MCOLN1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MCOLN1
Entrez Gene ID	57192
Full Name	mucolipin 1
Synonyms	MG-2,ML1,ML4,MLIV,MST080,MSTP080,TRP-ML1,TRPM-L1,TRPML1
General protein information	Preferred Names mucolipin 1 Names mucolipin-1 mucolipidin mucolipidosis type IV protein transient receptor potential channel mucolipin 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.2
Summary	This gene encodes a memberof the transient receptor potential (TRP) cation channel gene family. The transmembrane protein localizes to intracellular vesicular membranes including lysosomes, and functions in the late endocytic pathway and in the regulation of lysosomal exocytosis. The channel is permeable to Ca(2+), Fe(2+), Na(+), K(+), and H(+), and is modulated by changes in Ca(2+) concentration. Mutations in this gene result in mucolipidosis type IV. [provided by RefSeq, Oct 2009].
Disorder MIM:	605248
Disorder Html:	Mucolipidosis IV, 252650 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_020533.2	NP_065394.1	mucolipin-1
NM_020533.3	NP_065394.1	mucolipin-1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	MCOLN1	XP_854284.1
Xenopus tropicalis (tropical clawed frog)	mcoln1	NP_001011347.1
Pan troglodytes (chimpanzee)	MCOLN1	XP_001152409.1
	MCOLN1	XP_001089857.1
Mus musculus (house mouse)	Mcoln1	NP_444407.1
Rattus norvegicus (Norway rat)	Mcoln1	NP_001099373.1
Gallus gallus (chicken)	MCOLN1	XP_423829.4
Bos taurus (cattle)	MCOLN1	NP_001159604.1
Homo sapiens (human)	MCOLN1	NP_065394.1
Danio rerio (zebrafish)	mcoln1b	XP_001336199.1

Gene Ontology
Bibliography

Related articles in PubMed

Human TRPML1 channel structures in open and closed conformations.
Schmiege P, Fine M, Blobel G, Li X
Nature550(7676)366-370(2017 Oct)

The lysosomal Ca
Cao Q, Yang Y, Zhong XZ, Dong XP
The Journal of biological chemistry292(20)8424-8435(2017 05)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

findings suggest that TRPML1 may function as a key lysosomal Ca(2+) channel controlling both lysosome biogenesis and reformat
Title: The lysosomal Ca

These data suggest that lysosomal adenosine accumulation impairs lysosome function by inhibiting TRPML1 and subsequently leads to cell death in B-lymphocytes.
Title: Inhibition of Transient Receptor Potential Channel Mucolipin-1 (TRPML1) by Lysosomal Adenosine Involved in Severe Combined Immunodeficiency Diseases.

These results reveal that mTOR is a new type of calmodulin-dependent kinase, and TRPML1, lysosomal calcium and calmodulin play essential regulatory roles in the mTORC1 signaling pathway.
Title: Regulation of mTORC1 by lysosomal calcium and calmodulin.

TRPML1 supports both Ca(2+) release and Ca(2+) entry.
Title: Endo-lysosomal TRP mucolipin-1 channels trigger global ER Ca2+ release and Ca2+ influx.

Here we identify the lipid kinase PIKfyve as a regulator of an alternative pathway that distributes engulfed contents in support of intracellular macromolecular synthesis during macropinocytosis, entosis, and phagocytosis. We find that PIKfyve regulates vacuole size in part through its downstream effector, the cationic transporter TRPML1
Title: PIKfyve Regulates Vacuole Maturation and Nutrient Recovery following Engulfment.

The following MCOLN1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MCOLN1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18554	NM_020533.3 Latest version!	Homo sapiens mucolipin 1 (MCOLN1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu18554	NM_020533.2	Homo sapiens mucolipin 1 (MCOLN1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MCOLN1 ( NM_020533.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_065394.1 Homo sapiens mucolipin 1 (MCOLN1), mRNA.

