RSC1A1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RSC1A1
Entrez Gene ID	6248
Full Name	regulator of solute carriers 1
Synonyms	RS1
General protein information	Preferred Names regulator of solute carriers 1 Names regulatory solute carrier protein family 1 member 1 regulatory solute carrier protein, family 1, member 1 transporter regulator RS1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p36.21
Summary	The protein encoded by this intronless gene inhibits the expression of the solute carrier family 5 (sodium/glucose cotransporter), member 1 gene (SLC5A1) and downregulates exocytosis of the SLC5A1 protein. The encoded protein is sometimes found coating the trans-Golgi network and other times is localized to the nucleus, depending on the cell cycle stage. This protein also inhibits the expression of solute carrier family 22 (organic cation transporter), member 2 (SLC22A2). [provided by RefSeq, Dec 2015]. COMPLETENESS: complete on the 3' end.
Disorder MIM:	601966

mRNA and Protein(s)

mRNA	Protein	Name
NM_006511.1	NP_006502.1	regulatory solute carrier protein family 1 member 1
NM_006511.2	NP_006502.1	regulatory solute carrier protein family 1 member 1

Pathways from BioSystems

Homologies

	RSC1A1	XP_001083464.1
Homo sapiens (human)	RSC1A1	NP_006502.1
Mus musculus (house mouse)	Rsc1a1	NP_076033.4

Gene Ontology
Bibliography

Related articles in PubMed

Protein RS1 (RSC1A1) Downregulates the Exocytotic Pathway of Glucose Transporter SGLT1 at Low Intracellular Glucose via Inhibition of Ornithine Decarboxylase.
Chintalapati C, Keller T, Mueller TD, Gorboulev V, Sch?fer N, Zilkowski I, Veyhl-Wichmann M, Geiger D, Groll J, Koepsell H
Molecular pharmacology90(5)508-521(2016 Nov)

Phosphorylation of RS1 (RSC1A1) Steers Inhibition of Different Exocytotic Pathways for Glucose Transporter SGLT1 and Nucleoside Transporter CNT1, and an RS1-Derived Peptide Inhibits Glucose Absorption.
Veyhl-Wichmann M, Friedrich A, Vernaleken A, Singh S, Kipp H, Gorboulev V, Keller T, Chintalapati C, Pipkorn R, Pastor-Anglada M, Groll J, Koepsell H
Molecular pharmacology89(1)118-32(2016 Jan)

Novel shuttling domain in a regulator (RSC1A1) of transporter SGLT1 steers cell cycle-dependent nuclear location.
Filatova A, Leyerer M, Gorboulev V, Chintalapati C, Reinders Y, M?ller TD, Srinivasan A, H?bner S, Koepsell H
Traffic (Copenhagen, Denmark)10(11)1599-618(2009 Nov)

Tripeptides of RS1 (RSC1A1) inhibit a monosaccharide-dependent exocytotic pathway of Na+-D-glucose cotransporter SGLT1 with high affinity.
Vernaleken A, Veyhl M, Gorboulev V, Kottra G, Palm D, Burckhardt BC, Burckhardt G, Pipkorn R, Beier N, van Amsterdam C, Koepsell H
The Journal of biological chemistry282(39)28501-13(2007 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Binding of RS1-Reg to ODC1 inhibits the enzymatic activity at low intracellular glucose, which is blunted at high intracellular glucose.
Title: Protein RS1 (RSC1A1) Downregulates the Exocytotic Pathway of Glucose Transporter SGLT1 at Low Intracellular Glucose via Inhibition of Ornithine Decarboxylase.

Observational study of gene-disease association. (HuGE Navigator)
Title: Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.

RSC1A1 codes for a 67-kDa protein named RS1 that mediates transcriptional and post-transcriptional regulation of Na(+)-D-glucose cotransporter SGLT1.
Title: Tripeptides of RS1 (RSC1A1) inhibit a monosaccharide-dependent exocytotic pathway of Na+-D-glucose cotransporter SGLT1 with high affinity.

