LMBRD1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LMBRD1
Entrez Gene ID	55788
Full Name	LMBR1 domain containing 1
Synonyms	C6orf209,LMBD1,MAHCF,NESI
General protein information	Preferred Names LMBR1 domain containing 1 Names probable lysosomal cobalamin transporter HDAg-L-interacting protein NESI hepatitis delta antigen-L interacting protein liver regeneration p-53 related protein nuclear export signal-interacting protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6q13
Summary	This gene encodes a lysosomal membrane protein that may be involved in the transport and metabolism of cobalamin. This protein also interacts with the large form of the hepatitis delta antigen and may be required for the nucleocytoplasmic shuttling of the hepatitis delta virus. Mutations in this gene are associated with the vitamin B12 metabolism disorder termed, homocystinuria-megaloblastic anemia complementation type F.[provided by RefSeq, Oct 2009].
Disorder MIM:	612625
Disorder Html:	Methylmalonic aciduria and homocystinuria, cblF type, 277380 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001367271.1	NP_001354200.1	probable lysosomal cobalamin transporter isoform 2
NM_018368.4	NP_060838.3	probable lysosomal cobalamin transporter isoform 1
NM_001363722.2	NP_001350651.1	probable lysosomal cobalamin transporter isoform 2
NM_018368.3	NP_060838.3	probable lysosomal cobalamin transporter
XM_011535941.1	XP_011534243.1	probable lysosomal cobalamin transporter isoform X1
NM_001367272.1	NP_001354201.1	probable lysosomal cobalamin transporter isoform 2

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	LMBRD1	NP_001006413.1
Mus musculus (house mouse)	Lmbrd1	NP_080995.2
Danio rerio (zebrafish)	lmbrd1	NP_001008612.1
Xenopus tropicalis (tropical clawed frog)	lmbrd1	NP_001072184.1
Homo sapiens (human)	LMBRD1	NP_060838.3
Pan troglodytes (chimpanzee)	LMBRD1	XP_001136147.1
	LMBRD1	XP_001111444.1
Canis lupus familiaris (dog)	LMBRD1	XP_003639484.1
Rattus norvegicus (Norway rat)	Lmbrd1	NP_631928.2
Magnaporthe oryzae (rice blast fungus)	MGG_00740	XP_003718260.1
Bos taurus (cattle)	LMBRD1	NP_001030264.1
Neurospora crassa	NCU02100	XP_964094.1

Gene Ontology
Bibliography

Related articles in PubMed

Clinical or ATPase domain mutations in ABCD4 disrupt the interaction between the vitamin B
Fettelschoss V, Burda P, Sagn? C, Coelho D, De Laet C, Lutz S, Suormala T, Fowler B, Pietrancosta N, Gasnier B, Bornhauser B, Froese DS, Baumgartner MR
The Journal of biological chemistry292(28)11980-11991(2017 07)

Translocation of the ABC transporter ABCD4 from the endoplasmic reticulum to lysosomes requires the escort protein LMBD1.
Kawaguchi K, Okamoto T, Morita M, Imanaka T
Scientific reports630183(2016 Jul)

Purification and interaction analyses of two human lysosomal vitamin B12 transporters: LMBD1 and ABCD4.
Deme JC, Hancock MA, Xia X, Shintre CA, Plesa M, Kim JC, Carpenter EP, Rosenblatt DS, Coulton JW
Molecular membrane biology31(7-8)250-61(2014 Nov-Dec)

LMBD1 protein serves as a specific adaptor for insulin receptor internalization.
Tseng LT, Lin CL, Tzen KY, Chang SC, Chang MF
The Journal of biological chemistry288(45)32424-32(2013 Nov)

Nuclear export signal-interacting protein forms complexes with lamin A/C-Nups to mediate the CRM1-independent nuclear export of large hepatitis delta antigen.
Huang C, Jiang JY, Chang SC, Tsay YG, Chen MR, Chang MF
Journal of virology87(3)1596-604(2013 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that ABCD4 lysosomal targeting depends on co-expression of and interaction with LMBRD1; mutations in LMBRD1 and ABCD4 that result in cobalamin metabolism disorders cblF and cblJ (or mutations in ATPase domain) disrupt interactions between LMBRD1 and ABCD4. (LMBRD1 = nuclear export signal-interacting protein; ABCD4 = ATP-binding cassette, sub-family D (ALD), member 4)
Title: Clinical or ATPase domain mutations in ABCD4 disrupt the interaction between the vitamin B

Results propose a model whereby membrane-bound LMBD1 and ABCD4 facilitate the vectorial delivery of lysosomal vitamin B12 to cytoplasmic MMACHC.
Title: Purification and interaction analyses of two human lysosomal vitamin B12 transporters: LMBD1 and ABCD4.

LMBD1 plays an imperative role in mediating and regulating the endocytosis of the IR.
Title: LMBD1 protein serves as a specific adaptor for insulin receptor internalization.

These data indicate that by forming complexes with lamin A/C and nucleoporins, NESI facilitates the CRM1-independent nuclear export of large hepatitis delta antigen.
Title: Nuclear export signal-interacting protein forms complexes with lamin A/C-Nups to mediate the CRM1-independent nuclear export of large hepatitis delta antigen.

novel mutations in LMBRD1 in three patients
Title: Novel splice site mutations and a large deletion in three patients with the cblF inborn error of vitamin B12 metabolism.