Price & Availability↑

CloneID	OHu18554
Clone ID Related Accession (Same CDS sequence)	NM_020533.2 , NM_020533.3
Accession Version	NM_020533.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1743bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	mucolipin-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC356874.1, BC005149.2 and AA831948.1. This sequence is a reference standard in the RefSeqGene project. On Oct 8, 2009 this sequence version replaced NM_020533.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC005149.2, AK222673.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACAGCCC CGGCGGGTCC GCGCGGCTCA GAGACCGAGC GGCTTCTGAC CCCCAACCCC 
GGGTATGGGA CCCAGGCGGG GCCTTCACCG GCCCCTCCGA CACCCCCAGA AGAGGAAGAC 
CTTCGCCGTC GTCTCAAATA CTTTTTCATG AGTCCCTGCG ACAAGTTTCG AGCCAAGGGC 
CGCAAGCCCT GCAAGCTGAT GCTGCAAGTG GTCAAGATCC TGGTGGTCAC GGTGCAGCTC 
ATCCTGTTTG GGCTCAGTAA TCAGCTGGCT GTGACATTCC GGGAAGAGAA CACCATCGCC 
TTCCGACACC TCTTCCTGCT GGGCTACTCG GACGGAGCGG ATGACACCTT CGCAGCCTAC 
ACGCGGGAGC AGCTGTACCA GGCCATCTTC CATGCTGTGG ACCAGTACCT GGCGTTGCCT 
GACGTGTCAC TGGGCCGGTA TGCGTATGTC CGTGGTGGGG GTGACCCTTG GACCAATGGC 
TCAGGGCTTG CTCTCTGCCA GCGGTACTAC CACCGAGGCC ACGTGGACCC GGCCAACGAC 
ACATTTGACA TTGATCCGAT GGTGGTTACT GACTGCATCC AGGTGGATCC CCCCGAGCGG 
CCCCCTCCGC CCCCCAGCGA CGATCTCACC CTCTTGGAAA GCAGCTCCAG TTACAAGAAC 
CTCACGCTCA AATTCCACAA GCTGGTCAAT GTCACCATCC ACTTCCGGCT GAAGACCATT 
AACCTCCAGA GCCTCATCAA TAATGAGATC CCGGACTGCT ATACCTTCAG CGTCCTGATC 
ACGTTTGACA ACAAAGCACA CAGTGGGCGG ATCCCCATCA GCCTGGAGAC CCAGGCCCAC 
ATCCAGGAGT GTAAGCACCC CAGTGTCTTC CAGCACGGAG ACAACAGCTT CCGGCTCCTG 
TTTGACGTGG TGGTCATCCT CACCTGCTCC CTGTCCTTCC TCCTCTGCGC CCGCTCACTC 
CTTCGAGGCT TCCTGCTGCA GAACGAGTTT GTGGGGTTCA TGTGGCGGCA GCGGGGACGG 
GTCATCAGCC TGTGGGAGCG GCTGGAATTT GTCAATGGCT GGTACATCCT GCTCGTCACC 
AGCGATGTGC TCACCATCTC GGGCACCATC ATGAAGATCG GCATCGAGGC CAAGAACTTG 
GCGAGCTACG ACGTCTGCAG CATCCTCCTG GGCACCTCGA CGCTGCTGGT GTGGGTGGGC 
GTGATCCGCT ACCTGACCTT CTTCCACAAC TACAATATCC TCATCGCCAC ACTGCGGGTG 
GCCCTGCCCA GCGTCATGCG CTTCTGCTGC TGCGTGGCTG TCATCTACCT GGGCTACTGC 
TTCTGTGGCT GGATCGTGCT GGGGCCCTAT CATGTGAAGT TCCGCTCACT CTCCATGGTG 
TCTGAGTGCC TGTTCTCGCT CATCAATGGG GACGACATGT TTGTGACGTT CGCCGCCATG 
CAGGCGCAGC AGGGCCGCAG CAGCCTGGTG TGGCTCTTCT CCCAGCTCTA CCTTTACTCC 
TTCATCAGCC TCTTCATCTA CATGGTGCTC AGCCTCTTCA TCGCGCTCAT CACCGGCGCC 
TACGACACCA TCAAGCATCC CGGCGGCGCA GGCGCAGAGG AGAGCGAGCT GCAGGCCTAC 
ATCGCACAGT GCCAGGACAG CCCCACCTCC GGCAAGTTCC GCCGCGGGAG CGGCTCGGCC 
TGCAGCCTTC TCTGCTGCTG CGGAAGGGAC CCCTCGGAGG AGCATTCGCT GCTGGTGAAT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065394.1
CDS	142..1884
Translation	MTAPAGPRGSETERLLTPNPGYGTQAGPSPAPPTPPEEEDLRRRLKYFFMSPCDKFRAKGRKPCKLMLQVVKILVVTVQLILFGLSNQLAVTFREENTIAFRHLFLLGYSDGADDTFAAYTREQLYQAIFHAVDQYLALPDVSLGRYAYVRGGGDPWTNGSGLALCQRYYHRGHVDPANDTFDIDPMVVTDCIQVDPPERPPPPPSDDLTLLESSSSYKNLTLKFHKLVNVTIHFRLKTINLQSLINNEIPDCYTFSVLITFDNKAHSGRIPISLETQAHIQECKHPSVFQHGDNSFRLLFDVVVILTCSLSFLLCARSLLRGFLLQNEFVGFMWRQRGRVISLWERLEFVNGWYILLVTSDVLTISGTIMKIGIEAKNLASYDVCSILLGTSTLLVWVGVIRYLTFFHNYNILIATLRVALPSVMRFCCCVAVIYLGYCFCGWIVLGPYHVKFRSLSMVSECLFSLINGDDMFVTFAAMQAQQGRSSLVWLFSQLYLYSFISLFIYMVLSLFIALITGAYDTIKHPGGAGAEESELQAYIAQCQDSPTSGKFRRGSGSACSLLCCCGRDPSEEHSLLVN

