HMHB1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HMHB1
Entrez Gene ID	57824
Full Name	histocompatibility minor HB-1
Synonyms	HB-1,HB-1Y,HLA-HB1
General protein information	Preferred Names histocompatibility minor HB-1 Names minor histocompatibility protein HB-1 minor histocompatibility antigen HB-1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q31.3
Summary	This gene encodes one of the minor histocompatibility antigens, which play an important role in the induction of cytotoxic T lymphocyte (CTL) reactivity against leukemia after human histocompatibility leukocyte antigen (HLA)-identical allogeneic bone marrow transplantation (BMT). This gene is only expressed in B cell acute lymphoblastic leukemia cells and Epstein-Barr virus-transformed B cells. The translation of this mRNA initiates at a non-AUG (CUG) codon. [provided by RefSeq, Jul 2008].
Disorder MIM:	609961

mRNA and Protein(s)

mRNA	Protein	Name
NM_021182.1	NP_067005.1	minor histocompatibility protein HB-1
NM_021182.2	NP_067005.1	minor histocompatibility protein HB-1
NM_021182.3	NP_067005.1	minor histocompatibility protein HB-1

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Improved genotyping of the human minor histocompatibility antigen HB-1 by polymerase chain reaction with sequence-specific primers using a complementary oligonucleotide.
Park MJ, Choi HB, Kim TG
Tissue antigens76(6)482-6(2010 Dec)

Degree of predicted minor histocompatibility antigen mismatch correlates with poorer clinical outcomes in nonmyeloablative allogeneic hematopoietic cell transplantation.
Larsen ME, Kornblit B, Larsen MV, Masmas TN, Nielsen M, Thiim M, Garred P, Stryhn A, Lund O, Buus S, Vindelov L
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation16(10)1370-81(2010 Oct)

Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
Trynka G, Zhernakova A, Romanos J, Franke L, Hunt KA, Turner G, Bruinenberg M, Heap GA, Platteel M, Ryan AW, de Kovel C, Holmes GK, Howdle PD, Walters JR, Sanders DS, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, Kelleher D, Barisani D, Bardella MT, McManus R, van Heel DA, Wijmenga C
Gut58(8)1078-83(2009 Aug)

Role of minor histocompatibility antigens in renal transplantation.
Heinold A, Opelz G, Scherer S, Ruhenstroth A, Laux G, Doehler B, Tran TH
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons8(1)95-102(2008 Jan)

A human minor histocompatibility antigen specific for B cell acute lymphoblastic leukemia.
Dolstra H, Fredrix H, Maas F, Coulie PG, Brasseur F, Mensink E, Adema GJ, de Witte TM, Figdor CG, van de Wiel-van Kemenade E
The Journal of experimental medicine189(2)301-8(1999 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Improved genotyping of the human minor histocompatibility antigen HB-1 by polymerase chain reaction with sequence-specific primers using a complementary oligonucleotide.
Title: Improved genotyping of the human minor histocompatibility antigen HB-1 by polymerase chain reaction with sequence-specific primers using a complementary oligonucleotide.

Observational study of gene-disease association. (HuGE Navigator)
Title: Degree of predicted minor histocompatibility antigen mismatch correlates with poorer clinical outcomes in nonmyeloablative allogeneic hematopoietic cell transplantation.

Observational study of gene-disease association. (HuGE Navigator)
Title: Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.

Observational study of gene-disease association. (HuGE Navigator)
Title: Role of minor histocompatibility antigens in renal transplantation.

The paper described that non-AUG (CTG) translation initiation codon at nucleotide positions 108-110 was used for the encoded protein.
Title: A human minor histocompatibility antigen specific for B cell acute lymphoblastic leukemia.

The following HMHB1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HMHB1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17086	NM_021182.3 Latest version!	Homo sapiens histocompatibility minor HB-1 (HMHB1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu17086	NM_021182.1	Homo sapiens histocompatibility minor HB-1 (HMHB1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu17086	NM_021182.2	Homo sapiens histocompatibility minor HB-1 (HMHB1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HMHB1 ( NM_021182.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_067005.1 Homo sapiens histocompatibility minor HB-1 (HMHB1), mRNA.

Price & Availability↑

CloneID	OHu17086
Clone ID Related Accession (Same CDS sequence)	NM_021182.1 , NM_021182.2 , NM_021182.3
Accession Version	NM_021182.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 126bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-22
Organism	Homo sapiens(human)
Product	minor histocompatibility protein HB-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF103884.1. ##Evidence-Data-START## Transcript exon combination :: AF103884.1, BC096711.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA2142680 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## non-AUG initiation codon :: PMID: 9892612 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121

CTGGAGGAGC AGCCAGAATG CAGAGAAGAA AAAAGAGGTT CTCTGCATGT TTGGAAGTCG 
GAATTGGTTG AAGTTGAAGA TGATGTGTAT CTGAGGCACA GCTCTTCCCT GACTTATAGG 
CTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067005.1
CDS	108..233
Translation	LEEQPECREEKRGSLHVWKSELVEVEDDVYLRHSSSLTYRL

Target ORF information:

RefSeq Version	NM_021182.1
Organism	Homo sapiens(human)
Definition	Homo sapiens histocompatibility minor HB-1 (HMHB1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021182.1

ORF Insert Sequence:

1
61
121

CTGGAGGAGC AGCCAGAATG CAGAGAAGAA AAAAGAGGTT CTCTGCATGT TTGGAAGTCG 
GAATTGGTTG AAGTTGAAGA TGATGTGTAT CTGAGGCACA GCTCTTCCCT GACTTATAGG 
CTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HMHB1 ( NM_021182.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_067005.1 Homo sapiens histocompatibility minor HB-1 (HMHB1), mRNA.