The following LMBRD1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LMBRD1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22026	NM_018368.4 Latest version!	Homo sapiens LMBR1 domain containing 1 (LMBRD1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu69762	NM_001363722.2 Latest version!	Homo sapiens LMBR1 domain containing 1 (LMBRD1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu69762	NM_001367272.1 Latest version!	Homo sapiens LMBR1 domain containing 1 (LMBRD1), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu69762	NM_001367271.1 Latest version!	Homo sapiens LMBR1 domain containing 1 (LMBRD1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu69762	XM_011535941.1 Latest version!	Homo sapiens LMBR1 domain containing 1 (LMBRD1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
View Old Accession Versions >>
OHu22026	NM_018368.3	Homo sapiens LMBR1 domain containing 1 (LMBRD1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LMBRD1 ( NM_018368.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_060838.3 Homo sapiens LMBR1 domain containing 1 (LMBRD1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22026
Clone ID Related Accession (Same CDS sequence)	NM_018368.4 , NM_018368.3
Accession Version	NM_018368.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1623bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-06
Organism	Homo sapiens(human)
Product	probable lysosomal cobalamin transporter isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA028310.1, BC047073.1, AL583831.6, BJ995961.1 and AL358133.11. This sequence is a reference standard in the RefSeqGene project. On Nov 15, 2018 this sequence version replaced NM_018368.3. Transcript Variant: This variant (1) encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.26697.1, SRR1660803.118843.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000649934.3/ ENSP00000497690.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGACTT CTGGCGCGGC CTCGGCGGAG CTGGTGATCG GCTGGTGCAT ATTCGGCCTC 
TTACTACTGG CTATTTTGGC ATTCTGCTGG ATATATGTTC GTAAATACCA AAGTCGGCGG 
GAAAGTGAAG TTGTCTCCAC CATAACAGCA ATTTTTTCTC TAGCAATTGC ACTTATCACA 
TCAGCACTTC TACCAGTGGA TATATTTTTG GTTTCTTACA TGAAAAATCA AAATGGTACA 
TTTAAGGACT GGGCTAATGC TAATGTCAGC AGACAGATTG AGGACACTGT ATTATACGGT 
TACTATACTT TATATTCTGT TATATTGTTC TGTGTGTTCT TCTGGATCCC TTTTGTCTAC 
TTCTATTATG AAGAAAAGGA TGATGATGAT ACTAGTAAAT GTACTCAAAT TAAAACGGCA 
CTCAAGTATA CTTTGGGATT TGTTGTGATT TGTGCACTGC TTCTTTTAGT TGGTGCCTTT 
GTTCCATTGA ATGTTCCCAA TAACAAAAAT TCTACAGAGT GGGAAAAAGT GAAGTCCCTA 
TTTGAAGAAC TTGGAAGTAG TCATGGTTTA GCTGCATTGT CATTTTCTAT CAGTTCTCTG 
ACCTTGATTG GAATGTTGGC AGCTATAACT TACACAGCCT ATGGCATGTC TGCGTTACCT 
TTAAATCTGA TAAAAGGCAC TAGAAGCGCT GCTTATGAAC GTTTGGAAAA CACTGAAGAC 
ATTGAAGAAG TAGAACAACA CATTCAAACG ATTAAATCAA AAAGCAAAGA TGGTCGACCT 
TTGCCAGCAA GGGATAAACG CGCCTTAAAA CAATTTGAAG AAAGGTTACG AACACTTAAG 
AAGAGAGAGA GGCATTTAGA ATTCATTGAA AACAGCTGGT GGACAAAATT TTGTGGCGCT 
CTGCGTCCCC TGAAGATCGT CTGGGGAATA TTTTTCATCT TAGTTGCATT GCTGTTTGTA 
ATTTCTCTCT TCTTGTCAAA TTTAGATAAA GCTCTTCATT CAGCTGGAAT AGATTCTGGT 
TTCATAATTT TTGGAGCTAA CCTGAGTAAT CCACTGAATA TGCTTTTGCC TTTACTACAA 
ACAGTTTTCC CTCTTGATTA TATTCTTATA ACAATTATTA TTATGTACTT TATTTTTACT 
TCAATGGCAG GAATTCGAAA TATTGGCATA TGGTTCTTTT GGATTAGATT ATATAAAATC 
AGAAGAGGTA GAACCAGGCC CCAAGCACTC CTTTTTCTCT GCATGATACT TCTGCTTATT 
GTCCTTCACA CTAGCTACAT GATTTATAGT CTTGCTCCCC AATATGTTAT GTATGGAAGC 
CAAAATTACT TAATAGAGAC TAATATAACT TCTGATAATC ATAAAGGCAA TTCAACCCTT 
TCTGTGCCAA AGAGATGTGA TGCAGATGCT CCTGAAGATC AGTGTACTGT TACCCGGACA 
TACCTATTCC TTCACAAGTT CTGGTTCTTC AGTGCTGCTT ACTATTTTGG TAACTGGGCC 
TTTCTTGGGG TATTTTTGAT TGGATTAATT GTATCCTGTT GTAAAGGGAA GAAATCGGTT 
ATTGAAGGAG TAGATGAAGA TTCAGACATA AGTGATGATG AGCCCTCTGT CTATTCTGCT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060838.3
CDS	130..1752
Translation	MATSGAASAELVIGWCIFGLLLLAILAFCWIYVRKYQSRRESEVVSTITAIFSLAIALITSALLPVDIFLVSYMKNQNGTFKDWANANVSRQIEDTVLYGYYTLYSVILFCVFFWIPFVYFYYEEKDDDDTSKCTQIKTALKYTLGFVVICALLLLVGAFVPLNVPNNKNSTEWEKVKSLFEELGSSHGLAALSFSISSLTLIGMLAAITYTAYGMSALPLNLIKGTRSAAYERLENTEDIEEVEQHIQTIKSKSKDGRPLPARDKRALKQFEERLRTLKKRERHLEFIENSWWTKFCGALRPLKIVWGIFFILVALLFVISLFLSNLDKALHSAGIDSGFIIFGANLSNPLNMLLPLLQTVFPLDYILITIIIMYFIFTSMAGIRNIGIWFFWIRLYKIRRGRTRPQALLFLCMILLLIVLHTSYMIYSLAPQYVMYGSQNYLIETNITSDNHKGNSTLSVPKRCDADAPEDQCTVTRTYLFLHKFWFFSAAYYFGNWAFLGVFLIGLIVSCCKGKKSVIEGVDEDSDISDDEPSVYSA

Target ORF information:

RefSeq Version	NM_018368.4
Organism	Homo sapiens(human)
Definition	Homo sapiens LMBR1 domain containing 1 (LMBRD1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018368.4

ORF Insert Sequence:

ATGGCGACTT CTGGCGCGGC CTCGGCGGAG CTGGTGATCG GCTGGTGCAT ATTCGGCCTC 
TTACTACTGG CTATTTTGGC ATTCTGCTGG ATATATGTTC GTAAATACCA AAGTCGGCGG 
GAAAGTGAAG TTGTCTCCAC CATAACAGCA ATTTTTTCTC TAGCAATTGC ACTTATCACA 
TCAGCACTTC TACCAGTGGA TATATTTTTG GTTTCTTACA TGAAAAATCA AAATGGTACA 
TTTAAGGACT GGGCTAATGC TAATGTCAGC AGACAGATTG AGGACACTGT ATTATACGGT 
TACTATACTT TATATTCTGT TATATTGTTC TGTGTGTTCT TCTGGATCCC TTTTGTCTAC 
TTCTATTATG AAGAAAAGGA TGATGATGAT ACTAGTAAAT GTACTCAAAT TAAAACGGCA 
CTCAAGTATA CTTTGGGATT TGTTGTGATT TGTGCACTGC TTCTTTTAGT TGGTGCCTTT 
GTTCCATTGA ATGTTCCCAA TAACAAAAAT TCTACAGAGT GGGAAAAAGT GAAGTCCCTA 
TTTGAAGAAC TTGGAAGTAG TCATGGTTTA GCTGCATTGT CATTTTCTAT CAGTTCTCTG 
ACCTTGATTG GAATGTTGGC AGCTATAACT TACACAGCCT ATGGCATGTC TGCGTTACCT 
TTAAATCTGA TAAAAGGCAC TAGAAGCGCT GCTTATGAAC GTTTGGAAAA CACTGAAGAC 
ATTGAAGAAG TAGAACAACA CATTCAAACG ATTAAATCAA AAAGCAAAGA TGGTCGACCT 
TTGCCAGCAA GGGATAAACG CGCCTTAAAA CAATTTGAAG AAAGGTTACG AACACTTAAG 
AAGAGAGAGA GGCATTTAGA ATTCATTGAA AACAGCTGGT GGACAAAATT TTGTGGCGCT 
CTGCGTCCCC TGAAGATCGT CTGGGGAATA TTTTTCATCT TAGTTGCATT GCTGTTTGTA 
ATTTCTCTCT TCTTGTCAAA TTTAGATAAA GCTCTTCATT CAGCTGGAAT AGATTCTGGT 
TTCATAATTT TTGGAGCTAA CCTGAGTAAT CCACTGAATA TGCTTTTGCC TTTACTACAA 
ACAGTTTTCC CTCTTGATTA TATTCTTATA ACAATTATTA TTATGTACTT TATTTTTACT 
TCAATGGCAG GAATTCGAAA TATTGGCATA TGGTTCTTTT GGATTAGATT ATATAAAATC 
AGAAGAGGTA GAACCAGGCC CCAAGCACTC CTTTTTCTCT GCATGATACT TCTGCTTATT 
GTCCTTCACA CTAGCTACAT GATTTATAGT CTTGCTCCCC AATATGTTAT GTATGGAAGC 
CAAAATTACT TAATAGAGAC TAATATAACT TCTGATAATC ATAAAGGCAA TTCAACCCTT 
TCTGTGCCAA AGAGATGTGA TGCAGATGCT CCTGAAGATC AGTGTACTGT TACCCGGACA 
TACCTATTCC TTCACAAGTT CTGGTTCTTC AGTGCTGCTT ACTATTTTGG TAACTGGGCC 
TTTCTTGGGG TATTTTTGAT TGGATTAATT GTATCCTGTT GTAAAGGGAA GAAATCGGTT 
ATTGAAGGAG TAGATGAAGA TTCAGACATA AGTGATGATG AGCCCTCTGT CTATTCTGCT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LMBRD1 ( NM_018368.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_060838.3 Homo sapiens LMBR1 domain containing 1 (LMBRD1), mRNA.