Target ORF information:

RefSeq Version	NM_020533.2
Organism	Homo sapiens(human)
Definition	Homo sapiens mucolipin 1 (MCOLN1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020533.2

ORF Insert Sequence:

ATGACAGCCC CGGCGGGTCC GCGCGGCTCA GAGACCGAGC GGCTTCTGAC CCCCAACCCC 
GGGTATGGGA CCCAGGCGGG GCCTTCACCG GCCCCTCCGA CACCCCCAGA AGAGGAAGAC 
CTTCGCCGTC GTCTCAAATA CTTTTTCATG AGTCCCTGCG ACAAGTTTCG AGCCAAGGGC 
CGCAAGCCCT GCAAGCTGAT GCTGCAAGTG GTCAAGATCC TGGTGGTCAC GGTGCAGCTC 
ATCCTGTTTG GGCTCAGTAA TCAGCTGGCT GTGACATTCC GGGAAGAGAA CACCATCGCC 
TTCCGACACC TCTTCCTGCT GGGCTACTCG GACGGAGCGG ATGACACCTT CGCAGCCTAC 
ACGCGGGAGC AGCTGTACCA GGCCATCTTC CATGCTGTGG ACCAGTACCT GGCGTTGCCT 
GACGTGTCAC TGGGCCGGTA TGCGTATGTC CGTGGTGGGG GTGACCCTTG GACCAATGGC 
TCAGGGCTTG CTCTCTGCCA GCGGTACTAC CACCGAGGCC ACGTGGACCC GGCCAACGAC 
ACATTTGACA TTGATCCGAT GGTGGTTACT GACTGCATCC AGGTGGATCC CCCCGAGCGG 
CCCCCTCCGC CCCCCAGCGA CGATCTCACC CTCTTGGAAA GCAGCTCCAG TTACAAGAAC 
CTCACGCTCA AATTCCACAA GCTGGTCAAT GTCACCATCC ACTTCCGGCT GAAGACCATT 
AACCTCCAGA GCCTCATCAA TAATGAGATC CCGGACTGCT ATACCTTCAG CGTCCTGATC 
ACGTTTGACA ACAAAGCACA CAGTGGGCGG ATCCCCATCA GCCTGGAGAC CCAGGCCCAC 
ATCCAGGAGT GTAAGCACCC CAGTGTCTTC CAGCACGGAG ACAACAGCTT CCGGCTCCTG 
TTTGACGTGG TGGTCATCCT CACCTGCTCC CTGTCCTTCC TCCTCTGCGC CCGCTCACTC 
CTTCGAGGCT TCCTGCTGCA GAACGAGTTT GTGGGGTTCA TGTGGCGGCA GCGGGGACGG 
GTCATCAGCC TGTGGGAGCG GCTGGAATTT GTCAATGGCT GGTACATCCT GCTCGTCACC 
AGCGATGTGC TCACCATCTC GGGCACCATC ATGAAGATCG GCATCGAGGC CAAGAACTTG 
GCGAGCTACG ACGTCTGCAG CATCCTCCTG GGCACCTCGA CGCTGCTGGT GTGGGTGGGC 
GTGATCCGCT ACCTGACCTT CTTCCACAAC TACAATATCC TCATCGCCAC ACTGCGGGTG 
GCCCTGCCCA GCGTCATGCG CTTCTGCTGC TGCGTGGCTG TCATCTACCT GGGCTACTGC 
TTCTGTGGCT GGATCGTGCT GGGGCCCTAT CATGTGAAGT TCCGCTCACT CTCCATGGTG 
TCTGAGTGCC TGTTCTCGCT CATCAATGGG GACGACATGT TTGTGACGTT CGCCGCCATG 
CAGGCGCAGC AGGGCCGCAG CAGCCTGGTG TGGCTCTTCT CCCAGCTCTA CCTTTACTCC 
TTCATCAGCC TCTTCATCTA CATGGTGCTC AGCCTCTTCA TCGCGCTCAT CACCGGCGCC 
TACGACACCA TCAAGCATCC CGGCGGCGCA GGCGCAGAGG AGAGCGAGCT GCAGGCCTAC 
ATCGCACAGT GCCAGGACAG CCCCACCTCC GGCAAGTTCC GCCGCGGGAG CGGCTCGGCC 
TGCAGCCTTC TCTGCTGCTG CGGAAGGGAC CCCTCGGAGG AGCATTCGCT GCTGGTGAAT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MCOLN1 ( NM_020533.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_065394.1 Homo sapiens mucolipin 1 (MCOLN1), mRNA.