RS1 inhibits the dynamin-dependent release of SGLT1-containing vesicles from the trans-golgi network
Title: Transporter regulator RS1 (RSC1A1) coats the trans-Golgi network and migrates into the nucleus.

hRS1 protein exhibits glucose-dependent, short-term inhibition of hSGLT1 and hOCT2 by inhibiting the release of vesicles from the trans-Golgi network
Title: RS1 (RSC1A1) regulates the exocytotic pathway of Na+-D-glucose cotransporter SGLT1.

The following RSC1A1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RSC1A1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31185	NM_006511.2 Latest version!	Homo sapiens regulator of solute carriers 1 (RSC1A1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$363.30 $519.00
View Old Accession Versions >>
OHu31185	NM_006511.1	Homo sapiens regulatory solute carrier protein, family 1, member 1 (RSC1A1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$363.30 $519.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RSC1A1 ( NM_006511.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_006502.1 Homo sapiens regulatory solute carrier protein, family 1, member 1 (RSC1A1), mRNA.

Price & Availability↑

CloneID	OHu31185
Clone ID Related Accession (Same CDS sequence)	NM_006511.1 , NM_006511.2
Accession Version	NM_006511.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1854bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2014-01-31
Organism	Homo sapiens(Human)
Product	regulatory solute carrier protein family 1 member 1
Comment

ATGTCATCAT TACCAACTTC AGATGGGTTT AACCATCCCG CCCGTTCTTC AGGACAGAGT 
CCTGATGTTG GTAATCCTAT GAGTCTTGCT CGCTCTGTCT CTGCTTCAGT CTGCCCTATC 
AAGCCCAGTG ACTCAGATCG CATTGAACCT AAAGCTGTGA AGGCTTTGAA GGCTTCAGCT 
GAATTCCAGC TAAACTCTGA AAAGAAAGAA CATCTTTCTT TACAAGATCT TTCTGATCAT 
GCTTCCTCAG CAGACCATGC TCCAACAGAC CAGAGTCCAG CTATGCCTAT GCAGAATTCA 
TCCGAAGAAA TAACTGTTGC AGGTAATCTG GAGAAATCTG CTGAAAGAAG CACCCAGGGC 
CTCAAATTTC ATCTCCATAC AAGACAGGAA GCTAGTTTAT CTGTCACATC TACTAGGATG 
CATGAACCAC AGATGTTTCT AGGTGAAAAG GATTGGCATC CAGAAAATCA GAACCTGAGT 
CAAGTGAGTG ACCCTCAGCA GCACGAAGAA CCAGGGAATG AACAGTATGA GGTTGCACAA 
CAAAAAGCTT CACATGACCA AGAATATCTT TGTAACATAG GGGACCTTGA GCTTCCTGAA 
GAAAGGCAAC AGAATCAACA CAAAATTGTT GATTTGGAAG CTACGATGAA AGGAAATGGG 
CTCCCACAGA ATGTGGATCC TCCAAGTGCG AAGAAAAGTA TTCCATCTTC AGAATGCAGT 
GGCTGCTCAA ATTCAGAAAC ATTTATGGAA ATCGATACAG CTCAACAGTC CCTAGTTACT 
TTGCTTAATT CAACAGGCAG GCAGAATGCC AATGTCAAGA ACATTGGTGC ATTGGATCTC 
ACTTTAGATA ATCCCTTGAT GGAAGTAGAA ACATCAAAAT GTAACCCTTC ATCTGAAATT 
TTGAATGATT CCATTTCCAC TCAGGATTTA CAGCCCCCAG AAACTAATGT TGAAATACCT 
GGAACAAATA AAGAATATGG CCATTACTCC TCTCCAAGTC TCTGTGGCAG TTGTCAGCCT 
TCTGTGGAGT CAGCAGAAGA ATCTTGCCCG TCTATAACGG CAGCCTTGAA AGAACTTCAT 
GAACTTTTGG TTGTTAGCAG TAAACCAGCT TCAGAAAATA CATCTGAAGA AGTAATCTGT 
CAATCAGAAA CCATAGCTGA GGGCCAAACC AGTATTAAAG ACCTTTCTGA AAGATGGACC 
CAAAATGAGC ATCTTACCCA GAATGAACAG TGTCCACAAG TCTCCTTTCA TCAGGCCATA 
TCTGTATCAG TGGAGACAGA AAAATTAACA GGTACTTCAT CTGACACTGG AAGAGAAGCT 
GTAGAAAATG TAAACTTCAG GAGTCTAGGT GATGGCCTGT CAACCGATAA GGAAGGTGTC 
CCCAAATCTA GGGAATCCAT AAATAAGAAC CGTTCTGTCA CTGTAACCTC AGCTAAAACA 
TCCAATCAGT TACACTGCAC CTTAGGTGTA GAAATTTCAC CCAAACTTTT AGCAGGTGAG 
GAGGATGCAC TCAATCAGAC TTCTGAGCAA ACTAAGTCTT TGTCATCCAA TTTCATATTG 
GTTAAAGACT TAGGTCAGGG CATACAGAAT TCAGTAACAG ACAGGCCTGA AACCAGAGAA 
AATGTCTGTC CTGATGCTTC GAGGCCATTA CTTGAATATG AACCACCTAC CAGCCATCCA 
TCATCAAGTC CTGCCATTCT TCCACCATTG ATTTTTCCTG CCACAGATAT TGACCGCATT 
CTCCGTGCTG GCTTTACTTT GCAGGAAGCT CTTGGAGCTT TGCATCGAGT TGGTGGGAAT 
GCAGACCTTG CACTTCTTGT TTTGCTCGCA AAAAACATCG TAGTTCCTAC ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