Price & Availability↑

CloneID	OHu22026
Clone ID Related Accession (Same CDS sequence)	NM_018368.4 , NM_018368.3
Accession Version	NM_018368.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1623bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	probable lysosomal cobalamin transporter
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA028310.1, BC047073.1, AL583831.6 and BJ995961.1. This sequence is a reference standard in the RefSeqGene project. On Oct 23, 2009 this sequence version replaced NM_018368.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.91597.1, SRR1660803.192858.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGACTT CTGGCGCGGC CTCGGCGGAG CTGGTGATCG GCTGGTGCAT ATTCGGCCTC 
TTACTACTGG CTATTTTGGC ATTCTGCTGG ATATATGTTC GTAAATACCA AAGTCGGCGG 
GAAAGTGAAG TTGTCTCCAC CATAACAGCA ATTTTTTCTC TAGCAATTGC ACTTATCACA 
TCAGCACTTC TACCAGTGGA TATATTTTTG GTTTCTTACA TGAAAAATCA AAATGGTACA 
TTTAAGGACT GGGCTAATGC TAATGTCAGC AGACAGATTG AGGACACTGT ATTATACGGT 
TACTATACTT TATATTCTGT TATATTGTTC TGTGTGTTCT TCTGGATCCC TTTTGTCTAC 
TTCTATTATG AAGAAAAGGA TGATGATGAT ACTAGTAAAT GTACTCAAAT TAAAACGGCA 
CTCAAGTATA CTTTGGGATT TGTTGTGATT TGTGCACTGC TTCTTTTAGT TGGTGCCTTT 
GTTCCATTGA ATGTTCCCAA TAACAAAAAT TCTACAGAGT GGGAAAAAGT GAAGTCCCTA 
TTTGAAGAAC TTGGAAGTAG TCATGGTTTA GCTGCATTGT CATTTTCTAT CAGTTCTCTG 
ACCTTGATTG GAATGTTGGC AGCTATAACT TACACAGCCT ATGGCATGTC TGCGTTACCT 
TTAAATCTGA TAAAAGGCAC TAGAAGCGCT GCTTATGAAC GTTTGGAAAA CACTGAAGAC 
ATTGAAGAAG TAGAACAACA CATTCAAACG ATTAAATCAA AAAGCAAAGA TGGTCGACCT 
TTGCCAGCAA GGGATAAACG CGCCTTAAAA CAATTTGAAG AAAGGTTACG AACACTTAAG 
AAGAGAGAGA GGCATTTAGA ATTCATTGAA AACAGCTGGT GGACAAAATT TTGTGGCGCT 
CTGCGTCCCC TGAAGATCGT CTGGGGAATA TTTTTCATCT TAGTTGCATT GCTGTTTGTA 
ATTTCTCTCT TCTTGTCAAA TTTAGATAAA GCTCTTCATT CAGCTGGAAT AGATTCTGGT 
TTCATAATTT TTGGAGCTAA CCTGAGTAAT CCACTGAATA TGCTTTTGCC TTTACTACAA 
ACAGTTTTCC CTCTTGATTA TATTCTTATA ACAATTATTA TTATGTACTT TATTTTTACT 
TCAATGGCAG GAATTCGAAA TATTGGCATA TGGTTCTTTT GGATTAGATT ATATAAAATC 
AGAAGAGGTA GAACCAGGCC CCAAGCACTC CTTTTTCTCT GCATGATACT TCTGCTTATT 
GTCCTTCACA CTAGCTACAT GATTTATAGT CTTGCTCCCC AATATGTTAT GTATGGAAGC 
CAAAATTACT TAATAGAGAC TAATATAACT TCTGATAATC ATAAAGGCAA TTCAACCCTT 
TCTGTGCCAA AGAGATGTGA TGCAGATGCT CCTGAAGATC AGTGTACTGT TACCCGGACA 
TACCTATTCC TTCACAAGTT CTGGTTCTTC AGTGCTGCTT ACTATTTTGG TAACTGGGCC 
TTTCTTGGGG TATTTTTGAT TGGATTAATT GTATCCTGTT GTAAAGGGAA GAAATCGGTT 
ATTGAAGGAG TAGATGAAGA TTCAGACATA AGTGATGATG AGCCCTCTGT CTATTCTGCT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060838.3
CDS	277..1899
Translation	MATSGAASAELVIGWCIFGLLLLAILAFCWIYVRKYQSRRESEVVSTITAIFSLAIALITSALLPVDIFLVSYMKNQNGTFKDWANANVSRQIEDTVLYGYYTLYSVILFCVFFWIPFVYFYYEEKDDDDTSKCTQIKTALKYTLGFVVICALLLLVGAFVPLNVPNNKNSTEWEKVKSLFEELGSSHGLAALSFSISSLTLIGMLAAITYTAYGMSALPLNLIKGTRSAAYERLENTEDIEEVEQHIQTIKSKSKDGRPLPARDKRALKQFEERLRTLKKRERHLEFIENSWWTKFCGALRPLKIVWGIFFILVALLFVISLFLSNLDKALHSAGIDSGFIIFGANLSNPLNMLLPLLQTVFPLDYILITIIIMYFIFTSMAGIRNIGIWFFWIRLYKIRRGRTRPQALLFLCMILLLIVLHTSYMIYSLAPQYVMYGSQNYLIETNITSDNHKGNSTLSVPKRCDADAPEDQCTVTRTYLFLHKFWFFSAAYYFGNWAFLGVFLIGLIVSCCKGKKSVIEGVDEDSDISDDEPSVYSA

Target ORF information:

RefSeq Version	NM_018368.3
Organism	Homo sapiens(human)
Definition	Homo sapiens LMBR1 domain containing 1 (LMBRD1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018368.3

ORF Insert Sequence:

ATGGCGACTT CTGGCGCGGC CTCGGCGGAG CTGGTGATCG GCTGGTGCAT ATTCGGCCTC 
TTACTACTGG CTATTTTGGC ATTCTGCTGG ATATATGTTC GTAAATACCA AAGTCGGCGG 
GAAAGTGAAG TTGTCTCCAC CATAACAGCA ATTTTTTCTC TAGCAATTGC ACTTATCACA 
TCAGCACTTC TACCAGTGGA TATATTTTTG GTTTCTTACA TGAAAAATCA AAATGGTACA 
TTTAAGGACT GGGCTAATGC TAATGTCAGC AGACAGATTG AGGACACTGT ATTATACGGT 
TACTATACTT TATATTCTGT TATATTGTTC TGTGTGTTCT TCTGGATCCC TTTTGTCTAC 
TTCTATTATG AAGAAAAGGA TGATGATGAT ACTAGTAAAT GTACTCAAAT TAAAACGGCA 
CTCAAGTATA CTTTGGGATT TGTTGTGATT TGTGCACTGC TTCTTTTAGT TGGTGCCTTT 
GTTCCATTGA ATGTTCCCAA TAACAAAAAT TCTACAGAGT GGGAAAAAGT GAAGTCCCTA 
TTTGAAGAAC TTGGAAGTAG TCATGGTTTA GCTGCATTGT CATTTTCTAT CAGTTCTCTG 
ACCTTGATTG GAATGTTGGC AGCTATAACT TACACAGCCT ATGGCATGTC TGCGTTACCT 
TTAAATCTGA TAAAAGGCAC TAGAAGCGCT GCTTATGAAC GTTTGGAAAA CACTGAAGAC 
ATTGAAGAAG TAGAACAACA CATTCAAACG ATTAAATCAA AAAGCAAAGA TGGTCGACCT 
TTGCCAGCAA GGGATAAACG CGCCTTAAAA CAATTTGAAG AAAGGTTACG AACACTTAAG 
AAGAGAGAGA GGCATTTAGA ATTCATTGAA AACAGCTGGT GGACAAAATT TTGTGGCGCT 
CTGCGTCCCC TGAAGATCGT CTGGGGAATA TTTTTCATCT TAGTTGCATT GCTGTTTGTA 
ATTTCTCTCT TCTTGTCAAA TTTAGATAAA GCTCTTCATT CAGCTGGAAT AGATTCTGGT 
TTCATAATTT TTGGAGCTAA CCTGAGTAAT CCACTGAATA TGCTTTTGCC TTTACTACAA 
ACAGTTTTCC CTCTTGATTA TATTCTTATA ACAATTATTA TTATGTACTT TATTTTTACT 
TCAATGGCAG GAATTCGAAA TATTGGCATA TGGTTCTTTT GGATTAGATT ATATAAAATC 
AGAAGAGGTA GAACCAGGCC CCAAGCACTC CTTTTTCTCT GCATGATACT TCTGCTTATT 
GTCCTTCACA CTAGCTACAT GATTTATAGT CTTGCTCCCC AATATGTTAT GTATGGAAGC 
CAAAATTACT TAATAGAGAC TAATATAACT TCTGATAATC ATAAAGGCAA TTCAACCCTT 
TCTGTGCCAA AGAGATGTGA TGCAGATGCT CCTGAAGATC AGTGTACTGT TACCCGGACA 
TACCTATTCC TTCACAAGTT CTGGTTCTTC AGTGCTGCTT ACTATTTTGG TAACTGGGCC 
TTTCTTGGGG TATTTTTGAT TGGATTAATT GTATCCTGTT GTAAAGGGAA GAAATCGGTT 
ATTGAAGGAG TAGATGAAGA TTCAGACATA AGTGATGATG AGCCCTCTGT CTATTCTGCT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LMBRD1 ( NM_001367271.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001354200.1 Homo sapiens LMBR1 domain containing 1 (LMBRD1), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu69762
Clone ID Related Accession (Same CDS sequence)	NM_001367271.1 , NM_001363722.2 , XM_011535941.1 , NM_001367272.1
Accession Version	NM_001367271.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1404bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-06
Organism	Homo sapiens(human)
Product	probable lysosomal cobalamin transporter isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL590702.17, AL583831.6 and AL358133.11. On Nov 15, 2018 this sequence version replaced XM_011535941.1. Transcript Variant: This variant (3) differs in the 5' structure, resulting in the use of a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2, 3 and 4 encode the same isoform. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.10526.1, SRR1660805.137858.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGAAAAATC AAAATGGTAC ATTTAAGGAC TGGGCTAATG CTAATGTCAG CAGACAGATT 
GAGGACACTG TATTATACGG TTACTATACT TTATATTCTG TTATATTGTT CTGTGTGTTC 
TTCTGGATCC CTTTTGTCTA CTTCTATTAT GAAGAAAAGG ATGATGATGA TACTAGTAAA 
TGTACTCAAA TTAAAACGGC ACTCAAGTAT ACTTTGGGAT TTGTTGTGAT TTGTGCACTG 
CTTCTTTTAG TTGGTGCCTT TGTTCCATTG AATGTTCCCA ATAACAAAAA TTCTACAGAG 
TGGGAAAAAG TGAAGTCCCT ATTTGAAGAA CTTGGAAGTA GTCATGGTTT AGCTGCATTG 
TCATTTTCTA TCAGTTCTCT GACCTTGATT GGAATGTTGG CAGCTATAAC TTACACAGCC 
TATGGCATGT CTGCGTTACC TTTAAATCTG ATAAAAGGCA CTAGAAGCGC TGCTTATGAA 
CGTTTGGAAA ACACTGAAGA CATTGAAGAA GTAGAACAAC ACATTCAAAC GATTAAATCA 
AAAAGCAAAG ATGGTCGACC TTTGCCAGCA AGGGATAAAC GCGCCTTAAA ACAATTTGAA 
GAAAGGTTAC GAACACTTAA GAAGAGAGAG AGGCATTTAG AATTCATTGA AAACAGCTGG 
TGGACAAAAT TTTGTGGCGC TCTGCGTCCC CTGAAGATCG TCTGGGGAAT ATTTTTCATC 
TTAGTTGCAT TGCTGTTTGT AATTTCTCTC TTCTTGTCAA ATTTAGATAA AGCTCTTCAT 
TCAGCTGGAA TAGATTCTGG TTTCATAATT TTTGGAGCTA ACCTGAGTAA TCCACTGAAT 
ATGCTTTTGC CTTTACTACA AACAGTTTTC CCTCTTGATT ATATTCTTAT AACAATTATT 
ATTATGTACT TTATTTTTAC TTCAATGGCA GGAATTCGAA ATATTGGCAT ATGGTTCTTT 
TGGATTAGAT TATATAAAAT CAGAAGAGGT AGAACCAGGC CCCAAGCACT CCTTTTTCTC 
TGCATGATAC TTCTGCTTAT TGTCCTTCAC ACTAGCTACA TGATTTATAG TCTTGCTCCC 
CAATATGTTA TGTATGGAAG CCAAAATTAC TTAATAGAGA CTAATATAAC TTCTGATAAT 
CATAAAGGCA ATTCAACCCT TTCTGTGCCA AAGAGATGTG ATGCAGATGC TCCTGAAGAT 
CAGTGTACTG TTACCCGGAC ATACCTATTC CTTCACAAGT TCTGGTTCTT CAGTGCTGCT 
TACTATTTTG GTAACTGGGC CTTTCTTGGG GTATTTTTGA TTGGATTAAT TGTATCCTGT 
TGTAAAGGGA AGAAATCGGT TATTGAAGGA GTAGATGAAG ATTCAGACAT AAGTGATGAT 
GAGCCCTCTG TCTATTCTGC TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001354200.1
CDS	347..1750
Translation	MKNQNGTFKDWANANVSRQIEDTVLYGYYTLYSVILFCVFFWIPFVYFYYEEKDDDDTSKCTQIKTALKYTLGFVVICALLLLVGAFVPLNVPNNKNSTEWEKVKSLFEELGSSHGLAALSFSISSLTLIGMLAAITYTAYGMSALPLNLIKGTRSAAYERLENTEDIEEVEQHIQTIKSKSKDGRPLPARDKRALKQFEERLRTLKKRERHLEFIENSWWTKFCGALRPLKIVWGIFFILVALLFVISLFLSNLDKALHSAGIDSGFIIFGANLSNPLNMLLPLLQTVFPLDYILITIIIMYFIFTSMAGIRNIGIWFFWIRLYKIRRGRTRPQALLFLCMILLLIVLHTSYMIYSLAPQYVMYGSQNYLIETNITSDNHKGNSTLSVPKRCDADAPEDQCTVTRTYLFLHKFWFFSAAYYFGNWAFLGVFLIGLIVSCCKGKKSVIEGVDEDSDISDDEPSVYSA

Target ORF information:

RefSeq Version	NM_001367271.1
Organism	Homo sapiens(human)
Definition	Homo sapiens LMBR1 domain containing 1 (LMBRD1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001367271.1

ORF Insert Sequence:

ATGAAAAATC AAAATGGTAC ATTTAAGGAC TGGGCTAATG CTAATGTCAG CAGACAGATT 
GAGGACACTG TATTATACGG TTACTATACT TTATATTCTG TTATATTGTT CTGTGTGTTC 
TTCTGGATCC CTTTTGTCTA CTTCTATTAT GAAGAAAAGG ATGATGATGA TACTAGTAAA 
TGTACTCAAA TTAAAACGGC ACTCAAGTAT ACTTTGGGAT TTGTTGTGAT TTGTGCACTG 
CTTCTTTTAG TTGGTGCCTT TGTTCCATTG AATGTTCCCA ATAACAAAAA TTCTACAGAG 
TGGGAAAAAG TGAAGTCCCT ATTTGAAGAA CTTGGAAGTA GTCATGGTTT AGCTGCATTG 
TCATTTTCTA TCAGTTCTCT GACCTTGATT GGAATGTTGG CAGCTATAAC TTACACAGCC 
TATGGCATGT CTGCGTTACC TTTAAATCTG ATAAAAGGCA CTAGAAGCGC TGCTTATGAA 
CGTTTGGAAA ACACTGAAGA CATTGAAGAA GTAGAACAAC ACATTCAAAC GATTAAATCA 
AAAAGCAAAG ATGGTCGACC TTTGCCAGCA AGGGATAAAC GCGCCTTAAA ACAATTTGAA 
GAAAGGTTAC GAACACTTAA GAAGAGAGAG AGGCATTTAG AATTCATTGA AAACAGCTGG 
TGGACAAAAT TTTGTGGCGC TCTGCGTCCC CTGAAGATCG TCTGGGGAAT ATTTTTCATC 
TTAGTTGCAT TGCTGTTTGT AATTTCTCTC TTCTTGTCAA ATTTAGATAA AGCTCTTCAT 
TCAGCTGGAA TAGATTCTGG TTTCATAATT TTTGGAGCTA ACCTGAGTAA TCCACTGAAT 
ATGCTTTTGC CTTTACTACA AACAGTTTTC CCTCTTGATT ATATTCTTAT AACAATTATT 
ATTATGTACT TTATTTTTAC TTCAATGGCA GGAATTCGAA ATATTGGCAT ATGGTTCTTT 
TGGATTAGAT TATATAAAAT CAGAAGAGGT AGAACCAGGC CCCAAGCACT CCTTTTTCTC 
TGCATGATAC TTCTGCTTAT TGTCCTTCAC ACTAGCTACA TGATTTATAG TCTTGCTCCC 
CAATATGTTA TGTATGGAAG CCAAAATTAC TTAATAGAGA CTAATATAAC TTCTGATAAT 
CATAAAGGCA ATTCAACCCT TTCTGTGCCA AAGAGATGTG ATGCAGATGC TCCTGAAGAT 
CAGTGTACTG TTACCCGGAC ATACCTATTC CTTCACAAGT TCTGGTTCTT CAGTGCTGCT 
TACTATTTTG GTAACTGGGC CTTTCTTGGG GTATTTTTGA TTGGATTAAT TGTATCCTGT 
TGTAAAGGGA AGAAATCGGT TATTGAAGGA GTAGATGAAG ATTCAGACAT AAGTGATGAT 
GAGCCCTCTG TCTATTCTGC TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LMBRD1 ( NM_001363722.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001350651.1 Homo sapiens LMBR1 domain containing 1 (LMBRD1), transcript variant 2, mRNA.

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CloneID	OHu69762
Clone ID Related Accession (Same CDS sequence)	NM_001367271.1 , NM_001363722.2 , XM_011535941.1 , NM_001367272.1
Accession Version	NM_001363722.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1404bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	probable lysosomal cobalamin transporter isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL590702.17, AL583831.6 and AL358133.11. On Nov 15, 2018 this sequence version replaced NM_001363722.1. Transcript Variant: This variant (2) differs in the 5' structure, resulting in the use of a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2, 3 and 4 encode the same isoform. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.173680.1, SRR1803611.220867.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAAAATC AAAATGGTAC ATTTAAGGAC TGGGCTAATG CTAATGTCAG CAGACAGATT 
GAGGACACTG TATTATACGG TTACTATACT TTATATTCTG TTATATTGTT CTGTGTGTTC 
TTCTGGATCC CTTTTGTCTA CTTCTATTAT GAAGAAAAGG ATGATGATGA TACTAGTAAA 
TGTACTCAAA TTAAAACGGC ACTCAAGTAT ACTTTGGGAT TTGTTGTGAT TTGTGCACTG 
CTTCTTTTAG TTGGTGCCTT TGTTCCATTG AATGTTCCCA ATAACAAAAA TTCTACAGAG 
TGGGAAAAAG TGAAGTCCCT ATTTGAAGAA CTTGGAAGTA GTCATGGTTT AGCTGCATTG 
TCATTTTCTA TCAGTTCTCT GACCTTGATT GGAATGTTGG CAGCTATAAC TTACACAGCC 
TATGGCATGT CTGCGTTACC TTTAAATCTG ATAAAAGGCA CTAGAAGCGC TGCTTATGAA 
CGTTTGGAAA ACACTGAAGA CATTGAAGAA GTAGAACAAC ACATTCAAAC GATTAAATCA 
AAAAGCAAAG ATGGTCGACC TTTGCCAGCA AGGGATAAAC GCGCCTTAAA ACAATTTGAA 
GAAAGGTTAC GAACACTTAA GAAGAGAGAG AGGCATTTAG AATTCATTGA AAACAGCTGG 
TGGACAAAAT TTTGTGGCGC TCTGCGTCCC CTGAAGATCG TCTGGGGAAT ATTTTTCATC 
TTAGTTGCAT TGCTGTTTGT AATTTCTCTC TTCTTGTCAA ATTTAGATAA AGCTCTTCAT 
TCAGCTGGAA TAGATTCTGG TTTCATAATT TTTGGAGCTA ACCTGAGTAA TCCACTGAAT 
ATGCTTTTGC CTTTACTACA AACAGTTTTC CCTCTTGATT ATATTCTTAT AACAATTATT 
ATTATGTACT TTATTTTTAC TTCAATGGCA GGAATTCGAA ATATTGGCAT ATGGTTCTTT 
TGGATTAGAT TATATAAAAT CAGAAGAGGT AGAACCAGGC CCCAAGCACT CCTTTTTCTC 
TGCATGATAC TTCTGCTTAT TGTCCTTCAC ACTAGCTACA TGATTTATAG TCTTGCTCCC 
CAATATGTTA TGTATGGAAG CCAAAATTAC TTAATAGAGA CTAATATAAC TTCTGATAAT 
CATAAAGGCA ATTCAACCCT TTCTGTGCCA AAGAGATGTG ATGCAGATGC TCCTGAAGAT 
CAGTGTACTG TTACCCGGAC ATACCTATTC CTTCACAAGT TCTGGTTCTT CAGTGCTGCT 
TACTATTTTG GTAACTGGGC CTTTCTTGGG GTATTTTTGA TTGGATTAAT TGTATCCTGT 
TGTAAAGGGA AGAAATCGGT TATTGAAGGA GTAGATGAAG ATTCAGACAT AAGTGATGAT 
GAGCCCTCTG TCTATTCTGC TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001350651.1
CDS	324..1727
Translation	MKNQNGTFKDWANANVSRQIEDTVLYGYYTLYSVILFCVFFWIPFVYFYYEEKDDDDTSKCTQIKTALKYTLGFVVICALLLLVGAFVPLNVPNNKNSTEWEKVKSLFEELGSSHGLAALSFSISSLTLIGMLAAITYTAYGMSALPLNLIKGTRSAAYERLENTEDIEEVEQHIQTIKSKSKDGRPLPARDKRALKQFEERLRTLKKRERHLEFIENSWWTKFCGALRPLKIVWGIFFILVALLFVISLFLSNLDKALHSAGIDSGFIIFGANLSNPLNMLLPLLQTVFPLDYILITIIIMYFIFTSMAGIRNIGIWFFWIRLYKIRRGRTRPQALLFLCMILLLIVLHTSYMIYSLAPQYVMYGSQNYLIETNITSDNHKGNSTLSVPKRCDADAPEDQCTVTRTYLFLHKFWFFSAAYYFGNWAFLGVFLIGLIVSCCKGKKSVIEGVDEDSDISDDEPSVYSA

