SPRR2A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SPRR2A
Entrez Gene ID	6700
Full Name	small proline rich protein 2A
General protein information	Preferred Names small proline rich protein 2A Names small proline-rich protein 2A 2-1 SPR-2A
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q21.3
Disorder MIM:	182267

mRNA and Protein(s)

mRNA	Protein	Name
NM_005988.3	NP_005979.1	small proline-rich protein 2A
NM_005988.2	NP_005979.1	small proline-rich protein 2A

Pathways from BioSystems

Homologies

Homo sapiens (human)	SPRR2A	NP_005979.1
Pan troglodytes (chimpanzee)	SPRR2A	XP_003308528.1

Gene Ontology
Bibliography

Related articles in PubMed

RNA sequencing and pathway analysis identify tumor necrosis factor alpha driven small proline-rich protein dysregulation in chronic rhinosinusitis.
Ramakrishnan VR, Gonzalez JR, Cooper SE, Barham HP, Anderson CB, Larson ED, Cool CD, Diller JD, Jones K, Kinnamon SC
American journal of rhinology & allergy31(5)283-288(2017 Sep)

Small proline rich protein 2a in benign and malignant liver disease.
Mizuguchi Y, Isse K, Specht S, Lunz JG 3rd, Corbitt N, Takizawa T, Demetris AJ
Hepatology (Baltimore, Md.)59(3)1130-43(2014 Mar)

SPRR2A expression in cholangiocarcinoma increases local tumor invasiveness but prevents metastasis.
Specht S, Isse K, Nozaki I, Lunz JG 3rd, Demetris AJ
Clinical & experimental metastasis30(7)877-90(2013 Oct)

SPRR2A enhances p53 deacetylation through HDAC1 and down regulates p21 promoter activity.
Mizuguchi Y, Specht S, Lunz JG 3rd, Isse K, Corbitt N, Takizawa T, Demetris AJ
BMC molecular biology1320(2012 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SPRR2a modulates ZEB-1 signaling by way of miR-200c/141-associated epithelial mesenchyme transition through SH3-domain networks and contributes to benign and malignant wound-healing responses.
Title: Small proline rich protein 2a in benign and malignant liver disease.

SPRR2A-associated tumor behavior was mimicked by MUC1 shRNA, which induced EMT and, like SPRR2A+ cells, showed reduced metastatic capabilities
Title: SPRR2A expression in cholangiocarcinoma increases local tumor invasiveness but prevents metastasis.

SPRR2A functions as a suppressor of p53-dependent transcriptional activity, which otherwise might impede cellular processes needed for epithelial wound repair responses.
Title: SPRR2A enhances p53 deacetylation through HDAC1 and down regulates p21 promoter activity.

Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families.
Title: Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families.

Small proline-rich proteins (SPRR2A) function as SH3 domain ligands, increase resistance to injury and are associated with epithelial-mesenchymal transition (EMT) in cholangiocytes.
Title: Small proline-rich proteins (SPRR) function as SH3 domain ligands, increase resistance to injury and are associated with epithelial-mesenchymal transition (EMT) in cholangiocytes.

The following SPRR2A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SPRR2A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20188	NM_005988.3 Latest version!	Homo sapiens small proline rich protein 2A (SPRR2A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu20188	NM_005988.2	Homo sapiens small proline rich protein 2A (SPRR2A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SPRR2A ( NM_005988.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005979.1 Homo sapiens small proline rich protein 2A (SPRR2A), mRNA.

Price & Availability↑

CloneID	OHu20188
Clone ID Related Accession (Same CDS sequence)	NM_005988.3 , NM_005988.2
Accession Version	NM_005988.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 219bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	small proline-rich protein 2A
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BE710686.1, X53064.1 and CA433267.1. On Nov 23, 2018 this sequence version replaced NM_005988.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA766540.1, DA763239.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000392653.3/ ENSP00000376423.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCTTATC AACAGCAGCA GTGCAAGCAG CCCTGCCAGC CACCTCCTGT GTGCCCCACG 
CCAAAGTGCC CAGAGCCATG TCCACCCCCG AAGTGCCCTG AGCCCTGCCC ACCACCAAAG 
TGTCCACAGC CCTGCCCACC TCAGCAGTGC CAGCAGAAAT ATCCTCCTGT GACACCTTCC 
CCACCCTGCC AGTCAAAGTA TCCACCGAAG AGCAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005979.1
CDS	62..280
Translation	MSYQQQQCKQPCQPPPVCPTPKCPEPCPPPKCPEPCPPPKCPQPCPPQQCQQKYPPVTPSPPCQSKYPPKSK

