Gene Symbol | SMOC2 |
Entrez Gene ID | 64094 |
Full Name | SPARC related modular calcium binding 2 |
Synonyms | DTDP1,MST117,MSTP117,MSTP140,SMAP2,bA270C4A.1,bA37D8.1,dJ421D16.1 |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene encodes a member of the SPARC family (secreted protein acidic and rich in cysteine/osteonectin/BM-40), which are highly expressed during embryogenesis and wound healing. The gene product is a matricellular protein which promotes matrix assembly and can stimulate endothelial cell proliferation and migration, as well as angiogenic activity. Associated with pulmonary function, this secretory gene product contains a Kazal domain, two thymoglobulin type-1 domains, and two EF-hand calcium-binding domains. The encoded protein may serve as a target for controlling angiogenesis in tumor growth and myocardial ischemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]. |
Disorder MIM: | |
Disorder Html: | Dentin dysplasia, type I, with microdontia and misshapen teeth, 125400 (3) |