Target ORF information:

RefSeq Version	NM_001363722.2
Organism	Homo sapiens(human)
Definition	Homo sapiens LMBR1 domain containing 1 (LMBRD1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001363722.2

ORF Insert Sequence:

ATGAAAAATC AAAATGGTAC ATTTAAGGAC TGGGCTAATG CTAATGTCAG CAGACAGATT 
GAGGACACTG TATTATACGG TTACTATACT TTATATTCTG TTATATTGTT CTGTGTGTTC 
TTCTGGATCC CTTTTGTCTA CTTCTATTAT GAAGAAAAGG ATGATGATGA TACTAGTAAA 
TGTACTCAAA TTAAAACGGC ACTCAAGTAT ACTTTGGGAT TTGTTGTGAT TTGTGCACTG 
CTTCTTTTAG TTGGTGCCTT TGTTCCATTG AATGTTCCCA ATAACAAAAA TTCTACAGAG 
TGGGAAAAAG TGAAGTCCCT ATTTGAAGAA CTTGGAAGTA GTCATGGTTT AGCTGCATTG 
TCATTTTCTA TCAGTTCTCT GACCTTGATT GGAATGTTGG CAGCTATAAC TTACACAGCC 
TATGGCATGT CTGCGTTACC TTTAAATCTG ATAAAAGGCA CTAGAAGCGC TGCTTATGAA 
CGTTTGGAAA ACACTGAAGA CATTGAAGAA GTAGAACAAC ACATTCAAAC GATTAAATCA 
AAAAGCAAAG ATGGTCGACC TTTGCCAGCA AGGGATAAAC GCGCCTTAAA ACAATTTGAA 
GAAAGGTTAC GAACACTTAA GAAGAGAGAG AGGCATTTAG AATTCATTGA AAACAGCTGG 
TGGACAAAAT TTTGTGGCGC TCTGCGTCCC CTGAAGATCG TCTGGGGAAT ATTTTTCATC 
TTAGTTGCAT TGCTGTTTGT AATTTCTCTC TTCTTGTCAA ATTTAGATAA AGCTCTTCAT 
TCAGCTGGAA TAGATTCTGG TTTCATAATT TTTGGAGCTA ACCTGAGTAA TCCACTGAAT 
ATGCTTTTGC CTTTACTACA AACAGTTTTC CCTCTTGATT ATATTCTTAT AACAATTATT 
ATTATGTACT TTATTTTTAC TTCAATGGCA GGAATTCGAA ATATTGGCAT ATGGTTCTTT 
TGGATTAGAT TATATAAAAT CAGAAGAGGT AGAACCAGGC CCCAAGCACT CCTTTTTCTC 
TGCATGATAC TTCTGCTTAT TGTCCTTCAC ACTAGCTACA TGATTTATAG TCTTGCTCCC 
CAATATGTTA TGTATGGAAG CCAAAATTAC TTAATAGAGA CTAATATAAC TTCTGATAAT 
CATAAAGGCA ATTCAACCCT TTCTGTGCCA AAGAGATGTG ATGCAGATGC TCCTGAAGAT 
CAGTGTACTG TTACCCGGAC ATACCTATTC CTTCACAAGT TCTGGTTCTT CAGTGCTGCT 
TACTATTTTG GTAACTGGGC CTTTCTTGGG GTATTTTTGA TTGGATTAAT TGTATCCTGT 
TGTAAAGGGA AGAAATCGGT TATTGAAGGA GTAGATGAAG ATTCAGACAT AAGTGATGAT 
GAGCCCTCTG TCTATTCTGC TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LMBRD1 ( NM_001367272.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001354201.1 Homo sapiens LMBR1 domain containing 1 (LMBRD1), transcript variant 4, mRNA.

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CloneID	OHu69762
Clone ID Related Accession (Same CDS sequence)	NM_001367271.1 , NM_001363722.2 , XM_011535941.1 , NM_001367272.1
Accession Version	NM_001367272.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1404bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-06
Organism	Homo sapiens(human)
Product	probable lysosomal cobalamin transporter isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK290069.1, AL590702.17 and AL358133.11. On Nov 15, 2018 this sequence version replaced XM_024446488.1. Transcript Variant: This variant (4) differs in the 5' structure, resulting in the use of a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2, 3 and 4 encode the same isoform. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.157130.1, SRR1803613.212231.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGAAAAATC AAAATGGTAC ATTTAAGGAC TGGGCTAATG CTAATGTCAG CAGACAGATT 
GAGGACACTG TATTATACGG TTACTATACT TTATATTCTG TTATATTGTT CTGTGTGTTC 
TTCTGGATCC CTTTTGTCTA CTTCTATTAT GAAGAAAAGG ATGATGATGA TACTAGTAAA 
TGTACTCAAA TTAAAACGGC ACTCAAGTAT ACTTTGGGAT TTGTTGTGAT TTGTGCACTG 
CTTCTTTTAG TTGGTGCCTT TGTTCCATTG AATGTTCCCA ATAACAAAAA TTCTACAGAG 
TGGGAAAAAG TGAAGTCCCT ATTTGAAGAA CTTGGAAGTA GTCATGGTTT AGCTGCATTG 
TCATTTTCTA TCAGTTCTCT GACCTTGATT GGAATGTTGG CAGCTATAAC TTACACAGCC 
TATGGCATGT CTGCGTTACC TTTAAATCTG ATAAAAGGCA CTAGAAGCGC TGCTTATGAA 
CGTTTGGAAA ACACTGAAGA CATTGAAGAA GTAGAACAAC ACATTCAAAC GATTAAATCA 
AAAAGCAAAG ATGGTCGACC TTTGCCAGCA AGGGATAAAC GCGCCTTAAA ACAATTTGAA 
GAAAGGTTAC GAACACTTAA GAAGAGAGAG AGGCATTTAG AATTCATTGA AAACAGCTGG 
TGGACAAAAT TTTGTGGCGC TCTGCGTCCC CTGAAGATCG TCTGGGGAAT ATTTTTCATC 
TTAGTTGCAT TGCTGTTTGT AATTTCTCTC TTCTTGTCAA ATTTAGATAA AGCTCTTCAT 
TCAGCTGGAA TAGATTCTGG TTTCATAATT TTTGGAGCTA ACCTGAGTAA TCCACTGAAT 
ATGCTTTTGC CTTTACTACA AACAGTTTTC CCTCTTGATT ATATTCTTAT AACAATTATT 
ATTATGTACT TTATTTTTAC TTCAATGGCA GGAATTCGAA ATATTGGCAT ATGGTTCTTT 
TGGATTAGAT TATATAAAAT CAGAAGAGGT AGAACCAGGC CCCAAGCACT CCTTTTTCTC 
TGCATGATAC TTCTGCTTAT TGTCCTTCAC ACTAGCTACA TGATTTATAG TCTTGCTCCC 
CAATATGTTA TGTATGGAAG CCAAAATTAC TTAATAGAGA CTAATATAAC TTCTGATAAT 
CATAAAGGCA ATTCAACCCT TTCTGTGCCA AAGAGATGTG ATGCAGATGC TCCTGAAGAT 
CAGTGTACTG TTACCCGGAC ATACCTATTC CTTCACAAGT TCTGGTTCTT CAGTGCTGCT 
TACTATTTTG GTAACTGGGC CTTTCTTGGG GTATTTTTGA TTGGATTAAT TGTATCCTGT 
TGTAAAGGGA AGAAATCGGT TATTGAAGGA GTAGATGAAG ATTCAGACAT AAGTGATGAT 
GAGCCCTCTG TCTATTCTGC TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001354201.1
CDS	343..1746
Translation	MKNQNGTFKDWANANVSRQIEDTVLYGYYTLYSVILFCVFFWIPFVYFYYEEKDDDDTSKCTQIKTALKYTLGFVVICALLLLVGAFVPLNVPNNKNSTEWEKVKSLFEELGSSHGLAALSFSISSLTLIGMLAAITYTAYGMSALPLNLIKGTRSAAYERLENTEDIEEVEQHIQTIKSKSKDGRPLPARDKRALKQFEERLRTLKKRERHLEFIENSWWTKFCGALRPLKIVWGIFFILVALLFVISLFLSNLDKALHSAGIDSGFIIFGANLSNPLNMLLPLLQTVFPLDYILITIIIMYFIFTSMAGIRNIGIWFFWIRLYKIRRGRTRPQALLFLCMILLLIVLHTSYMIYSLAPQYVMYGSQNYLIETNITSDNHKGNSTLSVPKRCDADAPEDQCTVTRTYLFLHKFWFFSAAYYFGNWAFLGVFLIGLIVSCCKGKKSVIEGVDEDSDISDDEPSVYSA