NP_006502.1

Translation

MSSLPTSDGFNHPARSSGQSPDVGNPMSLARSVSASVCPIKPSDSDRIEPKAVKALKASAEFQLNSEKKEHLSLQDLSDHASSADHAPTDQSPAMPMQNSSEEITVAGNLEKSAERSTQGLKFHLHTRQEASLSVTSTRMHEPQMFLGEKDWHPENQNLSQVSDPQQHEEPGNEQYEVAQQKASHDQEYLCNIGDLELPEERQQNQHKIVDLEATMKGNGLPQNVDPPSAKKSIPSSECSGCSNSETFMEIDTAQQSLVTLLNSTGRQNANVKNIGALDLTLDNPLMEVETSKCNPSSEILNDSISTQDLQPPETNVEIPGTNKEYGHYSSPSLCGSCQPSVESAEESCPSITAALKELHELLVVSSKPASENTSEEVICQSETIAEGQTSIKDLSERWTQNEHLTQNEQCPQVSFHQAISVSVETEKLTGTSSDTGREAVENVNFRSLGDGLSTDKEGVPKSRESINKNRSVTVTSAKTSNQLHCTLGVEISPKLLAGEEDALNQTSEQTKSLSSNFILVKDLGQGIQNSVTDRPETRENVCPDASRPLLEYEPPTSHPSSSPAILPPLIFPATDIDRILRAGFTLQEALGALHRVGGNADLALLVLLAKNIVVPT

Target ORF information:

RefSeq Version	NM_006511.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens regulatory solute carrier protein, family 1, member 1 (RSC1A1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006511.1

ORF Insert Sequence:

ATGTCATCAT TACCAACTTC AGATGGGTTT AACCATCCCG CCCGTTCTTC AGGACAGAGT 
CCTGATGTTG GTAATCCTAT GAGTCTTGCT CGCTCTGTCT CTGCTTCAGT CTGCCCTATC 
AAGCCCAGTG ACTCAGATCG CATTGAACCT AAAGCTGTGA AGGCTTTGAA GGCTTCAGCT 
GAATTCCAGC TAAACTCTGA AAAGAAAGAA CATCTTTCTT TACAAGATCT TTCTGATCAT 
GCTTCCTCAG CAGACCATGC TCCAACAGAC CAGAGTCCAG CTATGCCTAT GCAGAATTCA 
TCCGAAGAAA TAACTGTTGC AGGTAATCTG GAGAAATCTG CTGAAAGAAG CACCCAGGGC 
CTCAAATTTC ATCTCCATAC AAGACAGGAA GCTAGTTTAT CTGTCACATC TACTAGGATG 
CATGAACCAC AGATGTTTCT AGGTGAAAAG GATTGGCATC CAGAAAATCA GAACCTGAGT 
CAAGTGAGTG ACCCTCAGCA GCACGAAGAA CCAGGGAATG AACAGTATGA GGTTGCACAA 
CAAAAAGCTT CACATGACCA AGAATATCTT TGTAACATAG GGGACCTTGA GCTTCCTGAA 
GAAAGGCAAC AGAATCAACA CAAAATTGTT GATTTGGAAG CTACGATGAA AGGAAATGGG 
CTCCCACAGA ATGTGGATCC TCCAAGTGCG AAGAAAAGTA TTCCATCTTC AGAATGCAGT 
GGCTGCTCAA ATTCAGAAAC ATTTATGGAA ATCGATACAG CTCAACAGTC CCTAGTTACT 
TTGCTTAATT CAACAGGCAG GCAGAATGCC AATGTCAAGA ACATTGGTGC ATTGGATCTC 
ACTTTAGATA ATCCCTTGAT GGAAGTAGAA ACATCAAAAT GTAACCCTTC ATCTGAAATT 
TTGAATGATT CCATTTCCAC TCAGGATTTA CAGCCCCCAG AAACTAATGT TGAAATACCT 
GGAACAAATA AAGAATATGG CCATTACTCC TCTCCAAGTC TCTGTGGCAG TTGTCAGCCT 
TCTGTGGAGT CAGCAGAAGA ATCTTGCCCG TCTATAACGG CAGCCTTGAA AGAACTTCAT 
GAACTTTTGG TTGTTAGCAG TAAACCAGCT TCAGAAAATA CATCTGAAGA AGTAATCTGT 
CAATCAGAAA CCATAGCTGA GGGCCAAACC AGTATTAAAG ACCTTTCTGA AAGATGGACC 
CAAAATGAGC ATCTTACCCA GAATGAACAG TGTCCACAAG TCTCCTTTCA TCAGGCCATA 
TCTGTATCAG TGGAGACAGA AAAATTAACA GGTACTTCAT CTGACACTGG AAGAGAAGCT 
GTAGAAAATG TAAACTTCAG GAGTCTAGGT GATGGCCTGT CAACCGATAA GGAAGGTGTC 
CCCAAATCTA GGGAATCCAT AAATAAGAAC CGTTCTGTCA CTGTAACCTC AGCTAAAACA 
TCCAATCAGT TACACTGCAC CTTAGGTGTA GAAATTTCAC CCAAACTTTT AGCAGGTGAG 
GAGGATGCAC TCAATCAGAC TTCTGAGCAA ACTAAGTCTT TGTCATCCAA TTTCATATTG 
GTTAAAGACT TAGGTCAGGG CATACAGAAT TCAGTAACAG ACAGGCCTGA AACCAGAGAA 
AATGTCTGTC CTGATGCTTC GAGGCCATTA CTTGAATATG AACCACCTAC CAGCCATCCA 
TCATCAAGTC CTGCCATTCT TCCACCATTG ATTTTTCCTG CCACAGATAT TGACCGCATT 
CTCCGTGCTG GCTTTACTTT GCAGGAAGCT CTTGGAGCTT TGCATCGAGT TGGTGGGAAT 
GCAGACCTTG CACTTCTTGT TTTGCTCGCA AAAAACATCG TAGTTCCTAC ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RSC1A1 ( NM_006511.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_006502.1 Homo sapiens regulator of solute carriers 1 (RSC1A1), mRNA.

