAC CGGCTCGTAC 
TCCATCAATT TCGTTCAAAA TCCAAATAAT AACAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TTC1 ( NM_001282500.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001269429.1 Homo sapiens tetratricopeptide repeat domain 1 (TTC1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu00658
Clone ID Related Accession (Same CDS sequence)	NM_003314.3 , NM_003314.2 , NM_001282500.1
Accession Version	NM_001282500.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 879bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	tetratricopeptide repeat protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP245572.1, DN989835.1, AC068657.6, AC008706.5, U46570.1 and BQ017702.1. On Sep 13, 2013 this sequence version replaced XM_005265981.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.59205.1, SRR1163658.283957.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGGAGA AGTCAGAGAA CTGTGGGGTT CCAGAGGATC TGTTAAATGG TTTGAAGGTT 
ACAGATACTC AGGAAGCCGA GTGTGCTGGC CCTCCAGTTC CTGATCCCAA AAATCAGCAT 
TCCCAGAGTA AGCTGCTCAG GGATGATGAG GCCCATCTCC AGGAGGACCA GGGAGAAGAG 
GAGTGTTTTC ATGACTGCAG TGCCTCATTT GAGGAGGAGC CAGGAGCGGA CAAGGTTGAG 
AACAAATCTA ATGAAGATGT GAATTCCTCT GAACTAGATG AAGAATACCT AATAGAACTG 
GAAAAAAACA TGTCGGATGA AGAGAAACAG AAAAGAAGAG AAGAGAGCAC TAGACTAAAG 
GAGGAGGGAA ATGAACAGTT TAAGAAAGGA GATTATATAG AAGCTGAAAG TTCTTATAGT 
CGAGCCCTCG AAATGTGCCC ATCCTGCTTC CAAAAGGAGA GGTCGATTCT ATTTTCAAAT 
AGAGCTGCAG CAAGGATGAA ACAGGACAAG AAAGAAATGG CCATCAATGA CTGCAGCAAA 
GCAATTCAAT TAAACCCCAG CTATATCAGG GCAATATTGA GGAGAGCAGA GTTGTATGAG 
AAGACGGACA AGCTAGATGA AGCCCTGGAA GACTATAAAT CTATATTAGA AAAAGATCCA 
TCAATACATC AAGCAAGAGA AGCTTGTATG AGATTACCTA AGCAAATTGA AGAACGTAAT 
GAAAGACTAA AAGAAGAGAT GTTAGGTAAA TTAAAAGATC TTGGGAACTT GGTTCTCCGA 
CCTTTTGGGC TCTCCACGGA AAATTTCCAG ATCAAACAGG ATTCCTCTAC CGGCTCGTAC 
TCCATCAATT TCGTTCAAAA TCCAAATAAT AACAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001269429.1
CDS	121..999
Translation	MGEKSENCGVPEDLLNGLKVTDTQEAECAGPPVPDPKNQHSQSKLLRDDEAHLQEDQGEEECFHDCSASFEEEPGADKVENKSNEDVNSSELDEEYLIELEKNMSDEEKQKRREESTRLKEEGNEQFKKGDYIEAESSYSRALEMCPSCFQKERSILFSNRAAARMKQDKKEMAINDCSKAIQLNPSYIRAILRRAELYEKTDKLDEALEDYKSILEKDPSIHQAREACMRLPKQIEERNERLKEEMLGKLKDLGNLVLRPFGLSTENFQIKQDSSTGSYSINFVQNPNNNR

Target ORF information:

RefSeq Version	NM_001282500.1
Organism	Homo sapiens(human)
Definition	Homo sapiens tetratricopeptide repeat domain 1 (TTC1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001282500.1

ORF Insert Sequence:

ATGGGGGAGA AGTCAGAGAA CTGTGGGGTT CCAGAGGATC TGTTAAATGG TTTGAAGGTT 
ACAGATACTC AGGAAGCCGA GTGTGCTGGC CCTCCAGTTC CTGATCCCAA AAATCAGCAT 
TCCCAGAGTA AGCTGCTCAG GGATGATGAG GCCCATCTCC AGGAGGACCA GGGAGAAGAG 
GAGTGTTTTC ATGACTGCAG TGCCTCATTT GAGGAGGAGC CAGGAGCGGA CAAGGTTGAG 
AACAAATCTA ATGAAGATGT GAATTCCTCT GAACTAGATG AAGAATACCT AATAGAACTG 
GAAAAAAACA TGTCGGATGA AGAGAAACAG AAAAGAAGAG AAGAGAGCAC TAGACTAAAG 
GAGGAGGGAA ATGAACAGTT TAAGAAAGGA GATTATATAG AAGCTGAAAG TTCTTATAGT 
CGAGCCCTCG AAATGTGCCC ATCCTGCTTC CAAAAGGAGA GGTCGATTCT ATTTTCAAAT 
AGAGCTGCAG CAAGGATGAA ACAGGACAAG AAAGAAATGG CCATCAATGA CTGCAGCAAA 
GCAATTCAAT TAAACCCCAG CTATATCAGG GCAATATTGA GGAGAGCAGA GTTGTATGAG 
AAGACGGACA AGCTAGATGA AGCCCTGGAA GACTATAAAT CTATATTAGA AAAAGATCCA 
TCAATACATC AAGCAAGAGA AGCTTGTATG AGATTACCTA AGCAAATTGA AGAACGTAAT 
GAAAGACTAA AAGAAGAGAT GTTAGGTAAA TTAAAAGATC TTGGGAACTT GGTTCTCCGA 
CCTTTTGGGC TCTCCACGGA AAATTTCCAG ATCAAACAGG ATTCCTCTAC CGGCTCGTAC 
TCCATCAATT TCGTTCAAAA TCCAAATAAT AACAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

An inter-species protein-protein interaction network across vast evolutionary distance.
Molecular systems biology12(4)865(2016 Apr)
Zhong Q,Pevzner SJ,Hao T,Wang Y,Mosca R,Menche J,Taipale M,Ta?an M,Fan C,Yang X,Haley P,Murray RR,Mer F,Gebreab F,Tam S,MacWilliams A,Dricot A,Reichert P,Santhanam B,Ghamsari L,Calderwood MA,Rolland T,Charloteaux B,Lindquist S,Barab?si AL,Hill DE,Aloy P,Cusick ME,Xia Y,Roth FP,Vidal M

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Cell164(4)805-17(2016 Feb)
Yang X,Coulombe-Huntington J,Kang S,Sheynkman GM,Hao T,Richardson A,Sun S,Yang F,Shen YA,Murray RR,Spirohn K,Begg BE,Duran-Frigola M,MacWilliams A,Pevzner SJ,Zhong Q,Trigg SA,Tam S,Ghamsari L,Sahni N,Yi S,Rodriguez MD,Balcha D,Tan G,Costanzo M,Andrews B,Boone C,Zhou XJ,Salehi-Ashtiani K,Charloteaux B,Chen AA,Calderwood MA,Aloy P,Roth FP,Hill DE,Iakoucheva LM,Xia Y,Vidal M

A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.
Cell158(2)434-448(2014 Jul)
Taipale M,Tucker G,Peng J,Krykbaeva I,Lin ZY,Larsen B,Choi H,Berger B,Gingras AC,Lindquist S

Activation of Ras-dependent signaling pathways by G(14) -coupled receptors requires the adaptor protein TPR1.
Journal of cellular biochemistry113(11)3486-97(2012 Nov)
Kwan DH,Yung LY,Ye RD,Wong YH

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TTC1 cDNA ORF clone, Homo sapiens(human)

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