Target ORF information:

RefSeq Version	NM_001367272.1
Organism	Homo sapiens(human)
Definition	Homo sapiens LMBR1 domain containing 1 (LMBRD1), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001367272.1

ORF Insert Sequence:

ATGAAAAATC AAAATGGTAC ATTTAAGGAC TGGGCTAATG CTAATGTCAG CAGACAGATT 
GAGGACACTG TATTATACGG TTACTATACT TTATATTCTG TTATATTGTT CTGTGTGTTC 
TTCTGGATCC CTTTTGTCTA CTTCTATTAT GAAGAAAAGG ATGATGATGA TACTAGTAAA 
TGTACTCAAA TTAAAACGGC ACTCAAGTAT ACTTTGGGAT TTGTTGTGAT TTGTGCACTG 
CTTCTTTTAG TTGGTGCCTT TGTTCCATTG AATGTTCCCA ATAACAAAAA TTCTACAGAG 
TGGGAAAAAG TGAAGTCCCT ATTTGAAGAA CTTGGAAGTA GTCATGGTTT AGCTGCATTG 
TCATTTTCTA TCAGTTCTCT GACCTTGATT GGAATGTTGG CAGCTATAAC TTACACAGCC 
TATGGCATGT CTGCGTTACC TTTAAATCTG ATAAAAGGCA CTAGAAGCGC TGCTTATGAA 
CGTTTGGAAA ACACTGAAGA CATTGAAGAA GTAGAACAAC ACATTCAAAC GATTAAATCA 
AAAAGCAAAG ATGGTCGACC TTTGCCAGCA AGGGATAAAC GCGCCTTAAA ACAATTTGAA 
GAAAGGTTAC GAACACTTAA GAAGAGAGAG AGGCATTTAG AATTCATTGA AAACAGCTGG 
TGGACAAAAT TTTGTGGCGC TCTGCGTCCC CTGAAGATCG TCTGGGGAAT ATTTTTCATC 
TTAGTTGCAT TGCTGTTTGT AATTTCTCTC TTCTTGTCAA ATTTAGATAA AGCTCTTCAT 
TCAGCTGGAA TAGATTCTGG TTTCATAATT TTTGGAGCTA ACCTGAGTAA TCCACTGAAT 
ATGCTTTTGC CTTTACTACA AACAGTTTTC CCTCTTGATT ATATTCTTAT AACAATTATT 
ATTATGTACT TTATTTTTAC TTCAATGGCA GGAATTCGAA ATATTGGCAT ATGGTTCTTT 
TGGATTAGAT TATATAAAAT CAGAAGAGGT AGAACCAGGC CCCAAGCACT CCTTTTTCTC 
TGCATGATAC TTCTGCTTAT TGTCCTTCAC ACTAGCTACA TGATTTATAG TCTTGCTCCC 
CAATATGTTA TGTATGGAAG CCAAAATTAC TTAATAGAGA CTAATATAAC TTCTGATAAT 
CATAAAGGCA ATTCAACCCT TTCTGTGCCA AAGAGATGTG ATGCAGATGC TCCTGAAGAT 
CAGTGTACTG TTACCCGGAC ATACCTATTC CTTCACAAGT TCTGGTTCTT CAGTGCTGCT 
TACTATTTTG GTAACTGGGC CTTTCTTGGG GTATTTTTGA TTGGATTAAT TGTATCCTGT 
TGTAAAGGGA AGAAATCGGT TATTGAAGGA GTAGATGAAG ATTCAGACAT AAGTGATGAT 
GAGCCCTCTG TCTATTCTGC TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LMBRD1 ( XM_011535941.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011534243.1 Homo sapiens LMBR1 domain containing 1 (LMBRD1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu69762
Clone ID Related Accession (Same CDS sequence)	NM_001367271.1 , NM_001363722.2 , XM_011535941.1 , NM_001367272.1
Accession Version	XM_011535941.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1404bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	probable lysosomal cobalamin transporter isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAAAATC AAAATGGTAC ATTTAAGGAC TGGGCTAATG CTAATGTCAG CAGACAGATT 
GAGGACACTG TATTATACGG TTACTATACT TTATATTCTG TTATATTGTT CTGTGTGTTC 
TTCTGGATCC CTTTTGTCTA CTTCTATTAT GAAGAAAAGG ATGATGATGA TACTAGTAAA 
TGTACTCAAA TTAAAACGGC ACTCAAGTAT ACTTTGGGAT TTGTTGTGAT TTGTGCACTG 
CTTCTTTTAG TTGGTGCCTT TGTTCCATTG AATGTTCCCA ATAACAAAAA TTCTACAGAG 
TGGGAAAAAG TGAAGTCCCT ATTTGAAGAA CTTGGAAGTA GTCATGGTTT AGCTGCATTG 
TCATTTTCTA TCAGTTCTCT GACCTTGATT GGAATGTTGG CAGCTATAAC TTACACAGCC 
TATGGCATGT CTGCGTTACC TTTAAATCTG ATAAAAGGCA CTAGAAGCGC TGCTTATGAA 
CGTTTGGAAA ACACTGAAGA CATTGAAGAA GTAGAACAAC ACATTCAAAC GATTAAATCA 
AAAAGCAAAG ATGGTCGACC TTTGCCAGCA AGGGATAAAC GCGCCTTAAA ACAATTTGAA 
GAAAGGTTAC GAACACTTAA GAAGAGAGAG AGGCATTTAG AATTCATTGA AAACAGCTGG 
TGGACAAAAT TTTGTGGCGC TCTGCGTCCC CTGAAGATCG TCTGGGGAAT ATTTTTCATC 
TTAGTTGCAT TGCTGTTTGT AATTTCTCTC TTCTTGTCAA ATTTAGATAA AGCTCTTCAT 
TCAGCTGGAA TAGATTCTGG TTTCATAATT TTTGGAGCTA ACCTGAGTAA TCCACTGAAT 
ATGCTTTTGC CTTTACTACA AACAGTTTTC CCTCTTGATT ATATTCTTAT AACAATTATT 
ATTATGTACT TTATTTTTAC TTCAATGGCA GGAATTCGAA ATATTGGCAT ATGGTTCTTT 
TGGATTAGAT TATATAAAAT CAGAAGAGGT AGAACCAGGC CCCAAGCACT CCTTTTTCTC 
TGCATGATAC TTCTGCTTAT TGTCCTTCAC ACTAGCTACA TGATTTATAG TCTTGCTCCC 
CAATATGTTA TGTATGGAAG CCAAAATTAC TTAATAGAGA CTAATATAAC TTCTGATAAT 
CATAAAGGCA ATTCAACCCT TTCTGTGCCA AAGAGATGTG ATGCAGATGC TCCTGAAGAT 
CAGTGTACTG TTACCCGGAC ATACCTATTC CTTCACAAGT TCTGGTTCTT CAGTGCTGCT 
TACTATTTTG GTAACTGGGC CTTTCTTGGG GTATTTTTGA TTGGATTAAT TGTATCCTGT 
TGTAAAGGGA AGAAATCGGT TATTGAAGGA GTAGATGAAG ATTCAGACAT AAGTGATGAT 
GAGCCCTCTG TCTATTCTGC TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011534243.1
CDS	346..1749
Translation	MKNQNGTFKDWANANVSRQIEDTVLYGYYTLYSVILFCVFFWIPFVYFYYEEKDDDDTSKCTQIKTALKYTLGFVVICALLLLVGAFVPLNVPNNKNSTEWEKVKSLFEELGSSHGLAALSFSISSLTLIGMLAAITYTAYGMSALPLNLIKGTRSAAYERLENTEDIEEVEQHIQTIKSKSKDGRPLPARDKRALKQFEERLRTLKKRERHLEFIENSWWTKFCGALRPLKIVWGIFFILVALLFVISLFLSNLDKALHSAGIDSGFIIFGANLSNPLNMLLPLLQTVFPLDYILITIIIMYFIFTSMAGIRNIGIWFFWIRLYKIRRGRTRPQALLFLCMILLLIVLHTSYMIYSLAPQYVMYGSQNYLIETNITSDNHKGNSTLSVPKRCDADAPEDQCTVTRTYLFLHKFWFFSAAYYFGNWAFLGVFLIGLIVSCCKGKKSVIEGVDEDSDISDDEPSVYSA