Price & Availability↑

CloneID	OHu31185
Clone ID Related Accession (Same CDS sequence)	NM_006511.1 , NM_006511.2
Accession Version	NM_006511.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1854bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-25
Organism	Homo sapiens(human)
Product	regulatory solute carrier protein family 1 member 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK314753.1, CR999543.1, CN345288.1 and AI240658.1. On Dec 17, 2015 this sequence version replaced NM_006511.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCATCAT TACCAACTTC AGATGGGTTT AACCATCCCG CCCGTTCTTC AGGACAGAGT 
CCTGATGTTG GTAATCCTAT GAGTCTTGCT CGCTCTGTCT CTGCTTCAGT CTGCCCTATC 
AAGCCCAGTG ACTCAGATCG CATTGAACCT AAAGCTGTGA AGGCTTTGAA GGCTTCAGCT 
GAATTCCAGC TAAACTCTGA AAAGAAAGAA CATCTTTCTT TACAAGATCT TTCTGATCAT 
GCTTCCTCAG CAGACCATGC TCCAACAGAC CAGAGTCCAG CTATGCCTAT GCAGAATTCA 
TCCGAAGAAA TAACTGTTGC AGGTAATCTG GAGAAATCTG CTGAAAGAAG CACCCAGGGC 
CTCAAATTTC ATCTCCATAC AAGACAGGAA GCTAGTTTAT CTGTCACATC TACTAGGATG 
CATGAACCAC AGATGTTTCT AGGTGAAAAG GATTGGCATC CAGAAAATCA GAACCTGAGT 
CAAGTGAGTG ACCCTCAGCA GCACGAAGAA CCAGGGAATG AACAGTATGA GGTTGCACAA 
CAAAAAGCTT CACATGACCA AGAATATCTT TGTAACATAG GGGACCTTGA GCTTCCTGAA 
GAAAGGCAAC AGAATCAACA CAAAATTGTT GATTTGGAAG CTACGATGAA AGGAAATGGG 
CTCCCACAGA ATGTGGATCC TCCAAGTGCG AAGAAAAGTA TTCCATCTTC AGAATGCAGT 
GGCTGCTCAA ATTCAGAAAC ATTTATGGAA ATCGATACAG CTCAACAGTC CCTAGTTACT 
TTGCTTAATT CAACAGGCAG GCAGAATGCC AATGTCAAGA ACATTGGTGC ATTGGATCTC 
ACTTTAGATA ATCCCTTGAT GGAAGTAGAA ACATCAAAAT GTAACCCTTC ATCTGAAATT 
TTGAATGATT CCATTTCCAC TCAGGATTTA CAGCCCCCAG AAACTAATGT TGAAATACCT 
GGAACAAATA AAGAATATGG CCATTACTCC TCTCCAAGTC TCTGTGGCAG TTGTCAGCCT 
TCTGTGGAGT CAGCAGAAGA ATCTTGCCCG TCTATAACGG CAGCCTTGAA AGAACTTCAT 
GAACTTTTGG TTGTTAGCAG TAAACCAGCT TCAGAAAATA CATCTGAAGA AGTAATCTGT 
CAATCAGAAA CCATAGCTGA GGGCCAAACC AGTATTAAAG ACCTTTCTGA AAGATGGACC 
CAAAATGAGC ATCTTACCCA GAATGAACAG TGTCCACAAG TCTCCTTTCA TCAGGCCATA 
TCTGTATCAG TGGAGACAGA AAAATTAACA GGTACTTCAT CTGACACTGG AAGAGAAGCT 
GTAGAAAATG TAAACTTCAG GAGTCTAGGT GATGGCCTGT CAACCGATAA GGAAGGTGTC 
CCCAAATCTA GGGAATCCAT AAATAAGAAC CGTTCTGTCA CTGTAACCTC AGCTAAAACA 
TCCAATCAGT TACACTGCAC CTTAGGTGTA GAAATTTCAC CCAAACTTTT AGCAGGTGAG 
GAGGATGCAC TCAATCAGAC TTCTGAGCAA ACTAAGTCTT TGTCATCCAA TTTCATATTG 
GTTAAAGACT TAGGTCAGGG CATACAGAAT TCAGTAACAG ACAGGCCTGA AACCAGAGAA 
AATGTCTGTC CTGATGCTTC GAGGCCATTA CTTGAATATG AACCACCTAC CAGCCATCCA 
TCATCAAGTC CTGCCATTCT TCCACCATTG ATTTTTCCTG CCACAGATAT TGACCGCATT 
CTCCGTGCTG GCTTTACTTT GCAGGAAGCT CTTGGAGCTT TGCATCGAGT TGGTGGGAAT 
GCAGACCTTG CACTTCTTGT TTTGCTCGCA AAAAACATCG TAGTTCCTAC ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006502.1
CDS	157..2010
Translation	MSSLPTSDGFNHPARSSGQSPDVGNPMSLARSVSASVCPIKPSDSDRIEPKAVKALKASAEFQLNSEKKEHLSLQDLSDHASSADHAPTDQSPAMPMQNSSEEITVAGNLEKSAERSTQGLKFHLHTRQEASLSVTSTRMHEPQMFLGEKDWHPENQNLSQVSDPQQHEEPGNEQYEVAQQKASHDQEYLCNIGDLELPEERQQNQHKIVDLEATMKGNGLPQNVDPPSAKKSIPSSECSGCSNSETFMEIDTAQQSLVTLLNSTGRQNANVKNIGALDLTLDNPLMEVETSKCNPSSEILNDSISTQDLQPPETNVEIPGTNKEYGHYSSPSLCGSCQPSVESAEESCPSITAALKELHELLVVSSKPASENTSEEVICQSETIAEGQTSIKDLSERWTQNEHLTQNEQCPQVSFHQAISVSVETEKLTGTSSDTGREAVENVNFRSLGDGLSTDKEGVPKSRESINKNRSVTVTSAKTSNQLHCTLGVEISPKLLAGEEDALNQTSEQTKSLSSNFILVKDLGQGIQNSVTDRPETRENVCPDASRPLLEYEPPTSHPSSSPAILPPLIFPATDIDRILRAGFTLQEALGALHRVGGNADLALLVLLAKNIVVPT