Price & Availability↑

CloneID	OHu18554
Clone ID Related Accession (Same CDS sequence)	NM_020533.2 , NM_020533.3
Accession Version	NM_020533.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1743bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-18
Organism	Homo sapiens(human)
Product	mucolipin-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC356874.1, BC005149.2 and AA831948.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_020533.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.642112.1, BC005149.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000264079.11/ ENSP00000264079.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGACAGCCC CGGCGGGTCC GCGCGGCTCA GAGACCGAGC GGCTTCTGAC CCCCAACCCC 
GGGTATGGGA CCCAGGCGGG GCCTTCACCG GCCCCTCCGA CACCCCCAGA AGAGGAAGAC 
CTTCGCCGTC GTCTCAAATA CTTTTTCATG AGTCCCTGCG ACAAGTTTCG AGCCAAGGGC 
CGCAAGCCCT GCAAGCTGAT GCTGCAAGTG GTCAAGATCC TGGTGGTCAC GGTGCAGCTC 
ATCCTGTTTG GGCTCAGTAA TCAGCTGGCT GTGACATTCC GGGAAGAGAA CACCATCGCC 
TTCCGACACC TCTTCCTGCT GGGCTACTCG GACGGAGCGG ATGACACCTT CGCAGCCTAC 
ACGCGGGAGC AGCTGTACCA GGCCATCTTC CATGCTGTGG ACCAGTACCT GGCGTTGCCT 
GACGTGTCAC TGGGCCGGTA TGCGTATGTC CGTGGTGGGG GTGACCCTTG GACCAATGGC 
TCAGGGCTTG CTCTCTGCCA GCGGTACTAC CACCGAGGCC ACGTGGACCC GGCCAACGAC 
ACATTTGACA TTGATCCGAT GGTGGTTACT GACTGCATCC AGGTGGATCC CCCCGAGCGG 
CCCCCTCCGC CCCCCAGCGA CGATCTCACC CTCTTGGAAA GCAGCTCCAG TTACAAGAAC 
CTCACGCTCA AATTCCACAA GCTGGTCAAT GTCACCATCC ACTTCCGGCT GAAGACCATT 
AACCTCCAGA GCCTCATCAA TAATGAGATC CCGGACTGCT ATACCTTCAG CGTCCTGATC 
ACGTTTGACA ACAAAGCACA CAGTGGGCGG ATCCCCATCA GCCTGGAGAC CCAGGCCCAC 
ATCCAGGAGT GTAAGCACCC CAGTGTCTTC CAGCACGGAG ACAACAGCTT CCGGCTCCTG 
TTTGACGTGG TGGTCATCCT CACCTGCTCC CTGTCCTTCC TCCTCTGCGC CCGCTCACTC 