Target ORF information:

RefSeq Version	XM_011535941.1
Organism	Homo sapiens(human)
Definition	Homo sapiens LMBR1 domain containing 1 (LMBRD1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011535941.1

ORF Insert Sequence:

ATGAAAAATC AAAATGGTAC ATTTAAGGAC TGGGCTAATG CTAATGTCAG CAGACAGATT 
GAGGACACTG TATTATACGG TTACTATACT TTATATTCTG TTATATTGTT CTGTGTGTTC 
TTCTGGATCC CTTTTGTCTA CTTCTATTAT GAAGAAAAGG ATGATGATGA TACTAGTAAA 
TGTACTCAAA TTAAAACGGC ACTCAAGTAT ACTTTGGGAT TTGTTGTGAT TTGTGCACTG 
CTTCTTTTAG TTGGTGCCTT TGTTCCATTG AATGTTCCCA ATAACAAAAA TTCTACAGAG 
TGGGAAAAAG TGAAGTCCCT ATTTGAAGAA CTTGGAAGTA GTCATGGTTT AGCTGCATTG 
TCATTTTCTA TCAGTTCTCT GACCTTGATT GGAATGTTGG CAGCTATAAC TTACACAGCC 
TATGGCATGT CTGCGTTACC TTTAAATCTG ATAAAAGGCA CTAGAAGCGC TGCTTATGAA 
CGTTTGGAAA ACACTGAAGA CATTGAAGAA GTAGAACAAC ACATTCAAAC GATTAAATCA 
AAAAGCAAAG ATGGTCGACC TTTGCCAGCA AGGGATAAAC GCGCCTTAAA ACAATTTGAA 
GAAAGGTTAC GAACACTTAA GAAGAGAGAG AGGCATTTAG AATTCATTGA AAACAGCTGG 
TGGACAAAAT TTTGTGGCGC TCTGCGTCCC CTGAAGATCG TCTGGGGAAT ATTTTTCATC 
TTAGTTGCAT TGCTGTTTGT AATTTCTCTC TTCTTGTCAA ATTTAGATAA AGCTCTTCAT 
TCAGCTGGAA TAGATTCTGG TTTCATAATT TTTGGAGCTA ACCTGAGTAA TCCACTGAAT 
ATGCTTTTGC CTTTACTACA AACAGTTTTC CCTCTTGATT ATATTCTTAT AACAATTATT 
ATTATGTACT TTATTTTTAC TTCAATGGCA GGAATTCGAA ATATTGGCAT ATGGTTCTTT 
TGGATTAGAT TATATAAAAT CAGAAGAGGT AGAACCAGGC CCCAAGCACT CCTTTTTCTC 
TGCATGATAC TTCTGCTTAT TGTCCTTCAC ACTAGCTACA TGATTTATAG TCTTGCTCCC 
CAATATGTTA TGTATGGAAG CCAAAATTAC TTAATAGAGA CTAATATAAC TTCTGATAAT 
CATAAAGGCA ATTCAACCCT TTCTGTGCCA AAGAGATGTG ATGCAGATGC TCCTGAAGAT 
CAGTGTACTG TTACCCGGAC ATACCTATTC CTTCACAAGT TCTGGTTCTT CAGTGCTGCT 
TACTATTTTG GTAACTGGGC CTTTCTTGGG GTATTTTTGA TTGGATTAAT TGTATCCTGT 
TGTAAAGGGA AGAAATCGGT TATTGAAGGA GTAGATGAAG ATTCAGACAT AAGTGATGAT 
GAGCCCTCTG TCTATTCTGC TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Clinical or ATPase domain mutations in ABCD4 disrupt the interaction between the vitamin B
The Journal of biological chemistry292(28)11980-11991(2017 07)
Fettelschoss V,Burda P,Sagn? C,Coelho D,De Laet C,Lutz S,Suormala T,Fowler B,Pietrancosta N,Gasnier B,Bornhauser B,Froese DS,Baumgartner MR

Translocation of the ABC transporter ABCD4 from the endoplasmic reticulum to lysosomes requires the escort protein LMBD1.
Scientific reports630183(2016 Jul)
Kawaguchi K,Okamoto T,Morita M,Imanaka T

Purification and interaction analyses of two human lysosomal vitamin B12 transporters: LMBD1 and ABCD4.
Molecular membrane biology31(7-8)250-61(2014 Nov-Dec)
Deme JC,Hancock MA,Xia X,Shintre CA,Plesa M,Kim JC,Carpenter EP,Rosenblatt DS,Coulton JW

LMBD1 protein serves as a specific adaptor for insulin receptor internalization.
The Journal of biological chemistry288(45)32424-32(2013 Nov)
Tseng LT,Lin CL,Tzen KY,Chang SC,Chang MF

Nuclear export signal-interacting protein forms complexes with lamin A/C-Nups to mediate the CRM1-independent nuclear export of large hepatitis delta antigen.
Journal of virology87(3)1596-604(2013 Feb)
Huang C,Jiang JY,Chang SC,Tsay YG,Chen MR,Chang MF

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LMBRD1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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