SLC10A1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SLC10A1
Entrez Gene ID	6554
Full Name	solute carrier family 10 member 1
Synonyms	NTCP
General protein information	Preferred Names solute carrier family 10 member 1 Names sodium/bile acid cotransporter Na(+)/bile acid cotransporter Na(+)/taurocholate transport protein Na/taurocholate cotransporting polypeptide cell growth-inhibiting gene 29 protein growth-inhibiting protein 29 sodium/taurocholate cotransporter sodium/taurocholate cotransporting polypeptide solute carrier family 10 (sodium/bile acid cotransporter family), member 1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q24.1
Summary	The protein encoded by this gene belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids; the ileal sodium/bile acid cotransporter with an apical cell localization that absorbs bile acids from the intestinal lumen, bile duct and kidney, and the liver-specific sodium/bile acid cotransporter, represented by this protein, that is found in the basolateral membranes of hepatocytes. Bile acids are the catabolic product of cholesterol metabolism, hence this protein is important for cholesterol homeostasis. [provided by RefSeq, Oct 2011].
Disorder MIM:	182396

mRNA and Protein(s)

mRNA	Protein	Name
NM_003049.3	NP_003040.1	sodium/bile acid cotransporter
NM_003049.4	NP_003040.1	sodium/bile acid cotransporter

Pathways from BioSystems

Homologies

	SLC10A1	XP_001110268.1
Rattus norvegicus (Norway rat)	Slc10a1	NP_058743.1
Canis lupus familiaris (dog)	SLC10A1	XP_537494.2
Homo sapiens (human)	SLC10A1	NP_003040.1
Bos taurus (cattle)	SLC10A1	NP_001039804.1
Mus musculus (house mouse)	Slc10a1	NP_001171032.1
Danio rerio (zebrafish)	slc10a1	XP_690745.4
Pan troglodytes (chimpanzee)	SLC10A1	XP_510035.2
Xenopus tropicalis (tropical clawed frog)	LOC100489580	XP_002936944.2

Gene Ontology
Bibliography

Related articles in PubMed

Lack of Ser267Phe variant of sodium taurocholate cotransporting polypeptide among Moroccans regardless of hepatitis B virus infection status.
Ezzikouri S, Chihab H, Elhabazi A, Wakrim L, Benjelloun S
BMC infectious diseases17(1)99(2017 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The data showed that S267F of sodium taurocholate cotransporting polypeptide is not associated with hepatitis B virus infection, and is not prevalent in the general Moroccan population.
Title: Lack of Ser267Phe variant of sodium taurocholate cotransporting polypeptide among Moroccans regardless of hepatitis B virus infection status.

These results uncover NTCP as a mediator of innate antiviral immune responses in the liver.
Title: Solute Carrier NTCP Regulates Innate Antiviral Immune Responses Targeting Hepatitis C Virus Infection of Hepatocytes.

the present study indicated that the common variants in the regulatory elements of NTCP may not influence the expression level of SLC10A1 at transcriptional regulation, and ultimately may not be associated with HBV susceptibility.
Title: Genetic variants in the regulatory region of SLC10A1 are not associated with the risk of hepatitis B virus infection and clearance.

In conclusion, NTCP appeared inefficient to mediate infection by serum-derived hepatitis B virus.
Title: Unusual Features of Sodium Taurocholate Cotransporting Polypeptide as a Hepatitis B Virus Receptor.

For Tibetans and Uygurs, no association of the three NTCP SNPs (rs7154439, rs4646287 and rs2296651) and their haplotypes with hepatitis B virus chronicity was observed.
Title: Polymorphisms in sodium taurocholate cotransporting polypeptide are not associated with hepatitis B virus clearance in Chinese Tibetans and Uygurs.

The following SLC10A1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLC10A1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu15010	NM_003049.4 Latest version!	Homo sapiens solute carrier family 10 member 1 (SLC10A1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu15010	NM_003049.3	Homo sapiens solute carrier family 10 member 1 (SLC10A1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SLC10A1 ( NM_003049.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003040.1 Homo sapiens solute carrier family 10 member 1 (SLC10A1), mRNA.