CTTCGAGGCT TCCTGCTGCA GAACGAGTTT GTGGGGTTCA TGTGGCGGCA GCGGGGACGG 
GTCATCAGCC TGTGGGAGCG GCTGGAATTT GTCAATGGCT GGTACATCCT GCTCGTCACC 
AGCGATGTGC TCACCATCTC GGGCACCATC ATGAAGATCG GCATCGAGGC CAAGAACTTG 
GCGAGCTACG ACGTCTGCAG CATCCTCCTG GGCACCTCGA CGCTGCTGGT GTGGGTGGGC 
GTGATCCGCT ACCTGACCTT CTTCCACAAC TACAATATCC TCATCGCCAC ACTGCGGGTG 
GCCCTGCCCA GCGTCATGCG CTTCTGCTGC TGCGTGGCTG TCATCTACCT GGGCTACTGC 
TTCTGTGGCT GGATCGTGCT GGGGCCCTAT CATGTGAAGT TCCGCTCACT CTCCATGGTG 
TCTGAGTGCC TGTTCTCGCT CATCAATGGG GACGACATGT TTGTGACGTT CGCCGCCATG 
CAGGCGCAGC AGGGCCGCAG CAGCCTGGTG TGGCTCTTCT CCCAGCTCTA CCTTTACTCC 
TTCATCAGCC TCTTCATCTA CATGGTGCTC AGCCTCTTCA TCGCGCTCAT CACCGGCGCC 
TACGACACCA TCAAGCATCC CGGCGGCGCA GGCGCAGAGG AGAGCGAGCT GCAGGCCTAC 
ATCGCACAGT GCCAGGACAG CCCCACCTCC GGCAAGTTCC GCCGCGGGAG CGGCTCGGCC 
TGCAGCCTTC TCTGCTGCTG CGGAAGGGAC CCCTCGGAGG AGCATTCGCT GCTGGTGAAT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065394.1
CDS	128..1870
Translation	MTAPAGPRGSETERLLTPNPGYGTQAGPSPAPPTPPEEEDLRRRLKYFFMSPCDKFRAKGRKPCKLMLQVVKILVVTVQLILFGLSNQLAVTFREENTIAFRHLFLLGYSDGADDTFAAYTREQLYQAIFHAVDQYLALPDVSLGRYAYVRGGGDPWTNGSGLALCQRYYHRGHVDPANDTFDIDPMVVTDCIQVDPPERPPPPPSDDLTLLESSSSYKNLTLKFHKLVNVTIHFRLKTINLQSLINNEIPDCYTFSVLITFDNKAHSGRIPISLETQAHIQECKHPSVFQHGDNSFRLLFDVVVILTCSLSFLLCARSLLRGFLLQNEFVGFMWRQRGRVISLWERLEFVNGWYILLVTSDVLTISGTIMKIGIEAKNLASYDVCSILLGTSTLLVWVGVIRYLTFFHNYNILIATLRVALPSVMRFCCCVAVIYLGYCFCGWIVLGPYHVKFRSLSMVSECLFSLINGDDMFVTFAAMQAQQGRSSLVWLFSQLYLYSFISLFIYMVLSLFIALITGAYDTIKHPGGAGAEESELQAYIAQCQDSPTSGKFRRGSGSACSLLCCCGRDPSEEHSLLVN

Target ORF information:

RefSeq Version	NM_020533.3
Organism	Homo sapiens(human)
Definition	Homo sapiens mucolipin 1 (MCOLN1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020533.3

ORF Insert Sequence:

ATGACAGCCC CGGCGGGTCC GCGCGGCTCA GAGACCGAGC GGCTTCTGAC CCCCAACCCC 
GGGTATGGGA CCCAGGCGGG GCCTTCACCG GCCCCTCCGA CACCCCCAGA AGAGGAAGAC 
CTTCGCCGTC GTCTCAAATA CTTTTTCATG AGTCCCTGCG ACAAGTTTCG AGCCAAGGGC 
CGCAAGCCCT GCAAGCTGAT GCTGCAAGTG GTCAAGATCC TGGTGGTCAC GGTGCAGCTC 
ATCCTGTTTG GGCTCAGTAA TCAGCTGGCT GTGACATTCC GGGAAGAGAA CACCATCGCC 
TTCCGACACC TCTTCCTGCT GGGCTACTCG GACGGAGCGG ATGACACCTT CGCAGCCTAC 
ACGCGGGAGC AGCTGTACCA GGCCATCTTC CATGCTGTGG ACCAGTACCT GGCGTTGCCT 
GACGTGTCAC TGGGCCGGTA TGCGTATGTC CGTGGTGGGG GTGACCCTTG GACCAATGGC 
TCAGGGCTTG CTCTCTGCCA GCGGTACTAC CACCGAGGCC ACGTGGACCC GGCCAACGAC 
ACATTTGACA TTGATCCGAT GGTGGTTACT GACTGCATCC AGGTGGATCC CCCCGAGCGG 
CCCCCTCCGC CCCCCAGCGA CGATCTCACC CTCTTGGAAA GCAGCTCCAG TTACAAGAAC 
CTCACGCTCA AATTCCACAA GCTGGTCAAT GTCACCATCC ACTTCCGGCT GAAGACCATT 
AACCTCCAGA GCCTCATCAA TAATGAGATC CCGGACTGCT ATACCTTCAG CGTCCTGATC 
ACGTTTGACA ACAAAGCACA CAGTGGGCGG ATCCCCATCA GCCTGGAGAC CCAGGCCCAC 
ATCCAGGAGT GTAAGCACCC CAGTGTCTTC CAGCACGGAG ACAACAGCTT CCGGCTCCTG 
TTTGACGTGG TGGTCATCCT CACCTGCTCC CTGTCCTTCC TCCTCTGCGC CCGCTCACTC 
CTTCGAGGCT TCCTGCTGCA GAACGAGTTT GTGGGGTTCA TGTGGCGGCA GCGGGGACGG 
GTCATCAGCC TGTGGGAGCG GCTGGAATTT GTCAATGGCT GGTACATCCT GCTCGTCACC 
AGCGATGTGC TCACCATCTC GGGCACCATC ATGAAGATCG GCATCGAGGC CAAGAACTTG 
GCGAGCTACG ACGTCTGCAG CATCCTCCTG GGCACCTCGA CGCTGCTGGT GTGGGTGGGC 
GTGATCCGCT ACCTGACCTT CTTCCACAAC TACAATATCC TCATCGCCAC ACTGCGGGTG 
GCCCTGCCCA GCGTCATGCG CTTCTGCTGC TGCGTGGCTG TCATCTACCT GGGCTACTGC 
TTCTGTGGCT GGATCGTGCT GGGGCCCTAT CATGTGAAGT TCCGCTCACT CTCCATGGTG 
TCTGAGTGCC TGTTCTCGCT CATCAATGGG GACGACATGT TTGTGACGTT CGCCGCCATG 
CAGGCGCAGC AGGGCCGCAG CAGCCTGGTG TGGCTCTTCT CCCAGCTCTA CCTTTACTCC 
TTCATCAGCC TCTTCATCTA CATGGTGCTC AGCCTCTTCA TCGCGCTCAT CACCGGCGCC 
TACGACACCA TCAAGCATCC CGGCGGCGCA GGCGCAGAGG AGAGCGAGCT GCAGGCCTAC 
ATCGCACAGT GCCAGGACAG CCCCACCTCC GGCAAGTTCC GCCGCGGGAG CGGCTCGGCC 
TGCAGCCTTC TCTGCTGCTG CGGAAGGGAC CCCTCGGAGG AGCATTCGCT GCTGGTGAAT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Human TRPML1 channel structures in open and closed conformations.
Nature550(7676)366-370(2017 Oct)
Schmiege P,Fine M,Blobel G,Li X

The lysosomal Ca
The Journal of biological chemistry292(20)8424-8435(2017 05)
Cao Q,Yang Y,Zhong XZ,Dong XP

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MCOLN1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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