Target ORF information:

RefSeq Version	NM_005988.3
Organism	Homo sapiens(human)
Definition	Homo sapiens small proline rich protein 2A (SPRR2A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005988.3

ORF Insert Sequence:

ATGTCTTATC AACAGCAGCA GTGCAAGCAG CCCTGCCAGC CACCTCCTGT GTGCCCCACG 
CCAAAGTGCC CAGAGCCATG TCCACCCCCG AAGTGCCCTG AGCCCTGCCC ACCACCAAAG 
TGTCCACAGC CCTGCCCACC TCAGCAGTGC CAGCAGAAAT ATCCTCCTGT GACACCTTCC 
CCACCCTGCC AGTCAAAGTA TCCACCGAAG AGCAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SPRR2A ( NM_005988.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_005979.1 Homo sapiens small proline rich protein 2A (SPRR2A), mRNA.

Price & Availability↑

CloneID	OHu20188
Clone ID Related Accession (Same CDS sequence)	NM_005988.3 , NM_005988.2
Accession Version	NM_005988.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 219bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	small proline-rich protein 2A
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BE710686.1, X53064.1 and CA433267.1. On Apr 2, 2004 this sequence version replaced NM_005988.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279844.7014.1, ERR279834.3162.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2147975, SAMEA2158800 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCTTATC AACAGCAGCA GTGCAAGCAG CCCTGCCAGC CACCTCCTGT GTGCCCCACG 
CCAAAGTGCC CAGAGCCATG TCCACCCCCG AAGTGCCCTG AGCCCTGCCC ACCACCAAAG 
TGTCCACAGC CCTGCCCACC TCAGCAGTGC CAGCAGAAAT ATCCTCCTGT GACACCTTCC 
CCACCCTGCC AGTCAAAGTA TCCACCGAAG AGCAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005979.1
CDS	62..280
Translation	MSYQQQQCKQPCQPPPVCPTPKCPEPCPPPKCPEPCPPPKCPQPCPPQQCQQKYPPVTPSPPCQSKYPPKSK

Target ORF information:

RefSeq Version	NM_005988.2
Organism	Homo sapiens(human)
Definition	Homo sapiens small proline rich protein 2A (SPRR2A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005988.2

ORF Insert Sequence:

ATGTCTTATC AACAGCAGCA GTGCAAGCAG CCCTGCCAGC CACCTCCTGT GTGCCCCACG 
CCAAAGTGCC CAGAGCCATG TCCACCCCCG AAGTGCCCTG AGCCCTGCCC ACCACCAAAG 
TGTCCACAGC CCTGCCCACC TCAGCAGTGC CAGCAGAAAT ATCCTCCTGT GACACCTTCC 
CCACCCTGCC AGTCAAAGTA TCCACCGAAG AGCAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

RNA sequencing and pathway analysis identify tumor necrosis factor alpha driven small proline-rich protein dysregulation in chronic rhinosinusitis.
American journal of rhinology & allergy31(5)283-288(2017 Sep)
Ramakrishnan VR,Gonzalez JR,Cooper SE,Barham HP,Anderson CB,Larson ED,Cool CD,Diller JD,Jones K,Kinnamon SC

Small proline rich protein 2a in benign and malignant liver disease.
Hepatology (Baltimore, Md.)59(3)1130-43(2014 Mar)
Mizuguchi Y,Isse K,Specht S,Lunz JG 3rd,Corbitt N,Takizawa T,Demetris AJ

SPRR2A expression in cholangiocarcinoma increases local tumor invasiveness but prevents metastasis.
Clinical & experimental metastasis30(7)877-90(2013 Oct)
Specht S,Isse K,Nozaki I,Lunz JG 3rd,Demetris AJ

SPRR2A enhances p53 deacetylation through HDAC1 and down regulates p21 promoter activity.
BMC molecular biology1320(2012 Jun)
Mizuguchi Y,Specht S,Lunz JG 3rd,Isse K,Corbitt N,Takizawa T,Demetris AJ

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SPRR2A cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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