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CloneID	OHu15010
Clone ID Related Accession (Same CDS sequence)	NM_003049.3 , NM_003049.4
Accession Version	NM_003049.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1050bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	sodium/bile acid cotransporter
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL157789.6, AK314028.1, BC069799.1 and L21893.1. On Mar 24, 2009 this sequence version replaced NM_003049.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L21893.1, BC069799.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2162895 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGCCC ACAACGCGTC TGCCCCATTC AACTTCACCC TGCCACCCAA CTTTGGCAAG 
CGCCCCACAG ACCTGGCACT GAGCGTCATC CTGGTGTTCA TGTTGTTCTT CATCATGCTC 
TCGCTGGGCT GCACCATGGA GTTCAGCAAG ATCAAGGCTC ACTTATGGAA GCCTAAAGGG 
CTGGCCATCG CCCTGGTGGC ACAGTATGGC ATCATGCCCC TCACGGCCTT TGTGCTGGGC 
AAGGTCTTCC GGCTGAAGAA CATTGAGGCA CTGGCCATCT TGGTCTGTGG CTGCTCACCT 
GGAGGGAACC TGTCCAATGT CTTCAGTCTG GCCATGAAGG GGGACATGAA CCTCAGCATT 
GTGATGACCA CCTGCTCCAC CTTCTGTGCC CTTGGCATGA TGCCTCTCCT CCTGTACATC 
TACTCCAGGG GGATCTATGA TGGGGACCTG AAGGACAAGG TGCCCTATAA AGGCATCGTG 
ATATCACTGG TCCTGGTTCT CATTCCTTGC ACCATAGGGA TCGTCCTCAA ATCCAAACGG 
CCACAATACA TGCGCTATGT CATCAAGGGA GGGATGATCA TCATTCTCTT GTGCAGTGTG 
GCCGTCACAG TTCTCTCTGC CATCAATGTG GGGAAGAGCA TCATGTTTGC CATGACACCA 
CTCTTGATTG CCACCTCCTC CCTGATGCCT TTTATTGGCT TTCTGCTGGG TTATGTTCTC 
TCTGCTCTCT TCTGCCTCAA TGGACGGTGC AGACGCACTG TCAGCATGGA GACTGGATGC 
CAAAATGTCC AACTCTGTTC CACCATCCTC AATGTGGCCT TTCCACCTGA AGTCATTGGA 
CCACTTTTCT TCTTTCCCCT CCTCTACATG ATTTTCCAGC TTGGAGAAGG GCTTCTCCTC 
ATTGCCATAT TTTGGTGCTA TGAGAAATTC AAGACTCCCA AGGATAAAAC AAAAATGATC 
TACACAGCTG CCACAACTGA AGAAACAATT CCAGGAGCTC TGGGAAATGG CACCTACAAA 
GGGGAGGACT GCTCCCCTTG CACAGCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003040.1
CDS	135..1184
Translation	MEAHNASAPFNFTLPPNFGKRPTDLALSVILVFMLFFIMLSLGCTMEFSKIKAHLWKPKGLAIALVAQYGIMPLTAFVLGKVFRLKNIEALAILVCGCSPGGNLSNVFSLAMKGDMNLSIVMTTCSTFCALGMMPLLLYIYSRGIYDGDLKDKVPYKGIVISLVLVLIPCTIGIVLKSKRPQYMRYVIKGGMIIILLCSVAVTVLSAINVGKSIMFAMTPLLIATSSLMPFIGFLLGYVLSALFCLNGRCRRTVSMETGCQNVQLCSTILNVAFPPEVIGPLFFFPLLYMIFQLGEGLLLIAIFWCYEKFKTPKDKTKMIYTAATTEETIPGALGNGTYKGEDCSPCTA

Target ORF information:

RefSeq Version	NM_003049.3
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 10 member 1 (SLC10A1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003049.3

ORF Insert Sequence:

ATGGAGGCCC ACAACGCGTC TGCCCCATTC AACTTCACCC TGCCACCCAA CTTTGGCAAG 
CGCCCCACAG ACCTGGCACT GAGCGTCATC CTGGTGTTCA TGTTGTTCTT CATCATGCTC 
TCGCTGGGCT GCACCATGGA GTTCAGCAAG ATCAAGGCTC ACTTATGGAA GCCTAAAGGG 
CTGGCCATCG CCCTGGTGGC ACAGTATGGC ATCATGCCCC TCACGGCCTT TGTGCTGGGC 
AAGGTCTTCC GGCTGAAGAA CATTGAGGCA CTGGCCATCT TGGTCTGTGG CTGCTCACCT 
GGAGGGAACC TGTCCAATGT CTTCAGTCTG GCCATGAAGG GGGACATGAA CCTCAGCATT 
GTGATGACCA CCTGCTCCAC CTTCTGTGCC CTTGGCATGA TGCCTCTCCT CCTGTACATC 
TACTCCAGGG GGATCTATGA TGGGGACCTG AAGGACAAGG TGCCCTATAA AGGCATCGTG 
ATATCACTGG TCCTGGTTCT CATTCCTTGC ACCATAGGGA TCGTCCTCAA ATCCAAACGG 
CCACAATACA TGCGCTATGT CATCAAGGGA GGGATGATCA TCATTCTCTT GTGCAGTGTG 
GCCGTCACAG TTCTCTCTGC CATCAATGTG GGGAAGAGCA TCATGTTTGC CATGACACCA 
CTCTTGATTG CCACCTCCTC CCTGATGCCT TTTATTGGCT TTCTGCTGGG TTATGTTCTC 
TCTGCTCTCT TCTGCCTCAA TGGACGGTGC AGACGCACTG TCAGCATGGA GACTGGATGC 
CAAAATGTCC AACTCTGTTC CACCATCCTC AATGTGGCCT TTCCACCTGA AGTCATTGGA 
CCACTTTTCT TCTTTCCCCT CCTCTACATG ATTTTCCAGC TTGGAGAAGG GCTTCTCCTC 
ATTGCCATAT TTTGGTGCTA TGAGAAATTC AAGACTCCCA AGGATAAAAC AAAAATGATC 
TACACAGCTG CCACAACTGA AGAAACAATT CCAGGAGCTC TGGGAAATGG CACCTACAAA 
GGGGAGGACT GCTCCCCTTG CACAGCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLC10A1 ( NM_003049.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003040.1 Homo sapiens solute carrier family 10 member 1 (SLC10A1), mRNA.

Price & Availability↑

CloneID	OHu15010
Clone ID Related Accession (Same CDS sequence)	NM_003049.3 , NM_003049.4
Accession Version	NM_003049.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1050bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-09
Organism	Homo sapiens(human)
Product	sodium/bile acid cotransporter
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK314028.1, BC069799.1, L21893.1 and AL157789.6. On Nov 23, 2018 this sequence version replaced NM_003049.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189664.103981.1, SRR5189664.104510.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145122, SAMEA2155590 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000216540.5/ ENSP00000216540.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGGCCC ACAACGCGTC TGCCCCATTC AACTTCACCC TGCCACCCAA CTTTGGCAAG 
CGCCCCACAG ACCTGGCACT GAGCGTCATC CTGGTGTTCA TGTTGTTCTT CATCATGCTC 
TCGCTGGGCT GCACCATGGA GTTCAGCAAG ATCAAGGCTC ACTTATGGAA GCCTAAAGGG 
CTGGCCATCG CCCTGGTGGC ACAGTATGGC ATCATGCCCC TCACGGCCTT TGTGCTGGGC 
AAGGTCTTCC GGCTGAAGAA CATTGAGGCA CTGGCCATCT TGGTCTGTGG CTGCTCACCT 
GGAGGGAACC TGTCCAATGT CTTCAGTCTG GCCATGAAGG GGGACATGAA CCTCAGCATT 
GTGATGACCA CCTGCTCCAC CTTCTGTGCC CTTGGCATGA TGCCTCTCCT CCTGTACATC 
TACTCCAGGG GGATCTATGA TGGGGACCTG AAGGACAAGG TGCCCTATAA AGGCATCGTG 
ATATCACTGG TCCTGGTTCT CATTCCTTGC ACCATAGGGA TCGTCCTCAA ATCCAAACGG 
CCACAATACA TGCGCTATGT CATCAAGGGA GGGATGATCA TCATTCTCTT GTGCAGTGTG 
GCCGTCACAG TTCTCTCTGC CATCAATGTG GGGAAGAGCA TCATGTTTGC CATGACACCA 
CTCTTGATTG CCACCTCCTC CCTGATGCCT TTTATTGGCT TTCTGCTGGG TTATGTTCTC 
TCTGCTCTCT TCTGCCTCAA TGGACGGTGC AGACGCACTG TCAGCATGGA GACTGGATGC 
CAAAATGTCC AACTCTGTTC CACCATCCTC AATGTGGCCT TTCCACCTGA AGTCATTGGA 
CCACTTTTCT TCTTTCCCCT CCTCTACATG ATTTTCCAGC TTGGAGAAGG GCTTCTCCTC 
ATTGCCATAT TTTGGTGCTA TGAGAAATTC AAGACTCCCA AGGATAAAAC AAAAATGATC 
TACACAGCTG CCACAACTGA AGAAACAATT CCAGGAGCTC TGGGAAATGG CACCTACAAA 
GGGGAGGACT GCTCCCCTTG CACAGCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003040.1
CDS	87..1136
Translation	MEAHNASAPFNFTLPPNFGKRPTDLALSVILVFMLFFIMLSLGCTMEFSKIKAHLWKPKGLAIALVAQYGIMPLTAFVLGKVFRLKNIEALAILVCGCSPGGNLSNVFSLAMKGDMNLSIVMTTCSTFCALGMMPLLLYIYSRGIYDGDLKDKVPYKGIVISLVLVLIPCTIGIVLKSKRPQYMRYVIKGGMIIILLCSVAVTVLSAINVGKSIMFAMTPLLIATSSLMPFIGFLLGYVLSALFCLNGRCRRTVSMETGCQNVQLCSTILNVAFPPEVIGPLFFFPLLYMIFQLGEGLLLIAIFWCYEKFKTPKDKTKMIYTAATTEETIPGALGNGTYKGEDCSPCTA