Target ORF information:

RefSeq Version	NM_006511.2
Organism	Homo sapiens(human)
Definition	Homo sapiens regulator of solute carriers 1 (RSC1A1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006511.2

ORF Insert Sequence:

ATGTCATCAT TACCAACTTC AGATGGGTTT AACCATCCCG CCCGTTCTTC AGGACAGAGT 
CCTGATGTTG GTAATCCTAT GAGTCTTGCT CGCTCTGTCT CTGCTTCAGT CTGCCCTATC 
AAGCCCAGTG ACTCAGATCG CATTGAACCT AAAGCTGTGA AGGCTTTGAA GGCTTCAGCT 
GAATTCCAGC TAAACTCTGA AAAGAAAGAA CATCTTTCTT TACAAGATCT TTCTGATCAT 
GCTTCCTCAG CAGACCATGC TCCAACAGAC CAGAGTCCAG CTATGCCTAT GCAGAATTCA 
TCCGAAGAAA TAACTGTTGC AGGTAATCTG GAGAAATCTG CTGAAAGAAG CACCCAGGGC 
CTCAAATTTC ATCTCCATAC AAGACAGGAA GCTAGTTTAT CTGTCACATC TACTAGGATG 
CATGAACCAC AGATGTTTCT AGGTGAAAAG GATTGGCATC CAGAAAATCA GAACCTGAGT 
CAAGTGAGTG ACCCTCAGCA GCACGAAGAA CCAGGGAATG AACAGTATGA GGTTGCACAA 
CAAAAAGCTT CACATGACCA AGAATATCTT TGTAACATAG GGGACCTTGA GCTTCCTGAA 
GAAAGGCAAC AGAATCAACA CAAAATTGTT GATTTGGAAG CTACGATGAA AGGAAATGGG 
CTCCCACAGA ATGTGGATCC TCCAAGTGCG AAGAAAAGTA TTCCATCTTC AGAATGCAGT 
GGCTGCTCAA ATTCAGAAAC ATTTATGGAA ATCGATACAG CTCAACAGTC CCTAGTTACT 
TTGCTTAATT CAACAGGCAG GCAGAATGCC AATGTCAAGA ACATTGGTGC ATTGGATCTC 
ACTTTAGATA ATCCCTTGAT GGAAGTAGAA ACATCAAAAT GTAACCCTTC ATCTGAAATT 
TTGAATGATT CCATTTCCAC TCAGGATTTA CAGCCCCCAG AAACTAATGT TGAAATACCT 
GGAACAAATA AAGAATATGG CCATTACTCC TCTCCAAGTC TCTGTGGCAG TTGTCAGCCT 
TCTGTGGAGT CAGCAGAAGA ATCTTGCCCG TCTATAACGG CAGCCTTGAA AGAACTTCAT 
GAACTTTTGG TTGTTAGCAG TAAACCAGCT TCAGAAAATA CATCTGAAGA AGTAATCTGT 
CAATCAGAAA CCATAGCTGA GGGCCAAACC AGTATTAAAG ACCTTTCTGA AAGATGGACC 
CAAAATGAGC ATCTTACCCA GAATGAACAG TGTCCACAAG TCTCCTTTCA TCAGGCCATA 
TCTGTATCAG TGGAGACAGA AAAATTAACA GGTACTTCAT CTGACACTGG AAGAGAAGCT 
GTAGAAAATG TAAACTTCAG GAGTCTAGGT GATGGCCTGT CAACCGATAA GGAAGGTGTC 
CCCAAATCTA GGGAATCCAT AAATAAGAAC CGTTCTGTCA CTGTAACCTC AGCTAAAACA 
TCCAATCAGT TACACTGCAC CTTAGGTGTA GAAATTTCAC CCAAACTTTT AGCAGGTGAG 