Price & Availability↑

CloneID	OHu17086
Clone ID Related Accession (Same CDS sequence)	NM_021182.1 , NM_021182.2 , NM_021182.3
Accession Version	NM_021182.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 126bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-03-10
Organism	Homo sapiens(human)
Product	minor histocompatibility protein HB-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC025765.6. On Mar 11, 2019 this sequence version replaced NM_021182.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AF103884.1, BC113971.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA2142680 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## non-AUG initiation codon :: PMID: 9892612 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121

CTGGAGGAGC AGCCAGAATG CAGAGAAGAA AAAAGAGGTT CTCTGCATGT TTGGAAGTCG 
GAATTGGTTG AAGTTGAAGA TGATGTGTAT CTGAGGCACA GCTCTTCCCT GACTTATAGG 
CTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067005.1
CDS	108..233
Translation	LEEQPECREEKRGSLHVWKSELVEVEDDVYLRHSSSLTYRL

Target ORF information:

RefSeq Version	NM_021182.2
Organism	Homo sapiens(human)
Definition	Homo sapiens histocompatibility minor HB-1 (HMHB1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021182.2

ORF Insert Sequence:

1
61
121

CTGGAGGAGC AGCCAGAATG CAGAGAAGAA AAAAGAGGTT CTCTGCATGT TTGGAAGTCG 
GAATTGGTTG AAGTTGAAGA TGATGTGTAT CTGAGGCACA GCTCTTCCCT GACTTATAGG 
CTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HMHB1 ( NM_021182.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_067005.1 Homo sapiens histocompatibility minor HB-1 (HMHB1), mRNA.

Price & Availability↑

CloneID	OHu17086
Clone ID Related Accession (Same CDS sequence)	NM_021182.1 , NM_021182.2 , NM_021182.3
Accession Version	NM_021182.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 126bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-28
Organism	Homo sapiens(human)
Product	minor histocompatibility protein HB-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC025765.6. On Jun 2, 2019 this sequence version replaced NM_021182.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AF103884.1, BC113971.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA2142680 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## non-AUG initiation codon :: PMID: 9892612 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121

CTGGAGGAGC AGCCAGAATG CAGAGAAGAA AAAAGAGGTT CTCTGCATGT TTGGAAGTCG 
GAATTGGTTG AAGTTGAAGA TGATGTGTAT CTGAGGCACA GCTCTTCCCT GACTTATAGG 
CTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067005.1
CDS	108..233
Translation	LEEQPECREEKRGSLHVWKSELVEVEDDVYLRHSSSLTYRL

Target ORF information:

RefSeq Version	NM_021182.3
Organism	Homo sapiens(human)
Definition	Homo sapiens histocompatibility minor HB-1 (HMHB1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021182.3

ORF Insert Sequence:

1
61
121

CTGGAGGAGC AGCCAGAATG CAGAGAAGAA AAAAGAGGTT CTCTGCATGT TTGGAAGTCG 
GAATTGGTTG AAGTTGAAGA TGATGTGTAT CTGAGGCACA GCTCTTCCCT GACTTATAGG 
CTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Improved genotyping of the human minor histocompatibility antigen HB-1 by polymerase chain reaction with sequence-specific primers using a complementary oligonucleotide.
Tissue antigens76(6)482-6(2010 Dec)
Park MJ,Choi HB,Kim TG

Degree of predicted minor histocompatibility antigen mismatch correlates with poorer clinical outcomes in nonmyeloablative allogeneic hematopoietic cell transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation16(10)1370-81(2010 Oct)
Larsen ME,Kornblit B,Larsen MV,Masmas TN,Nielsen M,Thiim M,Garred P,Stryhn A,Lund O,Buus S,Vindelov L

Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
Gut58(8)1078-83(2009 Aug)
Trynka G,Zhernakova A,Romanos J,Franke L,Hunt KA,Turner G,Bruinenberg M,Heap GA,Platteel M,Ryan AW,de Kovel C,Holmes GK,Howdle PD,Walters JR,Sanders DS,Mulder CJ,Mearin ML,Verbeek WH,Trimble V,Stevens FM,Kelleher D,Barisani D,Bardella MT,McManus R,van Heel DA,Wijmenga C

Role of minor histocompatibility antigens in renal transplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons8(1)95-102(2008 Jan)
Heinold A,Opelz G,Scherer S,Ruhenstroth A,Laux G,Doehler B,Tran TH

A human minor histocompatibility antigen specific for B cell acute lymphoblastic leukemia.
The Journal of experimental medicine189(2)301-8(1999 Jan)
Dolstra H,Fredrix H,Maas F,Coulie PG,Brasseur F,Mensink E,Adema GJ,de Witte TM,Figdor CG,van de Wiel-van Kemenade E

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HMHB1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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