Target ORF information:

RefSeq Version	NM_003049.4
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 10 member 1 (SLC10A1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003049.4

ORF Insert Sequence:

ATGGAGGCCC ACAACGCGTC TGCCCCATTC AACTTCACCC TGCCACCCAA CTTTGGCAAG 
CGCCCCACAG ACCTGGCACT GAGCGTCATC CTGGTGTTCA TGTTGTTCTT CATCATGCTC 
TCGCTGGGCT GCACCATGGA GTTCAGCAAG ATCAAGGCTC ACTTATGGAA GCCTAAAGGG 
CTGGCCATCG CCCTGGTGGC ACAGTATGGC ATCATGCCCC TCACGGCCTT TGTGCTGGGC 
AAGGTCTTCC GGCTGAAGAA CATTGAGGCA CTGGCCATCT TGGTCTGTGG CTGCTCACCT 
GGAGGGAACC TGTCCAATGT CTTCAGTCTG GCCATGAAGG GGGACATGAA CCTCAGCATT 
GTGATGACCA CCTGCTCCAC CTTCTGTGCC CTTGGCATGA TGCCTCTCCT CCTGTACATC 
TACTCCAGGG GGATCTATGA TGGGGACCTG AAGGACAAGG TGCCCTATAA AGGCATCGTG 
ATATCACTGG TCCTGGTTCT CATTCCTTGC ACCATAGGGA TCGTCCTCAA ATCCAAACGG 
CCACAATACA TGCGCTATGT CATCAAGGGA GGGATGATCA TCATTCTCTT GTGCAGTGTG 
GCCGTCACAG TTCTCTCTGC CATCAATGTG GGGAAGAGCA TCATGTTTGC CATGACACCA 
CTCTTGATTG CCACCTCCTC CCTGATGCCT TTTATTGGCT TTCTGCTGGG TTATGTTCTC 
TCTGCTCTCT TCTGCCTCAA TGGACGGTGC AGACGCACTG TCAGCATGGA GACTGGATGC 
CAAAATGTCC AACTCTGTTC CACCATCCTC AATGTGGCCT TTCCACCTGA AGTCATTGGA 
CCACTTTTCT TCTTTCCCCT CCTCTACATG ATTTTCCAGC TTGGAGAAGG GCTTCTCCTC 
ATTGCCATAT TTTGGTGCTA TGAGAAATTC AAGACTCCCA AGGATAAAAC AAAAATGATC 
TACACAGCTG CCACAACTGA AGAAACAATT CCAGGAGCTC TGGGAAATGG CACCTACAAA 
GGGGAGGACT GCTCCCCTTG CACAGCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Lack of Ser267Phe variant of sodium taurocholate cotransporting polypeptide among Moroccans regardless of hepatitis B virus infection status.
BMC infectious diseases17(1)99(2017 Jan)
Ezzikouri S,Chihab H,Elhabazi A,Wakrim L,Benjelloun S

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SLC10A1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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