GAGGATGCAC TCAATCAGAC TTCTGAGCAA ACTAAGTCTT TGTCATCCAA TTTCATATTG 
GTTAAAGACT TAGGTCAGGG CATACAGAAT TCAGTAACAG ACAGGCCTGA AACCAGAGAA 
AATGTCTGTC CTGATGCTTC GAGGCCATTA CTTGAATATG AACCACCTAC CAGCCATCCA 
TCATCAAGTC CTGCCATTCT TCCACCATTG ATTTTTCCTG CCACAGATAT TGACCGCATT 
CTCCGTGCTG GCTTTACTTT GCAGGAAGCT CTTGGAGCTT TGCATCGAGT TGGTGGGAAT 
GCAGACCTTG CACTTCTTGT TTTGCTCGCA AAAAACATCG TAGTTCCTAC ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Protein RS1 (RSC1A1) Downregulates the Exocytotic Pathway of Glucose Transporter SGLT1 at Low Intracellular Glucose via Inhibition of Ornithine Decarboxylase.
Molecular pharmacology90(5)508-521(2016 Nov)
Chintalapati C,Keller T,Mueller TD,Gorboulev V,Sch?fer N,Zilkowski I,Veyhl-Wichmann M,Geiger D,Groll J,Koepsell H

Phosphorylation of RS1 (RSC1A1) Steers Inhibition of Different Exocytotic Pathways for Glucose Transporter SGLT1 and Nucleoside Transporter CNT1, and an RS1-Derived Peptide Inhibits Glucose Absorption.
Molecular pharmacology89(1)118-32(2016 Jan)
Veyhl-Wichmann M,Friedrich A,Vernaleken A,Singh S,Kipp H,Gorboulev V,Keller T,Chintalapati C,Pipkorn R,Pastor-Anglada M,Groll J,Koepsell H

Novel shuttling domain in a regulator (RSC1A1) of transporter SGLT1 steers cell cycle-dependent nuclear location.
Traffic (Copenhagen, Denmark)10(11)1599-618(2009 Nov)
Filatova A,Leyerer M,Gorboulev V,Chintalapati C,Reinders Y,M?ller TD,Srinivasan A,H?bner S,Koepsell H

Tripeptides of RS1 (RSC1A1) inhibit a monosaccharide-dependent exocytotic pathway of Na+-D-glucose cotransporter SGLT1 with high affinity.
The Journal of biological chemistry282(39)28501-13(2007 Sep)
Vernaleken A,Veyhl M,Gorboulev V,Kottra G,Palm D,Burckhardt BC,Burckhardt G,Pipkorn R,Beier N,van Amsterdam C,Koepsell H

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RSC1A1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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